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  • 1
    Unknown
    Notre Dame : University of Notre Dame Press
    (Revisions)  
    Keywords: Catholic Church, Doctrines. ; Thomas,, Aquinas, Saint,, 1225?-1274., Summa contra gentiles. ; Apologetics. ; Theology, Doctrinal.
    Pages: x, 242 p.
    ISBN: 0-585-30770-9
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  • 2
    Call number: 08-EDV WEN
    Keywords: Image processing ; Computer vision
    Pages: xv, 444 p. : ill.
    ISBN: 3540556729
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    08-EDV WEN departmental collection or stack – please contact the library
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  • 3
    Call number: QZ200:532
    Keywords: Cancer / Mathematical models ; Models, Biological ; Neoplasms / physiopathology ; Neoplasms / pathology ; Neoplastic Processes ; Multiscale modeling
    Description / Table of Contents: Evolution, regulation and disruption of homeostasis and its role in carcinogenesis / Alexander R.A. Anderson ... [et al.] -- Cancer cell : linking oncogenic signaling to molecular structure / Jeremy E. Purvis ... [et al.] -- Has cancer sculpted the genome? : modeling linkage and the role of tetraploidy in neoplastic progression / Carlo C. Maley, Walter Lewis and Brian J. Reid -- Catastrophes and complex networks in genomically unstable tumorigenesis / Ricard Sole -- A stochastic multi-scale model framework for intestinal stem cell homeostasis / Larry W. Jean and E. Georg Luebeck -- Multiscale modeling of colonic crypts and early colorectal cancer / A.G. Fletcher ... [et al.] -- The physical microenvironment in somatic evolution of cancer / Robert A. Gatenby -- Multi-scale modeling of cell motion in three-dimensional environments / Dewi Harjanto and Muhammad H. Zaman -- Simulating cancer growth with agent-based models / Zhihui Wang ... [et al.] -- Diffusional instability as a mechanism of tumor invasion / Hermann B. Frieboes, John Lowengrub and Vittorio Cristini -- Continuum models of mesenchymal cell migration and sprouting angiogenesis / Michael Bergdorf, Florian Milde and Petros Koumoutsakos -- Do tumor invasion strategies follow basic physical laws? / C. Guiot, P.P. Delsanto and A.S. Gliozzi -- Multi-scale mathematical modelling of vascular tumour growth : an exercise in transatlantic cooperation / Mark A.J. Chaplain ... [et al.] -- A multiscale simulation framework for modeling solid tumor growth with an explicit vessel network / S. Hirsch ... [et al.] -- Building stochastic models for cancer growth and treatment / Natalia L. Komarova -- Bridging from multi-scale modeling to practical clinical applications in the study of human gliomas / Gargi Chakraborty ... [et al.] -- Personalization of reaction-diffusion tumor growth models in MR images : application to brain gliomas characterization and radiotherapy planning / Ender Konukoglu ... [et al.] -- In silico
    Pages: xxiv, 460 p. : ill.
    ISBN: 9781439814406
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    QZ200:532 on loan
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  • 4
    Publication Date: 2018-08-02
    Description: Head and neck squamous cell carcinoma (HNSCC) accounts for 300,000 deaths per year worldwide, and overall survival rates have shown little improvement over the past three decades. Current treatment methods including surgery, chemotherapy, and radiotherapy leave patients with secondary morbidities. Thus, treatment of HNSCC may benefit from exploration of natural compounds as chemopreventive agents. With excellent safety profiles, reduced toxicities, antioxidant properties, and general acceptance for use as dietary supplements, natural compounds are viewed as a desirable area of investigation for chemoprevention. Though most of the field is early in development, numerous studies display the potential utility of natural compounds against HNSCC. These compounds face additional challenges such as low bioavailability for systemic delivery, potential toxicities when consumed in pharmacologic doses, and acquired resistance. However, novel delivery vehicles and synthetic analogues have shown to overcome some of these challenges. This review covers 11 promising natural compounds in the chemoprevention of HNSCC including vitamin A, curcumin, isothiocyanate, green tea, luteolin, resveratrol, genistein, lycopene, bitter melon, withaferin A, and guggulsterone. The review discusses the therapeutic potential and associated challenges of these agents in the chemopreventive efforts against HNSCC. Cancer Prev Res; 11(8); 441–50. ©2018 AACR .
    Print ISSN: 1940-6207
    Electronic ISSN: 1940-6215
    Topics: Medicine
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  • 5
    Publication Date: 2018-02-16
    Description: B-cell maturation antigen (BCMA) is a promising therapeutic target for multiple myeloma (MM), but expression is variable, and early reports of BCMA targeting chimeric antigen receptors (CARs) suggest antigen downregulation at relapse. Dual-antigen targeting increases targetable tumor antigens and reduces the risk of antigen-negative disease escape. "A proliferation-inducing ligand" (APRIL) is a natural high-affinity ligand for BCMA and transmembrane activator and calcium-modulator and cyclophilin ligand (TACI). We quantified surface tumor expression of BCMA and TACI on primary MM cells (n = 50). All cases tested expressed BCMA, and 39 (78%) of them also expressed TACI. We engineered a third-generation APRIL-based CAR (ACAR), which killed targets expressing either BCMA or TACI ( P 〈 .01 and P 〈 .05, respectively, cf. control, effector-to-target [E:T] ratio 16:1). We confirmed cytolysis at antigen levels similar to those on primary MM, at low E:T ratios (56.2% ± 3.9% killing of MM.1s at 48 h, E:T ratio 1:32; P 〈 .01) and of primary MM cells (72.9% ± 12.2% killing at 3 days, E:T ratio 1:1; P 〈 .05, n = 5). Demonstrating tumor control in the absence of BCMA, we maintained cytolysis of primary tumor expressing both BCMA and TACI in the presence of a BCMA-targeting antibody. Furthermore, using an intramedullary myeloma model, ACAR T cells caused regression of an established tumor within 2 days. Finally, in an in vivo model of tumor escape, there was complete ACAR-mediated tumor clearance of BCMA + TACI – and BCMA – TACI + cells, and a single-chain variable fragment CAR targeting BCMA alone resulted in outgrowth of a BCMA-negative tumor. These results support the clinical potential of this approach.
    Keywords: Multiple Myeloma, Immunobiology and Immunotherapy, Lymphoid Neoplasia
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
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  • 6
    ISSN: 1365-2214
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine , Psychology
    Notes: Objective  To collect information about the pre-flight experiences of unaccompanied asylum seeking children (UASC) in the UK to increase the understanding of support needed on arrival in the UK.Methods  Retrospective social services case file and legal statement review and semi-structured in-depth interviews with 100 UASC.Results  Nearly half of all UASC have experienced separation from or loss of parents and/or family members (47%), and a further 41% had personally experienced or witnessed violence. Sexual violence (such as rape) was reported by 24% of African girls. Many children reported complex journeys to the UK.Conclusions  UASC arrive in the UK with a variety of potentially traumatic experiences. Whilst research is starting to identify some of the experiences of UASC, further culturally appropriate research is needed to identify their health and social needs after arrival. Further research will help to identify the specific experiences of UASC, indicating where services should be improved to deal with their complex and diverse needs.
    Type of Medium: Electronic Resource
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  • 7
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  174. Versammlung des Vereins Rheinisch-Westfälischer Augenärzte; 20120127-20120128; Essen; DOC12rwa83 /20120126/
    Publication Date: 2012-01-26
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 8
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  23. Jahrestagung der Retinologischen Gesellschaft; 20100924-20100925; Freiburg i. Br.; DOC10rg28 /20100921/
    Publication Date: 2010-09-24
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 9
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Kongress Medizin und Gesellschaft 2007; 20070917-20070921; Augsburg; DOC07gmds549 /20070906/
    Publication Date: 2007-09-07
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 10
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    German Medical Science; Düsseldorf, Köln
    In:  56. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie e.V. (DGNC), 3èmes journées françaises de Neurochirurgie (SFNC); 20050507-20050511; Strasbourg; DOCP175 /20050504/
    Publication Date: 2005-05-05
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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