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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    ISSN: 1600-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract Current WHO methods were employed to estimate the prevalence of oral pathology, dentofacial anomalies, periodontal disease, caries and prosthetic status as well as treatment needs in Tuvalu, a newly emergent nation in the South Pacific. Fluorosis was endemic but other disorders of teeth, mucosa or bone were extremely rare and the presence of dentofacial anomalies was very low. Periodontal disease was “moderate” at 15 years of age but seemed to be a predisposing factor in caries from the late teens onward. Comparison with a survey 8 years previously indicated that caries rates had risen from “very low” to “low” at 12 years of age but treatment services had improved markedly. More than half of persons in the 55–64 year age group required full maxillary and mandibular dentures whilst 10% already possessed them.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-4919
    Keywords: membrane ; drug resistance ; carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract A membrane protein recognized by monoclonal antibody SQM1 was identified in human squamous carcinomas, including those originating in the head and neck (SqCHN), lung and cervix. Cell lines derived from SqCHN of previously untreated patients expressed high amounts of this protein. In contrast, many cell lines established from SqCHN of patients previously treated with chemotherapy and/or radiation showed diminished amounts of this SQM1 protein. The expression of SQM1 antigen was determined in several SgCHN cell lines made resistant by exposure to methotrexate (MTX) in vitro. The parent cell lines all exhibited strong binding to SQM1 antibody. The MTX-resistant sublines showed much lower membrane binding of SQM1. The lowest SQM1 reactivity was found in cell lines with high resistance to MTX and with diminished rate of MTX transport. Some highly MTX-resistant cell lines which had high levels of dihydrofolate reductase, but which retained a high rate of MTX transport, also retained high levels of SQM1 binding. Reduced SQM1 protein was also found in SgCHN cells which developed resistance to the alkylating drug cis-platinum (CDDP) and which showed reduced membrane transport of CDDP. Cell growth kinetics and non-specific antigenic shifts were not responsible for the differences in SQM1 binding between the parent cell lines and their drug-resistant sublines. The finding of a novel protein which is reduced in cells resistant to MTX and CDDP could contribute to our understanding of the basic mechanisms of drug resistance. By detecting SQM1 protein in clinical specimens, it may be possible to monitor the development of drug resistance in tumors.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 0098-1273
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Depolarization ratios ρ have been measured over ranges of temperature T and molecular weight M for polystyrene (PS) dissolved in cyclohexane (1002 cm-1 Raman band) and for poly(dimethyl siloxane) (PDMS) dissolved in benzene (2907 cm-1 Raman band). The ranges in the case of PS are 15 〈 T 〈 65°C and 2 × 103 〈 M 〈 4 × 105 and in the case of PDMS are -3 〈 T 〈 60°C and M = 104. Measurements were also made of PDMS radii of gyration using conventional light scattering. The results are interpreted in terms of a theory connecting rotational isomeric populations with polymer extension. In the case of PDMS, an experimental value of the proportionality constant for trans isomers (D2 = -3.9 ± 0.9) is deduced. This is closer to the theoretical value than previous estimates but there is still some discrepancy. In the case of PS the isomeric changes resulting from extension are independent of M for M 〉 104. Deviations are observed for lower M.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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