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  • 1
    Keywords: Medicine ; Neurosciences ; Parasitology ; Behavioral Sciences ; Biomedicine ; Parasitology ; Behavioral Sciences ; Neurosciences ; Springer eBooks
    Description / Table of Contents: Introduction -- Parasites: an own world of cross reactions with their hosts -- Trait-mediated effects of parasites on invader-native interactions -- Cooperation or Conflict: Host manipulation in multiple infections -- Can parasites change thermal preferences of hosts? -- Host Manipulation by Toxoplasma gondii -- The brain worm story -- The bodyguard phenomenon -- Remote control: parasite induced phenotypic changes in fish -- Virus-induced behavioural changes in insects
    Abstract: This edited volume focuses on parasite-host relationships and the behavioral changes parasites may trigger in their hosts. Parasites have developed strategies which enhance their chances to find a host to survive inside its body and to become most easily transmitted to one another. Many of these parasites influence the host’s behavior by various mechanisms, so that the rate of their transmissions to further hosts becomes considerably enhanced in comparison to that of non-influenced specimens of the same host species. A broad number of recent studies elucidate more and more examples in an extreme spectrum of host-parasite relationships, where successful transmission and /or survival of a parasite inside a host is based on parasite-derived behavioral manipulations of the hosts. In the literature, an increasing numbers of papers appear which prove that these behavioral alterations are based on complicated psychoimmunologic, neuropharmacologic and genomically steered mechanisms. Researchers working in parasitology or behavioral sciences will find this work thought-provoking, instructive and informative
    Pages: XII, 192 p. 61 illus., 54 illus. in color. : online resource.
    Edition: 1st ed. 2015.
    ISBN: 9783319229362
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  • 2
    Keywords: Medicine ; Cancer Research ; Pharmaceutical technology ; Biomedicine ; Cancer Research ; Pharmaceutical Sciences/Technology ; Springer eBooks
    Description / Table of Contents: Introduction -- History and Current Regulatory Requirements -- Genotoxicity Testing of API and Impurities -- New Emerging Genotoxicity Tests -- Carcinogenicity Testing of Small Molecules -- Alternatives to the 2-Year Rodent Studies -- Addressing Positive Findings in Carcinogenicity Studies -- Investigating Tumor Signals in Clinical Trials -- Tumor Promoters -- Carcinogenicity Testing of Biologics -- In Silico Predictive Tests
    Abstract: This book provides an overview of the nonclinical testing strategies that are used to asses and de-risk the genotoxicity and carcinogenicity properties of human pharmaceuticals. It includes a review of relevant ICH guidelines, numerous case studies where follow-up studies were conducted to further investigate positive findings, and practical considerations for the use of alternative and emerging tests. With contributions from recognized experts in the pharmaceutical industry and health authorities, this volume presents a balanced view on the interpretation and application of genotoxicity and carcinogenicity regulatory guidances. ℗ Genotoxicity and Carcinogenicity Testing of Pharmaceuticals is a valuable resource for scientists, regulators, and consultants that are engaged in the conduct, reporting, and review of nonclinical studies. This book will also help academicians better understand and appreciate the complexity of the regulations and breadth of toxicology research that are necessary to support the development and marketing of new drugs
    Pages: X, 206 p. 15 illus., 8 illus. in color. : online resource.
    Edition: 1st ed. 2015.
    ISBN: 9783319220840
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  • 3
    Cham : Springer International Publishing
    Keywords: Medicine ; Pharmacotherapy ; Biomedicine ; Biomedicine general ; Pharmacotherapy ; Springer eBooks
    Description / Table of Contents: 1. Inpatient Warfarin Management -- 2. Ambulatory Warfarin Management -- 3. Unfractionated Heparin and Low Molecular Weight Heparin -- 4. Direct Oral Anticoagulants -- 5. Anticoagulation Reversal -- 6. Prevention of Venous Thromboembolism -- 7. Treatment of Venous Thromboembolism -- 8. Periprocedural Anticoagulation -- 9. Heparin Induced Thrombocytopenia -- 10. Anticoagulation Management in the Emergency Department -- 11. Anticoagulation Stewardship
    Abstract: In addition to acting as a training guide for pharmacists, pharmacy residents and pharmacy students who seek to practice in areas associated with patients on anticoagulant therapy, the information presented within highlights the growing role of the pharmacist in these contexts. Readers will find useful information on anticoagulant management across all pharmacy practice areas, including the inpatient, ambulatory, emergency services and transitions of care settings. Particular attention is given to summarizing best practices and providing ́€˜real world́€™ examples of ways in which pharmacists can be involved in anticoagulation management and the impact of such involvement. In the first major section of the book, each chapter focuses on the role of the pharmacist in the management of medication with a specific type of anticoagulants (e.g. warfarin, heparin and target-specific oral agents) in various healthcare settings.℗ A broader overview of the clinical management of anticoagulation therapy is provided in the second major section, including descriptions of the role of pharmacists in assessing venous thromboembolism risk, ensuring patients receive appropriate prophylactic therapy, and monitoring outcomes
    Pages: XVI, 274 p. 40 illus., 7 illus. in color. : online resource.
    Edition: 1st ed. 2015.
    ISBN: 9783319226026
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  • 4
    Keywords: Medicine ; Human Physiology ; Molecular Biology ; Neurosciences ; Medical Biochemistry ; Cell Physiology ; Biomedicine ; Human Physiology ; Neurosciences ; Molecular Medicine ; Medical Biochemistry ; Cell Physiology ; Springer eBooks
    Description / Table of Contents: Properties of the urothelium that establish the blood-urine barrier and their implications for drug delivery -- Towards understanding the role of the Na+-Ca2+ exchanger isoform 3 -- The secretion and Action of brush border enzymes in the mammalian small intestine.℗
    Abstract: Contents E. Lasic, T. Visnjar, and M. E. Kreft Properties of the urothelium that establish the blood-urine barrier and their implications for drug delivery L.Y.M. Michel, J.G.J. Hoenderop, and R.J.M. Bindels Towards understanding the role of the Na+-Ca2+ exchanger isoform 3 D.F. Hooton, R.G. Lentle, J. Monro, M.S.J. Wickham, and R.M. Simpson The secretion and action of brush border enzymes in the mammalian small intestine℗
    Pages: V, 118 p. 11 illus., 10 illus. in color. : online resource.
    ISBN: 9783319225036
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  • 5
    Keywords: Dentistry ; Life sciences ; Systems Biology ; Regenerative Medicine ; Tissue Engineering ; Life sciences ; Systems Biology ; Regenerative Medicine/Tissue Engineering ; Dentistry ; Springer eBooks
    Description / Table of Contents: 3D printing and biofabrication for load bearing tissue engineering -- Microfabrication of Cell-Laden Hydrogels for Engineering Mineralized and Load Bearing Tissues -- Electrospinning of bioinspired polymer scaffolds -- Bone tissue engineering challenges in oral & maxillofacial surgery -- Engineering Pre-vascularized Scaffolds for Bone Regeneration -- Morphogenic Peptides in Regeneration of Load Bearing Tissues -- Osseointegration of Plateau Root Form Implants: Unique Healing Pathway leading to Haversian-Like Long-Term Morphology -- Dentin matrix proteins in bone tissue engineering -- Multiphasic, Multistructured and Hierarchical Strategies for Cartilage Regeneration -- Anterior Cruciate Ligament: Structure, Injuries and Regenerative Treatments -- Hard-soft tissue interface engineering -- Cementum and periodontal ligament regeneration -- Amelogenin in enamel tissue engineering -- Whole tooth regeneration as a future dental treatment
    Abstract: This book offers a comprehensive overview of current challenges and strategies to regenerate load-bearing and calcified human tissues, including bone, cartilage,tendon, ligaments and dental structures (dentin, enamel, cementum and periodontal ligament). Tissue engineering has long held great promises as an improved treatment option for conditions affecting mineralized and load-bearing structures in the body. Although significant progress has been achieved in recent years, a number of challenges still exist. Scaffold vascularization, new biofabrication methods (3D printing, lithography, microfabrication), peptide conjugation methods, interface engineering, scaffold mechanical properties, iPS cells, organs-on-a-chip, are some of the topics discussed in this book. More specially, in the first section readers will find an overview of emerging biofabrication methods. In section 2, applied strategies for regeneration of (2.1) bone, cartilage and ligament, as well as (2.2) dentin, cementum, enamel and periodontal ligament are discussed across 14 chapters. While other volumes have addressed the regeneration of individual tissues, or exclusively focused on different regenerative strategies, the focus of this work is to bring together researchers integrating backgrounds in materials sciences, engineering, biology, mechanics, fluidics, etc, to address specific challenges common to regeneration of several load-bearing and calcified tissues. Therefore, this book provides a unique platform to stimulate progress in the regeneration of functional tissue substitutes. We envision that this book will represent a valuable reference source for university and college faculties, post-doctoral research fellows, senior graduate students, and researchers from R&D laboratories in their endeavors to fabricate biomimetic load bearing tissues
    Pages: X, 276 p. 60 illus., 54 illus. in color. : online resource.
    Edition: 1st ed. 2015.
    ISBN: 9783319223452
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  • 6
    Dordrecht : Springer
    Keywords: Medicine ; Oncology ; Immunology ; Pathology ; Cytology ; Biomedicine ; Cancer Research ; Immunology ; Cell Biology ; Pathology ; Biomedicine general ; Springer eBooks
    Abstract: After the discovery of milk fat globule-epidermal growth factor-factor 8 (MFG-E8) about two decades ago, a new era of delineating its potential beneficial role in several inflammatory diseases has begun to spout from the bench to translational research.℗ In MFG-E8 and Inflammation, the editor and contributors have gathered a remarkable collection covering novel discoveries on the rapidly growing field of MFG-E8 and Inflammation which includes not only the findings from their individual lobotomies, but also from a host of pioneering researchers of this field. MFG-E8 and Inflammation starts by describing the origin, structure, expression, functions and regulation of MFG-E8, and then on℗ continues thoughtfully exploring its potentiality as a marker for apoptotic, stressed and activated cells.℗ The topics cover the cellular and physiological function of MFG-E8, especially its role in efficient phagocytosis of apoptotic cells, intestinal barrier function, blood cell homeostasis and coagulation, and in the maintenance of the intact vascular system.℗ The role of MFG-E8 in macrophages, neutrophils, lymphocytes, dendritic cells, platelets, as well as non-hematopoietic cells is adequately described in the book.℗ The chapters also contain several lucid discussions on the recent discoveries of the roles of MFG-E8 in the autoimmune diseases, sepsis, tissue ischemia-reperfusion, hemorrhage, inflammatory bowel disease, acute lung injury, asthma, lung fibrosis, stroke, prion disease and Alzheimeŕ€™s disease with the potential focus on elucidating novel mechanistic pathways. MFG-E8 and Inflammation is an indispensable resource for scientists and clinical researchers working on fundamental or applied aspects of MFG-E8 pathobiology.℗ This book explores, dissects and reviews several noteworthy findings and striking future perspectives which not only rewrite the disease pathophysiology, but also update our understanding towards attaining novel therapeutic potentials against various inflammatory diseases
    Pages: XV, 198 p. 30 illus., 21 illus. in color. : online resource.
    ISBN: 9789401787659
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  • 7
    Keywords: Life sciences ; Agriculture ; Sustainable development ; Social policy ; Farm economics ; Life sciences ; Agriculture ; Sustainable development ; Agricultural Economics ; Social policy ; Springer eBooks
    Description / Table of Contents: Acknowledgements -- Introduction -- 1. Setting the stage -- 2. Eat well, eat better -- 3. Reducing losses and waste at consumption, distribution and processing levels -- 4. Reducing post-harvest losses in developing nations -- 5. Producing other goods -- 6. Managing ecosystem services -- 7. Will there be enough land? -- 8. The need to strive for productive yet ecological agriculture -- 9. Feeding the world starts with fighting poverty -- 10. Towards a global governance of food -- Conclusion -- References -- Glossary
    Abstract: Is the world headed toward a major food crisis? After several decades of seeming indifference, public opinion is slowly awakening to the fact that a daunting task lies ahead. If a global population of 9 billion by 2050 is to be fed adequately, more food must be produced, and this in keeping with increasingly stringent standards of quality and with respect for the environment. Not to mention the land that must be set aside for the production of energy resources, industrial goods,℗ carbon storage and the protection of biodiversity. To meet this challenge, societies must innovate, keep losses and waste in check, and reverse the current trend of excessive and imbalanced calorie intake. At the same time, the world must put an end to hunger and with it, the suffering of some one billion people. Researchers the world over have dedicated their lif這s work to finding viable solutions to these key issues on a global scale. In this work, the heads of two leading French agricultural research organisations, INRA℗ and CIRAD, shed light on the issue in terms that are clear and accessible to the public at large. The reader will find a wealth of information, thought provoking insight and some surprising solutions. The world can avert a crisis, provided it makes a firm commitment to profound change, notably in the consumption and production habits of todaý€™s western societies. Marion Guillou has been the President of the French National Institute for Agricultural Research (INRA) since 2004. A graduate of the ©œcole Polytechnique, she is an agricultural engineer and holds a doctorate in Food and Nutrition Sciences. G©♭rard Matheron has been the President of the French Agricultural Research Centre for International Development (CIRAD) since 2010. He is an agronomist and holds a doctorate in Quantitative Genetics
    Pages: XV, 226 p. 10 illus., 9 illus. in color. : online resource.
    ISBN: 9789401785693
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  • 8
    Keywords: Medicine ; Cytology ; Engineering ; Surfaces (Physics) ; Biomedicine ; Biomedicine general ; Medicine/Public Health, general ; Cell Biology ; Nanotechnology and Microengineering ; Characterization and Evaluation of Materials ; Springer eBooks
    Description / Table of Contents: 1 Presence in, and release of, nanomaterials from consumer products -- 2 Nanoparticle aggregation -- 3 Influences of nanomaterials on the barrier function of epithelial cells -- 4 Engineered nanoparticles induced brush border disruption in a human model of the intestinal epithelium -- 5 Nanoparticles: Cellular uptake and cytotoxicity. -6 Atomic force microscopy study of the interaction of DNA and nanoparticles -- 7 Intracellular signal modulation by nanomaterials -- 8 Nanomaterials: Impacts on cells and cell organelles -- 9 Design, synthesis, and functionalization of nanoparticles for therapeutic drug delivery -- 10 Preparation of nanoscale pulmonary drug delivery formulations by spray drying -- 11 Nanomedicine: The Promise and Challenges in Cancer Chemotherapy -- 12 Transgenerational effects of NMs -- 13 Stem cells and nanomaterials -- Index
    Abstract: The rapidly developing field of nanomaterials has expanded in many commercial areas.℗ More recent studies have begun to provide a foundation for understanding how nanomaterials influence cells and how they also can serve as methodological tools for studies in medicine and cell biology, include research into stem cells.℗ Recent investigations have shown affects of nanomaterials on specific subcellular structures, such as the actin-based brush border network in cells with an increasing emphasis on the barrier function of epithelial tissues.℗ ℗ While other studies have shown involvement of nanoparticles in specific cytoplasmic signal transduction events such as the rise in intracellular free calcium, a signaling event known to regulate many changes in cell architecture and function.℗ ℗ ℗ In parallel, nanomaterials are increasingly used in medicine for drug delivery, treatment of cancer, and an increasing number of new applications.℗ ℗ This book investigates these areas and also includes new methods for assessment in cell biology and medicine
    Pages: XI, 278 p. 70 illus., 42 illus. in color. : online resource.
    ISBN: 9789401787390
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  • 9
    Keywords: Life sciences ; Agriculture ; Plant anatomy ; Plant development ; Life sciences ; Agriculture ; Plant Anatomy/Development ; Plant Systematics/Taxonomy/Biogeography ; Springer eBooks
    Description / Table of Contents: Chapter 1. Introduction Utilization / Significance of Medicinal and Aromatic Plants -- Chapter 2. Botanical Aspects of Medicinal and aromatic Plants -- Chapter 3. Chemical Diversity of Medicinal Plants -- Chapter 4. Application of spectroscopic methods and hyphenated techniques to the analysis of complex plant extracts -- Chapter 5. Medicinal and aromatic plants (MAP): how do they adapt to the environment? -- Chapter 6. Breeding and germplasm preservation -- Chapter 7. Conservation of Wild Crafted Medicinal and Aromatic Plants and Their Habitats -- Chapter 8. Challenges and decision making in cultivation of medicinal and aromatic plants -- Chapter 9. Cultivation and Breeding of Cannabis sativa L. for Preparation of Standardized Extracts for Medicinal Purposes -- Chapter 10. Sustainable Fertilization in Medicinal and Aromatic Plants -- Chapter 11. Sustainable Weed, Disease And Pest Management In Medicinal And Aromatic Plants -- Chapter 12. Introduction to the precision medicinal plant production -- Chapter 13. Medicinal plants to control diseases and pests -- Chapter 14. Quality Assurance of Medicinal and Aromatic Plants- Good Agricultural & Collection Practices (GAP & GCP) -- Chapter 15. In vitro micropropagation of medicinal and aromatic plants -- Chapter 16. Herbal medicinal preparations in different parts of the world -- Chapter 17 Medicinal and Aromatic Plants in Scientific Databases -- Chapter 18. International Trade of Medicinal and Aromatic Plants -- Chapter 19. Medicinal Plants Conservation Strategies for Primary-Healthcare and Livelihood at Local Level: An Examination of Initiatives in South Asia -- Chapter 20. Phytogenic feed additives in animal nutrition -- Chapter 21. Multipurpose Herbs: Hidden Potentials and Dangers in the Garden
    Abstract: Medicinal and aromatic plants (MAPs) have accompanied mankind from its very early beginnings. Their utilization has co-evolved with homo sapiens itself. Evolution has brought about a profound increase in our scientific knowledge about these species, so that, to date, they find utilization in many facets of our life (eg. pharmaceutical products, feed- and food additives, cosmetics, etc.). Remarkably today, despite the new renaissance of MAPs usage,℗ ca. 80 % of the world́€™s population relies upon natural substances of plant origin, with most of these botanicals sourced from the wild state. This huge℗ increase in℗ demand has put an unparalleled large burden on the natural resources of MAPs endangering their existence. The first volume of the℗ series Medicinal Plants of the World, will briefly summarize the most essential current scientific knowledge about the sustainable sourcing of botanicals from both wild-crafting and cultivation. In these 21 chapters, eminent researchers of the topic will summarize latest scientific knowledge from the versatile and most varied scientific disciplines involved: botany, phytochemistry, plant breeding, biotechnology, agrotechnology, mechanization and economics. Individual chapters will deal with the essentials of phytomedical utilization, as well as utilization in the form of animal feed-additives. The volume concludes with a chapter on the poisonous MAPs in our homes, offices and modern everyday environments. The aim of this volume is to offer basic scientific information on MAPs. It will also enable readers of subsequent volumes to digest and℗ interpret the℗ other volumes in the℗ series, that will deal with important and characteristic wild-crafted and cultivated MAPs of the different geographic and℗ climatic regions of the world.℗ Thus, the series is meant to be a storehouse of up-to-date information on our global wealth of medicinal and aromatic plants on the basis of which MAPs will be collected, cultivated, traded and utilized in a sustainable way
    Pages: VIII, 460 p. 60 illus., 29 illus. in color. : online resource.
    Edition: 1st ed. 2015.
    ISBN: 9789401798105
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  • 10
    Keywords: Chemistry ; Biochemistry ; Nanochemistry ; Emerging infectious diseases ; Chemistry ; Medicinal Chemistry ; Nanochemistry ; Infectious Diseases ; Springer eBooks
    Description / Table of Contents: Auger-architectomics: Introducing a New Nanotechnology to Infectious Disease -- Rational Design of Antigens to Improve the Sero-diagnosis of Tick-borne Borreliosis in Central Regions of Russia -- Ayurvedic Bhasmas: Overview on Nanomaterialistic Aspects, Applications and Perspectives -- Nanobiosensors: Role in Cancer Detection and Diagnosis -- Cell Compatible Arginine Containing Cationic Polymer: One-pot Synthesis and Preliminary Biological Assessment -- Neuroinvasive and Neurotropic Human Respiratory Coronaviruses: Potential Neurovirulent Agents in Humans -- Bacteriophages as Potential Treatment Option for Antibiotic Resistant Bacteria
    Abstract: The book addresses the interdisciplinary scientific approach for the systemic understanding of connections between major human diseases and their treatment regime by applying the tools and techniques of nanotechnology. It also highlights the interdisciplinary collaborative researches for innovation in Biomedical Sciences. The book is a℗ first volume which presents collection of best papers presented in the First International Conference on Infectious Diseases and Nanomedicine held during Dec. 15-18, 2012 in Kathmandu, Nepal. The book focuses mainly on the topics: emerging infectious diseases; antimicrobial agents, vaccines and immunity; drug design, drug delivery and tissue engineering; and nanomaterials and biomedical materials
    Pages: XIII, 119 p. 25 illus. : online resource.
    ISBN: 9788132217770
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