Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Keywords: Oncology ; Medicine ; Cancer Research ; Molecular Medicine ; Springer eBooks
    Description / Table of Contents: Introduction to the Acquisition of Resistance to Targeted Therapy -- Targeting the Tumor Microenvironment to Overcome Resistance to Targeted Therapy -- Current Challenges and Applications of Oncolytic Viruses in Overcoming Resistance to Therapies in Cancer -- Novel Methods to Overcome Acquired Resistance to Immunotherapy -- Therapies to Overcome Multidrug-Resistant Receptors -- Overcoming Resistance to PARP Inhibition -- Novel Methods of Overcoming HER2 Therapy Resistance in Breast Cancer -- Emerging Novel Therapies for Overcoming Resistance to Targeted Therapies -- Targeting Epigenetic Regulators in Cancer to Overcome Resistance to Targeted Therapy -- Nanomedicine and Drug Delivery Systems in Overcoming Resistance to Targeted Therapy -- Index
    Abstract: Targeted therapies were initially developed to exploit the upregulation and dependence on key oncogenic pathways critical to cancer progression. Additionally, they also presented as a method to overcome chemoresistance by supplementing conventional therapeutic regimens with targeted therapies. However, the development of resistance to these combinatorial approaches has led to the reassessment of currently available therapeutic options to overcome resistance to targeted therapy. This book aims to provide an update on the advancements in the therapeutic arms race between cancer, clinicians and scientists alike to overcome resistance to targeted therapies. Subject experts provide a comprehensive overview of the challenges and solutions to resistance to several conventional targeted therapies in addition to providing a discussion on broad topics including targeting components of the tumor microenvironment, emerging therapeutic options, and novel areas to be explored concerning nanotechnology and the epigenome
    Pages: XVIII, 320 p. 31 illus., 29 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9783030214777
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 286 (1980), S. 164-166 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We first immunized various aged C57BL/6J male mice intraperitoneally (i.p.) with a highly thymiodependent antigen, trinitrophenylated bovine ?-globulin (TNP-BGG) in complete Freund's adjuvant (CFA). Splenic anti-TNP plaque-forming cell (PFC) responses were assayed 2 weeks after immunization. As ...
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 6
    ISSN: 0197-8462
    Keywords: electromagnetic field ; protein synthesis ; Escherichia coli ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: Escherichia coli JM83 {F- ara Δ(lac-proAB) rpsL [φ80dΔ(lacZ)M15]} in midlog growth phase at 30 °C were exposed to 60 Hz sinusoidal magnetic field of 3 mT of nonuniform diverging flux, inducing a nonuniform electric field with a maximum intensity of 32 μV/cm using an inductor coil. Exposed and unexposed control cells were maintained at 30.8 ± 0.1 °C and 30.5 ± 0.1 °C, respectively. Quadruplicate samples of exposed and unexposed E. coli cells were simultaneously radiolabeled with 35S-L-methionine at 10 min intervals over 2 hr. Radiochemical incorporation into proteins was analyzed via liquid scintillation counting and by denaturing 12.5% polyacrylamide gel electrophoresis. The results showed that E. coli exposed to a 60 Hz magnetic field of 3 mT exhibited no qualitative or quantitative changes in protein synthesis compared to unexposed cells. Thus small prokaryotic cells (less than 2 μm × 0.5 μm) under constant-temperature conditions do not alter their protein synthesis following exposure to 60 Hz magnetic fields at levels at 3 mT. © 1994 Wiley-Liss, Inc.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Age 12 (1989), S. 25-35 
    ISSN: 1574-4647
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Immunological reactions that occur in the respiratory tract in response to infectious agents have recently gained distinct attention. Humoral (1–20) and cellular immune reactions (16, 21–34) have been identified in the lungs of a number of animal species and of man. Respiratory tract infections occur frequently among the elderly and constitute one of the leading causes of death. Aged humans have a greater mortality from pneumonia (35), influenza (36), tuberculosis (37), infective endocarditis (38), urinary tract (39) and intraabdominal (40) infections. Perla and Marmorston reviewed the effects of aging on natural resistance to infection (41–42), and focused on four factors as major determinants of resistance in old age: (a) changes in structure and function of vital organs, especially endocrine glands and the splenic lymphatic apparatus; (b) underlying pathological conditions facilitating microbial invasion; (c) alterations in circulatory and nervous systems which lead to trophic changes and tissue anoxia; and (d) prolonged subclinical vitamin and mineral deficiencies. Some investigators have postulated that the predisposition of the aged to infections is not due to a declining immune response (42–43), rather than to other physiologic changes of aging. Many studies of animals and man have linked the increase of infectious disease in the aged to reduced immunological vigor (44–47), in particular, deficiency of T-cell dependent immune responses (reviewed in 48–51). These studies which focused on the circulating immune system (peripheral blood, spleen, and peripheral lymph nodes) while clearly important, have not included information on age-related changes in the mucosal immune system. Studies on mucosal immunity are obviously relevant for elucidating the mechanisms of infectious diseases in the elderly. The importance of such information is emphasized by accumulating evidence that microorganisms entering the host encounter a functionally compartmentalized and distinct lymphoid area underlying the mucosal surfaces of the lung, genital tract, and intestine. These distinct lymphoid areas are characterized by unique immune cell populations, cell trafficking and homing patterns, and immune responsiveness (reviewed in 48, 52–54). This critique will review and present work on local immune functions of the nasopharyngeal tract, with particular emphasis to the age-associated decline in resistance to infections. The meager data available in the literature wlll be organized in this review under humoral and cellular aspects of both animal and human studies.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...