Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Keywords: POPULATION ; ASSOCIATION ; WOMEN ; MEN ; POSTMENOPAUSAL WOMEN ; ELDERLY-MEN ; trabecular bone ; older men ; BONE ; BINDING GLOBULIN ; BODY-COMPOSITION ; FREE TESTOSTERONE ; SERUM TESTOSTERONE ; LONGITUDINAL CHANGES ; VERTEBRAL FRACTURES
    Abstract: Sex steroid hormones influence bone mineral density (BMD) in women, but are less well-studied in men. We evaluated the association of serum total and free sex steroid hormones and SHBG with osteopaenia in a nationally representative sample of men aged 20-90 years. BMD and sex steroid hormones were measured among participants in NHANES III, a cross-sectional study of the US population. A total of 1185 adult men in morning examination session of Phase I of NHANES III (1988-91). Relation of oestradiol (E-2), testosterone, and SHBG concentrations with BMD. Osteopaenia was defined as 1-2.5 SD below the mean for white men aged 20-29 years. Men in the lowest quartile of free E-2 had 70% increased odds (OR = 1.69, 95% CI 0.95-2.98) of osteopaenia compared with men in the highest quartile. Men in the lowest quartile of free testosterone had nearly four times the odds of osteopaenia than those in the highest quartile (OR = 3.82, 95% CI 1.87-7.78). Lower concentrations of SHBG appeared protective against osteopaenia (P-trend = 0.01). Neither total testosterone nor total E-2 was associated with BMD, although men with clinically low E-2 (〈 20 ng/l) had lower BMD (0.930 g/cm(2), 95% CI 0.88-0.98) than men with normal-range E-2 (1.024 g/cm(2), 95% CI 1.01-1.04; P = 0.004). Findings for free E-2 were most pronounced among elderly men, while the findings for free testosterone were most pronounced among younger men. In this nationally representative study, men with lower free E-2, lower free testosterone, and higher SHBG concentrations in circulation were more likely to have low BMD
    Type of Publication: Journal article published
    PubMed ID: 18485120
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    Keywords: CANCER ; PROSTATE ; SAMPLE ; ASSOCIATION ; HEALTH ; CIGARETTE-SMOKING ; MEN ; smoking ; prostate cancer ; PROSTATE-CANCER ; US ; NETHERLANDS ; ALCOHOL ; CONSUMPTION ; nutrition ; physical activity ; SERUM ; REGRESSION ; BODY-MASS INDEX ; USA ; HORMONES ; TESTOSTERONE ; older men ; FREE ESTRADIOL ; 3RD NATIONAL-HEALTH ; NUTRITION EXAMINATION SURVEY ; BONE-MINERAL DENSITY ; URINARY-TRACT SYMPTOMS ; HORMONE-BINDING GLOBULIN ; FREE TESTOSTERONE ; sex hormone-binding globulin ; COGNITIVE FUNCTION ; REPRESENTATIVE SAMPLE ; SURVEY NHANES-III
    Abstract: We evaluated the associations of smoking, alcohol consumption, and physical activity with sex steroid hormone concentrations among 1,275 men a parts per thousand yen20 years old who participated in the Third National Health and Nutrition Examination Survey (NHANES III). Serum concentrations of testosterone, estradiol, and sex hormone-binding globulin (SHBG) were measured. We compared geometric mean concentrations across levels of smoking, alcohol, and physical activity using multiple linear regression. Current smokers had higher total testosterone (5.42, 5.10, and 5.26 ng/ml in current, former, and never smokers), free testosterone (0.110, 0.102, and 0.104 ng/ml), total estradiol (40.0, 34.5, and 33.5 pg/ml), and free estradiol (1.05, 0.88, and 0.84 pg/ml) compared with former and never smokers (all p a parts per thousand currency sign 0.05). Men who consumed a parts per thousand yen1 drink/day had lower SHBG than men who drank less frequently (31.5 vs. 34.8 nmol/l, p = 0.01); total (p-trend = 0.08) and free testosterone (p-trend = 0.06) increased with number of drinks per day. Physical activity was positively associated with total (p-trend = 0.01) and free testosterone (p-trend = 0.05). In this nationally representative sample of men, smoking, alcohol, and physical activity were associated with hormones and SHBG, thus these factors should be considered as possible confounders or upstream variables in studies of hormones and men's health, including prostate cancer
    Type of Publication: Journal article published
    PubMed ID: 19277882
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    Keywords: EXPRESSION ; EXPOSURE ; POPULATION ; SAMPLE ; ASSOCIATION ; HEALTH ; PLASMA ; AGE ; MEN ; smoking ; MASS-SPECTROMETRY ; nutrition ; ESTRADIOL ; NATIONAL-HEALTH ; SERUM ; ADULT ; LEVEL ; methods ; PHASE ; USA ; ENGLAND ; FREE TESTOSTERONE ; REPRODUCTIVE ENDOCRINE FUNCTION ; SEMEN QUALITY ; ZEEMAN BACKGROUND CORRECTION
    Abstract: Background: Studies investigating the association of cadmium and sex steroid hormones in men have been inconsistent, but previous studies were relatively small. Methods: In a nationally representative sample of 1,262 men participating in the morning examination session of phase 1 (1998-1991) of the third National Health and Nutrition Examination Survey, creatinine corrected urinary cadmium and serum concentrations of sex steroid hormones were measured following a standardized protocol. Results: After adjustment for age and race-ethnicity, higher cadmium levels were associated with higher levels of total testosterone, total estradiol, sex hormone-binding globulin, estimated free testosterone, and estimated free estradiol ( each p-trend 〈 0.05). After additionally adjusting for smoking status and serum cotinine, none of the hormones maintained an association with urinary cadmium ( each p-trend 〉 0.05). Conclusion: Urinary cadmium levels were not associated with sex steroid hormone concentrations in a large nationally representative sample of US men
    Type of Publication: Journal article published
    PubMed ID: 18294394
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...