Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 3 (1952), S. 51-56 
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The A. confronts 23 cases of cerebral abscesses treated by extirpation (mostly with administration of penicillin), with 23 other cases operated with a non-radical technic (repeated aspiration, decompression + drainage, marsupialization). In the first group the mortality reached 26% in the second group 47%. In the group of radical operations we must observe the difference between the mortality of primary operations (29%) and secondary ones (16%); the latter treatment brought more favourable results. The higher mortality in the group of a more conservative treatment is not due to the risks of the operation, but rather depends on fact that the majority of these operations was performed without penicillin and because they were often unable to suppress the pyogenic lesions completely. The good results of radical extirpations abscesses, hereby taking into consideration that the limitations to which the above mentioned methods are submitted are very small and that acute abscesses are not excluded, nor is it necessary to await the capsulation of the abscess: a delay that may easily be the cause of deadly complications.
    Abstract: Résumé L'auteur compare 23 cas d'abcès cérébraux opérés suivant les techniques radicales avec une autre série de 23 cas opérés suivant les techniques conversatives (aspirations répétées, décompression plus aspiration, drainage ou marsupialisation). On remarque que dans le premier groupe la mortalité opératoire a été de 26% tandis que dans le second elle s'est élevée à 47%. Dans le groupe des opérations radicales il parait digne de souligner les différences de mortalité existentes entre les extirpations primaires (29%) et les extirpations secondaires (16%), ce dernier type de traitement étant celui qui a donné les meilleurs résultats. La mortalité plus élevée du groupe où furent employées les techniques conservatrices ne dépend pas de la gravité des opérations en elles mêmes (qui peut se considérer comme nulle) mais bien du fait que la plupart furent pratiquées sans pénicilline et que l'intervention proprement dite ne peut éliminer la lésion pyogène en sa totalité. Les résultats de cette série d'extirpations radicales nous autorisent à considérer dans l'avenir avec un plus grand optimisme la chirurgie des abcès cérébraux, surtout en tenant compte que le nombre des limitations auquel est astreint l'emploi de cette méthode est pratiquement nul. Les abcès aigus ne représentent pas une contre-indication de l'ablation pour laquelle l'attente de l'encapsulation de l'abcès n'est pas nécessaire, excluant par conséquent les complications plus ou moins graves qui pourraient apparaitre au cours de ce délai opératoire.
    Notes: Zusammenfassung Es werden 23 Fälle von Gehirnabszessen nach radikalen Methoden operiert (die größere Anzahl davon in Verbindung mit Penicillin) mit einer zweiten Gruppe von 23 Fällen, nach nicht radikalen Methoden operiert (wiederholte Aspirationen, Dekompression plus Aspiration, Drainage, Marsupialisation) verglichen. In der ersten Gruppe betrug die Sterblichkeit 26%, während sie sich in der zweiten auf 47% belief. Bemerkenswert erscheint uns innerhalb der Gruppe der radikalen Operationen der Unterschied in der Sterblichkeit der primären Operationen (29%) und der sekundären (16%), so daß diese letztere Art der Behandlung die günstigeren Resultate aufweist. Die größere Sterblichkeit in der Gruppe, in welcher konservativere Verfahren angewandt wurden, ist nicht der Schwere der Operationen an sich (die als gering betrachtet werden kann) zuzuschreiben, sondern dem Umstand, daß die meisten Operationen ohne Penicillin ausgeführt wurden und daß die eigentliche Intervention öfters eine völlige Entfernung der pyogenen Läsion nicht erreichte. Die günstigen Ergebnisse unserer Serie von radikalen Exstirpationen erlaubt uns für die Zukunft einen größeren Optimismus bezüglich der Chirurgie von Gehirn-Abszessen, besonders wenn man in Betracht zieht, daß die Zahl der Einschränkungen, denen die Anwendung der erwähnten Methode unterworfen ist, sehr gering ist und daß weder die akuten Abszesse von ihr ausgeschlossen sind, noch die Notwendigkeit besteht, die Einkapselung des Abszesses abzuwarten, eine Verzögerung, die oft Anlaß von tödlichen Komplikationen sein kann.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Striatal neurons that contain GABA and enkephalin and project to the external segment of the pallidum are thought to be overactive in Parkinson's disease. Furthermore, it has been shown that the appearance of l-dopa-induced dyskinesias is correlated to an increase of preproenkephalin (PPE) mRNA expression and that some antagonists of glutamate receptors can prevent and reverse l-dopa-induced dyskinesias in parkinsonian rats. The aim of this study was therefore to analyse the effect of a systemic treatment with glutamate receptor antagonists, alone or in combination with l-dopa, on the PPE mRNA level in rats with a 6-hydroxydopamine-induced unilateral lesion of the nigrostriatal pathway. In vehicle-treated animals, PPE mRNA levels were markedly increased in the striatum on the lesioned side. Sub-chronic l-dopa treatment, with bi-daily injections for 22 days, induced a further increase in PPE mRNA expression in the denervated striatum. Administration of the AMPA receptor antagonist, LY293558, partially reversed the lesion-induced and l-dopa-induced increases in PPE mRNA expression. However, although the administration of the NMDA receptor antagonist MK801 showed a tendency to decrease this l-dopa induced overexpression, it did not reach significance. This study provides evidence that glutamatergic antagonists, and particularly AMPA antagonists, tend to reverse PPE neurochemical changes at the striatal level induced by l-dopa in hemiparkinsonian rats.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1619-7089
    Keywords: Normal young subjects ; Normal aged subjects ; Single-photon emission tomography ; Hexamethylpropylene amine oxime ; Regional cerebral blood flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of this study was to investigate the normal pattern of regional cerebral blood flow (rCBF) distribution in normal young and aged volunteers using technetium-99m hexamethylpropylene amine oxime (99m-Te-HMPAO) as a tracer. The region brain perfusion of young and aged subjects was compared, especially regarding rCBF differences due to age and gender, and interhemispheric rCBF asymmetries. Sixty-eight right-handed normal volunteers — 40 young (mean age 29.5±6.3 years) and 28 aged (mean age 71.2±4.3 years) — were included in the study. rCBF was estimated on the basis of a semiquantitative approach by means of a left/right index and two region/reference ratios, using the cerebellum and the whole brain activity as references. A good correlation between these two region/reference ratios was found (P〈0.005 in all cerebral regions). The highest rCBF ratios corresponded to the cerebellum, followed by the occipital lobe. The remaining cortical regions (temporal, parietal, frontal and basal ganglia) showed slightly lower values. The white matter showed rCBF ratios substantially lower than the grey matter. In neither young nor aged subjects were significant rCBF differences between the genders found in any of the two region/reference indices employed. Aged subjects showed significantly lower rCBF ratios than young subjects in the left frontal lobe and in the posterior region of the left temporal lobe. In both young and aged subjects, lower perfusion was found in the left hemisphere, except for the white matter region in both age groups and the frontal lobe in the young subjects. Aged subjects presented a slightly higher interhemispheric asymmetry in the frontal lobe. However, interhemispheric asymmetry was minimal (−1.01% to 3.14%). Consequently, a symmetrical rCBF distribution can be assumed between homologous regions, independent of age.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 9 (1961), S. 297-319 
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Das klinische Bild der primären Tumoren des 3. Ventrikels ist manchmal nur durch das Syndrom der intracraniellen Drucksteigerung geprägt. Intermittierendes Auftreten von Symptomen, manchmal hervorgerufen durch Lageänderungen des Kopfes, ist in gewisser Hinsicht charakteristisch für Kolloidcysten. Die symptomfreien Intervalle können bis zu 10 Jahre andauern. In manchen Fällen kann das Syndrom der intracraniellen Drucksteigerung vollständig verdeckt sein. Ebenso wie die eben erwähnten Symptome, die als eigentliche Ventrikelsymptome zu bezeichnen wären, können eine Anzahl von Störungen beobachtet werden, die den Strukturen der Nachbarschaft zuzuordnen sind. Sie werden entweder unmittelbar durch Druckeinwirkung auf die Ventrikelwand oder durch eine Beeinträchtigung der Blutversorgung paraventrikulärer Zellgruppen verursacht. Hierzu gehören cerebellare, extrapyramidale oder pyramidale Zeichen, Parästhesien oder Schmerzen in den Gliedmaßen, hypothalamische Symptome, Gesichtsfeldausfälle und tonische Anfälle mit Enthirnungsstarre oder Rückbeugung des Kopfes. Das Hirnstrombild zeigt in der Regel diffuse bilaterale Störungen, meist Gruppen von Theta- oder Delta-Wellen. Pinealistumoren, welche in den rückwärtigen 3. Ventrikel einwachsen, sind charakterisiert durch die Kombination von Symptomen eines Hydrocephalus mit Augenmuskelstörungen (Parinaudsches Syndrom), zentraler Taubheit, cerebellaren Störungen und endokrinen Ausfällen, wie Macrogenitosomia praecox (selten), Diabetes insipidus (bei 25% der Fälle) und Dystrophia adiposogenitalis (nur ausnahmsweise).
    Abstract: Summary The clinical picture of the primary tumors of the third ventricle is sometimes limited to a syndrome of raised intracranial pressure. Intermitent presentation of symptoms — sometimes brought about by postural head changes — is, to a certain point, characteristic of colloid cysts. The intervals of freedom from symptoms may last as long as 10 years. In certain cases, the syndrome of increased intracranial pressure may be completely blurred. As well as the above mentioned symptoms, which are, in reality, the true ventricular syndrome, a series of disturbances referring to neighbouring nervous structures may be observed. These are produced by compression of the ventricular walls or by defective blood irrigation of the paraventricular cell groups. Among them we may mention cerebellar, extrapyramidal or pyramidal signs, paraesthesias or pains in the limbs, hypothalamic symptoms, visual field defects and tonic fits with decerebrate rigidity or retroflexion of the head. Electroencephalography usually shows diffuse bilateral disturbances, generally bursts of 5 to 6 cps. activity. Pineal tumors which involves the posterior third ventricle, are characterised by the association of symptoms of hydrocephalus with eye signs (Parinaud symptom complex), central deafness, cerebellar signs and endocrine disturbances: macrogenitosomia praecox (infrequent), diabetes insipidus (in 25% of cases) and dystrophia adiposogenitalis (quite exceptional).
    Notes: Resumen Las manifestacíones de los tumores intrínsecos del III ventrículo quedan a menudo reducidas a un cuadro de hipertensión intracraneal. Es hasta cierto punto característico de los quistes coloides la presentación intermitente de los síntomas, a veces provocada por cambios de posición de la cabeza. Los intervalos libres pueden prolongarse hasta más de 10 años. En ciertos casos, el síndrome de hipertensión intracraneal puede quedar completamente esfumado. Además de los síntomas de hipertensión, que representan en realidad el síndrome ventricular propriamente dicho, pueden observarse una serie de manifestaciones de vecindad producidas por la compresión de las paredes del ventrículo o por una defectuosa irrigación sanguínea de los grupos celulares paraventriculares. Entre las mismas mencionaremos trastornos psíquicos, manifestaciones cerbelosas, síntomas extrapiramidales o piramidales, parestesias o dolores en las extremidades, síntomas diencefálicos, síntomas por parte de las vías ópticas y crisis tónicas de rigidez decerebrada o de retroflexión de la cabeza. La exploración electroencefalográfica muestra anomalías difusas y bilaterales, generalmente salvas de ondas theta o delta. Los tumores pineales se caracterizan por la asociación de síntomas de hipertensión intracraneal a un sindrome de Parinaud, sordera central, manifestaciones cerebelosas y trastornos endocrinos: macrogenitosomia precoz (de observación poco frecuente), diabetes insípida (en un 25% de los casos), distrofia adiposo-genital (observada excepcionalmente).
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 3 (1953), S. 369-388 
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary 5 cases of glioma of the lateral ventricle are reported (2 astrocytomas, 2 glioblastomas and 1 glioepithelioma). 4 of these cases have been operated on, resulting in one postoperatory death. Although there is no doubt as to the existence of circumscribed ependymomas of the lateral ventricles (observations ofBailey, Olivecrona, Ostertag et al.), our cases tend to confirm the opinion, put forward byJefferson andJackson, that the circumscribed ependymoma of the lateral ventricle is a relatively rare tumor and occurs less frequently than other types of initraventricular gliomas. The majority of deep ependymomas of the hemisphere are generally paraventricular tumors. The only ependymal tumor of this series shows itself in the form of a diffused mass filling the frontal horn and the cella media. It is worth mentioning the possibility of a glioblastoma multiforme growing within the cavity of a lateral ventricle because it represents a variation in the usual location of such tumors and, contrary to other deep glioblastomas (brain stem, diencephalon, etc.), offers a certain operatory interest.
    Abstract: Résumé On rapporte 5 cas de gliomes du ventricule latéral (2 astrocytomes, 2 glioblaslomes et 1 glioépithéliome). Quatre de ces malades ont été opères: il n'y a eu qu'un seul décès postopératoire. Quoiqu'on ne doute nullement de l'existence d'épendymomes circonscrits des ventricules latéraux (observations deBailey, Olivecrona, Ostertag et d'autres), nos données concordant avec celles deJefferson etJackson, suivant lesquelles l'épendymome circonscrit du ventricule latéral est une tumeur assez rare que se présente moins souvent que les autrés gliomes intraventriculaires. La plupart des épendymomes profonds de l'hémisphère sont généralement des tumeurs paraventriculaires. L'unique tumeur épendymaire de cette série, se présente sous forme d'une masse diffuse qui remplissait la corne frontale et le corps du ventricule. La possibilité d'un glioblastome multiforme se développant dans la cavité d'un ventricule latéral (observation 4), nous semble digne d'être prise en considération, car il s'agit d'une modalité topographique offrant un certain intérêt opératoire, ce qui n'est pas le cas avec les autres glioblastomes profonds (tronc cérébral, diencéphale, etc.).
    Notes: Zusammenfassung Es werden fünf Fälle von Gliomen der Seitenventrikel (zwei Astrocytome, zwei Glioblastome und ein Glioepitheliom) angeführt. Vier dieser Fälle wurden operiert, davon ein postoperativer Exitus. Obwohl das Bestehen von umschriebenen Ependimomen der Seitenventrikel nicht bezweifelt werden kann (Beobachtungen vonBailey, Olivecrona, Ostertag u. a.), begünstigt unsere Serie die Meinung (geäußert vonJefferson undJackson), daß das umschriebene Ependimom der Seitenventrikel in Wirklichkeit ein relativ seltener Tumor ist und weniger häufig auftritt als andere Arten von intraventrikulären Gliomen. Die Mehrzahl der tiefen Ependymomen der Hemisphären sind gewöhnlich paraventrikuläre Tumore. Der einzige ependymäre Tumor, der in diese Serie fällt, trat in der Form einer diffusen Masse auf, die das frontale Horn und den Ventrikel ausfüllte. Die Möglichkeit, daß ein Glioblastoma multiforme sich anfänglich nach der Höhle eines Seitenventrikels hin entwickelt (Beobachtung 4) scheint uns besonders erwähnenswert, da es sich um eine topographische Modalität des Glioblastoms handelt, die ein gewisses operatives Interesse darbietet, zum Unterschied von den übrigen tiefen Glioblastomen (Gehirnstamm, Diencephal usw.).
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 5 (1957), S. 371-384 
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In a personal series of 21 cases of brain cysticercosis, 12 cases proved to have epileptic seizures, but only 4 cases among them (the number 9, 10, 11 and 12, the most characteristic features of which have been presented in this paper) seem to fit in the term epilepsy by cysticercosis. This type of brain cysticercosis in which the epileptic symptomatology takes charge of the whole clinical picture, concerns the field of surgery of epilepsy and makes up a special chapter from the same.
    Abstract: Résumé Dans une série personnelle de 21 observations de cysticercose cérébrale on a observé 12 cas avec manifestations épileptiques. Seulement 4 cas, parmi ceux-ci (numéros 9, 10, 11 et 12, dont les traits plus caractéristiques ont été consignés dans le présent travail) méritent d'être classées sous le nom d'épilepsie par cysticerques. Ce type de cysticercose cérébrale, dans lequelle les manifestations épileptiques constituent d'un façon exclusive ou presque exclusive, la totalité du tableaux clinique, représente une modalité particulière dans le très large domaine de la chirurgie de l'épilepsie.
    Notes: Zusammenfassung In einer persönlichen Serie von 21 Beobachtungen über Gehirncysticerkose haben wir in 12 Fällen epileptische Äußerungen beobachtet. Jedoch nur bei 4 dieser Fälle (die Nummern 9, 10, 11 und 12), über deren wesentlichste Merkmale wir in dieser Arbeit berichten, trifft die Bezeichnung Cysticerken-Epilepsie wirklich zu. Diese Art der Gehirncysticerkose, in der die epileptischen Äußerungen ausschließlich oder fast ausschließlich die Totalität des klinischen Bildes ausmachen, bildet eine besondere Modalität innerhalb des Bereiches der Epilepsiechirurgie.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 7
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 8
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Inactivation of the subthalamic nucleus (STN) or the internal segment of the pallidum (GPi)/entopeduncular nucleus (EP) by deep brain stimulation or lesioning alleviates clinical manifestations of Parkinson's disease (PD) as well as reducing the side-effects of levodopa treatment. However, the effects of STN or entopeduncular nucleus (EP) lesion on levodopa-related motor fluctuations and on neurochemical changes induced by levodopa remain largely unknown. The effects of such lesions on levodopa-induced motor alterations were studied in 6-hydroxydopamine (6-OHDA)-lesioned rats and were assessed neurochemically by analyzing the functional activity of the basal ganglia nuclei, using the expression levels of the mRNAs coding for glutamic acid decarboxylase and cytochrome oxidase as molecular markers of neuronal activity. At the striatal level, preproenkephalin (PPE) mRNA levels were analyzed. We found in 6-OHDA-lesioned rats that a unilateral STN or EP lesion ipsilateral to the 6-OHDA lesion had no effect on either the shortening in the duration of the levodopa-induced rotational response or the levodopa-induced biochemical changes in the basal ganglia nuclei. In contrast, overexpression of PPE mRNA due to levodopa treatment was reversed by the STN or EP lesion. Our study thus shows that lesion of the EP or STN may counteract some of the neurochemical changes induced by levodopa treatment within the striatum.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 9
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Activation of glial cells is a prevalent response to neuronal damage in brain disease and ageing, with potential neuroprotective and neurotoxic consequences. We were interested in studying the role of glial activation on dopaminergic neurons of the substantia nigra in an animal model of Parkinson's disease. Thus, we evaluated the effect of a pre-existing glial activation on the dopaminergic neuronal death induced by striatal infusion of 6-hydroxydopamine. We established a model of local glial activation by stereotaxic infusion of interleukin-1β in the substantia nigra of adult rats. Interleukin-1β (20 ng) induced a marked activation of astrocytes at days 2, 5 and 10, revealed by heat-shock protein 27 and glial fibrillary acid protein immunohistochemistry, but did not affect the microglial markers OX-42 and heat-shock proteins 32 or 47. Intranigral infusion of interleukin-1β 5 days before a striatal injection of 6-hydroxydopamine significantly protected nigral dopaminergic cell bodies, but not striatal terminals from the 6-hydroxydopamine lesion. Also, in the animals pre-treated with interleukin-1β, a significant prevention of 6-hydroxydopamine-induced reduction of adjusting steps, but not of 6-hydroxydopamine-induced amphetamine rotations, were observed. These data show the characterization of a novel model of local astroglial activation in the substantia nigra and support the hypothesis of a neuroprotective role of activated astrocytes in Parkinson's disease.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 10
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: In Parkinson’s disease, nigrostriatal denervation leads to an overactivity of the subthalamic nucleus and its target areas, which is responsible of the clinical manifestations of the disease. Because the subthalamic nucleus uses glutamate as neurotransmitter and is innervated by glutamatergic fibers, pharmacological blockade of glutamate transmission might be expected to restore the cascade of neurochemical changes induced by a dopaminergic denervation within the basal ganglia. To test this hypothesis, two types of glutamate antagonists, the NMDA receptor antagonist MK-801 and the α-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptor antagonist LY293558, were administered systemically, either alone or in combination with L-DOPA, in rats with a unilateral 6-hydroxydopamine lesion of the nigrostriatal dopamine pathway. The effect of treatment was assessed neurochemically by analyzing at the cellular level the functional activity of basal ganglia output structures and the subthalamic nucleus using the expression levels of the mRNAs coding for glutamic acid decarboxylase and cytochrome oxidase, respectively, as molecular markers of neuronal activity. The present study shows that treatment with glutamate antagonists, and particularly with AMPA antagonists, alone or in combination with L-DOPA, reverses the overactivity of the subthalamic nucleus and its target areas induced by nigrostriatal denervation. These results furnish the neurochemical basis for the potential use of glutamate antagonists as therapeutic agents in Parkinson’s disease.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...