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  • 1
    ISSN: 1432-1084
    Keywords: MRI ; Psychiatry ; white matter
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract T2-weighted MRI scans of psychiatric patients with at least one white matter lesion (WML) were compared to 83 non-psychiatric controls with respect to WML number and distribution. MANOVA results in significant effects for sex, age and patient group with respect to WML number. In the psychiatric patients, infratentorial WML prevailed in organic psychoses. WML number was positively correlated with age with the exception of rith temporal lobe WML. Based on WML spatial distribution, four patient clusters were found. Clusters with widely distributed WML comprised older patients with late onset of illness; right frontal and temporal WML were associated with mania, euphoria and unstable mood.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1435-1463
    Keywords: Computed tomography (CT) ; functional magnetic resonance imaging (fMRI) ; late-onset depression ; late-onset paranoid disorder ; magnetic resonance imaging (MRI) ; magnetic resonance spectroscopy (MRS) ; normal pressure hydrocephalus (NPH) ; primary degenerative dementia ; psychiatry ; ultrasound ; vascular dementia ; white matter hyperintensities
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An outline is given of some of the methodological issues discussed in neuroradiological research on psychiatric illness. Strengths and shortcomings of magnetic resonance imaging (MRI) in depicting and quantifying brain structures are described. Temporal lobe anatomy and pathology are easily accessible to MRI, whereas limits on anatomical delineation hamper approaches to frontal lobe study. White matter hyperintense lesions are sensitively depicted by MRI, but specificity is limited. Distinction of vascular and primary degenerative dementia is considerably improved by CT and MRI analysis. Computed tomography (CT) and MRI have enhanced the understanding of treatable organic psychiatric disorders, e.g., normal pressure hydrocephalus. Subcortical and white matter pathology has been replicated in CT and MRI studies of late-onset psychiatric disorders, clinical overlap with cerebrovascular disease or neurodegeneration may be of import. Transcranial sonography findings of brainstem structural change specific to unipolar depression may contribute to the understanding of affective psychoses. Magnetic resonance spectroscopy and functional MRI are likely to stimulate psychiatric research in the future.
    Type of Medium: Electronic Resource
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