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  • 1
    Publication Date: 2006-04-21
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 2
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  48. Jahrestagung der Deutschen Gesellschaft der Plastischen, Rekonstruktiven und Ästhetischen Chirurgen (DGPRÄC), 55. Jahrestagung der Österreichischen Gesellschaft für Plastische, Ästhetische und Rekonstruktive Chirurgie, 22. Jahrestagung der Vereinigung der Deutschen Ästhetisch-Plastischen Chirurgen (VDÄPC); 20170914-20170916; Graz, Österreich; DOC159 /20170816/
    Publication Date: 2017-08-16
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 3
    Keywords: CANCER ; IN-VIVO ; POPULATION ; RISK ; GENE ; ASSOCIATION ; polymorphism ; POLYMORPHISMS ; BREAST-CANCER ; TRIAL ; HEALTH ; PROSPECTIVE COHORT ; SUPPLEMENTATION ; GLUTATHIONE-PEROXIDASE ; SUBSEQUENT RISK ; SERUM SELENIUM ; ERYTHROCYTE GPX ACTIVITY ; GLUTATHIONE-PEROXIDASE-1 ; NUTRITIONAL PREVENTION
    Abstract: Background: Evidence for an association between selenium status and prostate cancer risk is still inconclusive. Anticarcinogenic effects of selenium are supposedly mediated through cellular protective and redox properties of selenoenzymes in vivo. We evaluated the association between serum selenium status and prostate cancer risk in a population with relative low selenium concentrations considering effect modification by genetic variants in selenoprotein genes. Materials and Methods: A case-control study of 248 incident prostate cancer cases and 492 matched controls was nested within the EPIC-Heidelberg cohort. Baseline blood samples were analyzed for serum selenium and selenoprotein P concentrations and glutathione peroxidase activity. Genotyping was carried out for SEP15 (rs5859, rs540049), SEPP1 (rs3877899, rs7579), GPX1 (rs1050450), and GPX4 (rs713041). Conditional logistic regression was used to calculate adjusted odds ratios (OR) and 95% confidence intervals (95% CI). Results: The OR for prostate cancer was 0.89 (95% CI, 0.79-1.01) per 10 mu g/L increase of serum selenium concentration. This association was modified by rs1050450 (C〉T) in GPX1 (P-interaction = 0.03), with carriers of one or two T alleles having a significantly reduced OR of 0.87 (95% CI, 0.76-0.99). Furthermore, there was an association between rs7579 genotype in SEPP1 and prostate cancer risk (OR, 1.72; 95% CI, 0.99-2.98). Conclusions: Our results support a role of selenium and polymorphisms in selenoenzymes in prostate cancer etiology, which warrants confirmation in future studies. Impact: These findings might help to explain biological effects of selenium in prostate cancer development in order to overcome inconsistencies arising from former studies.
    Type of Publication: Journal article published
    PubMed ID: 20852007
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  • 4
    Keywords: EXPRESSION ; COHORT ; POLYMORPHISMS ; CARCINOGENS ; EPIC-GERMANY ; DNA-ADDUCTS ; METAANALYSIS ; MEAT CONSUMPTION ; CYTOCHROMES P450 ; COOKED MEAT
    Abstract: The association between heterocyclic aromatic amine (HCA) intake and prostate cancer (PCa) risk may be modified by genetic variation in enzymes involved in HCA metabolism. We examined this question in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition Heidelberg cohort. The study included 204 PCa cases and 360 matched controls. At baseline, participants provided dietary and lifestyle data and blood samples that were used for genotyping. Dietary HCA intake-2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP), 2-amino-3,8-dimethylimidazo [4,5-f]quinoxaline (MeIQx), and 2-amino-3,4,8-dimethylimidazo [4,5-f]quinoxaline (DiMeIQx-was estimated using information on meat consumption, cooking methods, and browning degree. Risk estimates for gene x HCA interactions were calculated by unconditional logistic regression. We found inverse associations between PhIP, MeIQx, or DiMeIQx intake and PCa risk when having 〈2 deletions of the GSTT1 and GSTM1 genes (P (interaction): 0.03, 0.01, and 0.03, respectively), which is supported by analysis of darkly browned meat consumption data. Statistically significant effect modification of both HCA (DiMeIQx) and darkly browned meat intake and PCa risk was observed for allelic variants of MnSOD (rs4880) (P (interaction): 0.02). Despite limitations due to study size, we conclude that the association between HCA intake and PCa risk could be modified by polymorphisms of GSTT1, GSTM1, and MnSOD.
    Type of Publication: Journal article published
    PubMed ID: 22564066
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  • 5
    Keywords: RISK-FACTORS ; MYOCARDIAL-INFARCTION ; DIABETES-MELLITUS ; PREVALENCE ; ISCHEMIC-STROKE ; POMERANIA SHIP ; PERIODONTAL-DISEASE ; AGGRESSIVE PERIODONTITIS ; ORAL-HEALTH ; PARTIAL-MOUTH
    Abstract: Background: To investigate the periodontal disease status in a multi-center cross-sectional study in Germany. Associations of dental, socio-economic, blood and biomedical variables with periodontal outcome parameters were evaluated. Methods: From 4 different centers N = 311 persons were included, drawn randomly from the registration offices. Maximal pocket depth (PD) was used as primary indicator for periodontitis. It was classified as: no/mild 〈= 3 mm, moderate 4-5 mm, severe 〉= 6 mm. Associations between socioeconomic (household income, education), lifestyle, and biomedical factors and PD or bleeding on probing (BOP) per site ("Yes"/"No") was analyzed with logistic regression analysis. Results: Mean age of subjects was 46.4 (range 20-77) years. A significantly higher risk of deeper pockets for smokers (OR = 2.4, current vs. never smoker) or persons with higher BMI (OR = 1.6, BMI increase by 5) was found. Severity of periodontitis was significantly associated with caries lesions (p = 0.01), bridges (p 〈 .0001), crowns (p 〈 .0001), leukocytes (p = 0.04), HbA1c (p 〈 .0001) and MCV (p = 0.04). PD was positively correlated with BOP. No significant associations with BOP were found in regression analysis. Conclusions: Earlier findings for BMI and smoking with severity of PD were confirmed. Dental variables might be influenced by potential confounding factors e.g. dental hygiene. For blood parameters interactions with unknown systemic diseases may exist.
    Type of Publication: Journal article published
    PubMed ID: 25604448
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  • 6
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Current Posters in Otorhinolaryngology - Head and Neck Surgery; VOL: 13; DOC016 /20170426/
    Publication Date: 2017-04-26
    Description: Einleitung: Es ist nicht bekannt, inwieweit die aktuelle Leitlinie und Studiendaten die Versorgungsrealität der Behandlung der idiopathischen Fazialisparese (IFP) widerspiegelt.Material und Methoden: Es wurde eine retrospektive populationsbezogene Untersuchung aller 2012 in Thüringen stationär behandelten 291 Patienten (46% weiblich, medianes Alter: 50 Jahre) vorgenommen (Behandlung in einer HNO-Klinik: 55%, Neurologie: 36%).Ergebnisse: Die multivariate Analyse zeigte, dass die Wahrscheinlichkeit, dass ein Grading der Parese (Odds Ratio [OR] =12,9; 95% Konfidenzintervall [KI] = 3,5 - 46,5), ein Schmecktest (OR = 6,8; KI = 1,14 - 44,4) oder ein Hörtest (OR = 32,5; KI = 1,4 - 711,2) erfolgte, in einer HNO-Klinik größer war als in einer Klinik für Neurologie, umgekehrt niedriger für ein cCT (OR = 0,2; KI = 0,1 - 0,6), eine Liquoruntersuchung (OR = 0,02; KI = 0,01 - 0,1), oder Konsultation einer anderen Fachdisziplin (OR = 0,11; KI = 0,01 - 0,4). Die kumulative Prednisolon-Äquivalentdosis zur Therapie variierte zwischen 100 bis 500 mg. Bei einem Follow-up von 4±8 Monaten zeigten 45% der Patienten eine Erholung auf House-Brackmann Grad I/II. Ein ausgefallener Stapediusreflex (Hazard Ratio [HR] = 0,4; KI = 0,2 - 1,0) war der einzige unabhängige diagnostischer Marker für ein schlechteres Outcome in der multivariaten Analyse. Eine Prednisolondosis 〉500mg (HR = 0,69; KI 0,4 to 0,8) und keine adjuvante Physiotherapie (HR = 0,6; KI = 0,4 to 0,84) waren unabhängige Behandlung-bezogene Prädiktoren für ein schlechteres Outcome.Schlussfolgerung: Die stationäre Behandlung der IFP ist im klinischen Alltag variabel und das Outcome geringer als nach klinischen Studien zu erwarten. Wir benötigen bessere Wege um die Erkenntnisse von klinischen Studien in den Klinikalltag zu übertragen.Der Erstautor gibt keinen Interessenkonflikt an.
    Keywords: ddc: 610
    Language: German
    Type: article
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  • 7
    Keywords: EXPRESSION ; BIOMARKERS ; prevention ; HEALTH ; genetics ; INHIBITORS ; SERUM ; SUPPLEMENTATION ; HOMEOSTASIS ; GENOME-WIDE ASSOCIATION
    Abstract: Increased dietary intake of Selenium (Se) has been suggested to lower prostate cancer mortality, but supplementation trials have produced conflicting results. Se is incorporated into 25 selenoproteins. The aim of this work was to assess whether risk of prostate cancer is affected by genetic variants in genes coding for selenoproteins, either alone or in combination with Se status. 248 cases and 492 controls from an EPIC-Heidelberg nested case-control study were subjected to two-stage genotyping with an initial screening phase in which 384 tagging-SNPs covering 72 Se-related genes were determined in 94 cases and 94 controls using the Illumina Goldengate methodology. This analysis was followed by a second phase in which genotyping for candidate SNPs identified in the first phase was carried out in the full study using Sequenom. Risk of high-grade or advanced stage prostate cancer was modified by interactions between serum markers of Se status and genotypes for rs9880056 in SELK, rs9605030 and rs9605031 in TXNRD2, and rs7310505 in TXNRD1. No significant effects of SNPs on prostate cancer risk were observed when grade or Se status was not taken into account. In conclusion, the risk of high-grade or advanced-stage prostate cancer is significantly altered by a combination of genotype for SNPs in selenoprotein genes and Se status. The findings contribute to explaining the biological effects of selenium intake and genetic factors in prostate cancer development and highlight potential roles of thioredoxin reductases and selenoprotein K in tumour progression.
    Type of Publication: Journal article published
    PubMed ID: 23133653
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  • 8
  • 9
    Keywords: CANCER ; cohort study ; RISK ; ASSOCIATION ; ALPHA ; OXIDATIVE STRESS ; REGRESSION ; RELATIVE VALIDITY ; BENIGN PROSTATIC HYPERPLASIA ; SELENOPROTEIN-P ; WHOLE-BLOOD ; GERMAN PART ; URINARY-TRACT SYMPTOMS ; SERUM SELENIUM ; EPIC-HEIDELBERG COHORT ; CHINESE SUBJECTS ; glucosinolate intake ; GPx ; GST-alpha ; PEROXIDASE ACTIVITIES ; SePP
    Abstract: OBJECTIVE To determine whether geographical differences in the distribution of benign prostatic hyperplasia (BPH) and migrant studies indicate that modifi able factors play a role in the aetiology of BPH. Oxidative stress produced by chronic inflammation could represent one of the causes, and antioxidants, including selenoproteins, may reduce the risk. SUBJECTS AND METHODS Conditional logistic regression was used to examine the associations of serum selenium and selenoprotein P concentrations and glutathione peroxidase activity with respect to the risk of BPH in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition-Heidelberg cohort, including 111 cases and 214 matched controls. In addition, dietary glucosinolate intake and the serum glutathione S-transferase alpha concentration was investigated. RESULTS The risk of BPH significantly decreased with an increasing serum selenium concentration; the risk estimate was 0.83 (35% CI 0.69-0.99) per 10 mu g/L increase in serum selenium concentration. However, no significant association was present for serum selenoprotein P concentration or glutathione peroxidase activity. Risk estimates for BPH decreased with a higher intake of glucosinolates, although the results were not statistically significant. CONCLUSION A low serum selenium concentration may increase the risk of BPH, although the findings reported in the present study need to be confirmed in larger, well-designed epidemiological studies
    Type of Publication: Journal article published
    PubMed ID: 22882569
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  • 10
    Keywords: Germany ; COHORT ; cohort study ; DISEASE ; POPULATION ; METABOLISM ; TIME ; FORM ; HEALTH ; AGE ; WOMEN ; MEN ; DATABASE ; DIET ; nutrition ; VEGETABLES ; FOOD-INTAKE ; 24-HOUR DIET RECALL ; dietary intake ; EPIC-Heidelberg ; ERROR ; broccoli ; QUANTITATIVE-DETERMINATION ; Brassica vegetables ; BRASSICA-OLERACEA ; BRUSSELS-SPROUTS ; CRUCIFEROUS VEGETABLES ; FERMENTED CABBAGE ; Food content ; Glucobrassicin ; Glucoraphanin ; Glucosinolates ; HEALTH-PROMOTING COMPOUNDS ; LOW-TEMPERATURE ; Sinigrin ; VAR.-CAPITATA ; WHITE CABBAGE
    Abstract: Background/Aims: To compile a database on content of individual glucosinolates in food and to describe the dietary intake of individual glucosinolates in a German population. Methods: Studies analysing the content of individual glucosinolates in food were aggregated to form a database of 26 individual glucosinolates in 18 vegetables and condiments consumed in Germany. This database was linked to food intake data derived from 24-hour diet recalls of 2,121 participants of the EPIC-Heidelberg cohort study. Results: Mean total glucosinolate intake (+/- standard error) was 14.2 (+/- 1.1) mg/day for men and 14.8 (+/- 1.3) mg/day for women. The intake increased with age and education; smokers ingested less glucosinolates than never or former smokers. The quantitatively most important individual glucosinolates were glucobrassicin and sinigrin with mean daily intakes of 3.5 (+/- 0.3) and 1.7 (+/- 0.2) mg/ day for men, and 4.2 (+/- 0.4) and 2.5 (+/- 0.4) mg/ day for women, respectively. Broccoli, Brussels sprouts and cauliflower contributed most to the total glucosinolate intake in this population. Conclusions: The established database allowed for the first time the estimation of dietary intake of individual glucosinolates. The database can be used for epidemiological research on the role of glucosinolates in health and disease. Copyright (C) 2009 S. Karger AG, Basel
    Type of Publication: Journal article published
    PubMed ID: 19295191
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