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  • 1
    Abstract: BACKGROUND: For desensitization of ABO-incompatible kidney transplant recipients we recently proposed nonantigen-specific immunoadsorption (IA) and rituximab. METHODS: We now compared clinical outcomes of 34 ABO-incompatible living-donor kidney recipients who were transplanted using this protocol with that of 68 matched ABO-compatible patients. In addition, we analyzed efficacy and cost of nonantigen-specific as compared to blood group antigen-specific IA. RESULTS: Before desensitization, the median isoagglutinin titer of 34 ABO-incompatible patients was 1:64 (Coombs technique). Patients received a median of 7 preoperative IA treatments. Twenty-four patients had a median of 2 additional plasmapheresis treatments to reach the preoperative target isoagglutinin titer of 1:8 or less. After a median postoperative follow-up of 22 months, overall graft survival in the ABO-incompatible group was not significantly different from that in ABO-compatible patients (log-rank P = 0.20), whereas patient survival tended to be lower (log-rank P = 0.05). The incidence of rejection episodes was 15% in both groups. The ABO-incompatible kidney recipients had a higher incidence of BK virus replication (P = 0.04) and nephropathy (P = 0.01) and showed more often colonization with multidrug resistant bacteria (P = 0.02). In comparison to blood group antigen-specific IA, nonantigen-specific IA showed equal efficacy but was associated with reduction in cost. CONCLUSIONS: Clinical outcomes of ABO-incompatible patients desensitized with a nonantigen-specific IA device and rituximab do not differ from that of matched ABO-compatible patients although a trend toward reduced patient survival was noted. Special attention must be paid to the higher incidence of BK virus infection in recipients of ABO-incompatible grafts.
    Type of Publication: Journal article published
    PubMed ID: 25989497
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  • 2
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    German Medical Science; Düsseldorf, Köln
    In:  Kooperative Versorgung - Vernetzte Forschung - Ubiquitäre Information; 49. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (gmds), 19. Jahrestagung der Schweizerischen Gesellschaft für Medizinische Informatik (SGMI) und Jahrestagung 2004 des Arbeitskreises Medizinische Informatik (ÖAKMI) der Österreichischen Computer Gesellschaft (OCG) und der Österreichischen Gesellschaft für Biomedizinische Technik (ÖGBMT); 20040926-20040930; Innsbruck; DOC04gmds067 /20040914/
    Publication Date: 2004-09-14
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 3
    ISSN: 0168-9452
    Keywords: 3-phosphoglycerate (chloroplast synthesis) ; CO"2 (chloroplast synthesis) ; aromatic amino acids ; valine
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1041
    Keywords: aspirin ; salicylic acid ; low-dose aspirin pharmacokinetics ; platelet function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of low-dose aspirin and the resulting salicylic acid were studied in 6 healthy volunteers. Each received a single 50-mg dose of (1) oral modified release capsules, (2) oral solution and (3) intravenous solution. The volunteers also received 50 mg modified release capsules daily for 6 days to determine the effect on collagen, ADP and arachidonate induced platelet aggregation and thromboxane production, and to compare the pharmacokinetics after repeated dosing with the parameters obtained after the single dose. The formulation and route of administration profoundly influenced several pharmacokinetic parameters for aspirin: the maximum concentration (Cmax, ng·ml−1) was 221 and 191 after modified release for single and chronic dosing respectively, 1323 after the oral solution and 6000 after intravenous injection; the time to achieve this maximum concentration (tmax, h) was 3.42 and 3.02 after modified release for single and chronic dosing respectively, and 0.29 after the oral solution; the area under the plasma drug concentration versus time curve (AUC, µg·h·ml−1) was 0.38 and 0.27 after modified release single and chronic dosing respectively, 0.68 after the oral solution and 1.57 after intravenous injection. The elimination of aspirin after the two solutions was at least biphasic. The terminal phase rate constant ranged from 1.52 h−1 after intravenous injection to 1.88 h−1 after the oral modified release form. The absorption of the oral forms of aspirin was complete as reflected by the total recovery of the doses as salicylic acid in urine. The pharmacokinetic parameters for salicylic acid showed similar tmax and Cmax for the oral solution and intravenous injection but, as for aspirin, Cmax was least and tmax greatest when the modified release form was used. After 7 days of modified release aspirin platelet aggregation and thromboxane formation in response to collagen and arachidonate were markedly inhibited. There was no inhibition of ADP-induced aggregation, but thromboxane production in response to ADP was abolished.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-0630
    Keywords: 64.75+g ; 76.80+y ; 81.30.Dz ; 81.40.Cd
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract Samples of the system LiNbO3-Fe2O3 prepared by water quenching and by the double-roller quenching method in the range up to 24 mol% Fe2O3 were investigated by Mössbauer and ESR spectroscopy. In the water quenched samples up to 11 mol% Fe2O3 only the Fe3+ and the Fe2+ valence states could be detected. The Fe2+ concentration decreased with increasing Fe2O3 content. Above 11 mol% Fe2O3 magnetically split Mössbauer spectra indicated the presence of Fe2O3 clusters. The isomer shift values of Fe3+ as a function of Fe2O3 concentration showed jumps at 6 and 11 mol% Fe2O3, whereas no significant changes could be detected in the quadrupole splitting values. The ESR data already exhibited the existence of isolated Fe3+ ions and of clusters with Fe-Fe distances less than 8 Å for the lowest Fe2O3 concentration. The cluster signal intensity increased with increasing Fe2O3 content. The roller quenched samples showed increased Fe2+ concentration as compared to the water quenched samples, which suggests that slow quenching results in iron oxidation and cluster formation. For low Fe2O3 concentrations a valence state change Fe3+⇄Fe2+ can easily be obtained by heat treatments in various atmospheres, whereas for higher Fe2O3 contents (9.8 mol%) precipitations ofα-Fe (in reducing atmosphere) and Fe2O3 (in air) could be observed in addition to the valence state changes of a remaining part of dissolved Fe ions. On the basis of the obtained results a model was suggested for the unusual behaviour of the lattice parameters observed in LiNbO3-Fe2O3.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Applied physics 64 (1997), S. 203-206 
    ISSN: 1432-0630
    Keywords: PACS: 72.20; 76; 81.10
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract. We obtained crystals of RuS2 doped with 57Fe from a Bi melt and determined the EPR hyperfine structure corresponding to 57Fe3+ in low-spin configuration. In crystals that were doped with both Fe and Cr an increase of the Fe3+ resonance and a simultaneous decrease of the Cr3+ resonance occurred by IR irradiation and revealed the same wavelength dependence. Compared with as-grown crystals the iron-doped crystals turned out to have a rather high electrical resistivity of about 104Omega cm at room temperature. For these iron-doped crystals two different activation energies of 0.04 eV and 0.35 eV of the free charge carriers (electrons) were determined from measurements of the electrical conductivity in the range of 94 K and 294 K.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1434-9957
    Keywords: Surgery planning ; Volume segmentation ; Virtual tools ; Force feedback ; Intra-operative navigation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract The primary goal of our research has been to implement an entirely computer-based maxillofacial surgery planning system [1]. An important step toward this goal is to make virtual tools available to the surgeon in order to carry out a three-dimensional (3D) cephalometrical analysis and to interactively define bone segments from skull and jaw bones. An easy-to-handle user interface employs visual and force-feedback devices to define subvolumes of a patient's volume dataset [2]. The defined subvolumes, together with their spatial arrangements based on the cephalometrical results, eventually lead to an operation plan. We have evaluated modern low-cost, force-feedback devices with regard to their ability to emulate the surgeon's working procedure. Once the planning of the procedure is complete, the planning results are transferred to the operating room. In our intra-operative concept the visualisation of planning data is speech controlled by the surgeon and correlated with the patient's position by an electromagnetic 3D sensor system.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 353 (1991), S. 615-616 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] TAXONOMY - the science of the classification of organisms - has come a long way since about 1960. Branching diagrams of possible relationships among organisms are now commonplace, giving biologists new opportunities to investigate evolutionary problems in terms of closeness of descent ...
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 53 (1998), S. 0 
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The highly specialized akysid catfish genus Breitensteinia is revised; two new species are described. Breitensteinia cessator is described from Sumatra and western Borneo. It can be distinguished by its large, wide-set eyes and evenly scattered brown spots on the dorsal and pectoral fins. Breitensteinia hypselurus is described from western Borneo. It can be distinguished by its relatively tall neural spines on caudal vertebrae, smooth posterior edge of dorsal spine, short caudal peduncle, and fewer vertebrae. Breitensteinia insignis is sexually dimorphic.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 0003-2697
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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