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  • 1
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    German Medical Science; Düsseldorf, Köln
    In:  50. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (gmds), 12. Jahrestagung der Deutschen Arbeitsgemeinschaft für Epidemiologie; 20050912-20050915; Freiburg im Breisgau; DOC05gmds197 /20050908/
    Publication Date: 2005-09-09
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 2
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  126. Kongress der Deutschen Gesellschaft für Chirurgie; 20090428-20090501; München; DOC09dgch11497 /20090423/
    Publication Date: 2009-05-06
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 3
    Keywords: INHIBITION ; MODEL ; GENE ; GENE-EXPRESSION ; METABOLISM ; MICE ; OBESITY ; inflammation ; MOUSE MODELS ; COACTIVATOR PGC-1 ; INSULIN-RESISTANCE ; TECHNOLOGY ; NUCLEAR RECEPTORS ; Hepatic expression of transcriptional cofactor TBL1 is impaired in fatty livers ; Hepatic deficiency in TBL1 promotes liver steatosis and hypertriglyceridemia ; Hepatic TBL1 acts in concert with TBLR1 and nuclear receptor PPARα ; NONALCOHOLIC FATTY LIVER ; STIMULATED LIPOPROTEIN RECEPTOR
    Abstract: The aberrant accumulation of lipids in the liver ("fatty liver") is tightly associated with several components of the metabolic syndrome, including type 2 diabetes, coronary heart disease, and atherosclerosis. Here we show that the impaired hepatic expression of transcriptional cofactor transducin beta-like (TBL) 1 represents a common feature of mono- and multigenic fatty liver mouse models. Indeed, the liver-specific ablation of TBL1 gene expression in healthy mice promoted hypertriglyceridemia and hepatic steatosis under both normal and high-fat dietary conditions. TBL1 deficiency resulted in inhibition of fatty acid oxidation due to impaired functional cooperation with its heterodimerization partner TBL-related (TBLR) 1 and the nuclear receptor peroxisome proliferator-activated receptor (PPAR) alpha. As TBL1 expression levels were found to also inversely correlate with liver fat content in human patients, the lack of hepatic TBL1/TBLR1 cofactor activity may represent a molecular rationale for hepatic steatosis in subjects with obesity and the metabolic syndrome.
    Type of Publication: Journal article published
    PubMed ID: 21459324
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  • 4
    ISSN: 1432-136X
    Keywords: Brown adipose tissue ; Cytochrom-c-oxidase ; Non-shivering thermogenesis ; Uncoupling protein mRNA ; Hamster, Phodopus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The bilateral lobe of interscapular brown adipose tissue of the Djungarian hamster was unilaterally denervated in order to study the role of the sympathetic innervation for maintenance and cold-induced increase of non-shivering thermogenesis. Denervation decreased the noradrenaline content of brown adipose tissue to less than 9% of the intact contralateral pad. This low noradrenaline level was maintained for 1–14 days after denervation. First, to study the role of the sympathetic innervation of brown adipose tissue in the maintenance of the high thermogenic capacity characteristic of the cold acclimated state, brown adipose tissue was denervated in hamsters either kept at thermoneutrality or acclimated to 5°C ambient temperature for 4 weeks. Cold-acclimated hamsters had elevated levels of uncoupling protein messenger ribonucleic acid (8.1-fold) and cytochrom-c oxidase-activity (3-fold). Denervation of brown adipose tissue decreased uncoupling protein-messenger ribonucleic acid level and cytochrom-c-oxidase-activity as compared to the intact pad in thermoneutral and in cold-acclimated hamsters. However, in cold-acclimated hamsters uncoupling protein-messenger ribonucleic acid level and cytochrom-c-oxidase-activity in denervated brown adipose tissue both were maintained on an elevated 6-fold higher levels as compared to thermoneutral controls. Second, to study the role of the sympathetic innervation of brown adipose tissue in the cold-induced increase in thermogenic capacity, hamsters were denervated prior to cold acclimation and responses were measured after 3 and 14 days of cold exposure. Uncoupling protein-messenger ribonucleic acid level and cytochrom-c-oxidase-activity of intact brown adipose tissue increased after 14 days cold acclimation. Denervation did not completely prevent a cold-induced 1.5-fold increase of cytochrom-c-oxidase-activity and a 3.2-fold increase of the uncoupling protein-messenger ribonucleic acid level in denervated brown adipose tissue after 14 days of cold acclimation. In conclusion, high levels of uncoupling protein-messenger ribonucleic acid and cytochrom-c-oxidase activity in brown adipose tissue of cold-acclimated hamsters can partially be maintained without intact sympathetic innervation, suggesting a considerable contribution of trophic factors not requiring sympathetic innervation for maintenance. The cold-induced increase of cytochrom-c-oxidase activity and expression of uncoupling protein-messenger ribonucleic acid largely depends upon sympathetic innervation of brown adipose tissue.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford : Blackwell Science Ltd, UK
    Anaesthesia 53 (1998), S. 0 
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We report the occurrence of an accidental pleural puncture by an epidural catheter that happened during the attempted induction of thoracic epidural anaesthesia using a paramedian approach in an awake patient. The incorrect placement of the catheter was recognised while the patient was undergoing thoracoscopic surgery. The possibility of accidental pleural puncture during attempted thoracic epidural catheter placement by either the paramedian or the midline approach should be borne in mind. A misplaced catheter may injure lung tissue and result in a potentially dangerous intra-operative tension pneumothorax.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1438-3888
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract During three cruises, carried out in March 1991, October 1991, and January 1992 off the Iberian Peninsula and Morocco, the abundant calanoid copepodCalanus helgolandicus (Claus) was collected from a depth of 1000 m to the surface. Differences in depth preference were correlated with the life stage and geographically differing vertical salinity structures. In autumn and winter, only stage V copepodids (CV) and adults were found, in spring also younger copepodid stages. Within the range of the Mediterranean outflow water (MOW), a sharp decline of abundances of all stages was evident during all cruises. In autumn 1991, the bulk of the population was recorded south of the MOW, in winter 1992 north of it. During winter, numbers had declined by 70%, supporting the idea that winter individuals represent the same generation as was encountered in autumn, and that they had been transported northwards. CV stages preferred the depth layer 400–800 m, in autumn and winter. Adults were found in autumn at the same depth south of the MOW, while they preferred the 0–400 m layers north of it. In winter, the abundance of adults increased, males preferred the 400–600 m depth layer, while females stayed at 200–400 m. In spring 1991, stages younger than CV were found in high densities, all stages concentrating in the upper 200 m. During the crosslope survey in spring off Portugal, an absolute abundance maximum of females was found. In contrast, offshore densities were very low. On the basis of these findings, the hypothesis of a Mediterranean centre of distribution and dispersal into the Atlantic is questioned. It is suggested that a separate, reproductively active population ofC. helgolandicus exists off NW. Africa.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1435-1803
    Keywords: Humanarterial smooth musclecells ; proliferation ; antisenseoligonucleotides ; c-myc
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of a c-myc antisense phosphorothioate DNA oligonucleotide were assessed on the proliferation rate of human arterial smooth muscle cells (HSMCs). Compared to a control oligonucleotide the antisense oligonucleotide suppressed the proliferation of HSMCs in a concentration-dependent manner without a major cytotoxic effect. Outgrowth of HSMCs from media explants was significantly inhibited as well. Induction of c-myc expression by serum stimulation of cells was blunted by the antisense oligonucleotide, as shown by immunoblotting. These results demonstrate that c-myc expression is an essential factor for proliferation of HSMCs after growth stimulation, and they show the potential of antisense technology for modulating gene expression of HSMCs in vitro.
    Type of Medium: Electronic Resource
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