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  • 1
    Publication Date: 2016-04-29
    Description: Synthetic methods produce libraries of colloidal nanocrystals with tunable physical properties by tailoring the nanocrystal size, shape, and composition. Here, we exploit colloidal nanocrystal diversity and design the materials, interfaces, and processes to construct all-nanocrystal electronic devices using solution-based processes. Metallic silver and semiconducting cadmium selenide nanocrystals are deposited to form high-conductivity and high-mobility thin-film electrodes and channel layers of field-effect transistors. Insulating aluminum oxide nanocrystals are assembled layer by layer with polyelectrolytes to form high-dielectric constant gate insulator layers for low-voltage device operation. Metallic indium nanocrystals are codispersed with silver nanocrystals to integrate an indium supply in the deposited electrodes that serves to passivate and dope the cadmium selenide nanocrystal channel layer. We fabricate all-nanocrystal field-effect transistors on flexible plastics with electron mobilities of 21.7 square centimeters per volt-second.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Choi, Ji-Hyuk -- Wang, Han -- Oh, Soong Ju -- Paik, Taejong -- Sung, Pil -- Sung, Jinwoo -- Ye, Xingchen -- Zhao, Tianshuo -- Diroll, Benjamin T -- Murray, Christopher B -- Kagan, Cherie R -- New York, N.Y. -- Science. 2016 Apr 8;352(6282):205-8. doi: 10.1126/science.aad0371.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA. Complex Assemblies of Soft Matter, CNRS-SOLVAY-PENN UMI 3254, Bristol, PA 19007-3624, USA. Rare Metals Research Center, Korea Institute of Geoscience and Mineral Resources, 124 Gwahang-no, Yuseong-Gu, Daejeon, 305-350, Korea. ; Department of Electrical and Systems Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA. ; Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA. Department of Materials Science and Engineering, Korea University, Seoul 136-713, Korea. ; Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA. ; Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA. Complex Assemblies of Soft Matter, CNRS-SOLVAY-PENN UMI 3254, Bristol, PA 19007-3624, USA. ; Department of Materials Science and Engineering, Yonsei University, Seoul 120-747, Korea. ; Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA. ; Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA. Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA. ; Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA. Department of Electrical and Systems Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA. Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA. kagan@seas.upenn.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27124455" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 2018-01-26
    Description: Endothelial deletion of Ino80 disrupts coronary angiogenesis and causes congenital heart disease Endothelial deletion of 〈i〉Ino80〈/i〉 disrupts coronary angiogenesis and causes congenital heart disease, Published online: 25 January 2018; doi:10.1038/s41467-017-02796-3 Heart development requires compaction of the ventricular wall into a dense myocardium at mid-gestation. Here, Rhee and colleagues show that the chromatin remodeller Ino80 is critical for the formation of the coronary vasculature, and show that coronary vessels are needed for successful cardiac compaction during embryonic development.
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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  • 3
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Interleukin-18 (IL-18) has multiple important pro-inflammatory effects, including the induction of interferon-γ (IFN-γ) in various diseases. In this study, we investigated the IL-18-producing activities in human pulmonary and pleural tuberculosis (TB) in response to purified protein derivative (PPD) antigen (Ag) from Mycobacterium tuberculosis. The most significant IL-18 production was found in chronic refractory TB (CRTB) patients. However, IFN-γ production in CRTB patients was significantly less than that in healthy tuberculin reactors or in patients with tuberculous pleurisy (TBP). Elevated levels of both IL-18 and IFN-γ were found in pleural fluids from TBP patients. In vitro production of IL-18 was dramatically decreased following an 18 h stimulation with PPD. However, IFN-γ was markedly increased in pleural mononuclear cells from TBP patients after in vitro stimulation with PPD. The mesothelial cell type was the main source of pro-IL-18 in pleural cells from TBP patients, suggesting an important role for these cells in TBP. Taken together, these data indicate that IL-18 is elevated in peripheral blood mononuclear cells from CRTB patients, as well as at the site of TBP, indicating a possible role for IL-18 in both protective immunity and pathologic responses in human TB.
    Type of Medium: Electronic Resource
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