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  • 1
    Keywords: Life sciences ; Human Physiology ; Lipids ; Cell Biology ; Life sciences ; Lipidology ; Cell Biology ; Human Physiology ; Springer eBooks
    Description / Table of Contents: PART I ENZYMES AND RECEPTORS FOR LIPID MEDIATORS -- 1 Lysophospholipid Acyltransferases -- 2 Phospholipase A2 -- 3 Prostaglandin Terminal Synthases as Novel Drug Targets -- 4 Pathophysiological Roles of Prostanoid Receptors in the Central Nervous System -- 5 Lipoxygenases: A Chronological Perspective on the Synthesis of S and R Fatty Acid Hydroperoxides -- 6 Leukotriene B4 Receptors -- 7 Platelet-Activating Factor (PAF) in Infectious Diseases -- 8 Lysophospholipid Mediators: Their Receptors and Synthetic Pathways -- 9 Sphingolipid Metabolism via Sphingosine 1-Phosphate and Its Role in Physiology, Pathology, and Nutrition -- 10 Fatty Acids Receptors -- 11 Omega-3 Fatty Acid Metabolism and Regulation of Inflammation -- PART II LIPID MEDIATORS IN DROSOPHILA AND ZEBRAFISH -- 12 Membrane Lipid Transporters in Drosophila melanogaster -- 13 Drosophila: A Model for Studying Prostaglandin Signaling -- 14 Zebrafish as a Model Animal for Studying Lysophosphatidic Acid Signaling -- 15 Sphingosine 1-Phosphate Signaling via Transporters in Zebrafish and Mice -- PART III LIPID MEDIATORS AND DISEASES -- 16 Lipid Mediator LPA-Induced Demyelination and Self-Amplification of LPA Biosynthesis in Chronic Pain Memory Mechanisms -- 17 Vascular Endothelial S1P2 Receptor Limits Tumor Angiogenesis and Hyperpermeability -- 18 Roles of Prostaglandins in Regulation of Pathological Angiogenesis and Lymphangiogenesis -- 19 Eicosanoids and Aortic Aneurysm -- 20 Cysteinyl Leukotrienes and Disease -- 21 Lipid Mediators and Skin Diseases -- 22 Roles and Actions of Arachidonic Acid-Derived Bioactive Lipids in Stress-Related Behaviors -- PART IV PROTOCOLS FOR ANALYZING LIPID MEDIATORS -- 23 Basic Techniques for Lipid Extraction from Tissues and Cells -- 24 Comprehensive Analysis of Eicosanoids -- 25 Mass Spectrometric Analysis of Phospholipids by Target Discovery Approach -- 26 Determination of Sphingolipids by LC-MS/MS -- 27 Lipid Machinery Investigation Using MALDI Imaging Mass Spectrometry. 28 Measuring Activation of Lipid G Protein-Coupled Receptors Using the TGF-α Shedding Assay -- 29 A Novel Anti-FLAG Monoclonal Antibody is Useful to Study GPCRs -- Index
    Abstract: This book summarizes the most recent progress in the studies of lipid mediators from the molecular to clinical level and introduces newly created tools for analysis including imaging mass spectrometry. Comprising 29 chapters divided into four major parts, the book describes the molecular natures of enzymes, transporters, and receptors for lipid mediators (Part I), the function of lipid mediators in Drosophila and Zebrafish (Part II), the relationships between lipid mediators and various diseases (Part III), and detailed procedures of extraction, preparation, and quantification of lipid mediators (Part IV). Research on lipid mediators initially started with analysis of the action of aspirin, and subsequent biochemical experiments identified many enzymes and receptors responsible for the biosynthesis and signal transduction of individual lipid mediators. Through the phenotypic analyses of transgenic and knockout mice, it has been shown that the dysregulation of some lipid mediators causes inflammatory, immune, or oncogenic disorders. Lipid mediators have attracted increased attention because their structures are conserved among different species, and their biosynthetic and signaling pathways have been deciphered at the molecular level. Many drugs that target lipid mediators are already being used in hospitals, and this book suggests further possibilities for development of a wide variety of such drugs. Very recently, highly sensitive mass spectrometry has begun to be used to identify novel lipid mediators that are present only in trace amounts in tissues but with robust biological activity. Written by international experts, this book provides readers a comprehensive view of lipid mediators and related topics and helps in the process of determining research targets for the near future
    Pages: IX, 426 p. 95 illus., 48 illus. in color. : online resource.
    Edition: 1st ed. 2015.
    ISBN: 9784431556695
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  • 2
    Keywords: Medicine ; Immunology ; Molecular Biology ; Cell Biology ; Biomedicine ; Molecular Medicine ; Immunology ; Cell Biology ; Springer eBooks
    Description / Table of Contents: Part I Basic Research for Innovative Medicine -- 1. Diverting Glycolysis to Combat Oxidative Stress -- 2. Metabolic Regulation by Nuclear Receptors -- 3. Fighting Fire with Fire in Cancer -- 4. Linear Polyubiquitination: a Crucial Regulator of NF-kB Activation -- 5. VCP, a major ATPase in the cells, as a novel drug target for currently incurable disorders -- 6. Roles of E-cadherin in hepatocarcinogenesis -- 7. The Hippo Signaling Pathway: A Candidate New Drug Target for Malignant Tumors -- 8. Inhibitory immunoreceptors on mast cells in allergy and inflammation -- 9. Doxycycline-inducible Autoimmune Blistering Skin Disease Model -- 10. T-cell Senescence and Autoimmunity -- Part II Translational Research for Innovative Medicine -- 11. IL-6: A new era for the treatment of autoimmune inflammatory diseases -- 12. Pathogenesis of Non-alcoholic Steatohepatitis and Its Potential Therapeutic Strategies -- 13. Multifaceted translational approach of major mental illness -- 14. Translational research of leptin in lipodystrophy and its related diseases -- 15. Translational research of the activation of the C-type natriuretic peptide (CNP)-guanylyl cyclase-B pathway for skeletal dysplasia -- 16. Clarity and Challenges in Tissue Fibrosis -- 17. TRP Channels: Their Function and Potentiality as Drug Targets -- 18. Autophagic Cell Death and Cancer Chemotherapeutics -- 19. Adrenomedullin as a Potential Therapeutic Agent for Refractory Ulcerative Colitis -- 20. RNA activation -- Part III New Technology for Innovative Medicine -- 21. Cardiac Reprogramming for Heart Repair -- 22. Development of a new in vivo optical probe for biological diagnosis and therapy -- 23. Introduction of mesenchymal stem cells for liver surgery (hepatectomy and transplantation) -- 24. Synaptic and axonal plasticity induction in the human cerebral cortex -- 25. TIM-3 is a novel therapeutic target for eradicating acute myelogenous leukemia stem cells -- 26. TGF-beta LAP degradation products, a novel biomarker and promising therapeutic target for liver fibrogenesis -- 27. Cell-based regenerative therapy for liver disease
    Abstract: This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization
    Pages: IX, 339 p. 105 illus., 90 illus. in color. : online resource.
    Edition: 1st ed. 2015.
    ISBN: 9784431556510
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  • 3
    Keywords: Life sciences ; Cancer Research ; Proteins ; Cell Biology ; Life sciences ; Protein Science ; Cell Biology ; Cancer Research ; Springer eBooks
    Description / Table of Contents: Preface -- Part I Novel Analytical Procedures for Signal Transduction -- 1 Phosphoproteomics-based Network Analysis of Cancer Cell Signaling Systems (Hiroko Kozuka-Hata and Masaaki Oyama) -- 2 Phos-tag-based Affinity Chromatography Techniques for Enrichment of the Phosphoproteome (Eiji Kinoshita, Emiko Kinoshita-Kikuta, and Tohru Koike) -- 3 Visualization of Intracellular Signaling with Fluorescence Resonance Energy Transfer-based Biosensors (Kazuhiro Aoki) -- 4 Technology of Wheat Cell-free Based Protein Array for Biochemical Analyses of Protein Kinases and Ubiquitin E3 Ligases (Hirotaka Takahashi, Keiichirou Nemoto, Ramadan Abdelaziz, Atsushi Uematsu, and Tatsuya Sawasaki) -- Part II Mathematical Simulation of Signal Transduction -- 5 Potential Roles of Spatial Parameters in the Regulation of NF-κB Oscillations, as Revealed by Computer Simulations (Daisuke Ohshima, Jun-ichiro Inoue, and Kazuhisa Ichikawa) -- 6 Stochastic Simulation of Stress Granules (Daisuke Ohshima, Kyoko Arimoto-Matsuzaki, Taichiro Tomida, Mutsuhiro Takekawa, and Kazuhisa Ichikawa) -- 7 Temporal Coding of Insulin Signaling (Hiroyuki Kubota and Shinya Kuroda) -- Part III Structural Analysis of Signal Transduction -- 8 Structural Biology of Protein Post-transcriptional Modifications and Cellular Signaling (Kazuki Kato, Hiroshi Nishimasu, Ryohei Ishii, Osamu Nureki, and Ryuichiro Ishitani) -- 9 Structural Basis for the Signal Initiation by TNF and TNFR (Teruya Nakamura, Yohei Mukai, Yasuo Tsutsumi, and Yuriko Yamagata) -- 10 Regulation of NF-κB Pathway by Linkage-specific Ubiquitin-binding Domains (Yusuke Sato) -- Part IV Regulation of Signal Transduction by Post-translational Modifications and Its Pathogenic Dysregulation -- 11 NF-κB Signaling and Lymphoid Malignancies (Shoji Yamaoka) -- 12 Ubiquitination-mediated NF-κB Regulation in Inflammatory Response (Fuminori Tokunaga) -- 13 NF-κB Signaling in Osteoclastogenesis (Yuu Taguchi, Jin Gohda, and Jun-ichiro Inoue) -- 14 Mitogen-activated Protein Kinase Signaling and Cancer (Mutsuhiro Takekawa and Yuji Kubota) -- 15 Critical Roles of the AKT Substrate Girdin in Disease Initiation and Progression (Atsushi Enomoto, Liang Weng, and Masahide Takahashi) -- 16 Protein Modifications Pace the Circadian Oscillation of Biological Clocks (Hikari Yoshitane and Yoshitaka Fukada) -- 17 Keap1-Nrf2 Regulatory System and Cancer (Keiko Taguchi and Masayuki Yamamoto) -- 18 Actin Filament Formation in Myofibrils and Cell Protrusions Regulated by Signal Transduction (Takeshi Endo and Kazunori Takano) -- 19 Molecular Signaling and its Pathogenic Alterations in Neuromuscular Junction Formation and Maintenance (Ryo Ueta and Yuji Yamanashi) -- 20 Post-translational Modification of Tcf/Lef: New Insights into the Regulation of Wnt/β-catenin Signaling (Tohru Ishitani) -- BM Index
    Abstract: This book is devoted to recent advances in analysis of the molecular basis and dynamics of post-translational modifications (PTMs) of proteins for a comprehensive understanding of their key roles in cell signaling networks and diverse biological processes, and their perturbation in a variety of life-threatening diseases such as cancer and inflammatory diseases. The book includes research regarding PTMs and methods of their investigation derived from interdisciplinary collaborations between leading scientists in the fields of molecular, medical, proteomic, structural, and mathematical biology. This book consists of four sections. The first part focuses on recent advances in procedures for analysis of PTMs and cell signaling. The second part is devoted to mathematical simulation of signal transduction pathways and of the formation of protein complexes in living cells. The third part deals with structural and functional analyses of proteins involved in the regulation of PTMs and cell signaling. The fourth part describes cutting-edge findings regarding critical signal transduction pathways and their dysregulation in human diseases. This book is aimed at both established scientists and students in various fields of biology including molecular, cellular, structural, proteomic, and mathematical biology. Readers can access cutting-edge research and methodologies in their own field as well as interdisciplinary research that impacts on their field. The book can function as a reference for pharmaceutical scientists, biomedical researchers, and clinicians for the development of molecular-targeted therapy of human diseases
    Pages: IX, 348 p. 86 illus., 46 illus. in color. : online resource.
    Edition: 1st ed. 2015.
    ISBN: 9784431555612
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  • 4
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    Tokyo : Springer Japan
    Keywords: Medicine ; Neurosciences ; Neurology ; Psychiatry ; Neurobiology ; Biomedicine ; Neurosciences ; Neurology ; Psychiatry ; Neurobiology ; Springer eBooks
    Description / Table of Contents: PART I A NEW CONCEPT OF NEURODEGENERATION IN BIOLOGY AND PATHOPHYSIOLOGY -- 1 Conformational disease and RNA disease theory in the context of neurodegenerative diseases -- 2 Brain-peripheral organ communication -- 3 The brain-immune network in spinal cord injury -- PART II CHANGES IN CLINICAL EVALUATION AND NEW BIOMARKERS -- 4 Renovation of clinical evaluation and new biomarkers -- 5 Clinical Systems Neuroscience -- PART III RISK FACTORS IN NEURODEGENERATION -- 6 Genetic risk factors for neurodegenerative diseases -- 7 Intermediate phenotypes approach for neuropsychiatric disorders -- PART IV FUTURE DIRECTIONS FOR THERAPY -- 8 Significance of mechanism-oriented research toward neuronal protection therapy against neurodegenerative disorders ~ ZNRF1 E3 ubiquitin ligase as a critical mediator for Wallerian degeneration and neuronal apoptosis -- 9 Drug development for neurodegenerative diseases -- 10 Physical therapy and rehabilitation in patients with degenerative cerebellar diseases: current evidence and future direction -- 11 Home- and Community-based medical care for neurodegenerative diseases -ALS as an illustration- -- PART V HEALTH PROMOTION: PREVENTION AND QUALITY OF LIFE -- 12 Information Environment and Brain Function: A New Concept of the Environment for the Brain -- 13 Social Implementation of Neurodegenerative Disease Research and Neuroethics.-
    Abstract: This book sheds new light on neurodegenerative disorders as systemic diseases. Classically, neuronal cell death was a hallmark of such disorders. However, it has become evident that neural dysfunction is more important in the pathophysiology of neurodegenerative disorders. More recently, the prionoid-spreading hypothesis of disease-causing molecules has attracted a great deal of attention. Therapeutic strategies thus must be reconsidered in the light that neurodegenerative disorders are indeed systemic diseases. The first part of this book introduces the concept of neurodegeneration in biology and pathophysiology. The second part focuses on clinical evaluation and biomarkers from the perspective of this new concept, while the third summarizes the risk factors of neurodegeneration. The fourth part of this work indicates future directions of treatment, and the final part discusses health promotion for prevention and quality of life. This book will be of interest to both researchers and medical personnel, and provides a fresh approach to neurodegenerative diseases, paving the way to new research and improved quality of health care for patients
    Pages: VIII, 304 p. 34 illus., 19 illus. in color. : online resource.
    Edition: 1st ed. 2015.
    ISBN: 9784431545415
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  • 5
    Keywords: Medicine ; Human Physiology ; Metabolic Diseases ; Pediatrics ; Biomedicine ; Human Physiology ; Metabolic Diseases ; Pediatrics ; Springer eBooks
    Abstract: JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder
    Pages: VI, 128 p. 30 illus., 10 illus. in color. : online resource.
    ISBN: 9783662482278
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  • 6
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    Berlin, Heidelberg : Springer
    Keywords: Life sciences ; Agriculture ; Bioinformatics ; Plant genetics ; Plant breeding ; Life sciences ; Plant Breeding/Biotechnology ; Plant Genetics & Genomics ; Agriculture ; Bioinformatics ; Springer eBooks
    Description / Table of Contents: 1 Economic/Academic importance -- 2 Background History of the National and International B. rapa Genome Sequencing Initiatives -- 3 Genomic Resources and Physical Mapping of the B. rapa Genome -- 4 De Novo Genome Assembly of Next-Generation Sequencing Data -- 5 Crop Genome Annotation: A Case Study for the Brassica rapa Genome -- 6 Miniature Transposable Elements (mTEs): Impacts and Uses in the Brassica genome -- 7 Genomic Survey of the Hidden Components of the B. rapa Genome -- 8 The Common Ancestral Genome of the Brassica Species -- 9 Genome Evolution after Whole-Genome Triplication: The Subgenome Dominance in Brassica rapa -- 10 Genome Triplication Drove the Diversification of Brassica Plants -- 11 Comparative Analysis of Gene Conversion between Duplicated Regions in Brassica rapa and B. oleracea Genomes -- 12 Molecular Mapping and Cloning of Genes and QTLs in B. rapa -- 13 Impact on Brassica breeding -- 14 The Database for Brassica Genome Studies—BRAD -- 15 Future Prospects
    Abstract: This book provides insights into the latest achievements in genomics research on Brassica rapa. It describes the findings on this Brassica species, the first of the U’s triangle that has been sequenced and a close relative to the model plant Arabidopsis, which provide a basis for investigations of major Brassica crop species. Further, the book focuses on the development of tools to facilitate the transfer of our rich knowledge on Arabidopsis to a cultivated Brassica crop. Key topics covered include genomic resources, assembly tools, annotation of the genome, transposable elements, comparative genomics, evolution of Brassica genomes, and advances in the application of genomics in the breeding of Brassica rapa crops
    Pages: VIII, 169 p. 38 illus., 36 illus. in color. : online resource.
    Edition: 1st ed. 2015.
    ISBN: 9783662479018
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  • 7
    Keywords: Dentistry ; Life sciences ; Infectious Diseases ; Microbiology ; Microscopy ; Life sciences ; Microbiology ; Dentistry ; Infectious Diseases ; Biological Microscopy ; Springer eBooks
    Description / Table of Contents: Part I: General Biological Aspects -- Ecology and Physiology of Root Canal Microbial Biofilm Communities -- Molecular Principles of Adhesion and Biofilm Formation -- Antimicrobial Resistance in Biofilm Communities -- Part II: Observational and Experimental Evidence -- The Use of Scanning Electron Microscopy (SEM) in Visualizing the Root Canal Biofilm -- Bacterial Biofilms and Endodontic Disease: Histo-Bacteriological and Molecular Exploration -- Laboratory Models of Biofilms: Development and Assessment -- Root Canal Anatomy: Implications in Biofilm Disinfection -- Part III: Outcome and Strategies of Treatment -- Biofilm-Associated Infections in Root Canals Treatment and Outcomes -- Root Canal Irrigation -- Inter-Appointment Medication with Calcium Hydroxide in Routine Cases of Root Canal Therapy -- Chapter 11. Advanced Therapeutic Options to Disinfect Root Canals
    Abstract: This book presents the current state of research on the basic scientific aspects of root canal biofilm biology within a clinically applicable context. Root canal biofilms are complex polymicrobial structures adhering to the root canal surface that are formed by microorganisms invading the pulpal space of teeth, and are associated with persistent root canal infections. Concerted efforts to study root canal biofilms have been made in the past decade, resulting in the publication of observational and experimental studies that detail the morphology and biology of these structures in infected root canals. In addition to confirming that bacteria in root canals do not exist in free-floating planktonic states as previously assumed, this new information on root canal biofilm infections has provided an opportunity to re-evaluate conventional clinical protocols and improve endodontic therapeutic measures
    Pages: XII, 366 p. 71 illus., 46 illus. in color. : online resource.
    ISBN: 9783662474150
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  • 8
    Keywords: Medicine ; Human Physiology ; Pharmacology ; Plant Biochemistry ; Biomedicine ; Human Physiology ; Pharmacology/Toxicology ; Plant Biochemistry ; Springer eBooks
    Abstract: Contens Kristina Friedland and Christian Harteneck Hyperforin - to be or not to be an activator of TRPC(6) ℗ Eric Honor©♭, Joana Raquel Martins, David Penton, Amanda Patel, and Sophie Demolombe The Piezo mechanosensitive ion channels: may the force be with you! ℗ Jonathan P. Mochel and Meindert Danhof Chronobiology and pharmacologic modulation of the renin-angiotensin aldosterone system in dogs: what have we learnt?
    Pages: V, 69 p. 15 illus., 10 illus. in color. : online resource.
    ISBN: 9783319265650
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  • 9
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    Cham : Springer International Publishing
    Keywords: Life sciences ; Proteomics ; Systems Biology ; Bacteriology ; Life sciences ; Systems Biology ; Proteomics ; Bacteriology ; Springer eBooks
    Description / Table of Contents: Metagenomics as a Tool for Enzyme Discovery: Hydrolytic Enzymes from Marine-related Metagenomes -- Investigating Bacterial Protein Synthesis Using Systems Biology Approaches -- Biology and Assembly of the Bacterial Envelope -- Comparative Genomics and Evolutionary Modularity of Prokaryotes -- Predicting Functional Interactions among Genes in Prokaryotes by Genomic Context -- Functional Implications for Domain Organization within Prokaryotic Rhomboid Proteases -- Mapping Transcription Regulatory Networks with ChIP-seq and RNA-seq -- Quantitative and Systems-Based Approaches for Deciphering Bacterial Membrane Interactome and Gene Function -- Toward Network Biology in E. coli Cell -- Genetic Interaction Scoring Procedure for Bacterial Species -- Mapping the Protein–Protein Interactome Networks Using Yeast Two-Hybrid Screens -- Biogenesis of Escherichia coli DMSO Reductase: A Network of Participants for Protein Folding and Complex Enzyme Maturation -- Microbial Proteome Profiling and Systems Biology: Applications to Mycobacterium tuberculosis -- Structural Aspects of Bacterial Outer Membrane Protein Assembly -- Substrate Interaction Networks of the Escherichia coli Chaperones: Trigger Factor, DnaK and GroEL -- Genetic, Biochemical, and Structural Analyses of Bacterial Surface Polysaccharides
    Abstract: This book focuses on innovative experimental and computational approaches for charting interaction networks in bacterial species. The first part of the volume consists of nine chapters, focusing on biochemical and genetics and genomics approaches including yeast two hybrid, metagenomics, affinity purification in combination with mass spectrometry, chromatin-immunoprecipitation coupled with sequencing, large-scale synthetic genetic screens, and quantitative-based mass spectrometry strategies for mapping the bacterial physical, functional, substrate, and regulatory interaction networks needed for interpreting biological networks, inferring gene function, enzyme discovery, and identifying new drug targets. The second part comprises five chapters, covering the network of participants for protein folding and complex enzyme maturation. It also covers the structural approaches required to understand bacterial intramembrane proteolysis and the structure and function of bacterial proteins involved in surface polysaccharides, outer membrane, and envelope assembly. This volume concludes with a focus on computational and comparative genomics approaches, especially network-based methods for predicting physical or functional interactions, and integrative analytical approaches for generating more reliable information on bacterial gene function. This book provides foundational knowledge in the understanding of prokaryotic systems biology by illuminating how bacterial genes f unction within the framework of global cellular processes. The book will enable the microbiology community to create substantive resources for addressing many pending unanswered questions, and facilitate the development of new technologies that can be applied to other bacterial species lacking experimental data
    Pages: IX, 319 p. 58 illus., 55 illus. in color. : online resource.
    ISBN: 9783319236032
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  • 10
    Keywords: Medicine ; Human Genetics ; Immunology ; Molecular Biology ; Neurosciences ; Neuroradiology ; Neurology ; Biomedicine ; Human Genetics ; Neurosciences ; Immunology ; Molecular Medicine ; Neuroradiology ; Neurology ; Springer eBooks
    Description / Table of Contents: HLA in MS. Helminth therapy for MS -- Sex differences in MS I -- Sex differences in MS II -- Environment and MS Biomarkers in MS -- Photoimmunology and regulation of disease in MS -- Modeling MS pathology -- Vitamin D. b-amyloid proteins and MS
    Abstract: Over the past decade, we have made great advances in the field of multiple sclerosis (MS) research, and this book focuses on those advances in MS pathogenesis and treatment. While some of these advances have been through new approaches and ideas that have emerged in the last decade such as the newly identified protective role that amyloid proteins may play in MS or the use of helminths to treat autoimmune diseases, others have evolved from previous theories and ideas that have only now gained momentum and a deeper understanding such as the role of HLA or gender in MS susceptibility. This book covers these emerging and evolving topics and highlights the substantial advancements made in elucidation of the factors regulating susceptibility or disease progression, identification of new ways to monitor or predict MS pathology, and development of new strategies for treating MS
    Pages: XII, 235 p. : online resource.
    Edition: 1st ed. 2015.
    ISBN: 9783319255439
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