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  • 1
    Cambridge : Cambridge University Press
    Call number: W26.5:122 ; C060:190
    Keywords: Clinical Trials as Topic / methods ; Genomics / methods ; Individualized Medicine / methods ; Neoplasms / genetics ; Research Design ; Tumor Markers, Biological / genetics
    Description / Table of Contents: Clinical trial basics -- Actionable prognostic biomarkers -- Phase II designs -- Enrichment designs -- Including both test positive and test negative patients -- Adaptive threshold design -- Multiple predictive biomarkers predictive analysis of clinical trials -- Prospective : retrospective design
    Pages: xii, 144 p.
    ISBN: 9781107401358
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    W26.5:122 available
    C060:190 departmental collection or stack – please contact the library
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  • 2
    Call number: C060:19
    Keywords: DNA microarrays / Statistical methods
    Pages: x, 199 p. : ill.
    ISBN: 0-387-00135-2
    Signatur Availability
    C060:19 departmental collection or stack – please contact the library
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  • 3
    ISSN: 0730-2312
    Keywords: osteosarcoma ; chondrosarcoma ; GCT ; oncogene alterations ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: We investigated the structure and the expression of various oncogenes in three of the most common human bone tumors - osteosarcoma (36 samples from 34 patients), giant cell tumor (10 patients), and chondrosarcoma (18 patients) - in an attempt to identify the genetic alterations associated with these malignancies. Alterations of RB and p53 were detected only in osteosarcomas. Alterations of c-myc, N-myc, and c-fos were detected in osteosarcomas and giant cell tumors. Ras alterations (H-ras, Ki-ras, N-ras) were rare. Chondrosarcomas did not contain any detectable genetic alterations. Our results suggest that alterations of c-myc, N-myc, and c-fos oncogenes occur in osteosarcomas, in addition to those previously described for the tumor suppressor genes RB and p53. Moreover, statistical analyses indicate that c-fos alterations occur more frequently in osteosarcoma patients with recurrent or metastatic disease. © 1996 Wiley-Liss, Inc.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
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