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  • 1
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  16. Deutscher Kongress für Versorgungsforschung (DKVF); 20171004-20171006; Berlin; DOCP139 /20170926/
    Publication Date: 2017-09-26
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 2
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Verbrennungsmedizin; VOL: 3; DOC01 /20090401/
    Publication Date: 2009-04-01
    Description: Based on the observation that, in addition to consolidation of osseous tissue, extracorporeal shock wave therapy (ESWT) effectuates a healing of skin lesions lying in the path of said shock waves, the effect of ESWT on partial thickness (IIa°) thermal lesions was studied by the Centre for Severely Burned Patients with Plastic Surgery at the Unfallkrankenhaus in Berlin in conjunction with the International Centre for Extracorporeal Shock Wave Therapy in Berlin. This took place within the framework of a clinical study to demonstrate the effects of extracorporeal shock wave therapy on superficial (IIa°) (IIb°) thernal lesions. Shock waves are small, high pressure sonic pulses and are characterised by a mixture of sound waves with a wide frequency spectrum. The application of shock waves was carried out once during the 24 hour period post trauma. Shock waves with an energy density of 0.1-0.14 mJ/m2 using 100 impulses per cm2 were applied. We present a case study of a 89 year old female patient with a IIb° scald on her buttock. The ESWT resulted in a complete reepithelisation on day 12 post trauma. Extracorporeal shock wave therapy presents a new complementary method of treatment of thermal lesions that leads to a significantly reduced healing period due to an accelerated rate of reepithelisation.
    Description: Ausgehend von der Beobachtung, dass die extrakorporale Stoßwellentherapie (ESWT) bei orthopädischer Anwendung neben der knöchernen Konsolidierung eine Abheilung von sich im Strahlengang befindlichen Hautläsionen bewirkte, wurde im Zentrum für Schwerbrandverletzte mit Plastischer Chirurgie des Unfallkrankenhauses Berlin in Zusammenarbeit mit dem Internationalen Zentrum für extrakorporale Stoßwellentherapie Berlin der Einfluss der ESWT auf oberflächliche (IIa°) und tief zweitgradige (IIb°) thermische Läsionen untersucht. In diesem Rahmen präsentieren wir die Fallvorstellung einer 89-jährigen Patientin, die sich eine IIb° Verbrühung am Gesäß zugezogen hatte. Die Anwendung der ESWT erfolgte 24 h post Trauma. Es wurden Stoßwellen der Energiedichte 0,1-0,14 mJ/m2 angewandt. Die ESWT wurde mit 100 Impulsen/cm2 appliziert. Es zeigte sich eine komplette Reepithelisierung am 12. Tag. Durch die extrakorporale Stoßwellentherapie steht eine neue Behandlungsoption im Sinne einer ergänzenden Methode in der Therapie thermischer Läsionen zur Verfügung, die zu einer verkürzten Abheilungsdauer durch eine beschleunigte Reepithelisierung führt.
    Keywords: extracorporal shockwave ; thermal lesion ; scald ; reepithelisation ; extrakorporale Stoßwelle ; thermische Läsion ; Verbrühung ; Reepithelisierung ; ddc: 610
    Language: English
    Type: article
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  • 3
    Abstract: Abstract: Most scientific organizations have established bibliographic databases to collect and present the scholarly output generated by their researchers and research projects. In many cases, an institutional repository is included to enable and promote open access. Besides publications lists on the Web, the data is even more valuable to support internal procedures such as reuse in citation management software for new publications or grant applications and in particular to alleviate the burden of administrative reporting according to complex sorting or filtering criteria.In 2010 the libraries and documentation departments of DESY (Hamburg), GSI (Darmstadt), Forschungszentrum Jülich (Jülich), Heinz Maier-Leibnitz Zentrum (MLZ) (Garching) and RWTH Aachen University (Aachen) founded join2 to establish such an infrastructure based on Invenio. Main focuses were a solution, which is easy to use and accepted by scientists, to incorporate specific and precise data sources of an organization on for example, people and projects, as well as (inter-)nationally accepted authority records -e.g. on journals- and sources for data import. By merging bibliographic database and repository the addition of full texts is encouraged, furthering OpenAccess. Local protected working areas for publication exchange serve as an additional value to the scientists. The project addresses that each organizations has its specifics and thus the infrastructure must be suitable configured and tailored while still profiting from the shared development resources.As a result six independent repositories are currently in operation. As an open project, we recently also welcomed Deutsches Krebsforschungszentrum (Heidelberg) as a new partner.join2 repositories today serve more than 20.000 staff members and more than 5.000 local visitors annually on campus. They provide more than 300.000 records as well as nearly 90.000 high quality authority records freely accessible on the Internet. This makes join2 one of the larger Invenio users world wide.We present the flexible structure of our project based on shared content, its various use cases and give an overview of its internal work flows. CERN Workshop on Innovations in Scholary Communication, OAI9, Geneva, Universtity of Geneva, Switzerland, 17 Jun 2015 - 19 Jun 2015
    Type of Publication: Miscellaneous publication
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  • 4
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  DAV 2008; 26. Jahrestagung der deutschsprachigen Arbeitsgemeinschaft für Verbrennungsbehandlung; 20080106-20080109; Engelberg; DOC08dav69 /20080630/
    Publication Date: 2008-07-01
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 5
    ISSN: 1432-2277
    Keywords: Key words Interleukin-1 receptor antagonist ; heart transplantation ; allograft rejection ; Heart transplantation ; interleukin-1 receptor antagonist ; Allograft rejection ; interleukin-1 receptor antagonist ; heart transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a pilot study we determined the serum levels of circulating interleukin-1 receptor antagonist (IL-1ra) in patients undergoing orthotopic heart transplantation and in control patients scheduled for open heart surgery without allograft transplantation. Blood samples were obtained from 12 transplant recipients and 7 controls prior to the operative procedures to determine baseline values. Serum levels of IL-1ra were measured within 12 h of decrossclamping of the aorta and every 24 h for the following 14 days. Endomyocardial biopsies were obtained weekly for the 1st month after transplantation. Compared to baseline values, IL-1ra serum levels 12 h after decrossclamping of the aorta were significantly higher both in the control group (507 ± 165 vs 3980 ± 452 pg/ml, P 〈 0.01) and among the transplant recipients (413 ± 180 vs 4117 ± 459 pg/ml, P 〈 0.01) IL-1ra levels remained significantly elevated for 2 and 5 days, respectively. There were no significant differences in the IL-1ra serum levels between the two groups throughout the observation period. Endomyocardial biopsies of two patients showed acute allograft rejection, Billingham grade III a and III b, respectively. In both cases, the rejection episodes were accompanied by a renewed and more pronounced elevation in the IL-1ra serum levels beyond 4000 pg/ml for at least 2 days. These preliminary results indicate that IL-1ra may be a nonspecific immune marker during the first few days after orthotopic heart transplantation and cardiopulmonary bypass. Moreover, renewed, prolonged increases in IL-1ra appear to be associated with rejection. Further studies are needed to confirm the predictive value of IL-1ra in the detection of acute allograft rejection.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 0012-821X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Geosciences , Physics
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Thirty patients with advanced renal cell carcinoma (RCC), 23 of whom had distant metastases in at least one organ, were entered after nephrectomy into a protocol involving vaccination with Newcastle disease virus (NDV)-modified autologous tumour material, with a subsequent induction week and repetitive bi-weekly cycles of interleukin-2 (rIL-2) and interferon α2b/rIFN-α2b at a lower s. c. dose (1.5 million Cetus units m−2 day−1 every 12 h on 2 days and 3 million IU/m2 once a day on days 1, 3 and 5). The inpatient treatment was followed by a maintenance phase during which 0.3 million Cetus units/m2 rIL-2 was given s. c. every 12 h on days 1–5 and 3 million IU m−2 day−1 rIFN-α2b was administered on days 1, 3, and 5 on an outpatient basis. All but 3 patients completed the induction week and 6 weeks of outpatient therapy. No grade 3 or 4 toxicities occurred during the therapy. Therapy was discontinued for 3 patients because of rapid tumour progression. Of the 23 evaluable RCC patients, 3 exhibited a complete response and 4 displayed partial remission, 7 showed stable disease during 1–18 months (median = 5 months) of therapy, and progression was seen in 9. We conclude that vaccination with autologous tumour material combined with s. c. rIL-2 and rIFN-α2b administration can induce regressions in patients with advanced RCC and that even in non-responding patients a more favourable course of the disease can be achieved.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Medical microbiology and immunology 46 (1904), S. 394-406 
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Medical microbiology and immunology 86 (1918), S. 263-276 
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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