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  • 1
    Keywords: RECEPTOR ; APOPTOSIS ; CANCER ; CANCER CELLS ; CELLS ; EXPRESSION ; GROWTH ; GROWTH-FACTOR ; IN-VITRO ; INHIBITOR ; proliferation ; SURVIVAL ; CELL ; Germany ; human ; KINASE ; PATHWAY ; SYSTEM ; METABOLISM ; MICE ; ACTIVATION ; RESPONSES ; RAT ; CONTRAST ; BIOLOGY ; CELL-LINE ; CANCER-CELLS ; EXTRACELLULAR-MATRIX ; BETA ; RECEPTORS ; pancreatic cancer ; chronic pancreatitis ; signaling ; fibrosis ; pancreas ; PANCREATIC-CANCER ; secretion ; NEURONS ; LEVEL ; NERVE ; FACTOR EXPRESSION ; pancreatic stellate cells ; LOOP-HELIX PROTEINS ; GROWTH-FACTORS ; STELLATE-CELLS ; growth factor ; FACTOR STIMULATION ; nerve growth factor ; p75 ; RECEPTOR P75 ; TGF ; TGF- ; TrkA ; UNDERGO APOPTOSIS
    Abstract: Nerve growth factor (NGF), a survival factor for neurons enforces pain by sensitizing nociceptors. Also in the pancreas, NGF was associated with pain and it can stimulate the proliferation of pancreatic cancer cells. Hepatic stellate cells (HSC) respond to NGF with apoptosis. Transforming growth factor (TGF)-, one of the strongest pro-fibrogenic activators of pancreatic stellate cells (PSC) induced NGF and its two receptors in an immortalized human cell line (ihPSC) and primary rat PSC (prPSC) as determined by RT-PCR, western blot, and immunofluorescence. In contrast to HSC, PSC expressed both NGF receptors, although p75NTR expression was weak in prPSC. In contrast to ihPSC TGF- activated both Smad signaling cascades in prPSC. NGF secretion was diminished by the activin-like kinase (ALK)-5 inhibitor SB431542, indicating the predominant role of ALK5 in activating the NGF system in PSC. While NGF did not affect proliferation or survival of PSC it induced expression of Inhibitor of Differentiation-1. We conclude that under conditions of upregulated TGF-, like fibrosis, NGF levels will also increase in PSC which might contribute to pancreatic wound healing responses
    Type of Publication: Journal article published
    PubMed ID: 19639490
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  • 2
    Keywords: RECEPTOR ; tumor ; carcinoma ; CELL ; Germany ; LUNG ; THERAPY ; CT ; DIAGNOSIS ; LUNG-CANCER ; DISEASE ; HISTORY ; liver ; PATIENT ; primary ; prognosis ; tumour ; LYMPH-NODES ; 5-FLUOROURACIL ; NO ; NEOPLASIA ; MALIGNANCIES ; METASTASIS ; metastases ; chemotherapy ; INVOLVEMENT ; SCINTIGRAPHY ; LIVER METASTASES ; SOMATOSTATIN ; POOR-PROGNOSIS ; pancreatic carcinoma ; ETOPOSIDE ; CELL CARCINOMA ; MALIGNANCY ; ENDOCRINE ; EXTRAPULMONARY ; GEMCITABINE ; NODES ; OF-THE-LITERATURE ; pancreas ; review ; small cell carcinoma ; somatostatin-analogue ; UNDIFFERENTIATED CARCINOMA
    Abstract: Small cell carcinoma (SCC) of the pancreas is a rare malignancy with an extremely poor prognosis. We present the case of a 74-year-old man with a 2-month history of upper abdominal discomfort who was diagnosed with SCC of the pancreas tail, involvement of peripancreatic and mesenteric lymph nodes and multiple liver metastases ( extended disease). A CT scan and a positive somatostatin receptor scintigraphy showed no evidence of a primary lung tumour. The diagnosis of a SCC was confirmed by biopsy. Local tumour control could be achieved by gemcitabine once a week and a long-acting somatostatin analogue once a month, but liver metastasis showed progress. Thus, 5-fluorouracil on a weekly basis was started. The patient died 8 months after diagnosis and had not been hospitalised in the meantime. Copyright (C) 2004 S. Karger AG, Basel and IAP
    Type of Publication: Journal article published
    PubMed ID: 15334003
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  • 3
    Keywords: SURVIVAL ; carcinoma ; CELL LUNG-CANCER ; COMBINATION ; Germany ; THERAPY ; DIAGNOSIS ; COHORT ; TIME ; PATIENT ; treatment ; chemotherapy ; TISSUE FACTOR ; SAFETY ; pancreatic carcinoma ; RANDOMIZED-TRIAL ; GEMCITABINE ; PHASE-III ; DRUG-DELIVERY ; REGIONAL CHEMOTHERAPY ; pancreatic ; RETROSPECTIVE ANALYSIS ; INTRAARTERIAL CHEMOTHERAPY ; low dose ; retrospective ; ARTERIAL INFUSION ; BLOOD-COAGULATION ; LEUKEMIA GROUP-B ; VITAMIN-K-ANTAGONISTS ; warfarin
    Abstract: Objective. To report the effect of regional combination chemotherapy in a cohort of patients with inoperable pancreatic carcinoma treated with or without low-dose warfarin. Material and methods. A retrospective analysis was performed on 180 patients with pancreatic carcinoma. Patients received one of seven regimens of chemotherapy. Unrelated to the type of chemotherapy, some patients received 1.25 mg warfarin daily. The primary end-point was median survival. Results. Treatment with warfarin resulted in improved median survival from the start of regional therapy ( warfarin versus no warfarin: 5.0 versus 2.3 months, n = 111 versus 69; p 〈 0.0001). This effect was not dependent on the type of chemotherapy used. Among the seven regimens examined, the one consisting of regional gemcitabine and mitomycin-C with systemic gemcitabine was associated with the longest median survival of 5.1 months from the start of regional therapy ( p = 0.006) and 12.7 months from diagnosis. This regimen combined with warfarin was associated with improved median survival ( 7.1 months, n = 32). Conclusions. Treatment with low-dose warfarin improved survival irrespective of the chemotherapy received. Of the regimens examined, the combination of regional gemcitabine and mitomycin-C with systemic gemcitabine was associated with the longest survival time. Survival was increased further by the addition of warfarin. These data provide a rationale, based on safety and efficacy, for a definitive study on the use of warfarin and combined regional and systemic chemotherapy in patients with pancreatic carcinoma
    Type of Publication: Journal article published
    PubMed ID: 16938724
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  • 4
    Keywords: INHIBITOR ; Germany ; LUNG ; SYSTEM ; SYSTEMS ; VENTILATION ; liver ; PATIENT ; kidney ; treatment ; FAILURE ; ELIMINATION ; albumin ; RECOVERY ; function ; UNIT ; BACTERIA ; lungs ; dialysis
    Abstract: ABSTRACT : BACKGROUND : Methylene bis(thiocyanate) (MBT) is a microbiocidal agent mainly used in industrial water cooling systems and paper mills as an inhibitor of algae, fungi, and bacteria. CASE PRESENTATION : We describe the first case of severe intoxication following inhalation of powder in an industrial worker. Profound cyanosis and respiratory failure caused by severe methemoglobinemia developed within several minutes. Despite immediate admission to the intensive care unit, where mechanical ventilation and hemodialysis for toxin elimination were initiated, multi-organ failure involving liver, kidneys, and lungs developed. While liver failure was leading, the patient was successfully treated with the MARS (molecular adsorbent recirculating system) procedure. CONCLUSION : Intoxication with MBT is a potentially life-threatening intoxication causing severe methemoglobinemia and multi-organ failure. Extracorporeal liver albumin dialysis (MARS) appears to be an effective treatment to allow recovery of hepatic function
    Type of Publication: Journal article published
    PubMed ID: 16608508
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  • 5
    Keywords: Germany ; CLASSIFICATION ; DISEASE ; liver ; RISK ; GENE ; METABOLISM ; ACCUMULATION ; PATIENT ; FREQUENCY ; polymorphism ; SUSCEPTIBILITY ; VARIANTS ; FREQUENCIES ; NO ; DIFFERENCE ; genetics ; HETEROZYGOSITY ; PATHOGENESIS ; GENOTYPES ; HEREDITARY ; LENGTH ; adenocarcinoma ; pathology ; DIABETES-MELLITUS ; PREVALENCE ; heredity ; chronic pancreatitis ; MELLITUS ; pancreas ; VARIANT ; INCREASE ; PANCREATITIS ; HEREDITARY HEMOCHROMATOSIS ; IRON ; analysis ; methods ; pancreatic ; pancreatic adenocarcinoma ; GENOTYPE ; USA ; RISK-FACTOR ; FRAGMENT ; Diabetes Mellitus ; genetic analysis ; CHRONIC-PANCREATITIS ; acute pancreatitis ; ALCOHOLIC LIVER-DISEASE ; C282Y ; CYS282TYR MUTATION ; CYSTIC-FIBROSIS GENE ; H63D MUTATIONS ; hemochromatosis ; HFE ; IRON-OVERLOAD ; melting ; NONALCOHOLIC STEATOHEPATITIS
    Abstract: Purpose: The homozygous p.C282Y variant of the HFE gene is a major risk factor for hereditary hemochromatosis, a disorder of iron metabolism resulting in progressive iron accumulation in a variety of organs including the pancreas. Heterozygosity of p.C282Y and p.H63D may increase susceptibility to chronic liver and pancreatic disease. This study determines the frequencies of p.C282Y and p.H63D alterations in patients with chronic pancreatitis and pancreatic adenocarcinoma. Methods: In total, 958 patients (349 with alcoholic pancreatitis, 343 with idiopathic pancreatitis, 64 with familial chronic pancreatitis, 34 with acute pancreatitis, and 168 with pancreatic adenocarcinoma) were enrolled and compared with 681 healthy and 100 alcoholic controls. Furthermore, 45 parent-offspring trios were included for segregation analysis. Genotyping of p.C282Y and p.H63D was performed by restriction fragment length polymorphism or melting curve analyses. Results: No significant differences were found in heterozygosity for p.C282Y and p.H63D when patients with alcoholic (8.0/21.5%), idiopathic (7.3/24.5%), or familial (9.8/ 23.0%) pancreatitis, or pancreatic adenocarcinoma (5.4/28.6%) were compared with healthy (6.2/24.8%) and alcoholic (7.0/25.0%) controls. Neither genotype was associated with the presence of secondary diabetes mellitus in patients with chronic pancreatitis. Conclusion: Although hemochromatosis is associated with pancreatic pathology, the p.C282Y and p.H63D variants do not play a significant role in the pathogenesis of chronic pancreatitis or pancreatic adenocarcinoma
    Type of Publication: Journal article published
    PubMed ID: 17666895
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  • 6
    Keywords: COMBINATION ; evaluation ; Germany ; VOLUME ; DISEASE ; TIME ; PATIENT ; IMPACT ; QUALITY ; NO ; FEASIBILITY ; prospective studies ; small bowel ; methods ; capsule endoscopy ; YIELD ; prospective ; prospective study ; PEOPLE ; WORLD ; China ; DOUBLE-BALLOON ENTEROSCOPY ; ELECTROLYTE ; laxative ; preparation ; PULL ENTEROSCOPY ; TRANSIT ; transit time ; visibility
    Abstract: AIM: To determine the effect of Prepacol (R), a combination of sodium phosphate and bisacodyl, on transit and quality of capsule endoscopy (CE). METHODS: Fivety two consecutive patients were included in this prospective study. CE was performed following a 12 h fasting period. Twenty six patients were randomized for additional preparation with Prepacol. The quality of CE was assessed separately for the proximal and the distal small bowel by 3 experienced endoscopists on the basis of a graduation which was initially developed with 20 previous CE. RESULTS: Preparation with Prepacol (R) accelerated small bowel transit time (262 55 min vs 287 97 min), but had no effect on the quality of CE. Visibility was significantly reduced in the distal compared to the proximal small bowel. CONCLUSION: The significantly reduced visibility of CE in the distal small bowel allocates the need for a good preparation. Since Prepacol (R) has no beneficial effect on CE the modality of preparation and the ideal time of application remains unclear. Further standardized examinations are necessary to identify sufficient preparation procedures and to determine the impact of the volume of the preparation solution. (c) 2008 WJG. All rights reserved
    Type of Publication: Journal article published
    PubMed ID: 18395907
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  • 7
    Keywords: CANCER ; IN-VITRO ; SURVIVAL ; carcinoma ; Germany ; THERAPY ; SUPPORT ; COHORT ; liver ; PATIENT ; NO ; chemotherapy ; drug delivery ; TISSUE FACTOR ; pancreatic carcinoma ; FEASIBILITY ; MOLECULAR-WEIGHT HEPARIN ; GEMCITABINE ; THERAPIES ; PHASE-III ; GRADE ; prospective studies ; REGIONAL CHEMOTHERAPY ; methods ; prospective ; prospective study ; ANEMIA ; VENOUS THROMBOEMBOLISM ; ARTERIAL INFUSION ; BLOOD-COAGULATION ; warfarin ; systemic
    Abstract: Aims: The aim is to prospectively examine the effect of regional gemcitabine and mitomycin-C with systemic gemcitabine together with warfarin in patients with inoperable pancreatic carcinoma, and compare the effect to systemic gemcitabine alone. Methods: Seventeen patients received 1.25 mg of warfarin daily, gemcitabine 800 mg/m(2) on day I and mitomycin-C 8 mg/m(2) on day 2 regionally and gemcitabine 800 mg/m(2) on day 14 peripherally. The cycle was repeated every 4 weeks. Results: Median survival since presentation was 6.8 months, while median total survival was 9.6 months. Excluding the 3 patients who died before receiving any therapy, the median survival since presentation resulted in 10.7 months and the median total Survival, 12.7 months. One patient developed bleeding that required transfusion and 2 patients developed anemia (Grades III/IV). Comparing these data to historical controls of large cohorts supports the notion that this regimen offers a viable alternative to systemic gemcitabine alone. Conclusion: A regimen consisting of regional gemcitabine and mitomycin-C with systemic gemcitabine and low-dose warfarin compares favorably to the gold standard of systemic gemcitabine. These data suggest the feasibility of a large prospective study on the use of warfarin and combined regional and systemic chemotherapy in patients with pancreatic carcinoma
    Type of Publication: Journal article published
    PubMed ID: 18836621
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  • 8
    ISSN: 0196-9781
    Keywords: Bombesin ; Immunoneutralization ; Pancreatic exocrine secretion ; Pancreatic polypeptide
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 0167-0115
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Regulatory Peptides 6 (1983), S. 13-23 
    ISSN: 0167-0115
    Keywords: alcoholic beverages ; dogs ; ethanol ; humans ; pancreatic polypeptide
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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