Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
Collection
Years
  • 1
    ISSN: 1365-2648
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Timing of quality of life (QoL) assessments as a source of error in oncological trials Aim of the study. To produce an empirical estimate of the nature and magnitude of the error produced by incorrect timing quality of life (QoL) measurements in patients receiving chemotherapy. Design. In a multicentre trial, 283 patients were randomized to receive either docetaxel (T) or sequential methotrexate and 5-fluorouracil (MF). The QoL was assessed at baseline and before each treatment using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30). The study design was retrospective. Data were analysed using t-tests. Results. Erroneous timing affected the QoL findings in both treatment arms. At baseline, there were statistically significant differences in the MF group on the nausea/vomiting scale, with ill-timed assessment showing more symptoms, and in the T group on the physical functioning scale with ill-timed assessments indicating better QoL. The mean scores of correct vs. incorrect timings over the first 14 cycles showed statistically significant differences on several scales. In the MF group, ill-timed assessments indicated significantly worse physical functioning and global QoL, and significantly more of the following symptoms: fatigue, nausea/vomiting, insomnia, appetite loss, and constipation. In the T group, ill-timed assessment showed better physical functioning, less dyspnoea and more insomnia than correctly timed assessments. The reasons for erroneous timing were not always detectable retrospectively. However, in some cases the MF group, being in standard treatment, seemed to have followed a clinical routine not involving the active participation of the study nurse responsible, whereas patients in the experimental T group were more consistently taken care of by the study nurses. Conclusions. Incorrect timing of QoL assessments in oncological trials jeopardises both the reliability of the QoL findings within treatment and the validity of QoL outcome comparisons between treatments. This issue should be emphasized in the planning of both the study design and clinical routines.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1572-9540
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Three crystallographically different structures of (Fe1−xVx)3 Ge have been studied by57Fe Mössbauer spectroscopy. The hexagonal phase, stable for low values ofx, is ferromagnetic with the spins parallel to thec-axis above a critical temperature, where a spin flip to thec-plane takes place. A V/Fe substitution in the near surrounding of an iron atom leads to a decrease in the isomer shift of −0.02 mm/s and an estimated reduction in the magnetic moment of 0.31μ B from 2.07μ B. A result for the intermediate cubic closed packed structure is that V populates only one type of metal sites. Furthermore, from similarities withα-Fe the average value of the change in isomer shift is found to be +0.075 mm/s and +0.02 mm/s per Ge/Fe substitution in the 1nn and 2nn shells, respectively. The spin polarization effect on the magnetic hyperfine field for iron is −8.6%, −0.4%, and −0.6% per Ge/Fe (1nn), Ge/Fe (2nn) and V/Fe (3nn) substitutions, respectively. The simple cubic compound (Fe0.7V0.3)3 Ge is non-magnetic down to at least 5 K. Here a decrease in the isomer shift of −0.05 mm/s is found for a V/Fe (1nn) substitution.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1572-9540
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The57Fe Mössbauer spectra of FeMnP show a remarkable magnetic distribution for T 175K, although all iron atoms are crystallographically equivalent. It seems possible to explain this distribution by a spin modulation described by coexistence of an antiferro — and a helimagnetic probe. A theoretical calculation performed, justifies this explanation.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    ISSN: 1573-6776
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary A derivative ofEscherichia coli strain W3110 with increased tryptophan synthas (TS) activity was studied in the biosynthesis of L-tryptophan and 5-hydroxy-L-tryptophan, respectively, in presence of precursors. Indole or 5-hydroxyindole was added to growing cells in minimal medium supplemented with tetracycline. The specific activity of TS for 5-hydroxyindole was about 5-fold lower compared with indole. However, this difference in enzyme activity was not observed when the specific productivity (qp) of L-tryptophan or 5-hydroxy-L-tryptophan, which was 0.14–0.15 g (g dry wt cells)−1 · h−1 was determined. In minimal medium L-serine was shown to limit the production of both tryptophan and its hydroxylated derivative. In presence of L-serine, qp, for L-tryptophan and 5-hydroxy-L-tryptophan were increased by a factor of about 3 and 2, respectively.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    ISSN: 1573-6776
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary A partial alcohol dehydrogenase, ADH I, deficient mutant, GRF 18-2 of S. cerevisiae has been isolated. The mutant is resistant to allyl alcohol and the spec. activity of ADH I is 15-fold reduced in the mutant. In a batch fermentation the mutant overproduces glycerol. The production is enhanced 6–7 fold compared with the wildtype strain and it amounts to about 40 per cent of the ethanol produced. The yield of ethanol and glycerol is 56 and 24 per cent respectively. Another mutant possibly defect in the gene for ADH II has a reduced capacity to oxidize ethanol.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...