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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Human genetics 〈Berlin〉 15 (1972), S. 289-318 
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Wir berichten über einen Patienten mit Ring-Chromosom 18, dessen klinische Symptomatik durch Dystrophie, Minderwuchs, stato-motorische und geistige Retardierung, Mikrocephalie, Dyskranie, Mittelgesichtsdysplasie mit ⌈carpshaped mouth”, Hypertelorismus, Epikanthus, Ohrmuschelanomalien, Ohrkanalstenose, beeinträchtigtes Hören, spindelförmige Finger, Muskelhypotonie, kongenitalen Herzfehler, vermehrte Wirbelbildung auf den Fingerbeeren und fehlenden IgA-Mangel ausgezeichnet ist. Phänische Merkmale der bisher publizierten Fälle mit 18r, 18p-und 18q-werden zusammengestellt und untereinander verglichen. Ein klar umrissenes 18 Ring-Syndrom läßt sich unseres Erachtens nicht abgrenzen. Alle beschriebenen 18r-Fälle zeigen klinisch Übergänge zu den Symptomkomplexen von 18p-und 18q-Patienten, so daß wir von einem 18p-/18q-—Deletionssyndrom sprechen möchten.
    Notes: Summary We report a patient with ring chromosome 18, whose clinical symptoms are characterized by dystrophy, short stature, psychomotorical retardation, microcephalus dyscrania, mid-face dysplasia with carpshaped mouth, hypertelorism, epicanthus, dysplasia of the external ears, stenosis of the ear canals, hearing loss, spindle-shaped fingers, hypotonia of the muscles, congenital heart defect, increased numbers of whorles on the fingertips; there is no IgA-deficiency. The phenotypical symptoms of previously published cases with 18r, 18-and 18q-are summarized and discussed. In our opinion delineation of a separate 18 ring syndrome is not justified. All the 18r cases described in the literature clinically overlap with the 18p-and 18q-patients; we therefore suggest to call it an 18p-/18q-deletion-syndrome.
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  • 2
    ISSN: 1432-2277
    Keywords: Cyclosporin A, carbohydrate metabolism, rat hepatocytes ; Immunosuppression, carbohydrate metabolism, rat hepatocytes ; Carbohydrate metabolism, immunosuppression, rat hepatocytes ; Hepatocytes, carbohydrate metabolism, immunosuppression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of different immunosuppressive drugs (prednisolone, azathioprine, cyclosporin A) on liver carbohydrate metabolism in the rat was investigated. Daily administration of prednisolone (3 mg/kg body weight) and azathioprine (2 mg/kg body weight) intraperitoneally for 2 weeks caused significantly lower liver glycogen content than that in NaCl-treated controls. Liver glucose and lactate content, as well as plasma glucose, glucagon, and serum insulin concentration of these animals, remained unchanged. There were no differences in any of these parameters between cyclosporin A (15 mg/kg body weight)-treated and vehicle (olive oil/ethanol)-treated animals. Prednisolone caused significantly lower glucose production in isolated rat hepatocytes using Na-pyruvate as the substrate, whereas glucose production was unchanged in hepatocytes of azathioprine-treated rats using pyruvate or l-serine as substrates. Glucose production from pyruvate or serine was significantly inhibited by cyclosporin A compared to the vehicle, but did not differ from the effects of azathioprine and prednisolone. Lactate production was significantly lower in cyclosporin-treated animals than in those given either the vehicle or azathioprine. Cyclosporin A completely reversed the inhibition of hepatocyte glycogen consumption caused by the vehicle. However, glycogen production in the presence of cyclosporin A was comparable to the effects of prednisolone and azathioprine. Finally, hepatocyte ketone body production using pyruvate as the substrate was higher in the presence of all immunosuppressive drugs. In the presence of serine, acetoacetate production increased in rats treated with 50 mg/kg body weight cyclosporin A, and β-hydroxybutyrate production in animals receiving 15 and 50 mg/kg body weight cyclosporin A.
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  • 3
    ISSN: 1432-0827
    Keywords: Osteoblasts ; Epidermal growth factor ; Tyrosine kinase ; G proteins ; Mitogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract Epidermal growth factor (EGF) has been found to stimulate proliferation in a variety of cell types. The EGF receptor is known to have tyrosine kinase activity [1], however, the role of this signal mechanism has not been established in bone cells. The aim of this study was to determine whether tyrosine kinase activity and G inhibitory (Gi) proteins are involved in EGF-stimulated proliferation in the osteoblastic cell line G292 and in primary culture osteoblasts isolated from neonatal rat calvaria. Cell proliferation was measured by 3H-thymidine incorporation using liquid scintillation spectrometry. EGF stimulates a dose-dependent increase in proliferation of G292 and primary culture cells above control. Genistein was able to inhibit the effects of EGF in the G292 cells. In the primary culture cells, genistein with EGF appeared to enhance proliferation compared with EGF alone or genistein alone. Tyrphostin 25, on the other hand, inhibited the EGF response in both of these cell types. Inactivation of Gi proteins with pertussis toxin was able to inhibit EGF-induced mitogenesis in the neonatal rat osteoblasts but did not appear to specifically inhibit this response in the G292 cells. These results suggest that although both of these osteoblastic cell types increase proliferation in response to EGF, their signal pathways are different.
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  • 4
    ISSN: 1432-0827
    Keywords: Osteoblast ; Plasma membrane ; Calcium ; Ion channel ; Cell proliferation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract Patch clamp physiological techniques were used to characterize the voltage-activated calcium currents (VACC) expressed in the plasma membrane of osteoblastic cells as a function of time in culture and proliferative state of the cell. Osteoblast-enriched preparations were isolated by collagenase digestions of newborn rat calvaria and cultured under different conditions which affected cell proliferation (i.e., low serum in the media to arrest proliferation). VACC were isolated by replacing the intracellular potassium with cesium, and adding 1 μM tetrodotoxin to the bath. Under conditions that favored cell proliferation, low cell density, and media supplemented with 10% fetal calf serum (FCS), a transient calcium current was not expressed until day 3 in culture. There was a statistically significant relationship between the precentage of cells expressing this current and the time in culture. The magnitude of the current significantly increased as days in culture increased. Under the same conditions, the sustained VACC was detected after 7 or 8 days in culture. However, arresting cell proliferation after 2 days in culture by reducing the FCS concentration to 0.01% induced the expression of the sustained VACC the next day. The data suggest that the expression of VACC in the plasma membrane of rat calvarial osteoblasts depends on the time in culture and the state of proliferation of the cells. These results should prove to be valuable in studying the functional significance of VACC in osteoblastic cells and their regulation by various bone regulatory agents.
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  • 5
    ISSN: 1432-086X
    Keywords: Key words: Interventional MRI—MR angiography—Percutaneous transluminal angioplasty—MRI, bioeffects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: Magnetic resonance (MR)-guided percutaneous vascular interventions have evolved to a practical possibility with the advent of open-configuration MR systems and real-time tracking techniques. The purpose of this study was to assess an MR-tracking percutaneous transluminal angioplasty (PTA) catheter with regard to its safety profile and functionality. Methods: Real-time, biplanar tracking of the PTA catheter was made possible by incorporating a small radiofrequency (RF) coil in the catheter tip and connecting it to a coaxial cable embedded in the catheter wall. To evaluate potentially hazardous thermal effects due to the incorporation of the coil, temperature measurements were performed within and around the coil under various scanning and tracking conditions at 1.5 Tesla (T). Catheter force transmission and balloon-burst pressure of the MR-tracking PTA catheter were compared with those of a standard PTA catheter. The dilatative capability of the angioplasty balloon was assessed in vitro as well as in vivo, in an isolated femoral artery segment in a swine. Results: The degree of heating at the RF coil was directly proportional to the power of the RF pulses. Heating was negligible with MR tracking, conventional spin-echo and low-flip gradient-echo sequences. Sequences with higher duty cycles, such as fast spin echo, produced harmful heating effects. Force transmission of the MR-tracking PTA catheter was slightly inferior to that of the standard PTA catheter, while balloon-burst pressures were similar to those of conventional catheters. The MR-tracking PTA catheter functioned well both in vitro and in vivo. Conclusion: The in vivo use of an MR-tracking PTA catheter is safe under most scanning conditions.
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  • 6
    ISSN: 1432-0673
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
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  • 7
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Neutrophils (PMN) are considered to be key components in the protection of the periodontium against pathogenic bacteria. We therefore compared five of the major characteristics of peripheral blood PMN (PB-PMN) (adherence, chemotaxis, phagocytosis, oxidaiive metabolism, and lysosomal granules) to those of normal crevicular neutrophils (CR-PMN) isolated from the same individuals. The data indicate that the presence of Fc and C3b receptors, and the production of superoxide are similar in CR-PMN and PB-PMN. In addition, healthy gingival sulci harbor a high percentage of stimulated PMN as determined by the nitroblue tetrazolium (NBT) reduction assay. The percentage of CR-PMN which phagocytized opsonized red blood cells (RBC) was lower than that of PB-PMN. The in vitro migration of CR-PMN was reduced as compared to that of PB-PMN. Crevicular neutrophils also have a diminished ability to adhere to glass surfaces which may be related to a direct non-cytotoxic effect of gingival fluid component(s) on CR-PMN. In addition, morphologic evidence indicates that specific granules are more depleted than azurophil granules in CR-PMN. Interpretation of studies of neutrophil functions in periodontal diseases must consider the observed differences between normal peripheral blood and crevicular neutrophils.
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  • 8
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
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  • 10
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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