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  • 1
    facet.materialart.
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    German Medical Science; Düsseldorf, Köln
    In:  67. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie, 89. Tagung der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie und 44. Tagung des Berufsverbandes der Fachärzte für Orthopädie; 20031111-20031116; Berlin; DOC03dguO23-5 /20031111/
    Publication Date: 2003-11-11
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 2
    facet.materialart.
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    German Medical Science; Düsseldorf, Köln
    In:  67. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie, 89. Tagung der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie und 44. Tagung des Berufsverbandes der Fachärzte für Orthopädie; 20031111-20031116; Berlin; DOC03dguO24-1 /20031111/
    Publication Date: 2003-11-11
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 3
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    ISSN: 0570-0833
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-5195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé. Cet article rapporte les détails techniques et les résultats cliniques de douze cas d’infection profonde de la hanche traités par révision chirurgicale en deux temps et utilisant un fantôme en ciment chargé de gentamycine et modeléà la main, mis en place temporairement dans l’intervalle entre la résection de la prothèse infectée et la réimplantation d’une nouvelle. Pendant ce traitement (4 mois) les patients furent pratiquement indolores, mobilisés et ayant bon contrôle du membre, et purent demeurer pendant les 2/3 du temps de traitement à domicile. Six des 12 fantômes échouèrent localement, ceci du à une luxation ou à une fracture du ciment, nécessitant une troisième intervention dans 3 cas. Une luxation du fantôme était due à un manque d’offset tête-col (P〈0,05) ou à un ancrage insuffisant dans le fût fémoral. Par contre aucune des prothèses ne s’infectèrent aprés la réimplantation. Sur la base des ces résultats nous proposons le concept du fantôme en ciment temporaire pour améliorer sur le point biologique aussi bien que mècanique le traitement des infections de hanche.
    Notes: Summary. We report the technical details and clinical results of twelve patients who had deep infections of implants in the hip joint and were treated by two-stage revision, using a gentamicin-loaded, hand-moulded cement spacer inserted for the period between resection and reimplantation arthroplasty. During management with the spacer, usually for 4 months, patients were almost free of pain and mobile with good leg control, spending 2/3 of the treatment period at home. Six of twelve spacers failed locally due to dislocation [5] or cement fracture [1], and more than two further episodes of surgery were required in 3 patients. Problems with dislocation of the spacer were significantly higher when the head to neck offset was lacking (P〈0.05) or when anchorage in the femoral shaft was poor. Nevertheless, infection after reimplantation arthroplasty did not occur by the time of follow-up (2.2 years). Based on these data, we consider that the use of the cement spacer is a promising approach to the treatment of complicated infections of the hip joint.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 2 (1937), S. 0 
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Chromatography A 200 (1980), S. 313-316 
    ISSN: 0021-9673
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-1041
    Keywords: Glucaric acid ; aminopyrine half life ; gamma-glutamyl-transpeptidase ; 6β-hydroxycortisol ; enzyme induction ; drug metabolism in man
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The 24 h urinary excretion of 6β-hydroxycortisol and D-glucaric acid, the plasma half-lives and total clearances of aminopyrine, and serum gamma-glutamyl-transpeptidase activity have been measured in nineteen healthy male volunteers. The study was done double blind and was conducted as a test of induction of microsomal drug metabolizing enzymes during and after daily doses of 6 mg clemastine, 300 mg phenobarbital or a placebo. The urinary excretion of 6β-hydroxycortisol and D-glucaric acid was significantly increased in the phenobarbital group, the standard for induction. No changes were observed after treatment with clemastine or placebo. Phenobarbital also reduced the half life of aminopyrine, but it was not affected by clemastine or placebo. Gamma-glutamyl-transpeptidase activity increased only in the phenobarbital group. The elimination constant k2 of aminopyrine and the excretion of glucaric acid in the pre-medication period were correlated (p〈0.05). The results indicate that the tests were of diagnostic value in determination of microsomal enzyme induction by phenobarbital. Failure to observe similar changes after treatment with clemastine imply failure of induction of this activity under the experimental conditions.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1433-044X
    Keywords: Schlüsselwörter Proximaler Humerus ; Fraktur ; Osteosynthese ; Komplikation ; Key words Proximal humerus ; Fracture ; Osteosynthesis ; Complication
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: The operative treatment of dislocated fractures of the proximal humerus has been evolving in recent years. Replacement using endoprostheses often results in only moderate functional outcome, and with the high risk of aseptic necrosis with ORIF, new methods of minimally invasive stabilisation have been developed. These methods reduce the opening of the fracture site to a minimum and thereby limit the risk of iatrogenic damage to local vascularity and the rotator cuff. This study reviewed 18 patients operated on with minimal osteosynthesis for dislocated four-part fractures of the proximal humerus from March 1991 to October 1994. Only tension band wiring with resorbable cords from woven polydioxanone was applied. After an average follow-up of 26 months (20 – 37 months), 72% (n = 13) of the four-part fractures were rated as good and very good results according to the Neer Score. In 16.7%, a complete head necrosis occurred, requiring a prosthetic replacement. Two patients with partial necrosis (11.1%) had a good functional outcome. With regard to these results, we recommend head-preserving tension band wiring with resorbable cords and preservation of the articular surface. At the present time the procedure seems comparable with prosthetic replacement in respect of shoulder function.
    Notes: Die operative Therapie dislozierter Humerusmehrsegmentfrakturen hat in den letzten Jahren einen Wandel erfahren. Nachdem die Anwendung von Endoprothesen oftmals nur mäßige funktionelle Resultate zeigte und die bisherigen Osteosyntheseverfahren ein hohes Nekroserisiko aufwiesen, werden zunehmend auch Minimalosteosynthesen als Stabilisierungsverfahren eingesetzt. Diese beruhen auf einer minimalen Darstellung der Fraktur und vermindern somit das Risiko einer iatrogenen Zirkulationsstörung und einer zusätzlichen Schädigung der Rotatorenmanschette. In unserer Studie wurden in der Zeit von März 1991 bis Oktober 1994 18 Patienten mit dislozierten 4-Fragment-Frakturen des proximalen Humerus durch Minimalosteosyntheseverfahren stabilisiert. Zur Anwendung kamen ausschließlich Zuggurtungen mit resorbierbaren Kordeln aus geflochtenen Polydioxanon. Nach einer durchschnittlichen Nachkontrollzeit von 26 (20 – 37) Monaten wiesen 72% (n = 13) der 4-Fragment-Frakturen gute und sehr gute funktionelle Ergebnisse unter Anwendung des Neer-Scores auf. In 16,7% (n = 3) kam es zu vollständigen Nekrosen, die einen prothetischen Ersatz erforderten; 2 Patienten mit partiellen Nekrosen (11,1%) wiesen gute funktionelle Ergebnisse auf. Anhand dieser Resultate empfehlen wir bei 4-Fragment-Frakturen mit erhaltener Artikulationsfläche die Zuggurtungsosteosynthese mit resorbierbaren Kordeln aus Polydioxanon. Sie scheint zum jetzigen Zeitpunkt bzgl. der Funktion und Schmerzqualität der Endprothetik ebenbürtig zu sein, weist aber alle Vorteile der kopferhaltenden Therapie auf.
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