Springer Online Journal Archives 1860-2000
Summary The pharmacokinetics of adriamycin, its metabolite adriamycinol, and antipyrine were studied in 17 patients with moderate tumor involvement of the liver and compared to that of 19 tumor patients with normal liver function (Preiss et al. 1985). The individual liver function parameters deviated from normal by a factor ranging from 2.5 to 12.2 the t 1/2α and t 1/2β, the AUC (corrected for body weight and dose) and the total body clearance (CL, corrected for body weight) of adriamycin did not differ significantly between the two groups of patients. Likewise, there was no difference in the kinetic parameters of antipyrine between the two groups. Unlike adriamycin and antipyrine, adriamycinol was found to have a significantly longer t 1/2term (60.5 vs 28.3 h, P〈0.001), an increased AUC (3.00 vs 1.43 h/ug per ml, P〈0.02), and a higher AUCadriamycinol/AUCadriamycin ratio (0.94 vs 0.52, P〈0.02) in patients with moderate tumor involvement of the liver. The CL, the AUC, and t1/2β of adriamycin correlated significantly (P〈0.001 and P〈0.01) with the corresponding kinetic parameters of antipyrine, but not with the usual liver function parameters. No correlation could be found between the kinetic parameters of adriamycinol and those of antipyrine.
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