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  • 1
    ISSN: 1590-3478
    Keywords: Multiple sclerosis ; Sexual function ; Symptom
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario È noto che disfunzioni sessuali possono verificarsi in pazienti con sclerosi multipla (SM). Questo studio si propone di descriverne l'occorrenza attraverso una analisi longitudinale. Quarantanove pazienti (27 femmine e 22 maschi) con SM definita sono stati intervistati ed esaminati due volte a 5 anni di distanza. Il numero di pazienti con disfunzioni sessuali risultò significativamente aumentato (p=0.009) senza significative differenze tra maschi e femmine. I maschi presentavano usualmente uno o due sintomi di disfunzione sessuale mentre le femmine ne avevano frequentemente due o più. Si conclude che il rischio di disfunzioni sessuali aumenta nel tempo. Ulteriori studi sono necessari sulle possibilità di trattamento.
    Notes: Abstract Sexual dysfunction is known to occur in multiple sclerosis (MS). The purpose of the study is to describe the change in sexual function and symptoms in a longitudinal study. Forty-nine patients (27 females, 22 males) with definite MS were interviewed and examined with 5 years interval. The number of patients with sexual dysfunction increased significantly (p=0.009) and involved females and males equally. Males usually had 1 or two symptoms of sexual dysfunction, while females frequently had 2 or more symptoms. It is concluded that the risk of sexual dysfunction increases over time. Further studies in treatment possibilities are needed.
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 91 (1988), S. 47-49 
    ISSN: 0942-0940
    Keywords: Treatment ; infection ; ventriculostomy ; CSF shunt ; external ventricular drainage ; ventriculitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The results of the treatment of 15 cases of ventriculitis related to the use of external ventricular drainage are presented. A review of the literature on the treatment of cerebrospinal fluid shunt infections combined with our data suggest the following treatment of venticulostomy-related ventriculitis: 1. Antibiotic treatment according to the resistance pattern of the infecting microorganism and 2. Removal or replacement of the ventricular drain. 3. One should wait for bacteriological cure before implanting a permanent internal drainage system.
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  • 3
    ISSN: 0942-0940
    Keywords: Ventriculostomy ; infection ; subarachnoid ; haemorrhage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a prospective study involving a total of 87 ventriculostomies, ventriculostomy-related infections (based upon a bacteriological definition) developed in 15 patients (17.2 per cent). Intraventricular haemorrhage was related to a higher infection rate. Infection was most frequent within the first days after the external ventricular drain (EVD) was inserted. There was no relation between infection and the number of manipulations of the EVD or antibiotic treatment during the time of EVD placement.
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  • 4
    ISSN: 1590-3478
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Neurological sciences 17 (1996), S. 393-399 
    ISSN: 1590-3478
    Keywords: Progressive multifocal leucoencephalopathy (PML) ; JC virus (JCV) ; Papovavirus ; Immunodeficiency ; HIV
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario La leucoencefalopatia progressiva multifocale (PML) è una rara malattia demienilizzante del sistema centrale causata da un papovavirus neurotropo denominato virus JC (JCV). Le regioni più frequentemente interessate sono gli emisferi cerebrali, con particolare riguardo alla regione parieto-occipitale, seguiti da cervelletto e troncoencefalo. La malattia si manifesta prevalentemente nel corso di malattie che determinano immunodepressione con alterazione della immunità cellulare (CMI). L'aumentato impiego di terapie radianti e immunosoppressive in relazione al diffondersi delle tecniche di trapianto o per il trattamento di malattie autoimmuni e tumorali, oltre alla comparsa della sindrome di immunodeficienza acquisita (AIDS), determinata dal virus della immunodeficienza umana (HIV), hanno determinato un considerevole incremento di frequenza della PML. IL decorso della malattia è il più delle volte rapido e fatale, tuttavia sono stati segnalati parecchi casi con sopravvivenza prolungata o addirittura remissione, cosa che ha indotto a sperimentare l'efficacia di vari trattamenti antivirali. Il solo farmaco dimostratosi finora efficace è la citosina arabinoside. In alcuni pazienti HIV positivi con PML la terapia immunomodulante con AZT/zidovudina può alleviare il decorso della malattia e migliorare la prognosi. Il sospetto di PML deve indurre ad uno studio immunologico completo prima di ricorrere alla biopsia cerebrale che rappresenta l'unico test diagnostico specifico. L'aumentata frequenza di osservazione della PML in relazione all'infezione HIV porterà probabilmente ad un miglioramento delle nostre conoscenze sulla patogenesi, con conseguente sperabile messa a punto di strategie terapeutiche efficaci.
    Notes: Abstract Progressive multifocal leucoencephalopathy (PML) is a rarely occurring demyelinating disease of the central nervous system caused by a neurotropic papovavirus named JC virus (JCV). The most frequently affected regions are the cerebral hemispheres, especially the parietooccipital region, followed by the cerebellum and brain stem. The disease occurs predominantly in individuals with an immunocompromised state and impaired cellular mediated immunity (CMI) due to other underlying illness. More extensive use of irradiation and immunosuppressive therapy in relation to increased transplantational activities as well as treatment of autoimmune diseases and malignancies, in addition to the appearance of the acquired immunodeficiency syndrome (AIDS) as a consequence of infection with the human immunodeficiency virus (HIV), has caused a considerable increase in the occurrence of PML. The course of the disease is still most often rapidly progressive and fatal, but several cases with prolonged survival and even remission have been reported, and various antiviral treatments have been tried. The only drug that until now has shown favourable results is cytosine arabinoside. In HIV-infected PML-patients immunomodulation with AZT/zidovudine may alleviate the course and improve the prognosis in some patients. Suspicion of PML should lead to an extensive immunological investigation before considering of brain biopsy, which is still the only specific test. On the basis of the increased frequency of PML in relation to HIV-infection, it is likely that our knowledge of the pathogenetic aspects will increase, which, hopefully, may lead to an effective therapeutic strategy.
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  • 6
    ISSN: 1590-3478
    Keywords: multiple sclerosis ; neuropsychology ; affective disorder ; symptom
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Scopo del presente lavoro è stato quello di esaminare la correlazione tra ansia e disabilità e di valutare se gli stati ansiosi fossero correlati con forme specifiche di disturbi cognitivi. Novantaquattro pazienti (42 femmine e 52 maschi) con SM definita sono stati reclutati nel presente studio. L'ansia è stata valutata secondo lo State-Trait Anxiety Inventory, la disabilità fisica mediante la scala di Kurtzke e per i disturbi cognitivi sono stati somministrati i seguenti test: Trail Making, Symbol Digit Modalities, Auditory Verbal Learning, Story Recall e Recurring Figures. I pazienti con un handicap moderato (DSS 4–5) mostravano segni di ansia e il disturbo era correlato con lo stato di ansia (p〈0.05; d.f. 1. 92). Pure il test Trail Making era correlato con l'ansia (p〈0.01; d.f. 1.86). Sulla base di questi e di precedenti studi, si conclude che l'ansia quò essere un segno di disfunzione cognitiva, di disturbi fisici o di pressione sociale.
    Notes: Abstract The aim of the study was to examine the correlation between anxiety and physical impairment and to discover whether anxiety correlated with specific forms of cognitive dysfunction. Ninetyfour patients (42 females, 52 males) with definite MS entered the study. Anxiety was measured using the State-Trait Anxiety Inventory, physical impairment by means of the Kurtzke Disability Status scale, and cognitive impairment by using the Trail Making, Symbol Digit Modalities, Auditory Verbal Learning, Story Recall and the Recurring Figures tests. Moderately handicapped patients (DSS 4–5) showed signs of anxiety, and physical impairment correlated with anxiety (p〈0.05; d.f. 1.92). Trail Making also correlated with anxiety (p〈0.01; d.f. 1.86). On the basis of the results of this and previous studies, it is concluded that anxiety can be a sign of cognitive dysfunction, physical impairment or social strain.
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Neurological sciences 14 (1993), S. 333-336 
    ISSN: 1590-3478
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
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  • 8
    ISSN: 1590-3478
    Keywords: Multiple sclerosis ; Pain ; Symptoms ; Treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario L'occorrenza di sindromi dolorose acute (durata inferiore a 1 mese) o croniche (durata superiore a 1 mese) è stata indagata in 49 pazienti (22 maschi e 27 femmine) con sclerosi multipla definita. Ciascun paziente è stato esaminato due volte con un intervallo di 5 anni tra i due controlli. Tra il primo e il secondo controllo si è osservato un significativo aumento di sindromi dolorose acute e croniche comprendenti tensione e dolore alle estremità, spasmi, lombalgia, segno di Lhermitte e dolori neuralgici. Tale aumento si è verificato sia nei maschi che nelle femmine ed è particolarmente evidente nei pazienti con deterioramento e disabilità.
    Notes: Abstract Forty-nine (22 males, 27 females) patients with definite multiple sclerosis were examined twice with 5 years interval regarding acute (less than 1 month duration) and chronic (more than 1 month duration) pain syndromes. From the first to the second examination a significant increase was found in the number of acute and chronic pain syndromes, including tension and pain in the extremities, spasms, low back pain, Lhermitte's sign and neuralgia. The increase included both men and women. The increase was especially found in patients with deterioration of disability.
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