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  • 1
    Charlottesville, Va : University of Virginia Library
    Keywords: Prose poems, American. ; American poetry., lcsh
    ISBN: 0-585-29681-2
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  • 2
    Raleigh, N.C : Alex Catalogue
    Keywords: American poetry., lcsh
    ISBN: 0-585-05161-5
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  • 3
    Keywords: Life sciences ; Cytology ; Stem Cells ; Life sciences ; Stem Cells ; Cell Biology ; Cell Physiology ; Springer eBooks
    Description / Table of Contents: Clinical Approach to the Diagnosis of Mitochondrial Disease -- Mitochondrial DNA Mutations and Their Effects on Complex I Biogenesis: Implications for Metabolic Disease -- Embryonic Stem Cells: A Signalling Perspective -- From Oocytes and Pluripotent Stem Cells to Fully Differentiated Fates: (Also) A Mitochondrial Odyssey -- From Pluripotency to Differentiation: The Role of mtDNA in Stem Cell Models of Mitochondrial Diseases -- The Role of Mitochondrial DNA in Tumor Cells -- Assisted Reproductive Technologies to Prevent the Transmission of mtDNA from one Generation to the Next
    Abstract: This volume investigates how the mitochondrial genome is transmitted, segregated, and inherited. It starts by describing mtDNA mutations and deletions and how these impact on the offspring’s well-being. It progresses to discuss how mutations to the mtDNA-nuclear-encoded transcription, replication and translational factors lead to mtDNA-depletion syndromes and how these affect cellular function and lead to the pathology of human mitochondrial disease. It also highlights the importance of the mitochondrial assembly factors and how mutations to these can lead to mitochondrial disease. The reader is then introduced to how mtDNA is transmitted through the oocyte and how stem cells can be used to study mitochondrial biogenesis and mtDNA replication and transcription in undifferentiated pluripotent and differentiating cells and how mitochondria adapt during this process. It then discusses how diseases like cancer are initiated and regulated by mutations to mitochondrial DNA and dysfunctional mitochondria. Finally, it draws on assisted reproductive technologies to discuss how some of these approaches might be adapted to prevent the transmission of mutant and deleted mtDNA from one generation to the next
    Pages: : digital.
    ISBN: 9781627031011
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  • 4
    Keywords: Medicine ; Immunology ; Allergy ; Emerging infectious diseases ; Biomedicine ; Immunology ; Allergology ; Infectious Diseases ; Springer eBooks
    Pages: : digital
    ISBN: 9781607615125
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  • 5
    Keywords: XML (Document markup language)
    Pages: xvii, 213 p.
    ISBN: 0596001193
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  • 6
    Edinburgh : Churchill Livingstone
    (Systemic pathology, v. 7)  
    Call number: QZ4:35/7(3)
    Keywords: Lymphatics / Diseases ; Thymus / Diseases ; Lymph nodes / Diseases ; Spleen / Diseases ; Lymph Nodes / immunology ; Lymphatic Diseases ; Spleen / immunology ; Thymus Gland / immunology ; Lymphoma / pathology
    Notes: 2nd edition has title: Systemic pathology. Thymus, lymph nodes, spleen, and lymphatics.
    Pages: 1042 p. : ill. (some col.)
    Edition: 3rd ed.
    ISBN: 044303429X
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  • 7
    Keywords: Medicine ; Cardiology ; Heart / Surgery ; Biomedicine ; Biomedicine general ; Cardiology ; Cardiac Surgery ; Springer eBooks
    Description / Table of Contents: Part I - ANATOMY, PHYSIOLOGY, CONGENITAL DEFECTS, and DISEASE -- The anatomy and function of the atrioventricular valves -- The anatomy and function of the semilunar valves -- Congenital heart defects that include cardiac valve abnormalities -- Acquired valve disease and processes -- Part II - VALVE REPAIR AND REPLACEMENT -- History of heart valve repair -- Heart valve disease -- Advanced 3D imaging and transcatheter valve repair/ implantation -- Transcatheter mitral repair and replacement -- Percutaneous pulmonary valve implantation: the first transcatheter valve -- Transcatheter aortic valve implantation -- Tissue engineered heart valves -- Part III - TESTING AND REGULATORY ISSUES -- In vitro testing of heart valve substitutes -- Numerical methods for design and evaluation of prosthetic heart valves -- Animal models for cardiac valve research -- The use of isolated heart models and anatomic specimens as means to enhance the design and testing of cardiac valve therapies -- Successful development and regulatory approval of replacement cardiac valves -- Clinical trial requirements for cardiac valves -- Index
    Abstract: Cardiovascular disease is the major cause of morbidity and mortality worldwide. While the past 40 years have brought major progress in cardiac valve repair and replacement, there remain large patient populations that do not receive such therapies. This, in turn, implies a great need for future basic, applied, and clinical research and, ultimately, therapeutic developments. Heart Valves is a state-of-the-art handbook dedicated to: 1) cardiac valve anatomy, 2) models for testing and research methods; 3) clinical trials; and 4) clinical needs and applications
    Pages: : digital.
    ISBN: 9781461461449
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  • 8
    Keywords: Medicine ; Medical Microbiology ; Infectious Diseases ; Epidemiology ; Bacteriology ; Medicine & Public Health ; Infectious Diseases ; Bacteriology ; Medical Microbiology ; Epidemiology ; Springer eBooks
    Description / Table of Contents: Preface -- Microbiology, Genomics, and Population Structure -- Epidemiology and Clinical Manifestations of Kingella kingae Disease -- Pathogenesis of Kingella kingae Disease -- Carriage and Transmission of Kingella kingae -- Advances in Diagnosis of Kingella kingae Disease -- Antibiotic Susceptibility of Kingella kinage -- Kingella kingae Treatment and Antibiotic Prophylaxis -- Experimental Methods for Studying Kingella kingae
    Abstract: This book describes the growing body of information on the epidemiology, clinical manifestations, transmission, pathogenesis, diagnosis, and treatment of Kingella kingae infections in young children. In addition, it covers experimental methods that have been developed to study the microbiology, genetics, and virulence factors of K. kingae, information that provides the foundation for new approaches to treatment and prevention of K. kingae disease. With this content in mind, excerpts from the book will be of relevance for clinicians who care for pediatric patients, for clinical microbiologists who are involved in detecting organisms in clinical specimens, and for scientists who are studying K. kingae in an effort to develop novel targets for antimicrobial therapy and new approaches to prevention. First isolated in the 1960s by Elizabeth O. King, a bacteriologist at the CDC, Kingella kingae was largely ignored over the next two decades as a human pathogen because of its uncommon recovery from patients with disease. However, in recent years K. kingae has been increasingly recognized as a clinically important pathogen in young children, and is currently recognized as the leading cause of osteoarticular infections in young children in a growing number of countries. Research into this organism has grown tremendously over the past 15 years, resulting in a better appreciation of the importance of K. kingae in pediatric patients and of the molecular mechanisms of disease
    Pages: VII, 97 p. 18 illus., 10 illus. in color. : online resource.
    ISBN: 9783319437293
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  • 9
    ISSN: 1432-1246
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Die Autoren vollzogen an Kaninchen mit akuter Quecksilbervergiftung Untersuchungen des Eiweißspektrums, der Muco- und Lipoproteide Bowie der Aktivität der alkalischen Serumphosphatase. Gleichzeitig führten sie in vitro-Teste durch, um den Mechanismus zu klären, der zur Inaktivierung der Phosphatase führt. Die Ergebnisse zeigen, daß lösliche Quecksilbersalze, ix. injiziert, eine Verminderung des Gesamteiweißes verursachen, und zwar hauptsächlich der Albumine bei gleichzeitigem Anstieg der β-Globulin-Fraktion. Es wurde eine deutliche Hebung des Mucoproteidspiegels im Blutserum beobachtet. Das Lipoproteidbild des Serums zeigee eine charakteristische Abnahme der kleinmolekularen Fraktion α zugunsten der großmolekularen Fraktionen β and γ. Quecksilber-Ionen verursachen Aktivitätsabfall der alkalischen Phosphatase durch direkte Einwirkung auf das Enzym. Die Phosphataseaktivität verhält sich umgekehrt proportional zur Hg-Ionen Konzentration. Die Inaktivierung erfolgt wahrscheinlich durch Blockierung der Amino- und Carboxylgruppen des Enzymeiweißes.
    Type of Medium: Electronic Resource
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  • 10
    German Medical Science GMS Publishing House; Düsseldorf
    In:  18th Symposium on Infections in the Immunocompromised Host; 20140615-20140617; Berlin; DOC14ichs38 /20140603/
    Publication Date: 2014-06-04
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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