Springer Online Journal Archives 1860-2000
Summary Sera of rabbits, immunized with water-salt extract from the tissue of Guerin's carcinoma and normal rat erythrocytes, react with the antigens of the tumor tissue, the uterus; kidney, and erythrocytes. This points to the presence of a common antigen in these tissues and erythrocytes. It is possible to extract (to a considerable extent) antigens common to the erythrocyte antigens from the water-salt extract of tumor tissue by means of antierythrocytic serum in the presence of the guinea pig serum complement. Antigens, common to the tissue of a homologous normal organ (uterus), are retained in such an exhausted extract. These data show that at least two types of antigens are present in the tumor tissue (along with other antigens) i.e., species and tissue ones. The commoness of antigenic properties of Guerin's carcinoma, normal uterus, kidney tissue, and erythrocytes were also demonstrated by the tissue culture method.
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