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  • 1
    ISSN: 0304-8853
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1435-1803
    Keywords: Nisoldipine ; hypertrophic cardiomyopathy ; diastolic function ; systolic function ; exercise tolerance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Nisoldipine is a second generation dihydropyridine calcium antagonist having characteristics of strong coronary artery dilating effect and less negative inotropic action. The purpose of this study was to evaluate the effect of nisoldipine on the cardiac function (systolic and diastolic) and the exercise tolerance in patients with hypertrophic cardiomyopathy (HCM).Subjects: Twenty-three patients with HCM were studied.Methods: We measured the following indices using M-mode and pulsed wave Doppler echocardiography before and after nisoldipine therapy; left ventricular fractional shortening (LVFS), isometric relaxation time (IRT), deceleration half-time (DHT) of early diastolic mitral (E) flow, late diastolic mitral (A) flow and A/E ratio. Symptomlimited treadmill exercise test was performed. Exercise tolerance (EX) time was measured. Nisoldipine of 10mg/day was orally administered. Same tests were repeated on day 14 and after 6 months.Results: 1) Short-term effects; LVFS did not change (55.9±5.9%→57.0±7.4%, NS) after 2 weeks. However, LV diastolic function significantly improved (IRT; 92.1±7.7 ms→85.2±11.6 ms, p〈0.05, DHT; 70.7±16.2 ms→63.3±3.7 ms, p〈0.05). EX time increased (8.9±2.6 min→ 10.0±3.3 min, p〈0.05). 2) Long-term effects; LV diastolic function had a tendency toward improvement, but is statistically not significant (IRT; 91.1±7.6→83.8±11.6 ms, DHT; 73.1±23.4→61.0±11.4 ms, A/E; 1.26±0.29→1.11±0.36) after 6 months. EX time was significantly increased (9.4±1.7→ 10.1±1.7 min, p〈0.05).Conclusions: Nisoldipine improved LV diastolic dysfunction and exercise tolerance in patients with HCM. These effects were similar to the first generation calcium antagonists. LV diastolic dysfunction may be improved due to the reduction of intracellular calcium concentration and the relief of myocardial ischemia by strong coronary artery dilating effect. However, nisoldipine did not affect the LV systolic function because of its less negative inotropic effect.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The addition of Be to TbFeCo thin-film layers results in the gradual deterioration of carrier-to-noise ratio (CNR) and optimized recording power Pw compared with that of Cr. Be and Cr composite-doped disks, whose CNR maintain over 54 dB at a recording frequency of 1 MHz, prevent bit-error-rate (BER) levels from increasing in accelerated environmental tests. It is noted that even prior to environmental stability testing, BER of Be-Cr composite-doped disks is less than that of nondoped disks. From the results obtained by Auger electron spectroscopy analysis, it is explained that this difference is caused by fluctuations in the reflections of disks resulting from varying thicknesses of extra layers formed as a result of reaction between TbFeCo and SiN. Finally, through the write-erase cycle test and differential scanning calorimetry analysis, it has been demonstrated that Be-Cr-doped disks possess a higher thermal durability than nondoped disks.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: In a rigid disk a very smooth surface is desirable for high density recording, while it tends to stick to the magnetic head. To avoid this difficulty, the mechanical texturing (M/T) is widely used. Unfortunately very low flying height can't be achieved with the M/T. To improve the flying height, authors have developed a new texturing process using anodically oxidized aluminum substrates named chemical texturing (C/T).1 Aluminum anodic oxide films have a regularly arranged honeycomb structure and uniform and roughness-controlled surfaces were formed by etching process of chemical texturing. In the present research, the relation between the recording and tribological properties and the etching conditions were investigated. On C/T substrates Cr, a longitudinal magnetic layer CoNi, C were sputtered in an inline sputtering equipment. The surface of the sputtered layer was flat (Ra〈5 A(ring)) and uniform. Magnetic and electrical properties (coercive force, squareness, over write, modulation and so on) were examined. In spite of isotropy on the disk surfaces, the modulation caused by the inline sputtering was not observed, and high coercive force of 1200 Oe was obtained. Tribological properties (gride height, CSS, friction) were measured. Gride height was lower than 0.1 μm, and CSS more than 30 000 cycles. In semi-pilot plant production, thousands of C/T disks were prepared. Yield of disks having less than 5 missing and/or extra pulses was higher than 95%.
    Type of Medium: Electronic Resource
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