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  • 1
    ISSN: 1432-1211
    Keywords: Key words Interferon gamma ; Polymorphism ; Promoter ; AIOS ; 3′UTR
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  Interferon gamma (IFN-gamma) is a multifunctional cytokine that is essential in the development of Th1 cells and in cellular responses to a variety of intracellular pathogens including human immunodeficiency virus (HIV-1). We screened genomic DNA samples from a predominately Caucasian male population of HIV-infected and healthy donors for polymorphisms in the human IFNG gene from –777 to +5608 by single-stranded conformational polymorphism. Surprisingly, the proximal promoter (–777 to transcription start) is invariant as no polymorphisms were found in over 100 samples tested. However, further screening revealed polymorphisms in other regions of the gene including a single base insertion in a poly-T tract in the first intron, three single base pair substitutions in the third intron, and another single base pair substitution in the 3′ untranslated region (UTR). Electrophoretic mobility shift assay was used to investigate whether these variants have altered DNA-binding abilities, since intronic enhancer elements have been reported for the IFNG gene. Oligonucleotides constructed for two third intron variants showed no difference in DNA-binding abilities as compared with wild-type sequences. However, the 3′UTR variant showed the formation of unique DNA-binding complexes to radiolabeled oligonucleotide probes as compared with the wild-type sequence. The influence of a CA-repeat microsatellite on AIDS disease progression in HIV-1 seroconverters was tested by a Cox proportional hazards model. There is no evidence of an association between alleles and infection with HIV-1 or progression to AIDS. We report an invariant proximal human IFNG promoter and the existence of multiple intronic variants and a potentially functional 3′UTR polymorphism.
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  • 2
    ISSN: 1432-5195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé  Nous avons réalisé une étude rétrospective comprenant sept fractures periprothetiques complexes du fémur distal chez sept porteurs de PTG. Toutes les fractures ont ete traitees par enclouage rétrograde du fémur. L’evolution post-opératoire et la réeducation à la marche étaient sans particularités chez tous les patients. Toutes les fractures ont consolidés sans problemes avec un bon alignement.
    Notes: Abstract  Seven patients who sustained complex distal femoral fractures above total knee arthroplasties all treated by supracondylar (retrograde) femoral nailing were retrospectively evaluated. All the patients demonstrated uncomplicated postoperative follow-ups and returned to weight bearing between 2 and 3 months after surgery. No delayed healing occurred and alignment of the femur was satisfactory.
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  • 3
    ISSN: 1432-5195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé  Nous avons realisé une étude rétrospective comprenant 80/107 prothèses totale de la hanche en utilisant une tige fémorale avec fixation proximale non- cimentée. L`age moyen des patients lors de l`intervention était de 58.6 ans. La durée moyenne d`observation post-opératoire était de 8.1 ans. Le score de Harris lors du dernier examen clinique était de 91.7. Une incorporation radiologique idéale était observée dans 77 tiges, 2 tiges étaient stables et 1 tige était descellée.
    Notes: Abstract  A series of total hip replacements was performed using a proximally porous coated, tapered femoral stem system. At a mean follow-up of 8.1 (5–13) years, 80 out of 107 hips were available for clinical and radiological examination. The mean age at the index procedurewas 58.6 years. The mean Harris Hip Score at final follow-up was 91.7. Radiological ingrowth was observed in 77 femoral stems, 2 stems were fibrous stable and 1 stem was loose.
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  • 4
    ISSN: 1432-5195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé   Nous avons réalisé une étude rétrospective comprenant 127 prothèses totales de la hanche en utilisant une cupule acetabulaire non cimentée. ’Age moyen des patients lors d’intervention était de 61.2 ans. La durée moyenned’ observation post-operatoire était de 10.6 ans. Le score de Harris lors du dernier examen clinique était de 89.9. Trois cupules étaient révisées pour descellement aseptique et deux inserts en polyéthylène étaient changés pour usure et ostéolyse. Neuf autres patients montraient une ostéolyse discrète. Deux cupules étaient stables avec une fixation dite «fibreuse». Aucune corrélation entre utilisation de vis pour la fixation primaire et le développement d’osteolyse n’a été trouvée.
    Notes: Abstract  A series of 198 total hip arthroplasties was performed using a porous-coated, hemispheric press-fit cup. One hundred and twenty-seven cups were available for clinical and radiological examination at mean follow-up of 10.6 years. The mean age at the index procedure was 61.2 years. The mean Harris hip score at final follow-up was 89.8. Three cups were revised for aseptic loosening and two liners were changed for eccentric wear and pelvic osteolysis. Nine additional patients showed mild or suspected osteolysis. Two cups were rated ”fibrous” stable. There was no correlation between additional screw fixation of the press-fit cup and osteolysis or revision.
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  • 5
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Unidirectional fluxes of different amino acids have been determined across newborn pig small intestine and colon. The systems responsible for amino acid transport are present in the same proportion in both tissues. Colonic transport of amino acids appears to represent a transient overspill function of the small intestine.
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 37 (1981), S. 868-870 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary All villus enterocytes in the newborn pig intestine take up alanine by a process which is largely Na-dependent. Uptake in the adult rabbit intestine is cinfined to enterocytes near the tips of villi. Previous conclusions about how transport changes during development are reviewed on the basis of these findings.
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  • 7
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Résumé Le potentiel transmural de l'intestin du poisson rouge, incubé in vitro, dépend partiellement de la présence de la glucose. Ce potentiel, dû à la glucose, est déterminé par la température d'acclimatation, et se réduit dans la mesure que cette température augmente. Cet aspect de l'acclimatation est complet 20 h après qu'on a élevé la température du milieu du poisson, et le puromycin entrave ces variations. Ces résultats suggèrent l'idée que les variations dans les propriétés des membranes de l'epithélium intestinal impliquent la synthèse des molécules de protéine.
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  • 8
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Resumen El intestino delgado del cerdo recién nacido, usado in vitro, transporta immunoglobulina G (IgG) de bovino más rápido que IgG de porcino. El transporte intestinal tanto de sodio como de fluido aumenta en presencia de IgG de bovino. Preparaciones de IgG de ovino, equino y humano son transportadas a igual velocidad que IgG de porcino. Estas proteínas no estimulan la transferencia de sodio o fluido. Esta diferencia en la velocidad de transporte entre IgG de bovino y porcino pone en duda la opinion general que sostiene que la absorción de proteína en el intestino de cerdo es enteramente no selectiva.
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 26 (1970), S. 736-738 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Résumé Des blastokystes ont été pris à des lapins 6 jours après l'accouplement et couvés in vitro pendant 7 h. Le transport d'eau et de chlorure de soude a été arrêté par l'ouabaine ou par refroidissement. L'acétazolamide met en équillibre les concentrations de bicarbonate-chlorure. Il nous semble donc que c'est le transport de l'ATPase qui extrait le chlorure de soude et que l'anhydrase carbonique y concourt maintenant une concentration elevée de bicarbonate à l'intérieur du blastokyste.
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  • 10
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Cells produced in the crypts of newborn pig ileum migrate onto villi during development. There is little or no corresponding loss of cells from villus tips during the first week of postnatal life. Villus growth during this period is largely responsible for the slow rate of cellular renewal seen to take place.
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