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  • 1
    ISSN: 1432-2013
    Keywords: Kidney ; Tubular Reabsorption ; Tubular Maximum ; $$P_{CO_2 } $$ ; Plasma [HCO 3 − ]
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Renal reabsorption of bicarbonate was examined in Merino ewes. In all experiments the bicarbonate reabsorption was directly related to that of sodium. When the rate of bicarbonate reabsorption was expressed as the ratio of bicarbonate over sodium reabsorption, no tubular maximum for bicarbonate could be demonstrated. Arterial pH or $$P_{CO_2 } $$ did not affect the reabsorption of bicarbonate except through alterations in the plasma bicarbonate concentration. The ratio of bicarbonate over sodium reabsorption was directly proportional to the plasma concentration of bicarbonate over a wide range. This evidence suggests that the ionic reabsorption of bicarbonate constitutes a major part of total bicarbonate reabsorption. It does not, however, exclude a contribution from an active hydrogen ion secretory process, as the kinetic properteis of such a process are as yet undetermined.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2013
    Keywords: Kidney ; Tubular reabsorption ; Bicarbonate ; PCO2 ; pH ; Carbonic anhydrase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Renal reabsorption of bicarbonate was studied in Merino ewes during carbonic anhydrase inhibition. Bicarbonate reabsorption was directly proportional to plasma bicarbonate concentration. No tubular maximum for bicarbonate was demonstrated. Elevation of arterialPCO2 or depression of arterial pH caused slight increases in bicarbonate reabsorption. The data suggest that bicarbonate is reabsorbed by 2 distinct processes. The quantitatively more significant process may involve ionic reabsorption of bicarbonate secondary to Na+ reabsorption and a relatively minor part of bicarbonate reabsorption may be secondary to H+ secretion.
    Type of Medium: Electronic Resource
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