Springer Online Journal Archives 1860-2000
Chemistry and Pharmacology
Abstract It is shown that, in contrast to hippuric acid, thiohippuric acid reacts with dimethylformamide in the presence of phosphorus oxychloride to give three compounds, viz., 2-phenyl-4-dimethylaminomethylene-5-thiazolone, 2-phenyl-4-dimethylamino-methyleneoxazole-5-thione, and 2-phenyl-4-formyl-5-chlorothiazole. The pathways of their formation are discussed. The structures of the compounds obtained and some transformations of 2-phenyl-4-formyl-5-chlorothiazole were studied. 2-Phenyl-4-formyl-5-hydroxy(mercapto) thiazoles and their methyl derivatives, as well as 2-phenyl-4-dimethylaminomethylenethiazole-5-thione, were synthesized from the latter.
Type of Medium: