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  • 1
    Call number: 01-PROE:88
    Keywords: Art, Modern / Exhibitions / Germany (West) ; Art, German / Exhibitions / Germany (West) ; Medicine and art / Exhibitions
    Notes: Exhibition catalog.
    Pages: 152 p. : ill. (some col.)
    ISBN: 3770119630
    Signatur Availability
    01-PROE:88 departmental collection or stack – please contact the library
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  • 2
    Keywords: Medicine ; Human Genetics ; Genetic Engineering ; Biomedicine ; Human Genetics ; Genetic Engineering ; Springer eBooks
    Description / Table of Contents: Comparison Between Agrobacterium-Mediated and Direct Gene Transfer Using the Gene Gun -- Transient Gene Expression in Epidermal Cells of Plant Leaves by Biolistic DNA Delivery -- Transformation of Nuclear DNA in Meristematic and Embryogenic Tissues -- Biolistic DNA Delivery to Leaf Tissue of Plants with the Non-Vacuum Gene Gun (HandyGun) -- HandGun-Mediated Inoculation of Plants with Viral Pathogens for Mechanistic Studies -- Biolistics-Based Gene Silencing in Plants Using a Modified Particle Inflow Gun -- Biolistic Transformation of Caenorhabditis elegans -- Improved Vectors for Selection of Transgenic Caenorhabditis elegans -- Biolistic Transformation of Brugia malayi -- Biolistic Transfection of Human Embryonic Kidney (HEK) 293 Cells -- Biolistic Transfection of Tumor Tissue Samples -- Biolistic Transfection of Freshly Isolated Adult Ventricular Myocytes -- Biolistic Transfection of Neurons in Organotypic Brain Slices -- Biolistic DNA Delivery to Mice with the Low Pressure Gene Gun -- Chemokine Overexpression in the Skin by Biolistic DNA Delivery -- Enhancement of Gene Gun-Induced Vaccine-Specific Cytotoxic T Cell Response by Administration of Chemotherapeutic Drugs -- Dendritic Cell-Specific Biolistic Transfection Using the Fascin Gene Promoter -- Particle-Mediated Administration of Plasmid DNA on Corneas of BALB/c Mice -- Optimizing Particle-Mediated Epidermal Delivery of an Influenza DNA Vaccine in Ferrets -- Methods for Monitoring Gene Gun-Induced HBV- and HCV-Specific Immune Responses in Mouse Models -- Gene Gun Immunization to Combat Malaria -- Identification of T-cell Epitopes of Mycobacterium tuberculosis with Biolistic DNA Vaccination -- Biolistic DNA Vaccination Against Trypanosoma Infection -- Biolistic DNA Vaccination Against Melanoma -- Biolistic DNA Vaccination Against Cervical Cancer -- Efficiency of Biolistic DNA Vaccination in Experimental Type I Allergy -- Safety Assessment of Biolistic DNA Vaccination -- DiOlistics: Delivery of Fluorescent Dyes into Cells -- Protein Antigen Delivery by Gene Gun-Mediated Epidermal Antigen Incorporation (EAI)
    Abstract: Biolistic transfection represents a direct physical gene transfer approach in which nucleic acids are precipitated on biologically inert high-density microparticles (usually gold or tungsten) and delivered directly through cell walls and/or membranes into the nucleus of target cells by high-velocity acceleration using a ballistic device such as the gene gun.℗ Biolistic DNA Delivery: Methods and Protocols provides a comprehensive collection of detailed protocols intended to provide the definitive practical guide for the novice as well as for the advanced gene transfer expert on how to introduce nucleic acids into eukaryotic cells using the biolistic technique. Split into six convenient sections, this detailed volume covers biolistic gene transfer into plants, nematodes, and mammalian cells, both in vitro and in vivo, as well as the use of gene gun-mediated DNA vaccination in various experimental animal models of human diseases, and the description of biolistic delivery of molecules other than nucleic acids. Written in the highly successful Methods in Molecular Biologý„Ø series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. ℗ All-inclusive and cutting-edge,℗ Biolistic DNA Delivery: Methods and Protocols brings together the knowledge and the experience of leading experts in the field of gene transfer in order to serve all researchers who wish to further our abilities in this vital field
    Pages: XIV, 415 p. 80 illus., 33 illus. in color. : digital.
    ISBN: 9781627031103
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  • 3
    Keywords: Medicine ; Toxicology ; Cell Physiology ; Endocrinology ; Metabolic Diseases ; Molecular Medicine ; Pharmacology/Toxicology ; Cell Physiology ; Endocrinology ; Metabolic Diseases ; Springer eBooks
    Description / Table of Contents: Part 1. Origin of Brown and Beige Adipocytes -- 1. Brown Adipose Tissue Development and Metabolism -- 2. Lessons from Cre-Mice and Indicator Mice -- 3. Aging of Brown and Beige/Brite Adipose Tissue -- 4. Adipogenesis in Primary Cell Culture -- 5. In Vitro Models for Study of Brown Adipocyte Biology -- 6. Brown-Like Adipocyte Progenitors Derived from Human iPS Cells: A New Tool for Anti-obesity Drug Discovery and Cell-Based Therapy? -- 7. Brown Adipose Tissue in Human Infants -- Part 2. Molecular Mechanisms of BAT Function and Signaling -- 8. Evolution of UCP1 -- 9. The Mechanism FA-Dependent H+ Transport by UCP1 -- 10. Role of cAMP and cGMP Signaling in Brown Fat -- 11. Fatty Acid Metabolites as Novel Regulators of Non-shivering Thermogenesis -- 12. Regulatory Small and Long Noncoding RNAs in Brite/Brown Adipose Tissue -- 13. Brown Adipokines -- Part 3 Detection of BAT in vivo -- 14. Infrared Thermography -- 15. In Vivo Detection of Human Brown Adipose Tissue During Cold and Exercise by PET/CT -- 16. Techniques and Applications of Magnetic Resonance Imaging for Studying Brown Adipose Tissue Morphometry and Function -- 17. Multispectral Optoacoustic Tomography of Brown Adipose Tissue -- 18. BAT Exosomes: Metabolic Crosstalk with Other Organs and Biomarkers for BAT Activity -- Part 4. Recruitment and Activation of human BAT -- 19. Activation of Human Brown Adipose Tissue (BAT): Focus on Nutrition and Eating -- 20. Translational Aspects of Brown Fat Activation by Food-Derived Stimulants -- 21. Translational Pharmacology and Physiology of Brown Adipose Tissue in Human Disease and Treatment
    Abstract: The main focus of this book is on brown adipose tissue and its metabolic function. The book provides a timely update on the latest research and shows where the field is heading. Brown adipose tissue (BAT) dissipates energy and has received considerable attention in the last few years, having been re-discovered in adult humans in 2007/9. Moreover, BAT might offer a target for novel therapies to address obesity, a health condition that has reached pandemic dimensions
    Pages: VIII, 424 p. 52 illus., 49 illus. in color. : online resource.
    ISBN: 9783030105136
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  • 4
    Unknown
    München : LUKON-Verl.-Ges.
    Call number: QZ200:472/2010,10
    Keywords: Oncology ; Neoplasms / diagnosis ; Neoplasms / therapy ; Hematologic Neoplasms
    Pages: ix, 672 p. : ill.
    ISBN: 9783933012166
    Signatur Availability
    QZ200:472/2010,10 available
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  • 5
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    Bern : Huber
    (Klinische Onkologie, 97)   (Praxis)  
    Call number: QZ200:449/1997
    Keywords: Neoplasms / therapy ; Medical Oncology ; Leukemia / in infancy & childhood
    Notes: Sonderband der "Praxis", Schweizerische Rundschau für Medizin anläßlich der Fortbildung "Klinische Onkologie 1997" 24. bis 28. Juni 1997.
    Pages: 395 p. : ill.
    Signatur Availability
    QZ200:449/1997 available
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  • 6
    Keywords: Medicine ; Pharmaceutical technology ; Biomedicine ; Pharmaceutical Sciences/Technology ; Springer eBooks
    Description / Table of Contents: 1 Introduction to Pharmacometrics and Quantitative Pharmacology with an Emphasis on Physiologically Based Pharmacokinetics -- 2 Personalized Medicine – Integrating Individual Exposure and Response Information at the Bedside -- 3 Pharmacometrics in Pediatrics -- 4 Pharmacometrics in Chronic Kidney Disease -- 5 Drug-Disease Model-Based Development of Therapeutic Agents for Treatment of Diabetes -- 6 Applied Pharmacometrics in the Obese Population -- 7 Pharmacometrics in Cardiovascular Safety -- 8 Pharmacometrics in Bacterial Infections -- 9 Pharmacometrics in Viral Infections -- 10 Applied Antifungal Pharmacometrics: Fluconazole and Echinocandins in the Treatment of Candidemia and Invasive Candidiasis -- 11 Pharmacometrics and Tuberculosis -- 12 Pharmacometrics in Pulmonary Diseases -- 13 State-of-the-Art Pharmacometric Models in Osteoporosis -- 14 Pharmacometrics in Psychiatric Diseases -- 15 Clinical Trial Simulation in Alzheimer's Disease -- 16 Pharmacometric Applications in Inflammation -- 17 Pharmacometrics in Dermatology -- 18 Pharmacometrics in Pain Management -- 19 Pharmacometrics of Hyperlipidemia
    Abstract: This comprehensive volume provides an update on the current state of pharmacometrics in drug development. It consists of nineteen chapters all written by leading scientists from the pharmaceutical industry, regulatory agencies and academia. After an introduction of the basic pharmacokinetic and pharmacodynamic concepts of pharmacometrics in drug development, the book presents numerous examples of specific applications that utilize pharmacometrics with modeling and simulations over a variety of therapeutic areas, including pediatrics, diabetes, obesity, infections, psychiatrics, Alzheimeŕ€™s disease, and dermatology, among others. The examples illustrate how results from all phases of drug development can be integrated in a more timely and cost-effective process. Applying pharmacometric decision tools during drug development can allow objective, data-based decision making. At the same time, the process can identify redundant or unnecessary experiments as well as some costly clinical trials that can be avoided. In addition to cost saving by expedited development of successful drug candidates, pharmacometrics has an important economic impact in drug product selection.℗ Unsuccessful drug candidates can be identified early and discontinued without expending efforts required for additional studies and allocating limited resources. Hence, pharmacometric modeling and simulation has become a powerful tool to bring new and better medications to the patient at a faster pace and with greater probability of success
    Pages: XIII, 565 p. 161 illus., 94 illus. in color. : online resource.
    ISBN: 9781493913046
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  • 7
    Unknown
    München : LUKON-Verl.-Ges.
    Call number: QZ200:472/2009,8
    Keywords: Oncology ; Neoplasms / diagnosis ; Neoplasms / therapy ; Hematologic Neoplasms
    Pages: ix, 466 p. : ill.
    ISBN: 3-933012-13-5
    Signatur Availability
    QZ200:472/2009,8 available
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  • 8
    Unknown
    Weinheim : Wiley-VCH
    Call number: QZ50:6
    Keywords: Human Genome Project ; Genome, Human ; Genomics / methods ; Cytosine / physiology
    Notes: Includes bibliographical references and index
    Pages: x , 178 p. : ill. (some col.) pbk
    ISBN: 3527304940
    Signatur Availability
    QZ50:6 available
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  • 9
    Call number: YY Diss Urba/Mag
    Keywords: DKFZ-publications / academic dissertations
    Pages: 245 p.
    Signatur Availability
    YY Diss Urba/Mag departmental collection or stack – please contact the library
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  • 10
    Unknown
    München : LUKON-Verl.-Ges.
    Call number: QZ200:472/2007,4
    Keywords: Oncology ; Neoplasms / diagnosis ; Neoplasms / therapy ; Hematologic Neoplasms
    ISBN: 3-933012-09-8
    Signatur Availability
    QZ200:472/2007,4 available
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