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  • 1
    ISSN: 1573-7446
    Keywords: alveolar septa ; endothelium ; epithelium ; lung ; Pasteurella multocida ; pneumocytes ; rabbits ; ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Sixteen 8- to 9-week-old Pasteurella multocida-free rabbits were divided into two equal groups. Eight rabbits in one group were inoculated intranasally with P. multocida type A:3. The other eight were inoculated intranasally with phosphate-buffered saline and used as controls. Nasal swabs taken before and after inoculation were cultured for bacterial isolation. Post-mortem nasal swabs and lung samples were cultured for bacteriological isolation. Nasal mucosa and lung samples were collected and processed for transmission electron microscopy. Pasteurella multocida was isolated from the nasal cavity of all infected rabbits and from the lungs of four infected rabbits. Degenerative ultrastructural changes in epithelial cells and endothelial cells were seen in the infected rabbits. Deciliation of the cilated epithelium and hyperplasia of the goblet cells in the nasal mucosa were noted. Thickening of the alveolar septa due to hyperplasia of type II pneumocytes, swelling of the endothelial lining of capillaries and infiltration of inflammatory cells were also observed. Intracellular invasion of the nasal epithelial cells and of type II pneumocytes by the organism was observed. Coccobacilli were observed in membrane-bound vacuoles in the cytoplasm of these cells. The vacuoles were adjacent to the host-cell mitochondria and some of these vacuoles appeared to be fused to the mitochondrial membrane. Some type I pneumocytes with intracellular membrane-bound vacuoles containing bacterial cells showed protrusions, which appeared to detach into the alveolar lumina. These results indicated that P. multocida serotype A:3 in rabbits can invade the epithelial cell and cause structural changes in the interstitium, epithelium and endothelium. Heterophils and macrophages appear to play important roles in tissue injury.
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  • 2
    ISSN: 1573-7438
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Deux essais effectués sur 2000 poulets de chair ont montré que ces poulets vaccinés avec du vaccin lyophilisé “F” soit à leur naissance, au 21 et au 42e jours ont été protégés à leur 14, 35, 56 et 70e jours lors d'épreuves infestantes par du virus de la maladie de Newcastle administré par voies intramusculaire, intranasale ou par contact. Un pourcentage élevé des oiseaux vaccinés a été protégé en dépit d'un niveau d'anticorps hemagglutinants constamment bas. Les autopsies pratiquées sur des animaux témoins et sur les animaux vaccinés morts à la suite d'épreuves infestantes ont montré que la plupart d'entre eux présentaient des lésions intestinales.
    Abstract: Resumen Se realizaron dos ensayos con 2,000 pollos de engorde los cuales se vacunaron con la vacuna F liofilizada contra Newcastle. Las vacunaciones se hicieron en forma seriada los dias 1, 21, y 42, protegiendo a las aves contra la descarga de virus virulento de Newcastle efectuada los días 14, 35, 56 y 70, administrada por vía intramuscular, intranasal y por contacto. Un alto porcentaje de los pollos fue protegido por la vacuna, aunque los títulos de anticuerpos IH fueron bajos. Las necropsias de las aves muertas durante los ensayos mostraron lesiones intestinales.
    Notes: Summary Two field trials carried out on 2,000 broiler chickens showed that chickens vaccinated with the lyophilised Newcastle disease (ND) “F” vaccine at 1, 21, and 42 days were protected when challenged at 14, 35, 56 and 70 days with the virulent strain of Newcastle disease virus (NDV) administered intramuscularly, intranasally, or by contact. A high percentage of the vaccinated birds were protected even though the haemaggglutination inhibition (HI) antibody levels were persistently low. Autopsies of the control and vaccinated birds that died from the challenge showed that most of the birds had lesions in the intestines.
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  • 3
    ISSN: 1573-7446
    Keywords: concurrent disease ; goats ; haemonchosis ; pasteurellosis ; stress
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1573-7446
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract One of 13 healthy dogs used in a pharmacokinetic study of imidocarb dipropionate died due to difficulty in breathing, tachycardia, weakness and profuse diarrhoea. Autopsy findings showed marked pulmonary congestion and oedema. Kidneys were grossly enlarged and markedly congested with extensive haemorrhage in the cortex and medulla. Marked tubulonephrosis was also exhibited microscopically. Liver and spleen were moderately enlarged and congested. The adverse effects of imidocarb may be due to excessive acetylcholine action.
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  • 5
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Due to the lack of a regional patch test series in our geographical area, the suitability of the European standard series was evaluated by patch testing dermatitis patients in Riyadh, Saudi Arabia. Of 240 consecutive patients with various forms of dermatitis, 136 (57%) showed 1 or more positive patch tests, women, 74 (54%), slightly outnumbering men, 62 (46%), Positive reactions were found to 21 of the 22 items in the test series. Sensitization was most common to nickel sulfate (51=37.5%), potassium dichromate (48=35%) and cobalt chloride (43 = 32%). The frequency of sensitization to nickel was higher in women (41=30%) while that to dichromate was higher in men (39=29%). Less reactions were found to fragrance mix (21 = 15%). formaldehyde (15=11%) and neomycin sulfate (15=11%). Sensitization to other allergens ranged between 10 and 1%. Less than 1% of patients (0.7%) reacted to benzocaine and none to primin. The frequency of occurrence of multiple sensitivities is also presented. We conclude that the European standard series is suitable for patch testing dermatitis patients in our region, with the exception of benzocaine and primin. The addition of 3 allergens that could be of local relevance is discussed.
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  • 6
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background. No reports are available on allergic contact dermatitis in Saudi Arabia, although it seems to be a common skin problem. We attempted to explore certain clinical aspects in addition to the profile of sensitizing allergens in our area. As no standard panel for patch testing is available in our geographic region, we examined the suitability of the European Standard Series. Methods. Patch testing was performed on 271 consecutive patients with various forms of dermatitis, referred for evaluation of possible allergic contact dermatitis. The study included 147 women and 124 men. The patients were between 12 and 75 years of age. Results. Out of 271 subjects, 152 (56.1%) showed one or more positive reactions. Of these, 80 (52.6%) were women and 72 (47.4%) were men. Almost one quarter of the patients (25.7%) presented with hand dermatitis.Positive reactions to 21 out of the 22 allergens were found. Sensitization was most common to nickel sulfate (39.5%), potassium dichromate (32.9%), and cobalt chloride (30.9%). Reactions to the other allergens ranged between 14.5% and 1.3%. Less than one percent of the patients (0.66%) reacted to benzocaine and showed no reaction to primin. Conclusions. Allergic contact dermatitis is a common skin problem in Saudi Arabia. Further studies that address the prevalence and incidence of the disease are indicated. The European Standard Series is suitable for patch testing patients in our community; however, we suggest exclusion of benzocaine and primin. The addition of three allergens of local relevance, black seed oil, local perfume mix, and henna, are presented and discussed. The formulation of a regional standard series for patch testing dermatitis patients in our geographic area requires further collaborative studies.
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