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  • 1
    Publication Date: 2018-03-30
    Description: Aim: Although tumor depth of invasion is strongly associated with risk of lymph node metastasis and long-term survival in patients with esophageal adenocarcinoma, the significance of differential T2 invasion (inner circular layer versus outer longitudinal layer) is unknown. The current study was undertaken to explore the hypothesis that greater T2-specific depth of invasion is associated with inferior long-term outcomes in patients with esophageal adenocarcinoma treated with esophagectomy. Patients and Methods: Demographic, treatment, and outcome data were collected for patients with resected pT2N0-3M0 esophageal adenocarcinoma treated between 2005 and 2015 pooled from four U.S. academic medical centers. Two blinded pathologists evaluated depth of muscularis propria tumor invasion. Univariate and Cox proportional hazard regression analyses were performed to identify prognostic factors for overall (OS) and disease-free (DFS) survival, and Kaplan–Meier analysis to compare survival differences specific to prognostic factors. Results: A total of 84 patients were identified for analysis (53 with circular invasion; 31 with longitudinal invasion), with a median age of 66 years. Sixty percent of patients (50/84) received induction therapy prior to esophagectomy. The median OS and DFS was 58 months (95% confidence interval(CI)=42 months-not reached) and 27 months (95% CI=13.7-66 months) respectively. Depth of muscularis propria invasion did not correlate with OS or DFS on univariate (p=0.42; and p=0.34, respectively) or multivariate (p=0.15 and p=0.21, respectively) analysis after adjustment for age, nodal status, perineural invasion, and tumor grade. These findings did not vary by induction therapy status. Conclusion: Depth of muscularis propria invasion does not appear to correlate with survival in patients with esophageal adenocarcinoma.
    Print ISSN: 0250-7005
    Electronic ISSN: 1791-7530
    Topics: Medicine
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  • 2
    Publication Date: 2018-06-15
    Description: Objective The Non Interventional Evaluation with Golumimab (GO-NICE) study aimed to document patient and treatment characteristics as well as clinical effectiveness and safety in adult patients newly treated with the tumour necrosis factor inhibitor golimumab (GLM). Design Prospective non-interventional study with 24-month observation per patient. Setting 158 office-based and clinical-based physicians in Germany. Intervention GLM administered in the 50 mg dose subcutaneously in monthly intervals under real-life conditions. Results Of the 1613 included patients, 1458 patients were eligible for final analysis: 474 patients with rheumatoid arthritis (RA, 54.9±13.4 years, 72.8% women, 64.7% biologic-naïve), 501 with psoriatic arthritis (PsA, 50.5±12.1 years, 54.1% women, 56.5% biologic-naïve) and 483 with ankylosing spondylitis (AS, 43.6±12.3 years, 66.5% men, 61.0% biologic-naïve). 664 patients completed follow-up (2-year retention rate 45.5%). Disease Activity Score 28-joint count erythrocyte sedimentation rate (DAS28-ESR) decreased from 5.0 to 2.9 after 24 months (p〈0.0001) in patients with RA, and Bath Ankylosing Spondylitis Disease Index score decreased from 5.1 to 2.4 (p〈0.0001) in patients with AS. Response rate calculated in patients with PsA by modified Psoriatic Arthritis Response Criteria was 67.9% after 24 months. Most adverse events were of mild or moderate nature, and no new safety signals were detected. According to the physicians’ clinical assessments, treatment with GLM was successful (no adverse drug reaction and a clear or moderate therapeutic effect in an individual patient) in 55.0%–56.6% of patients with RA, PsA and AS, respectively, at month 3, increasing from 74.5% to 76.1% at month 24. Conclusions GLM subcutaneously once monthly led to substantial improvements in clinical effectiveness in patients with various inflammatory rheumatic diseases who could be followed up in a real-life setting in Germany. The treatment was well tolerated, and the safety profile of GLM was consistent with that observed in the previous randomised controlled trials. Trial registration number NCT01313858 .
    Keywords: Open access, Rheumatology
    Electronic ISSN: 2044-6055
    Topics: Medicine
    Published by BMJ Publishing
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  • 3
    Keywords: Estime de soi chez l'adolescent. ; Identité chez l'adolescent. ; Identity (Psychology) in adolescence. ; Self-esteem in adolescence.
    Notes: Understanding early adolescent self and identity: an introduction / Thomas M. Brinthaupt & Richard P. Lipka -- Part I: Conceptual issues -- Self and identity in early adolescence: the pains and gains of knowing who and what you are / Catrin Finkenauer, Rutger C.M.E. Engels, Wim Meeus, & Annerieke Oosterwegel -- Self-esteem as a multifaceted construct / Michael H. Kernis -- Part II: School and the sense of self -- On academic identity formation in middle school settings during early adolescence: a motivational-contextual perspective / Robert W. Roeser & Shun Lau -- The ecology of middle grades school and possible selves: theory, research, and action / Peggy Clements & Edward Seidman -- Part III: Peer relationships and behavioral problems -- Self, self-esteem, conflicts, and best friendships in early adolescence / Margarita Azmitia -- Stability and change in global self-esteem and self-related affect / Françoise Alsaker & Dan Olweus -- Influence of competence and alcohol use on self-esteem: latent growth curve models using longitudinal data / Lawrence M. Scheier & Gilbert J. Botvin -- Part IV: Early adolescent interventions -- Identity in early adolescence via social change activities: experience of the adolescent social action program / Lily Dow Velarde, Randall G. Starling, & Nina B. Wallerstein -- A place to call home: youth organizations in the lives of inner city adolescents / Nancy L. Deutsch & Barton J. Hirsch -- Esteem-enhancement interventions during early adolescence / David L. DuBois, Carol Burk-Braxton, & Heather D. Tevendale
    Pages: x, 395 p.
    ISBN: 0-585-46373-5
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  • 4
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    CAMBRIDGE, MASS.: CELL PRESS
    Call number: QH301Z:84/72 Suppl.
    Keywords: Signalverarbeitung / Biologie ; Synapse
    Pages: 149 S.
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    QH301Z:84/72 Suppl. available
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  • 5
    Call number: QZ203AA1:8
    Keywords: Neoplasms / epidemiology ; Urban Health ; Risk Factors ; Los Angeles ; epidemiology
    Pages: viii, 645 p. : ill. (some col.)
    ISBN: 0124643515
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    QZ203AA1:8 available
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  • 6
    Call number: QZ241:9/25
    Keywords: Testicular Neoplasms / pathology ; Scrotum / pathology ; Spermatic Cord
    Notes: "Under the Auspices of Universities Associated for Research and Education in Pathology, Inc."
    Pages: 385 p. : numerous ill.
    ISBN: 1881041468
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    QZ241:9/25 available
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  • 7
    Keywords: Cytology ; Mass spectrometry ; Monoclonal antibodies ; Cell Biology ; Mass spectrometry ; Antibodies ; Springer eBooks
    Description / Table of Contents: Setting up Mass Cytometry in a Shared Resource Lab Environment -- Acquisition, Processing, and Quality Control of Mass Cytometry Data -- Visualization of Mass Cytometry Signal Background to Enable Optimal Core Panel Customization and Signal Threshold Gating -- Method for Tagging Antibodies with Metals for Mass Cytometry Experiments -- Scalable Conjugation and Characterization of Immunoglobulins with Stable Mass Isotope Reporters for Single-Cell Mass Cytometry Analysis -- Titration of Mass Cytometry Reagents -- Cell-Surface Barcoding of Live PBMC for Multiplexed Mass Cytometry -- Automated Cell Processing for Mass Cytometry Experiments -- Live Cell Barcoding for Efficient Analysis of Small Samples by Mass Cytometry -- Staining of Phosphorylated Signalling Markers Protocol for Mass Cytometry -- Multiplex MHC Class I Tetramer Combined with Intranuclear Staining by Mass Cytometry -- Analysis of the Murine Bone Marrow Haematopoietic System Using Mass and Flow Cytometry -- Mass Cytometric Cell Cycle Analysis -- Picturing Polarized Myeloid Phagocytes and Regulatory Cells by Mass Cytometry -- Quantitative Measurement of Cell-nanoparticle Interactions Using Mass Cytometry -- Data-Driven Flow Cytometry Analysis -- Analysis of Mass Cytometry Data -- Analysis of High Dimensional Phenotype Data Generated by Mass Cytometry or High Dimensional Flow Cytometry -- Computational Analysis of High Dimensional Mass Cytometry Data from Clinical Tissue Samples -- Supervised Machine Learning with CITRUS for Single Cell Biomarker Discovery
    Abstract: This book details a compilation of up-to-date and cutting-edge protocols in mass cytometry.. Chapters guide readers through setting up a facility, panel design and reagent preparation, sample preparation, specific applications, and data analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Mass Cytometry: Methods and Protocols aims to ensure successful results in the further study of this vital field
    Pages: XII, 338 p. 83 illus., 70 illus. in color. : online resource.
    ISBN: 9781493994540
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  • 8
    Call number: WN200:43/2012 ; E040:99
    Keywords: DKFZ-publications
    Notes: German and English contributions.
    Pages: xviii, 454 p. : ill.
    ISBN: 9783642285011
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    WN200:43/2012 available
    E040:99 departmental collection or stack – please contact the library
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  • 9
    Keywords: Medicine ; Human Physiology ; Neurosciences ; Biochemistry ; Cytology ; Cell Membranes ; Biomedicine ; Human Physiology ; Neurosciences ; Cell Physiology ; Animal Biochemistry ; Membrane Biology ; Springer eBooks
    Pages: : digital.
    ISBN: 9783642303388
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  • 10
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    New York, NY : Springer Science+Business Media, LLC
    Keywords: Medicine ; Radiology, Medical ; Orthopedic surgery ; Rheumatology ; Medicine & Public Health ; Imaging / Radiology ; Diagnostic Radiology ; Rheumatology ; Surgical Orthopedics ; Springer eBooks
    Pages: : digital
    ISBN: 9781441984388
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