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  • 1
    Keywords: Medicine ; Microbiology ; Medical parasitology ; Biomedicine ; Parasitology ; Medical Microbiology ; Health Promotion and Disease Prevention ; Springer eBooks
    Description / Table of Contents: Landmarks in the discovery of 〈i〉Blastocystis〈/i〉 stages -- Morphology of human and animal 〈i〉Blastocystis〈/i〉 isolates with special references to reproductive modes -- Epidemiology, transmission and zoonotic potential of 〈i〉Blastocystis〈/i〉 stages in humans and animals -- 〈i〉Blastocystis〈/i〉 – Host interactions: insights from in-vitro model systems -- Clinical aspects of 〈i〉Blastocystis〈/i〉 infections: advancements admidst controversies -- Molecular approaches on systematic position, genetic polymorphism and classification of 〈i〉Blastocystis〈/i〉 isolates from humans and animals -- What do we know about 〈i〉Blastocystis 〈/i〉analyzing research studies with statistical methods -- Behavioral decision analysis: how do we decide what makes us sick? -- Diarrheas in humans due to agents of diseases -- What are zoonotic diseases? -- Conclusions
    Abstract: 〈p〉The stages of Blastocystis have been known for 101 years. However, many facts are still disputed, e.g. even the question whether it is a true pathogen or a commensal present in sometimes life-threatening diarrheas. 〈/p〉〈p〉The present book evaluates in chapters contributed by renowned researchers the latest findings on:〈/p〉〈p〉•Landmarks in the discovery of Blastocystis〈/p〉〈p〉•Epidemiology, transmission and zoonotic potential〈/p〉〈p〉•Morphology of human and animal Blastocystis isolates〈/p〉〈p〉•Clinical aspects of Blastocystis infections〈/p〉〈p〉•Behavioral decision analysis: what makes us sick?〈/p〉〈p〉•Blastocystis-host interactions〈/p〉〈p〉•Molecular approaches on the systematical position〈/p〉〈p〉•Genetic polymorphism〈/p〉〈p〉•Blastocystis from a statistical point of view〈/p〉〈p〉•Diarrheas due to different agents of disease〈/p〉〈p〉•Zoonotic diseases in comparison〈/p〉〈p〉As such, this book provides a broad range of information for people working in this field, for physicians and veterinarians who are confronted with clinical cases, teachers, students and technical staff members in the fields of microbiology, parasitology and diagnostic methods.〈/p〉
    ISBN: 9783642327384
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  • 2
    Keywords: Life sciences ; Bioinformatics ; Proteomics ; Systems Biology ; Computational Biology ; Life sciences ; Computer Appl. in Life Sciences ; Systems Biology ; Computational Biology/Bioinformatics ; Proteomics ; Springer eBooks
    Description / Table of Contents: 1. Introduction -- 2. Systematic Strategies -- 3. Outcomes Assessment -- 4. Conceptual Models
    Abstract: This book is a practical review which focuses on computational analysis and on in silicoapproaches towards the systematic discovery of various key functional gene expression elements in microalgae as a model. So far, in this regard very little information is available. Efficient stepwise procedures for analysing the matrix attachment regions (MARs) are outlined, as well as for translation initiation sites (TIS), signal peptide (SP) sequences, gene optimization and transformation systems. These outlines can be efficiently deployed as practical models for the systematic discovery of key expression elements and for the optimization of cis/transgenes in other micro/organisms. The first chapter is an introduction on the key gene expression elements analysed in this book, including scaffold/matrix attachment regions, translation initiation sites, signal peptides as well as gene optimization. Chapter 2 focuses on systematic strategies and computational approaches toward in silico analysis of each factor. The analyses outcomes is assessed individually in chapter 3 followed by developing the specific conceptual models for each element in Chapter 4. The concluding remarks are discussed in Chapter 5. This work is of interest to computational and experimental biologists interested in transcriptional regulation analysis as well as to researchers and scientists who wish to consider the use of bioinformatics and computational biology in design, analysis, or regulatory reviews of key gene expression elements for the production of recombinant proteins experiments
    Pages: XVII, 120 p. 24 illus. : online resource.
    ISBN: 9783319903910
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  • 3
    Keywords: Life sciences ; Bioinformatics ; Life sciences ; Bioinformatics ; Springer eBooks
    Description / Table of Contents: MicroRNAs, Long Non-Coding RNAs, and Their Functions in Human Disease -- MicroRNA Expression: Protein Participants in MicroRNA Regulation -- Viral MicroRNAs, Host MicroRNAs Regulating Viruses, and Bacterial MicroRNA-Like RNAs -- MicroRNAs: Biomarkers, Diagnostics, and Therapeutics -- Relational Databases and Biomedical Big Data -- Semantic Technologies and Bio-Ontologies -- Genome-Wide Analysis of MicroRNA-Regulated Transcripts -- Computational Prediction of MicroRNA Target Genes, Target Prediction Databases, and Web Resources -- Exploring MicroRNA::Target Regulatory Interactions by Computing Technologies -- The Limitations of Existing Approaches in Improving MicroRNA Target Prediction Accuracy -- Genomic Regulation of MicroRNA Expression in Disease Development -- Next Generation Sequencing for MicroRNA Expression Profile -- Handling High-Dimension (High-Feature) MicroRNA Data -- Effective Removal of Noisy Data Via Batch Effect Processing -- Logical Reasoning (Inferencing) on MicroRNA Data -- Machine Learning Techniques in Exploring MicroRNA Gene Discovery, Targets, and Functions -- Involvement of MicroRNAs in Diabetes and Its Complications -- MicroRNA Regulatory Networks as Biomarkers in Obesity: The Emerging Role -- Expression of MicroRNAs in Thyroid Carcinoma
    Abstract: This thorough volume provides an in-depth introduction to and discussion of microRNAs (miRs) and their targets, miR functions, and computational techniques applied in miR research, thus serving the need for a comprehensive book focusing on miR target genes, miR regulation mechanisms, miR functions performed in various human diseases, and miR databases/knowledgebases. Without prior knowledge of the area of study, computational biologists, computer scientists, bioinformaticians, bench biologists, as well as clinical investigators will find it easy to follow the techniques in this collection. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detailed implementation advice that ensures successful results. Accessible and practical, Bioinformatics in MicroRNA Research functions as an ideal guide for researchers of all backgrounds to explore this vital area of study
    Pages: X, 285 p. 24 illus., 18 illus. in color. : online resource.
    ISBN: 9781493970469
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  • 4
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    Cambridge : Cambridge University Press
    Call number: QZ365WP145:132
    Keywords: Genital Neoplasms, Female
    Notes: Includes index.
    Pages: xiv, 234 p. : ill. (some col.)
    ISBN: 9780521730242
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    QZ365WP145:132 available
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  • 5
    Keywords: Medicine ; Biomedical Engineering ; Biotechnology ; Systems Biology ; Biomaterials ; Biomedicine ; Biomedical Engineering/Biotechnology ; Biomedical Engineering ; Systems Biology ; Biomaterials ; Biotechnology ; Springer eBooks
    Description / Table of Contents: Introduction -- The Minimal Cell -- Synthetic Proteins -- Biomimicry - Bottom-Up Approach -- The Tools -- Dealing with the Dangers
    Abstract: This textbook discusses the new relationship between artificial, synthetic material and living matter, and presents defined examples of approaches aiming for the creation of artificial cells. It also offers insights into the world of synthetic biology from its origins to the present day, showing what is currently possible in this discipline. Furthermore, it examines the ethical concerns and potential threats posed by this new field. The textbook is based on a lecture of the same title, held for master’s students at the University of Natural Resources and Life Sciences (BOKU), Vienna, and is primarily intended for students of synthetic biology, biotechnology and bioengineering. It is also of interest to research scientists from other disciplines wishing to learn more about the state of the art of synthetic biology and its future
    Pages: VI, 65 p. 51 illus. in color. : online resource.
    ISBN: 9783319731230
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  • 6
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    Dordrecht : Springer Science+Business Media
    Keywords: Medicine ; Oncology ; Cell receptors ; Cytokines ; Cytology ; Biomedicine ; Cancer Research ; Molecular Medicine ; Cytokines and Growth Factors ; Receptors ; Cell Biology ; Springer eBooks
    Pages: : digital
    ISBN: 9789048195220
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  • 7
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    New York, NY : Springer New York
    Keywords: Life sciences ; Biochemistry ; Life sciences ; Biochemistry, general ; Springer eBooks
    Description / Table of Contents: Optogenetic Control of Ras/Erk Signaling Using the Phy–PIF System -- Dissecting Kinase Effector Signaling Using the RapRTAP Methodology -- Single-Cell Imaging of ERK Signaling Using Fluorescent Biosensors -- Quantification of Cell Signaling Networks Using Kinase Activity Chemosensors -- Expression of Recombinant Phosphoproteins for Signal Transduction Studies -- Allosteric Modulation of Src-Family Kinases with ATP-Competitive Inhibitors -- Characterization of Ligand Binding to Pseudokinases Using a Thermal Shift Assay -- Proteomic Profiling of Protein Kinase Inhibitor Targets by Mass Spectrometry -- Utilizing the Luminex Magnetic Bead-Based Suspension Arrays for Rapid Multiplexed Phosphoprotein Quantification -- High-Content Imaging and RNAi Screens for Investigating Kinase Network Plasticity -- Analysis of Drug Resistance Using Kinome-Wide Functional Screens -- Identification and Validation of Driver Kinases from Next Generation Sequencing Data -- Label-Free Phosphoproteomic Approach for Kinase Signaling Analysis -- Cell-Specific Labeling for Analyzing Bidirectional Signaling by Mass Spectrometry -- Characterization of the Phospho-Adhesome by Mass Spectrometry-Based Proteomics -- Analysis of Phosphotyrosine Signaling Networks in Lung Cancer Cell Lines -- Targeted Analysis of Phosphotyrosine Signaling by Multiple-Reaction-Monitoring Mass Spectrometry -- Phosphoproteomic Analysis of Isolated Mitochondria in Yeast -- A Methodology for Comprehensive Analysis of Toll-Like Receptor Signaling in Macrophages -- Absolute Phosphorylation Stoichiometry Analysis by Motif-Targeting Quantitative Mass Spectrometry -- Identification of Plant Kinase Substrates Based on Kinase Assay-Linked Phosphoproteomics -- Mass Spectrometry Analysis of Spatial Protein Networks by Colocalization Analysis (COLA) -- Development of Selected Reaction Monitoring Methods to Systematically Quantify Kinase Abundance and Phosphorylation Stoichiometry in Human Samples -- Analysis of Signaling Networks at the Single Cell Level Using Mass Cytometry -- Magnetic Resonance Spectroscopy (MRS)-Based Methods for Examining Cancer Metabolism in Response to Oncogenic Kinases Drug Treatment -- Deconstructing the Metabolic Networks of Oncogenic Signaling Using Targeted Liquid-Chromatography Tandem Mass Spectrometry (LC-MS/MS) -- Modeling of Receptor Tyrosine Kinase Signaling: Computational and Experimental Protocols -- An Interdisciplinary Approach for Designing Kinetic Models of the Ras/MAPK Signaling Pathway -- Databases and Computational Tools for Evolutionary Analysis of Protein Phosphorylation -- Informatics Approaches for Predicting, Understanding, and Testing Cancer Drug Combinations -- Target Inhibition Maps Based on Responses to Kinase Inhibitors -- Partial Least Squares Regression Models for the Analysis of Kinase Signaling
    Abstract: This detailed volume describes cutting-edge techniques in three distinct and complementary areas of contemporary kinase biology research. Beginning with a section on synthetic biology, chemical biology, and screening approaches to kinase signaling networks, the book continues with sections on mass spectrometry and metabolic analysis of kinase signaling as well as computational analysis of kinase signaling networks. Written for the highly successful Methods in Molecular Biologyseries, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Kinase Signaling Networks aims to provide scientists with the tools necessary to overcome the technological bottlenecks that limit our ability to gain a deeper mechanistic understanding of kinase biology
    Pages: XVII, 537 p. 112 illus., 74 illus. in color. : online resource.
    ISBN: 9781493971541
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  • 8
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    Singapore : World Scientific
    Call number: QZ200:519 ; C060:136
    Keywords: Neoplasms / physiopathology ; Cell Transformation, Neoplastic ; Models, Theoretical
    Description / Table of Contents: Oncogenetic trees / Aniko Szabo and Kenneth M. Boucher -- Stochastic multistage cancer models : a fresh look at an old approach / Qi Zheng -- Cancer biology, cancer models and some new approaches to carcinogenesis / Wai Y. Tan, Chao W. Chen and Li J. Zhang -- Modeling the effects of radiation on cell cycle regulation and carcinogenesis / William D. Hazelton -- Cancer models, ionizing radiation, and genomic instability : a review / Mark P. Little -- Distribution of the sizes of metastases : mathematical and biomedical considerations / Leonid Hanin -- Mathematical models of cancer and their relevant insights / Evans Afenya -- Major epigenetic hypotheses of carcinogenesis revisited / King-Thom Chung -- Induction and repair of DNA damage formed by energetic electrons and light ions / Robert D. Stewart and Vladimir A. Semenenko -- Radiation-induced bystander effects / Linda C. DeVeaux -- A stochastic model of human colon cancer involving multiple pathways / Wai Y. Tan, Li J. Zhang, Chao W. Chen and J.M. Zhu -- Cancer risk assessment of environmental agents by stochastic and state space models of carcinogenesis / Wai Y. Tan, Chao W. Chen and Li J. Zhang -- Stochastic models for preneoplastic lesions and their application for cancer risk assessment / Annette Kopp-Schneider, Iris Burkholder, Jutta Groos and Lutz Edler -- Drug resistance in cancer models / Jaroslaw Smieja -- Bladder cancer screening by magnetic resonance imaging / Lihong Li, Zigang Wang and Zhengrong Liang -- Mathematical framework and wavelets applications in proteomics for cancer study / Don Hong and Ya Shyr -- Advanced statistical methods for the design and analysis of tumor xenograft experiments / Ming Tan and Hong-Bin Fang -- Analysis of occult tumor studies / Shesh N. Rai
    Pages: xxiv, 567 p. : ill.
    ISBN: 9789812779472
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    QZ200:519 available
    C060:136 departmental collection or stack – please contact the library
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  • 9
    Call number: YY Diss Tjon/Mag
    Keywords: DKFZ-publications / academic dissertations
    Notes: Thesis (Ph.D) -- Ruprecht-Karls-Universität, Heidelberg, 1963.
    Pages: 56 p.
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    YY Diss Tjon/Mag departmental collection or stack – please contact the library
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  • 10
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    Philadelphia : Wolters Kluwer Health / Lippincott Williams & Wilkins
    Call number: QZ241.5:13
    Keywords: Neoplasms / diagnosis ; Neoplasms / therapy ; Individualized Medicine / methods ; Medical Oncology / methods ; Molecular Diagnostic Techniques ; Molecular Targeted Therapy
    Notes: For online access to this volume please contact the library staff in room D124 (phone 3661, e-mail: http://www.dkfz.de/de/zbib/mitarbeiter/kontakt/fernleihe.php
    Pages: xxiii, 968 p. : ill.
    ISBN: 9781451131970
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    QZ241.5:13 available
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