Chromatography, liquid, on triacetylcellulose
1H-N M R, in the presence of an optically active auxiliary
Rotation hindered, about a =C—C= bond
Springer Online Journal Archives 1860-2000
Chemistry and Pharmacology
Abstract (+)- and (−)-1 (N,N,N′,N′-Tetramethyldithiooxamide) were enriched by semipreparative liquid chromatography on triacetylcellulose. According to1HNMR in the presence of an optically active auxiliary, the sample of (+)365-1 had an enantiomeric purity of 0,50±0,01, thus permitting to calculate the CD spectrum for the pure enantiomer. The CD and UV spectra are discussed in terms of qualitative MO theory. Thereby, the absolute configuration of (+)365-1 is determined to be (R).
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