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  • 1
    Call number: Q49.2:1 ; Q49.2:1a
    Keywords: Deutsches Krebsforschungszentrum Heidelberg ; Cancer / Research ; Oncology / Germany ; Architecture / Designs and plans
    Notes: Title on cover
    Pages: 54 p. : ill.
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    Q49.2:1 available
    Q49.2:1a available
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  • 2
    Keywords: Immunology ; Microbiology ; Gastroenterology ; Human Physiology ; Immunology ; Medical Microbiology ; Gastroenterology ; Human Physiology ; Springer eBooks
    Description / Table of Contents: Inflammation, immunity and vaccine development for the gastric pathogen Helicobacter pylori -- Impact of Helicobacter pylori Virulence Factors on the Host immune Response and Gastric Pathology -- Genetic polymorphisms in inflammatory and other regulators in gastric cancer: risks and clinical consequences -- MALT lymphoma as a model of chronic inflammation-induced gastric tumor development -- Crosstalk between DNA damage and inflammation in the multiple steps of gastric carcinogenesis -- Importance of toll-like receptors in pro-inflammatory and anti-inflammatory responses by Helicobacter pylori infection -- Role of NOD1 and ALPK1/TIFA signalling in innate immunity against Helicobacter pylori infection -- Carbohydrate-dependent and antimicrobial peptide defense mechanisms against Helicobacter pylori infections -- The sweeping role of cholesterol depletion in the persistence of Helicobacter pylori infections -- Helicobacter pylori deregulates T and B cell signaling to trigger immune evasion -- Mechanisms of inflammasome signaling, microRNA induction and resolution of inflammation by Helicobacter pylori -- Impact of the gastrointestinal microbiome in health and disease: co-evolution with the host immune system -- Resolution of gastric cancer-promoting inflammation: a novel strategy for anti-cancer therapy
    Abstract: This book focuses on immune reactions and interactions of humans with Helicobacter pylori - a human pathogen connected to gastritis, peptic ulcers and even gastric cancer. With nearly half of the world’s population colonized, it has been characterized as one of the most successful pathogens for more than 100,000 years of co-evolution with its host. The respective chapters discuss not only how H. pylori infection is considered a paradigm for persistent bacterial infection and chronic inflammation, but also how the infection might be connected to host protection against gastro-esophageal diseases, asthma, and other allergic disease manifestations. Readers will gain essential insights into the roles of specific factors in the immune response and learn about the impact of genetic polymorphisms on the risk of gastric carcinogenesis. In addition, the book discusses the strategies used by this bacterium, which allow it to colonize specific sites in the stomach, interact with the microbiome, evade immune surveillance and undermine the resolution of inflammation during persistent infection. This volume presents a concise summary of recent advances in the areas of induction, resolution and escape of inflammation, innate and adaptive immunity, gastric disease development, as well as treatment and vaccination against H. pylori. Accordingly, it offers a valuable asset for scientists and clinicians alike
    Pages: XXIV, 359 p. 29 illus., 28 illus. in color. : online resource.
    ISBN: 9783030151386
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  • 3
    Call number: YY Diss Samm/Mag
    Keywords: DKFZ-publications / academic dissertations
    Pages: 138 p.
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    YY Diss Samm/Mag departmental collection or stack – please contact the library
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  • 4
    Call number: YY Diss Rich/Mag
    Keywords: DKFZ-publications / academic dissertations
    Pages: 226 p.
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    YY Diss Rich/Mag departmental collection or stack – please contact the library
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  • 5
    Keywords: Medicine ; Cancer Research ; Medical Microbiology ; Gastroenterology ; Biomedicine ; Medical Microbiology ; Gastroenterology ; Cancer Research ; Springer eBooks
    Description / Table of Contents: The human stomach in health and disease: infection strategies by Helicobacter pylori -- Human and Helicobacter pylori Interactions Determine the Outcome of Gastric Diseases -- Immune evasion strategies and persistence of Helicobacter pylori -- Recent advances in Helicobacter pylori replication: possible implications in adaptation to a pathogenic lifestyle and perspectives for drug design -- The Helicobacter pylori Methylome: Roles in Gene Regulation and Virulence -- Structural insights into Helicobacter pylori Cag protein interactions with host cell factors -- Gastric organoids: An emerging model system to study Helicobacter pylori pathogenesis -- DNA Transfer and Toll-Like Receptor Modulation by Helicobacter pylori -- Exploiting the gastric epithelial barrier: Helicobacter pylori’s attack on tight and adherens junctions -- Helicobacter pylori-induced Changes in Gastric Acid Secretion and Upper Gastrointestinal Disease -- Impact of the microbiota and gastric disease development by Helicobacter pylori -- Pathogenesis of gastric cancer: genetics and molecular classification -- Helicobacter pylori-mediated genetic instability and gastric carcinogenesis -- Helicobacter pylori and extragastric diseases
    Abstract: This volume reviews the current state of research concerning bacterial virulence factors and the infection biology of Helicobacter pylori, which is the leading cause of peptic ulcers and gastric cancer worldwide. The chapters include cutting-edge findings on this fascinating microbe and discuss the general strategies of H. pylori infection and persistence, news on important H. pylori virulence factors, crosstalk with the microbiota, hot novel models and signaling mechanisms, risk factors of gastric disease and stomach cancer, and the impact of H. pylori infection on non-gastric diseases. Written by internationally respected scientists, this book will appeal to clinicians, researchers and advanced students alike
    Pages: XXIV, 347 p. 33 illus., 31 illus. in color. : online resource.
    ISBN: 9783319505206
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  • 6
    Call number: G260:41
    Pages: xii, 218 p. : ill.
    Edition: 3., überarb. Aufl.
    ISBN: 9783642309182
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    G260:41 departmental collection or stack – please contact the library
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  • 7
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    Heidelberg
    Call number: YY Diss Runz/Mag
    Keywords: DKFZ-publications / academic dissertations
    Pages: VI, 83 p.
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  • 8
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    Cham : Springer International Publishing
    Keywords: Medicine ; Medical Microbiology ; Parasitology ; Infectious Diseases ; Respiratory organs / Diseases ; Biomedicine ; Medical Microbiology ; Infectious Diseases ; Parasitology ; Pneumology/Respiratory System ; Springer eBooks
    Abstract: This volume details our current understanding of the architecture and signaling capabilities of known canonical and non-canonical inflammasome complexes and highlights their action, in particular in response to infection with important bacterial model organisms and the corresponding disease pathologies. The first chapters review new insights into the assembly and structures of inflammasome components and emphasize general strategies of up- and downstream signaling events. In addition, the authors specifically discuss the composition and activity of inflammasomes during infection with various gut pathogens (Salmonella, Shigella, Yersinia, Listeria and Helicobacter), respiratory pathogens (Mycobacterium, Legionella, Burkholderia and Streptococcus) as well as skin and soft tissue pathogens (Francisella and Staphylococcus). The discoveries presented provide a better understanding of the cellular and molecular biology of inflammasomes, which will pinpoint important new therapeutic targets for the treatment and prevention of multiple infectious diseases in the future. It is a valuable resource for students, scientists and clinicians, providing up-to-date information on this emerging research topic
    Pages: XI, 282 p. 29 illus., 28 illus. in color. : online resource.
    ISBN: 9783319411712
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  • 9
    Call number: QZ365WP870:392
    Keywords: Breast Neoplasms / prevention & control ; Breast Neoplasms / etiology ; Breast Neoplasms / surgery ; Breast Neoplasms / therapy
    Pages: 101 p.
    ISBN: 3-89599-734-X
    Signatur Availability
    QZ365WP870:392 on loan
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  • 10
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    Oxford : Clarendon
    Call number: B050:272
    Keywords: Graphical modeling (Statistics) ; Graph theory
    Pages: x,298p. : ill.
    Edition: Repr. with corr. 2004
    ISBN: 0198522193
    Signatur Availability
    B050:272 departmental collection or stack – please contact the library
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