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• 1
Electronic Resource
Springer
Biology and philosophy 4 (1989), S. 407-432
ISSN: 1572-8404
Keywords: evolution ; entropy ; information ; hierarchy ; ecology ; phylogeny ; natural selection
Source: Springer Online Journal Archives 1860-2000
Topics: Biology , Philosophy
Notes: Abstract Integrating concepts of maintenance and of origins is essential to explaining biological diversity. The unified theory of evolution attempts to find a common theme linking production rules inherent in biological systems, explaining the origin of biological order as a manifestation of the flow of energy and the flow of information on various spatial and temporal scales, with the recognition that natural selection is an evolutionarily relevant process. Biological systems persist in space and time by transfor ming energy from one state to another in a manner that generates structures which allows the system to continue to persist. Two classes of energetic transformations allow this; heat-generating transformations, resulting in a net loss of energy from the system, and conservative transformations, changing unusable energy into states that can be stored and used subsequently. All conservative transformations in biological systems are coupled with heat-generating transformations; hence, inherent biological production, or genealogical proesses, is positively entropic. There is a self-organizing phenomenology common to genealogical phenomena, which imparts an arrow of time to biological systems. Natural selection, which by itself is time-reversible, contributes to the organization of the self-organized genealogical trajectories. The interplay of genealogical (diversity-promoting) and selective (diversity-limiting) processes produces biological order to which the primary contribution is genealogical history. Dynamic changes occuring on times scales shorter than speciation rates are microevolutionary; those occuring on time scales longer than speciation rates are macroevolutionary. Macroevolutionary processes are neither redicible to, nor autonomous from, microevolutionary processes.
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• 2
Electronic Resource
Springer
Geometriae dedicata 30 (1989), S. 281-296
ISSN: 1572-9168
Source: Springer Online Journal Archives 1860-2000
Topics: Mathematics
Type of Medium: Electronic Resource
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• 3
Electronic Resource
Springer
Inventiones mathematicae 67 (1982), S. 173-187
ISSN: 1432-1297
Source: Springer Online Journal Archives 1860-2000
Topics: Mathematics
Notes: Abstract LetF be a field. For eachk〉1, letG be a finite group containing{x 1,...,x k }!×{y 1,...,y k}!. Then in the group algebraFG, $$co\dim _F \sum\limits_{j = 1}^{k - 1} {(1 + (x_j x_{j + 1} ))(1 + (y_j y_{j + 1} ))FG = \frac{{|G|}}{{2\pi i}}\oint\limits_{|z| = 1} {\frac{{dz}}{{J_0 (2\sqrt z )z^{k + 1} }}.} }$$ Connections with the theory of commutative Moufang loops are discussed, including a conjectured answer to Manin's problem of specifying the 3-rank of a finitely generated free commutative Moufang loop.
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• 4
Electronic Resource
[s.l.] : Nature Publishing Group
Nature structural & molecular biology 14 (2007), S. 861-868
ISSN: 1545-9985
Source: Nature Archives 1869 - 2009
Topics: Biology , Medicine
Notes: [Auszug] The cardioprotective function of high-density lipoprotein (HDL) is largely attributed to its ability to facilitate transport of cholesterol from peripheral tissues to the liver. However, HDL may become dysfunctional through oxidative modification, impairing cellular cholesterol efflux. Here we ...
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• 5
Electronic Resource
[s.l.] : Nature Publishing Group
Nature genetics 14 (1996), S. 55-61
ISSN: 1546-1718
Source: Nature Archives 1869 - 2009
Topics: Biology , Medicine
Notes: [Auszug] The apolipoprotein E (APOE) E4 allele is associated with Alzheimer's disease, cardiovascular disease, and decreased longevity. To probe the mechanism of these associations, cell lines were created which secrete each apoE isoform. ApoE conditioned media, purified apoE, and commercially obtained apoE ...
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• 6
Electronic Resource
Oxford, UK : Blackwell Science Ltd
Journal of neurochemistry 68 (1997), S. 0
ISSN: 1471-4159
Source: Blackwell Publishing Journal Backfiles 1879-2005
Topics: Medicine
Notes: Abstract: The ε4 allele of apolipoprotein E (apoE, protein; APOE, gene) is a major risk factor for Alzheimer's disease (AD). Genetically, the frequency of the ε4 allele is enriched in early-onset sporadic, late-onset familial, and common late-onset sporadic AD. ApoE is found in the extracellular amyloid-β (Aβ) deposits that are characteristic features of AD. In this study, we examined the interaction between Aβ and apoE isoforms. The apoE isoforms used in this study were either produced by stably transfected Chinese hamster ovary cells (CHO) or were from human plasma. We report that when similar concentrations of the apoE isoforms were used, native nonpurified apoE3 from recombinant CHO-derived sources bound Aβ, but apoE4 did not. In fact, in our system, binding of recombinant apoE4 to Aβ was never detectable, even after incubation for 4 days. Furthermore, using the same assay conditions, native apoE2, like apoE3, binds Aβ avidly. Furthermore, when human plasma apoE isoforms are tested in Aβ binding experiments, apoE3 bound Aβ more avidly than apoE4, and a major apoE/Aβ complex (the 40-kDa form) was observed with plasma apoE3 but not apoE4. These data extend our understanding of apoE isoform-dependent binding of Aβ by associating apoE2 with efficient apoE/Aβ complex formation and demonstrate that native apoE3 (whether recombinant or derived from human plasma) forms sodium dodecyl sulfate-stable apoE/Aβ complexes more readily than native apoE4. The different Aβ-binding properties of native apoE4 versus native apoE3 provide insight into the molecular mechanisms by which the APOE ε4 allele exerts its risk factor effects in AD.
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• 7
Electronic Resource
Oxford, UK : Blackwell Science Ltd
Journal of neurochemistry 79 (2001), S. 0
ISSN: 1471-4159
Source: Blackwell Publishing Journal Backfiles 1879-2005
Topics: Medicine
Notes: Cerebral apolipoprotein E (apoE) has been implicated in neuronal protection and repair. Due to the variable levels and types of estrogen receptors within different brain regions, the effect of estrogen on apoE and the mechanism of this effect may vary within different regions. Ovariectomized female C57BL/6 mice were treated with pharmacological levels of 17β-estradiol or placebo for 5 days, resulting in supraphysiological plasma levels of estradiol in the treated mice. ApoE and glial fibrillary acidic protein (GFAP) levels were measured in the cortex, hippocampus and diencephalon. 17β-Estradiol up-regulated apoE but not GFAP in the cortex and diencephalon, whereas in the hippocampus, GFAP and apoE were equally up-regulated. Treatment of estrogen receptor (ER) α knockout mice with 17β-estradiol or treatment of C57BL/6 mice with 17α-estradiol, a poor estrogen receptor agonist, specifically induced apoE in the cortex, but not in the diencephalon. These results indicate that 17β-estradiol effects on apoE are either directly or indirectly mediated by ERα in the diencephalon, while the effects in the cortex may be mediated by a non-classical mechanism or by ERβ. Measurement of mRNA levels in estrogen versus placebo-treated wild-type mice indicated that the effect of 17β-estradiol on apoE was not associated with changes in apoE mRNA levels.
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• 8
Electronic Resource
Oxford, UK : Blackwell Science Ltd
Journal of neurochemistry 90 (2004), S. 0
ISSN: 1471-4159
Source: Blackwell Publishing Journal Backfiles 1879-2005
Topics: Medicine
Notes: Aging and apolipoprotein E (APOE) isoform are among the most consistent risks for the development of Alzheimer's disease (AD). Metabolic factors that modulate risk have been elusive, though oxidative reactions and their by-products have been implicated in human AD and in transgenic mice with overt histological amyloidosis. We investigated the relationship between the levels of endogenous murine amyloid β (Aβ) peptides and the levels of a marker of oxidation in mice that never develop histological amyloidosis [i.e. APOE knockout (KO) mice with or without transgenic human APOEɛ3 or human APOEɛ4 alleles]. Aging-, gender-, and APOE-genotype-dependent changes were observed for endogenous mouse brain Aβ40 and Aβ42 peptides. Levels of the oxidized lipid F2-isoprostane (F2-isoPs) in the brains of the same animals as those used for the Aβ analyses revealed aging- and gender-dependent changes in APOE KO and in human APOEɛ4 transgenic KO mice. Human APOEɛ3 transgenic KO mice did not exhibit aging- or gender-dependent increases in F2-isoPs. In general, the changes in the levels of brain F2-isoPs in mice according to age, gender, and APOE genotype mirrored the changes in brain Aβ levels, which, in turn, paralleled known trends in the risk for human AD. These data indicate that there exists an aging-dependent, APOE-genotype-sensitive rise in murine brain Aβ levels despite the apparent inability of the peptide to form histologically detectable amyloid. Human APOEɛ3, but not human APOEɛ4, can apparently prevent the aging-dependent rise in murine brain Aβ levels, consistent with the relative risk for AD associated with these genotypes. The fidelity of the brain Aβ/F2-isoP relationship across multiple relevant variables supports the hypothesis that oxidized lipids play a role in AD pathogenesis, as has been suggested by recent evidence that F2-isoPs can stimulate Aβ generation and aggregation.
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• 9
Electronic Resource
College Park, Md. : American Institute of Physics (AIP)
Journal of Mathematical Physics 37 (1996), S. 3073-3098
ISSN: 1089-7658
Source: AIP Digital Archive
Topics: Mathematics , Physics
Notes: It has recently been discovered [A. A. Ungar, Am. J. Phys. 59, 824 (1991); 60, 815 (1992)] that the set R3c={v∈R3 : (parallel)v(parallel)〈c} of all relativistically admissible velocities in Euclidean three-space R3, with a binary operation ⊕ given by relativistic velocity addition, forms a gyrogroup (R3c,⊕). The gyrogroup (R3c,⊕) reduces to the group (R3,+) in the limit c→∞, + being the prerelativistic velocity addition (that is, the ordinary vector addition in the Euclidean three-space R3). The binary operation ⊕ in R3c is gyroassociative and gyrocommutative, as opposed to the binary operation + in R3 which is associative and commutative. In this article we extend the study of gyrogroups into that of Lorentz groups. In particular, we find that a gyrogroup must be equipped with a cocycle form in order to be extendible into a Lorentz group. We thus study gyrogroups that are equipped with a cocycle form, and their resulting Lorentz groups. Interestingly, the cocycle form needed for the extension of gyrogroups into Lorentz groups involves a cocycle identity which is known to be useful in various branches of mathematics [B. R. Ebanks and C. T. Ng, Aequat. Math. 46, 76 (1993)]. © 1996 American Institute of Physics.
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• 10
Electronic Resource
Oxford, UK : Blackwell Science Ltd
ISSN: 1460-9568
Source: Blackwell Publishing Journal Backfiles 1879-2005
Topics: Medicine
Notes: Alzheimer's disease is the most frequent neurodegenerative disorder in the aged population and is characterized by the deposition of the 40/42-residue amyloid β protein (Aβ), a proteolytic fragment of the β-amyloid precursor protein (APP). A common apolipoprotein E (apoE) polymorphism is associated with an increased risk of developing the disease. In order to assess the putative relationship between apoE and amyloidogenesis in the CNS, we prepared primary cortical neurons overexpressing humanized APP695 bearing the Swedish mutation (hAPP695sw) and we analysed APP expression and processing after: (i) coculture with primary astrocytes from wild-type, apoE-deficient (E0) mice, or mice overexpressing human apoE2, E3, or E4; (ii) treatment with conditioned media from apoE0, E2, E3 or E4 astrocytes; and (iii) treatment with human recombinant ApoE or human apoE purified from conditioned media of stably transfected RAW264 cells (E2, E3 and E4). Interestingly, a strong decrease in APP expression was observed only when neurons were cocultured with astrocytes (and independently of the apoE genotype considered), suggesting that cell–cell contact is required. Moreover, apoE4-secreting astrocytes, but not recombinant or purified apoE4, significantly increased Aβ production and decrease sAPPα secretion only when cultured in direct contact with neurons, whereas apoE2 astrocytes had a protective effect. We conclude that astrocytes: (i) strongly regulate neuronal APP expression in primary neurons, and (ii) promote the amyloidogenic pathway in an apoE4-dependent manner. Thus, apoE and astrocytic factor(s) may modulate the pathogenesis of Alzheimer's disease.
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