Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Keywords: EXPRESSION ; RESPONSES ; ASSOCIATION ; ethanol ; CONSUMPTION ; CANDIDATE GENES ; PROTEIN-INTERACTION NETWORKS ; VULNERABILITY ; LOW-LEVEL ; PREFERRING RATS
    Abstract: Genetic factors have as large role as environmental factors in the etiology of alcohol dependence (AD). Although genome-wide association studies (GWAS) enable systematic searches for loci not hitherto implicated in the etiology of AD, many true findings may be missed owing to correction for multiple testing. The aim of the present study was to circumvent this limitation by searching for biological system-level differences, and then following up these findings in humans and animals. Gene-set-based analysis of GWAS data from 1333 cases and 2168 controls identified 19 significantly associated gene-sets, of which 5 could be replicated in an independent sample. Clustered in these gene-sets were novel and previously identified susceptibility genes. The most frequently present gene, ie in 6 out of 19 gene-sets, was X-ray repair complementing defective repair in Chinese hamster cells 5 (XRCC5). Previous human and animal studies have implicated XRCC5 in alcohol sensitivity. This phenotype is inversely correlated with the development of AD, presumably as more alcohol is required to achieve the desired effects. In the present study, the functional role of XRCC5 in AD was further validated in animals and humans. Drosophila mutants with reduced function of Ku80-the homolog of mammalian XRCC5-due to RNAi silencing showed reduced sensitivity to ethanol. In humans with free access to intravenous ethanol self-administration in the laboratory, the maximum achieved blood alcohol concentration was influenced in an allele-dose-dependent manner by genetic variation in XRCC5. In conclusion, our convergent approach identified new candidates and generated independent evidence for the involvement of XRCC5 in alcohol dependence.
    Type of Publication: Journal article published
    PubMed ID: 25035082
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    Keywords: RECEPTOR ; human ; MODEL ; MODELS ; EXPOSURE ; RISK ; GENE ; TIME ; PATIENT ; ASSOCIATION ; FREQUENCY ; polymorphism ; POLYMORPHISMS ; single nucleotide polymorphism ; PATTERNS ; STRESS-RESPONSE ; DNA-BINDING ; ethanol ; INDIVIDUALS ; ALCOHOL ; CHILDREN ; PREVALENCE ; ALCOHOL-CONSUMPTION ; CONSUMPTION ; ENHANCER ; DISORDERS ; ADULTS ; DEPENDENCE ; MICE LACKING ; haplotype-tagging ; alcohol consumption ; animal model ; HORMONE-RECEPTOR ; TRANSCRIPTION FACTOR SP1 ; ADOLESCENTS ; AFFECTIVE-DISORDERS ; CORTICOTROPIN-RELEASING-FACTOR ; EARLY ADULTHOOD ; HPA-axis
    Abstract: To investigate the role of the corticotropin releasing hormone receptor 1 (CRHR1) in patterns of human alcohol drinking and its potential contribution to alcohol dependence, we analysed two independent samples: a sample of adolescents, which consisted of individuals from the 'Mannheim Study of Risk Children' (MARC), who had little previous exposure to alcohol, and a sample of alcohol-dependent adults, who met DSM-IV criteria of alcohol dependence. Following determination of allelic frequencies of 14 polymorphisms of the CRHR1 gene, two haplotype tagging (ht)SNPs discriminating between haplotypes with a frequency of 〉= 0.7% were identified. Both samples were genotyped and systematically examined for association with the htSNPs of CRHR1. In the adolescent sample, significant group differences between genotypes were observed in binge drinking, lifetime prevalence of alcohol intake and lifetime prevalence of drunkenness. The sample of adult alcohol-dependent patients showed association of CRHR1 with high amount of drinking. This is the first time that an association of CRHR1 with specific patterns of alcohol consumption has been reported. Our findings support results from animal models, suggesting an importance of CRHR1 in integrating gene environment effects in alcohol use disorders
    Type of Publication: Journal article published
    PubMed ID: 16550213
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    Abstract: The present study investigated the genetic contribution to alcohol dependence (AD) using genome-wide association data from three German samples. These comprised patients with: (i) AD; (ii) chronic alcoholic pancreatitis (ACP); and (iii) alcohol-related liver cirrhosis (ALC). Single marker, gene-based, and pathway analyses were conducted. A significant association was detected for the ADH1B locus in a gene-based approach (puncorrected = 1.2 x 10-6; pcorrected = 0.020). This was driven by the AD subsample. No association with ADH1B was found in the combined ACP + ALC sample. On first inspection, this seems surprising, since ADH1B is a robustly replicated risk gene for AD and may therefore be expected to be associated also with subgroups of AD patients. The negative finding in the ACP + ALC sample, however, may reflect genetic stratification as well as random fluctuation of allele frequencies in the cases and controls, demonstrating the importance of large samples in which the phenotype is well assessed.
    Type of Publication: Journal article published
    PubMed ID: 28714907
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    Keywords: Germany ; human ; KINASE ; TYROSINE KINASE ; COHORT ; NEW-YORK ; RISK ; GENE ; PROTEIN ; PATIENT ; TOLERANCE ; ASSOCIATION ; polymorphism ; single nucleotide polymorphism ; HUMANS ; NUMBER ; SNP ; REGION ; RELIABILITY ; PHENOTYPE ; SELECTION ; ALCOHOL ; INTERVIEW ; alcohol dependence,protein tyrosine kinase,fyn,early onset,withdrawal,alcohol intake,association,lin ; ETHANOL SENSITIVITY
    Abstract: Background: Decreased sensitivity to and increased tolerance for the effects of alcohol is a phenotype, which was shown to be associated with an increased risk for alcoholism in humans and was observed in protein tyrosine kinase (PTK) fyn knockout mice.Methods: We performed an association study of genetic variations of PTK fyn in 430 alcohol-dependent patients and 365 unrelated control subjects from two independent samples.Results: In a combined analysis, we found an association of alcohol dependence with the single nucleotide polymorphism (SNP) T137346C in the 5' untranslated region (UTR) of the gene. A relevant association could be excluded for the remaining two informative SNPs. Selection by phenotype showed that a high number of withdrawal symptoms, high amount of alcohol intake, and high maximum number of drinks compared with unrelated control subjects was associated with the SNP in the 5'-UTR region but not with the remaining SNPs.Conclusions: Our results indicate a possible association of alcohol dependence with a genotype of the SNP T137346C of the PTK fyn, with C being the risk allele
    Type of Publication: Journal article published
    PubMed ID: 14675807
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Dissoziative Identitätsstörung ; Multiple Persönlichkeitsstörung ; Paranoide Schizophrenie ; Persönlichkeitsstörung vom Borderlinetypus ; Dissoziative Störung ; Key words Dissociative identity disorder ; Multiple personality disorder ; Paranoid schizophrenia ; Borderline personality disorder ; Dissociation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Recently the concept of dissociative identity disorder (formerly known as multiple personality disorder) has attracted increasing public and scientific interest. However, it is rarely diagnosed in the clinical setting. The reported case of a 47-year-old woman with a history of child abuse demonstrates the problems of differential diagnosis. A number of psychopathologic symptoms pointed to a multiple personality disorder, but in the follow-up psychotic symptoms such as delusions, possible hallucinations and bizarre behavior clearly emerged. The differential diagnosis of dissociative identity disorder includes paranoid schizophrenia, as in the case described, borderline personality disorder, hysteria, simulation and the false memory syndrome. Finally, social and cultural factors have to be considered.
    Notes: Zusammenfassung In der letzten Zeit ist die dissoziative Identitätsstörung (multiple Persönlichkeitsstörung) zunehmend Gegenstand von öffentlichem und wissenschaftlichem Interesse geworden. Klinisch wird die Diagnose allerdings sehr selten gestellt. Anhand der vorliegenden Kasuistik sollen Schwierigkeiten der differentialdiagnostischen Abgrenzung aufgezeigt werden. Bei einer 47jährigen Patientin, die eigenanamnestisch im Kindesalter schweren psychosozialen Belastungsfaktoren mit Mißbrauch ausgesetzt war, ließen verschiedene psychopathologische Befunde zunächst an eine sog. multiple Persönlichkeit denken. Im Verlauf traten aber zunehmend psychotische Symptome, wie inhaltliche Denkstörungen, bizarres Verhalten und fragliche Halluzinationen in den Vordergrund. In die differentialdiagnostischen Überlegungen sind bei einer dissoziativen Identitätsstörung die paranoide Schizophrenie, wie im beschriebenen Fall, die Persönlichkeitsstörung vom Borderlinetyp, die Hysterie, die Simulation und das „false memory syndrome” einzubeziehen. Schließlich müssen auch Probleme, die sich aus der soziokulturellen Einbettung des Syndroms ergeben, diskutiert werden.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 6
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Methadonsubstitution ; Fahrtauglichkeit ; HIV-Infektion ; Key words Methadone substitution ; Driving ability ; HIV-infection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The aim of our experimental study was to gain informations and data on the driving ability of patients undergoing a methadone substitution programme as well as to explore the influence of an HIV infection. 28 patients, five of them HIV-positive, were compared to a control group equal in age, sex and education. For the traffic relevant tests the methadone patients showed significantly reduced performance. Six of the methadone patients passed the tests in a way regarded to have sufficient driving skills. We were unable to prove an influence of HIV infection on driving skills when lacking relevant somatic and neuropsychiatric symptoms. There was no significant correlation between the test results and patients age or dose of medication. We conclude that in general methadone substitution does not implicate driving inability although the majority of our patients showed some reduction of their psychomotoric skills.
    Notes: Zusammenfassung Ziel dieser experimentellen Studie war es, die Fahrtauglichkeit von Patienten unter Methadonsubstitution zu untersuchen, wobei auch der mögliche Einfluß einer HIV-Infektion geklärt werden sollte. Es wurden 28 Methadonpatienten, von denen 5 HIV-infiziert waren, mit einer in bezug auf Alter, Geschlecht und Schulbildung gemachten Kontrollgruppe verglichen. Dabei zeigten sich in den fahrrelevanten psychophysischen Leistungstests bei der Methadongruppe signifikante Einbußen. Einzeln betrachtet hatten 6 Methadonpatienten einen unauffälligen Testbefund und wären somit als fahrtauglich einzustufen. Einen Einfluß der HIV-Infektion auf die Leistungstests, beim Fehlen relevanter somatischer und neuropsychiatrischer Symptome, ließ sich nicht nachweisen. Auch ein Zusammenhang zwischen Testleistung und Alter bzw. Methadondosis konnte nicht festgestellt werden. Das Ergebnis dieser Studie zeigt, daß Methadoneinnahme nicht grundsätzlich mit Fahruntauglichkeit gleichzusetzen ist, sich aber doch bei einer großen Zahl methadonsubstituierter opiatabhängiger Patienten Anhaltspunkte für eine Beeinträchtigung der psychomotorischen Leistungsfähigkeit ergeben.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Der Nervenarzt 67 (1996), S. 891-895 
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Alkohol ; Alkoholhalluzinose ; Pathophysiologie ; Therapie ; Key words Alcohol ; Alcohol hallucinosis ; Pathophysiology ; Therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In recent years, little research has been focused on alcohol hallucinosis. The psychopathology of alcohol hallucinosis (vivid acoustic hallucinations, paranoid symptoms and fear) resembles paranoid schizophrenia, but other organic mental disorders have to be excluded too. Prognosis is usually good, but in 10–20 % of cases alcohol hallucinosis tends to become chronic. Possible pathophysiological mechanisms involved in the development of the syndrome are changes in dopaminergic transmission or other neurotransmitter systems and neuronal membranes, elevated levels of betacarbolines and an impaired auditory system. For treatment, highly potent neuroleptics (haloperidol) are the drugs of first choice. In the case of alcohol abstinence the prognosis is good, but otherwise the risk of a recurrence is high.
    Notes: Zusammenfassung Unter den Alkoholpsychosen zählt die Alkoholhalluzinose zu den vergleichsweise schlecht untersuchten Krankheitsbildern. Psychopathologisch ähnelt sie der paranoiden Schizophrenie mit den Leitsymptomen akustische Halluzinationen (Stimmenhören), Verfolgungswahn und Angst. Differentialdiagnostisch sind auch ein Alkoholdelir und andere organische Psychosen auszuschließen. Die Prognose ist in den meisten Fällen gut, in ca. 10–20 % der Fälle kommt es aber zu chronischen Halluzinosen, die sich phänomenologisch dann nur schwer von schizophreniformen Psychosen differenzieren lassen. Pathophysiologisch werden neben Veränderungen im dopaminergen System und anderen Neurotransmittern auch die Bedeutung von Betacarbolinen, Veränderung neuronaler Membranen und sensorische Störungen diskutiert. Zur Akutbehandlung sind eher hochpotente Neuroleptika vom Typ des Haloperidol indiziert. Bei Alkoholabstinenz ist die Prognose gut; in anderen Fällen ist mit häufigen Rezidiven zu rechnen.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 8
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Alkohol ; Abhängigkeit ; Psychopathologie ; Depression ; Affektive Störungen ; Key words Alcohol ; Dependence ; Psychopathology ; Depression ; Affective disorders
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The frequent comorbidity of psychiatric disorders and alcohol dependence has raised increasing interest in the scientific literature over the last few years. Special attention has been given to the coincidence of depressive syndromes and alcohol dependence. Depressive syndromes can both precede and follow the onset of alcohol dependence. Their diagnostic classification can cause considerable problems. In clinical studies, very different prevalence rates of depressive syndromes in alcohol-dependent persons were found. The frequency of primary depressive syndromes appeared to be substantially smaller than the frequency of secondary depressive syndromes. Epidemiological studies did not point at the exceedingly high comorbidity of affective disorders and alcohol dependence. In this review article, scientific results about possible causes of depressive syndromes in alcohol-dependent persons are demonstrated; genetic and neurobiological links between depression, alcohol dependence and the possible importance of changes in serotoninergic transmission are discussed; methodological problems are described, and implications of the comorbidity problem for treatment planning are presented.
    Notes: Zusammenfassung Die häufige Komorbidität von psychischen Erkrankungen und Alkoholabhängigkeit hat in der wissenschaftlichen Literatur in den letzten Jahren zunehmende Beachtung gefunden. Fokussiert wurde dabei v. a. die Koinzidenz von depressiven Syndromen und Alkoholabhängigkeit. Depressive Syndrome können einer Alkoholabhängigkeit zeitlich vorangehen oder auch folgen. Ihre diagnostische Zuordnung kann erhebliche Probleme bereiten. In klinischen Untersuchungen wurden bei Alkoholikern sehr unterschiedliche Prävalenzraten für depressive Syndrome berichtet. Die Häufigkeit von primär depressiven Syndromen war dabei wesentlich geringer als die sekundär depressiver Syndrome. Epidemiologische Untersuchungen zeigten eine vergleichsweise niedrige Komorbiditätsrate von affektiven Störungen und Alkoholabhängigkeit. In dieser Übersichtsarbeit werden Forschungsergebnisse über mögliche Ursachen depressiver Syndrome bei Alkoholikern dargestellt, genetische und neurobiologische Querverbindungen zwischen Depression und Alkoholabhängigkeit aufgezeigt, die Bedeutung von Veränderungen im serotonergen System diskutiert, methodische Probleme erörtert und Implikationen des Komorbiditätsproblems für die Behandlungsplanung dargelegt.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Der Nervenarzt 70 (1999), S. 76-80 
    ISSN: 1433-0407
    Keywords: Schlüsselwörter Psychiatrie ; Psychotherapie ; Internet ; Telemedizin ; Cybertherapie ; Key words Psychiatry ; Psychotherapy ; Internet ; Telemedicine ; Cybertherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The Internet is a fast growing medium, which is about to alter our all day life. Most impact is given to advantages of telemedicine to psychiatrists and psychotherapists as well as patients. After introduction of the essential features of the Internet practical aspects of medicine in Cyberspace for psychotherapists, psychiatrists and their patients are shown. Then, the general prohibition of advertisement for physicians is discussed on the bases of actual laws related to Internet activities. Relevant resources of medical information are shown with regard to the detailed facilities of using searchengines. Highlighting opportunities and possible resources of medicine in cyberspace, it is made clear, that the rising interest in telemedicine on Internet is more than justified. Finally, some risks of virtual communication are visible. Important and mentioned Web-sites are listed at the end.
    Notes: Zusammenfassung Das Internet ist im Begriff, zahlreiche Bereiche des zwischenmenschlichen Lebens zu verändern. Im Vordergrund der Betrachtung stehen Aspekte des Internet, die im Rahmen der Psychiatrie und Psychotherapie von aktueller Bedeutung sind. Nach der Einführung in das Wesen der Therapie im Internet werden praktische Aspekte der Medizin im virtuellen Raum für Psychotherapeuten und Psychiater sowie Patienten konkret aufgezeigt. Das Werbeverbot für Ärzte und die gesetzlichen Regelungen zur Selbstdarstellung im World Wide Web werden erörtert. Medizinische Informationsquellen werden aufgezeigt und die Möglichkeit zur detaillierten Suche im Internet erläutert. Schließlich werden einige der Risiken dieser Art der zwischenmenschlichen Kommunikation im Bereich der psychotherapeutischen und psychiatrischen Anwendungen anschaulich. Der Anhang gliedert tabellarisch erwähnte und wichtige Internet-Adressen.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 10
    ISSN: 1369-1600
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Because corticotrophin-releasing hormone (CRH) plays a central role in stress regulation, the possible role of CRH1 polymorphism for anxiety-related personality variables such as harm avoidance possibly associated with alcoholism was studied. The research instruments used to phenotype patients were adopted partly from the US collaborative study of the genetics of alcoholism and include a number of personality inventories such as the temperament and character inventory (TCI). Based on the examination of 170 alcoholic subjects no association was found between CRH1 receptor haplotypes of four single nuclotid polymorphisms (SNPs) and low and high temperament traits of harm avoidance, novelty seeking and reward dependence. The possible implications of these findings are discussed.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...