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  • 1
    ISSN: 1432-2013
    Keywords: Arterial blood pressure ; Baroreceptors ; Haemorrhage ; Shivering ; Thermoregulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract 1. Shivering in the barbitone-anaesthetised cat exposed to a lowered ambient temperature was reduced by transient haemorrhagic or drug induced hypotension such that there was a positive correlation between mean arterial blood pressure and the intensity of shivering. 2. Shivering which had been reduced by haemorrhage could be restored by the reinfusion of blood, centripetal stimulation of a buffer nerve or by the intravenous administration of methoxamine. 3. The intensity of shivering was increased by the intravenous injection of methoxamine and by stimulation of a buffer nerve, although the latter response was attenuated by intact buffer nerves. 4. There was a marked variation in the importance of the different buffer nerves in maintaining shivering. 5. Shivering was abolished by deafferentation of the baroreceptors and although it could be restored by electrical stimulation of a buffer nerve methoxamine was then without effect. 6. A prolonged period (90–120 min) of hypotension (50–60 mm Hg) impaired the ability to shiver even after the hypovolaemia and hypotension had been corrected.
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  • 2
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 168 (1951), S. 297-298 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The kidney was chosen for study because it shows the most striking changes in fluoroacetate poisoning1. However, this effect of adenosinetriphosphate was not confined to that organ, for an elevated citrate-level was also found in the diaphragm. These results suggest some interference with ...
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 172 (1953), S. 1044-1045 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Two groups of ten male rats (Porton strain), fed on M.R.C. Diet 41, were used, one group being given 20 mgm. DDD/100 gm. body-weight as a 4 per cent solution in arachis oil subcutaneously three times a week, the other group receiving an equivalent amount of arachis oil. DDD was obtained by ...
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The effect of ischaemic limb injury on the turnover of noradrenaline in the hypothalamus and brain stem has been studied in rats. There are theoretical reasons for thinking that these regions are activated in trauma and previous work showed that during limb-ischaemia the concentration of noradrenaline in the hypothalamus decreased by 27 per cent. The tourniquets were applied to both hind-limbs 1 h after the injection of [14C]-tyrosine when the labelling of the noradrenaline was maximal.During 4 h limb ischaemia the endogenous tyrosine concentration in the plasma decreased while that in the hypothalamus first rose and then fell. Changes in a similar direction in the brain stem were not statistically significant. Limb ischaemia did not affect the decline in the specific activity of the plasma or tissue tyrosine. It was concluded that the injury increased the utilization of tyrosine by the body.During the 4 h bilateral hind-limb ischaemia the rate of decline of [14C]noradrenaline was significantly increased in the brain stem but not in the hypothalamus. Conditions in the brain stem were sufficiently close to ‘steady-state’ to be able to conclude that the injury increased the metabolism of noradrenaline in the brain stem. Conditions in the hypothalamus were too complicated for definite conclusions to be drawn. The possible reasons for this and the limitations of this method for studying noradrenaline turnover are discussed.
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 18 (1971), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— The monoamine concentrations have been measured in four regions of the brain (hypothalamus, cortex, cerebellum and brain stem) in rats injured by either hind-limb ischaemia or scald. Both injuries produced a rapid fall in the noradrenaline concentration of the hypothalamus which recovered slowly if the injury was not fatal. This effect of injury was seen after pretreatment with a-methyl-p-tyrosine to inhibit noradrenaline synthesis, indicating an increased rate of utilization of noradrenaline after injury. These injuries did not affect the 5-hydroxytryptamine concentration in the hypothalamus, but changes were found in the concentration of this monoamine and in that of its metabolite, 5-hydroxyindole acetic acid, in the brain stem. It is concluded that these forms of injury had specific effects on the brain monoamines. The hypothalamic changes were not secondary to changes in core temperature or to hypotension or hypovolaemia and they are discussed in relation to the impairment of temperature regulation seen in the injured rat.
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