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  • 1
    Keywords: Chemistry ; Carbohydrates ; Cell Membranes ; Chemistry ; Carbohydrate Chemistry ; Membrane Biology ; Springer eBooks
    Description / Table of Contents: Human-Specific Evolutionary Changes in the Biology of Siglecs -- Structural Changes of GPI Anchor After Its Attachment to Proteins : Functional Significance -- Novel Insights In Membrane Biology Utilizing Fluorescence Recovery After Photobleaching -- Defects in Erythrocyte Membrane Skeletal Architecture -- Membrane Rafts in the Erythrocyte Membrane: A Novel Role of MPP1p55 -- Immuno-Modulatory Role of Porins: Host Immune Responses, Signalling Mechanisms and Vaccine Potential -- Vibrio cholerae Cytolysin: Structure-Function Mechanism of an Atypical β-barrel Pore-Forming Toxin -- New vis-tas in Lactosylceramide Research -- Plasma Membrane-Associated Sialidase Confers Cancer Initiation, Promotion and Progression -- A Signal with a Difference: The Role of GPI Anchor Signal Sequence in Dictating Conformation and Function of the Als5 Adhesin in Candida albicans -- Novel Chondroitin Sulfate Oligosaccharide Motifs as Biomarkers: Insights Into Their Involvement in Brain Development -- Role of Hyaluronidases in the Catabolism of Chondroitin Sulfate -- Pattern Recognition in Legume Lectins to Extrapolate Amino Acid Variability to Sugar Specificity -- Conformational Dynamics of Oligosaccharides Characterized by Paramagnetism-Assisted NMR Spectroscopy in Conjunction with Molecular Dynamics Simulation -- Characterization of Cholesterol Crystalline Domains in Model and Biological Membranes Using X-Ray Diffraction -- Role of Lipid-Mediated Effects in β2-Adrenergic Receptor Dimerization -- Effect of Temperature on the Phase Behaviour of Fully Saturated DAPC Lipid Bilayer: A Comparative Molecular Dynamics Simulation Study -- Biophysical Characterization of the Interaction of O-acylcholines with the Major Bovine Seminal Plasma Protein, PDC-109 -- Crystal Structure of Apo and Ligand Bound Vibrio cholerae Ribokinase (Vc-RK): Role of Monovalent Cation Induced Activation and Structural Flexibility in Sugar Phosphorylation -- Synthetic Glycolipids and (p)ppGpp Analogs: Development of Inhibitors for Mycobacterial Growth, Biofilm and Stringent Response -- Regulations of Glycolipid : Glycosyltransferase (GSL: GLTs) Genes Involved in SA-LeX and Related GSLs Biosysthesis in Carcinoma Cells by Biosimilar Apoptotic Agents : Potential Anticancer Drugs -- N-acetylglucosaminyl 1-phosphate Transferase: An Excellent Target for Developing New Generation Breast Cancer Therapeutic -- Involvement of Vascular Endothelial Growth Factor in Serotonin 1A Receptor-Mediated Neuroproliferation in Neonatal Mouse Hippcampus -- Structural Heterogeneity of Glycoform of Alpha-1 Acid Glycoprotein in Alcoholic Cirrhosis Patients
    Abstract: Consists of critical reviews and original research papers from the 2014 International Symposium on the "Biochemical Role of Eukaryotic Cell Surface Macromolecules". Topics covered include: ℗ʺ℗ neurochemical and biochemical analysis of cell surface glycoconjugates ℗ʺ℗ membrane skeletal organization ℗ʺ℗ GPCRs and other receptors ℗ʺ℗ biophysical approaches to study membrane interactions ℗ʺ℗ glycoconjugate metabolism ℗ʺ℗ dysregulation ℗ʺ℗ molecular mechanisms involved in cell-cell and cell-matrix interaction ℗ʺ℗ glycans in infectious and neurological diseases ℗ʺ cancer and glycosyltransferases as drug targets
    Pages: IX, 411 p. 127 illus., 72 illus. in color. : online resource.
    ISBN: 9783319112800
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  • 2
    Keywords: Life sciences ; Chemistry, Organic ; Carbohydrates ; Biochemistry ; Proteomics ; Cytology ; Cell Membranes ; Life sciences ; Biochemistry, general ; Organic Chemistry ; Carbohydrate Chemistry ; Cell Biology ; Membrane Biology ; Proteomics ; Springer eBooks
    Pages: : digital.
    ISBN: 9781461433811
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  • 3
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  The winged bean (Psophocarpus tetragonolobus) agglutinin (total lectin) and its basic (WBA I) and acidic isoform (WBA II) were used to analyze capillaries in sections from human muscle. The microvessels were clearly labeled after incubation with the lectins in both normal muscle and in old muscles with age-related type II atrophy or muscle fiber grouping. Muscle fibers, nerves, and connective tissue remained unstained. The total lectin detected muscle capillaries from all blood group AB0 individuals. The isoform WBA I reacted only with blood vessels in blood group A and B individuals, while the blood vessels in blood group 0 individuals were demonstrated with WBA II. WBA I staining was inhibited by p-nitrophenyl α-galactopyranoside and N-acetylgalactosamine, whereas 2′-fucosyllactose and preincubation with an antibody against type-1 chain H abolished capillary staining with WBA II. The study demonstrates the usefulness of WBA as a marker of capillaries in human muscle.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1573-4986
    Keywords: neoglycopeptides ; biodistribution ; membrane lectins ; in vivo uptake
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Complex typeN-linked oligosaccharides derived from fetuin, fibrinogen and thyroglobulin were coupled to acetyltyrosine affording a series of neoglycopeptides with retention of terminal structures and the β-anomeric configuration of their reducing endN-acetylglycosamine residue. The neoglycopeptides thus synthesized could be labelled to high specific activities with125I in the aromatic side chain of tyrosine. Analysis of the fate of these neoglycopeptides in conjunction with inhibition with asialofetuin and oligosaccharides of defined structure in micein vivo revealed the uptake of galactosylated biantennary compound by kidneys, in addition to the known itinerary of triantennary galactosylated complex oligosaccharide from fetuin to liver and the galactosylated biantennary chain with fucosylation in the core to bone marrows. On the other hand, the agalacto, aglucosamino biantennary chains with and without fucosylation in the core region are taken up by submaxillary glands while the conserved trimannosyl core with fucose is primarily concentrated in stomach tissue. These studies thus define new routes for the uptake of complexN-linked glycans and also subserve to identify lectins presumably involved in their recognition.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The antimicrobial biocide triclosan [5-chloro-2-(2,4-dichlorophenoxy)phenol] potently inhibits the growth of Plasmodium falciparum in vitro and, in a mouse model, Plasmodium berghei in vivo. Inhibition of [14C]acetate and [14C]malonyl-CoA incorporation into fatty acids in vivo and in vitro, ...
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  • 6
    ISSN: 1573-4935
    Keywords: saccharide binding ; soybean agglutinin ; tryptophan
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Modification of tryptophan side chains of soybean agglutinin (SBA) with N-bromosuccinimide results in a loss of the hemagglutinating and carbohydrate binding activities of the protein. One residue/subunit is probably essential for the binding activity. Modification leads to a large decrease in the fluorescene of the protein accompained by a blue shift. Iodide ion quenching of the protein fluorescence shows that saccharide binding results in a decreased accessibility of some of the tryptophan side chains. These results strongly point towards the involvement of tryptophan residues in the active site of SBA.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1573-4935
    Keywords: Peanut agglutinin ; baculovirus ; insect cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Peanut (Arachis hypogaea) seed lectin, PNA is widely used to identify tumor specific antigen (T-antigen), Galβ1-3GalNAc on the eukaryotic cell surface. The functional amino acid coding region of a cDNA clone, pBSH-PN was PCR amplified and cloned downstream of the polyhedrin promoter in the Autographa californica nucleopolyhedrovirus (AcNPV) based transfer vector pVL1393. Co-transfection of Spodoptera frugiperda cells (Sf9) with the transfer vector, pAcPNA and AcRP6 (a recombinant AcNPV having B-gal downstream of the polyhedrin promoter) DNAs produced a recombinant virus, AcPNA which expresses PNA. Infection of suspension culture of Sf9 cells with plaque purified AcPNA produced as much as 9.8 mg PNA per liter (2.0 × 106 cells/ml) of serum-free medium. Intracellularly expressed protein (re-PNA) was purified to apparent homogeneity by affinity chromatography using ECD-Sepharose. Polyclonal antibodies against natural PNA (n-PNA) cross-reacted with re-PNA. The subunit molecular weight (30kDa), hemagglutination activity, and carbohydrate specificity of re-PNA were found to be identical to that of n-PNA, thus confirming the abundant production of a functionally active protein in the baculovirus expression system.
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  • 8
    ISSN: 1573-4935
    Keywords: Urtica dioica agglutinin ; chitooligosaccharide-binding lectin ; Isothermal titration calorimetry ; thermodynamic parameters
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract UDA (Urtica dioica agglutinin) contains two hevein like domains with two non-identical interacting sites and is specific for chitooligosaccharides. The binding of chitooligosaccharides to UDA was studied by Isothermal Titration Calorimetry. Each site is composed of three subsites, each binding to a sugar residue. Thermodynamic parameters obtained show that while chitobiose has two independent non-interacting sites, chitotriose, chitotetrose and chitopentose have two interacting sites on each monomer of UDA. Values of binding enthalpy (ΔH) increase almost by a factor of 7 in going from chitobiose to chitotriose indicating the existence of three subsites in the combining site of UDA. The binding constant for chitotetrose and chitopentose increase without any further enhancement in the values of ΔH indicating that for oligomers larger than chitotriose interaction is favoured entropically.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 322 (1986), S. 119-120 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR-Of the three therapeutic approaches to acquired immune deficiency syndrome (AIDS) suggested by Klatzmann and Montagnier1, Singer and Shearer2 have highlighted the possibility of attenuation of the CD4+ cells, which are the host for the virus associated with AIDS (HTLV-III/LAV), by infusing ...
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  • 10
    ISSN: 1072-8368
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Jacalin, a tetrameric two-chain lectin (66,000 Mr) from jackfruit seeds, is highly specific for the tumour associated T-antigenic disaccharide. The crystal structure of jacalin with methyl-α-D-galactose reveals that each subunit has a three-fold symmetric β-prism fold made up of three ...
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