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  • 1
    German Medical Science GMS Publishing House; Düsseldorf
    In:  24. Jahrestagung der Deutschen Gesellschaft für Arterioskleroseforschung; 20100318-20100320; Blaubeuren; DOC10dgaf02 /20110323/
    Publication Date: 2011-03-23
    Description: Introduction: Patients suffering from stroke often show severe carotid artery atherosclerosis. To prevent this outcome, early detection and clear determination of lesion compounds in-vivo would be helpful for early treatment. Material and methods: Carotid artery lesions of 27 patients with 〉=70% internal carotid artery stenosis who underwent surgery were firstly analyzed using a 3D multi-contrast MRI protocol at 9.4 Tesla consisting of T1, T2, and T2* weighted sequences (spatial resolution ~100mum3). Thereafter, histology as the gold standard procedure was used for comparison. After formalin fixation the lesions were examined histologically using hematoxylin-Eosin and Elastic-van-Gieson stainings. They were classified according to the modified AHA criteria scheme and corresponding MRI slices were assessed. Results: Accuracy of plaque classification based on MR images using modified AHA criteria was 87.5% (86% to 89%). Conclusion: Compared to standard multi-contrast techniques, incorporation of T2* weighted imaging into multi-contrast MRI has proven to be valuable for identification of intraplaque hemorrhage and intraluminal thrombi. Further combinations e.g. with proton density may enhance accuracy regarding lesion composition and may help to identify patients eligible for preemptive treatment before symptom onset.
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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