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  • 1
    Keywords: CANCER ; radiotherapy ; carcinoma ; human ; neoplasms ; DIAGNOSIS ; RISK ; PATIENT ; kidney ; RISK-FACTORS ; CARCINOGENESIS ; colon ; ASSOCIATION ; BREAST ; LYMPHOMA ; AGE ; OVARIAN-CANCER ; risk factors ; CERVICAL-CANCER ; RATES ; cancer risk ; REGISTRATION ; CANCER-PATIENTS ; adenocarcinoma ; TOBACCO ; pancreatic cancer ; LONG-TERM SURVIVORS ; YOUNG ; REGISTRY ; REPRODUCTIVE FACTORS ; ASSOCIATIONS ; ENDOMETRIAL ; PANCREATIC-CANCER ; cancer registries ; TESTICULAR CANCER ; LYMPHOMAS ; cancer registry ; pooled analysis ; RISK-FACTOR ; CANCERS ; REGISTRIES ; CANCER-DIAGNOSIS ; pancreatic neoplasms ; MALIGNANT NEOPLASMS ; neoplasms,second primary
    Abstract: Studies of pancreatic cancer in the setting of second primary malignant neoplasms can provide etiologic clues. An international multicenter study was carried out using data from 13 cancer registries with a registration period up to year 2000. Cancer patients were followed up from the initial cancer diagnosis, and the occurrence of second primary malignant neoplasms was compared with expected values derived from local rates, adjusting for age, sex, and period of diagnosis. Results from individual registries were pooled by use of a fixed-effects model. People were at higher risk of developing pancreatic cancer within 10 years of a diagnosis of cancers of the pharynx, stomach, gallbladder, larynx, lung, cervix, corpus uteri, bladder, and eye and 10 years or later following a diagnosis of cancers of the stomach, colon, gallbladder, breast, cervix, placenta, corpus uteri, ovary, testis, bladder, kidney, and eye, as well as Hodgkin's and non-Hodgkin's lymphomas. Pancreatic cancer was connected with smoking-related cancers, confirming the etiologic role of tobacco. The associations with uterine and ovarian cancers suggest that reproductive factors might be implicated in pancreatic carcinogenesis. The elevated pancreatic cancer risk in young patients observed among several types of cancer implies a role of genetic factors. Radiotherapy is also suggested as a risk factor
    Type of Publication: Journal article published
    PubMed ID: 16421239
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  • 2
    Keywords: CANCER ; carcinoma ; neoplasms ; DIAGNOSIS ; FOLLOW-UP ; COHORT ; EPIDEMIOLOGY ; incidence ; POPULATION ; RISK ; RISKS ; SITE ; PATIENT ; prognosis ; RISK-FACTORS ; treatment ; LINKAGE ; DESIGN ; NUMBER ; AGE ; risk factors ; CANCER-PATIENTS ; CANCER PATIENTS ; TRENDS ; REGISTRY ; cancer registries ; PRIMARY TUMORS ; SWITZERLAND ; INTERVAL ; PRIMARY NEOPLASMS ; second primary cancers ; cancer registry ; pooled analysis ; RISK-FACTOR ; CANCERS ; REGISTRIES ; population-based ; PRIMARY MALIGNANCIES ; second primary cancer
    Abstract: Context: Increasing incidence and improved prognosis of thyroid cancer have led to concern about the development of second primary cancers, especially after radioiodine treatment. Thyroid cancer can also arise as a second primary neoplasm after other cancers. Objective: The objective of the study was to assess the risk of second primary cancer after thyroid cancer and vice versa. Design: This was a multinational record linkage study. Setting: The study was conducted at 13 population-based cancer registries in Europe, Canada, Australia, and Singapore. Patients or Other Participants: A cohort of 39,002 people (356,035 person-yr of follow-up) with primary thyroid cancer were followed up for SPN for up to 25 yr, and 1,990 cases of thyroid cancer were diagnosed after another primary cancer. Main Outcome Measures: To assess any possible excess of second primary neoplasms after thyroid cancer, the observed numbers of neoplasms were compared with expected numbers derived from age-, the cancer registries, yielding standardized incidence ratios (SIRs). The SIR of second primary thyroid cancer after various types of cancer was also calculated. Results: During the observation period, there were 2821 second primary cancers (all sites combined) after initial diagnosis of thyroid cancer, SIR of 1.31 ( 95% confidence interval 1.26 - 1.36) with significantly elevated risks for many specific cancers. Significantly elevated risks of second primary thyroid cancer were also seen after many types of cancer. Conclusion: Pooled data from 13 cancer registries show a 30% increased risk of second primary cancer after thyroid cancer and increased risks of thyroid cancer after various primary cancers. Although bias (detection, surveillance, misclassification) and chance may contribute to some of these observations, it seems likely that shared risk factors and treatment effects are implicated in many. When following up patients who have been treated for primary thyroid cancer, clinicians should maintain a high index of suspicion for second primary cancers
    Type of Publication: Journal article published
    PubMed ID: 16478820
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  • 3
    Keywords: CANCER ; carcinoma ; CELL ; LUNG ; PROSTATE ; COHORT ; EXPOSURE ; incidence ; liver ; RISK ; PATIENT ; kidney ; primary ; SKIN ; BREAST ; BREAST-CANCER ; LYMPHOMA ; DIFFERENCE ; DECREASE ; NUMBER ; AGE ; COUNTRIES ; PROSTATE-CANCER ; RATES ; skin cancer ; MELANOMA ; SWEDEN ; COLON-CANCER ; STOMACH ; SIR ; UNITED-STATES ; AUSTRALIA ; second cancer ; SKIN-CANCER ; basal cell carcinoma ; NON-HODGKINS-LYMPHOMA ; CELL CARCINOMA ; ONCOLOGY ; REGISTRY ; pancreas ; cancer registries ; non-Hodgkin lymphoma ; methods ; cancer registry ; CANCER INCIDENCE ; female ; CANCERS ; REGISTRIES ; E ; colorectal ; BASAL-CELL CARCINOMA ; second primary cancer ; SUN EXPOSURE ; vitamin D ; VITAMIN-D ; ULTRAVIOLET-RADIATION ; SUBSEQUENT RISK ; D METABOLITES
    Abstract: Background: Skin cancers are known to be associated with sun exposure, whereas sunlight through the production of vitamin D may protect against some cancers. The aim of this study was to assess whether patients with skin cancer have an altered risk of developing other cancers. Methods: The study cohort consisted of 416,134 cases of skin cancer and 3,776,501 cases of non-skin cancer as a first cancer extracted from 13 cancer registries. 10,886 melanoma and 35,620 non-melanoma skin cancer cases had second cancers. The observed numbers (0) of 46 types of second primary cancer after skin melanoma, basal cell carcinoma or non-basal cell carcinoma, and of skin cancers following non-skin cancers were compared to the expected numbers (E) derived from the age, sex and calendar period specific cancer incidence rates in each of the cancer registries (O/E = SIR, standardised incidence ratios). Rates from cancer registries classified to sunny countries (Australia, Singapore and Spain) and less sunny countries (Canada, Denmark, Finland, Iceland, Norway, Scotland, Slovenia and Sweden) were compared to each other. Results: SIR of all second solid primary cancers (except skin and lip) after skin melanoma were significantly lower for the sunny countries (SIR(S) = 1.03; 95% CI 0.99-1.08) than in the less sunny countries (SIR(L) = 1.14; 95%CI 1.11-1.17). The difference was more obvious after non-melanoma skin cancers: after basal cell carcinoma SIR(S)/SIR(L) = 0.65 (9S%CI = 0.58-0.72); after non-basal cell carcinoma SIR(S)/SIR(L) = 0.58 (95%CI = 0.50-0.67). In sunny countries, the risk of second primary cancer after non-melanoma skin cancers was lower for most of the cancers except for lip, mouth and non-Hodgkin lymphoma. Conclusions: Vitamin D production in the skin seems to decrease the risk of several solid cancers (especially stomach, colorectal, liver and gallbladder, pancreas, lung, female breast, prostate, bladder and kidney cancers). The apparently protective effect of sun exposure against second primary cancer is more pronounced after non-melanoma skin cancers than melanoma, which is consistent with earlier reports that non-melanoma skin cancers reflect cumulative sun exposure, whereas melanoma is more related to sunburn. (c) 2007 Elsevier Ltd. All rights reserved
    Type of Publication: Journal article published
    PubMed ID: 17540555
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  • 4
    Keywords: CANCER ; LUNG ; DIAGNOSIS ; FOLLOW-UP ; lung cancer ; LUNG-CANCER ; EPIDEMIOLOGY ; incidence ; POPULATION ; RISK ; SITE ; SITES ; PATIENT ; primary ; PATTERNS ; NUMBER ; AGE ; smoking ; RATES ; cancer risk ; REGION ; FRANCE ; SQUAMOUS-CELL CARCINOMA ; HEAD ; ALCOHOL ; PREVALENCE ; TOBACCO SMOKING ; second cancer ; MULTICENTER ; NECK-CANCER ; ONCOLOGY ; REGISTRY ; RE ; PATTERN ; head and neck cancer ; cancer registries ; SURVIVORS ; analysis ; MALIGNANT-TUMORS ; cancer registry ; pooled analysis ; USA ; CANCER INCIDENCE ; CANCERS ; population-based ; CANCER-RISK ; NOV ; ORAL-CAVITY ; ALCOHOL-DRINKING ; EXCESS ; POOLED-ANALYSIS ; second primary ; YOUNG-PATIENTS
    Abstract: The objective of the study was to assess the risk of second primary cancers (SPCs) following a primary head and neck cancer (oral cavity, pharynx and larynx) and the risk of head and neck cancer as a PC. The present investigation is a multicenter study from 13 population-based cancer registries. The study population involved 99,257 patients with a first primary head and neck cancer and contributed 489,855 person-years of follow-up. To assess the excess risk of SPCs following head and neck cancers, we calculated standardized incidence ratios (SIRs) by dividing the observed numbers of SPCs by the expected number of cancers calculated from accumulated person-years and the age, sex- and calendar period-specific first primary cancer incidence rates in each of the cancer registries. During the observation period, there were 10,826 cases of SPCs after head and neck cancer. For all cancer sites combined, the SIR of SPCs was 1.86 (95% CI = 1.83-1.90) and the 20-year cumulative risk was 36%. Lung cancer contributed to the highest proportion of the SPCs with a 20-year cumulative risk of 13%. Excess second head and neck cancer risk was observed 10 years after diagnosis with lymphohaematopoietic cancers. The most common SPC following a first primary head and neck cancer was lung cancer. However, the highest excess of SPCs was in the head and neck region. These patterns were consistent with the notion that the pattern of cancer in survivors of head and neck cancer is dominated by the effect of tobacco smoking and alcohol drinking. (C) 2008 Wiley-Liss, Inc
    Type of Publication: Journal article published
    PubMed ID: 18729183
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  • 5
    Keywords: CANCER ; LUNG ; neoplasms ; DIAGNOSIS ; FOLLOW-UP ; lung cancer ; LUNG-CANCER ; COHORT ; DISEASE ; RISK ; TIME ; PATIENT ; treatment ; BREAST ; breast cancer ; BREAST-CANCER ; MALIGNANCIES ; AGE ; BRCA1 ; OVARIAN-CANCER ; colorectal cancer ; smoking ; COLORECTAL-CANCER ; chemotherapy ; leukemia ; BLADDER-CANCER ; MUTATIONS ; paclitaxel ; MALIGNANCY ; ONCOLOGY ; REGRESSION ; FAMILIES ; INCREASE ; leukaemia ; female ; CANCERS ; RARE ; colorectal ; INCREASES ; multi-centre cohort study ; second primary cancer ; primary fallopian tube cancer ; PRIMARY-CARCINOMA
    Abstract: Primary fallopian tube cancer (PFTC) is a rare disease, and its aetiological factors are poorly understood. Studies on PFTC in the setting of 2nd primary malignant neoplasms can provide clues on aetiology and also define the possible side effects of different treatment modalities for PFTC. A cohort of 2,084 cases with first PFTC was extracted from the data from 13 cancer registries from Europe, Canada, Australia and Singapore and followed for second primary cancers within the period 1943-2000. Standardized incidence ratios (SIRs) were calculated and Poisson regression analyses were done to find out the RRs related to age at, period or and time since the PFTC diagnosis. There were 118 cancer cases observed after first PFTC (SIR 1.4, 95%CI 1.1-1.6). Elevated SIRs were seen for colorectal cancer (1.7, 95%CI 1.0-2.6), for breast cancer (1.5, 95%CI 1.1-2.2), for bladder cancer (2.8, 95%CI 1.0-6.0), for lung cancer (1.8, 95% CI 0.9-3.2) and for nonlymphoid leukaemia (3.7, 95%CI 1.0-9.4). Significant risk increases were detected for colorectal cancer during the 2nd to 5th year after the first PFTC diagnosis, for breast cancer in follow-up 10+ and for nonlymphoid leukaemia during the 2nd to 10th year. The clustering of cancers of the lung and bladder in PFTC patients may suggest shared smoking aetiology. The excess of colorectal and breast cancers after PFTC may indicate a genetic aetiology. (c) 2007 Wiley-Liss, Inc
    Type of Publication: Journal article published
    PubMed ID: 17266029
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  • 6
    Keywords: CANCER ; carcinoma ; CELL ; LUNG ; PROSTATE ; DIAGNOSIS ; FOLLOW-UP ; lung cancer ; LUNG-CANCER ; DEATH ; EPIDEMIOLOGY ; incidence ; RISK ; FAMILY ; ASSOCIATION ; BREAST ; breast cancer ; BREAST-CANCER ; MALIGNANCIES ; PATTERNS ; AGE ; ovarian cancer ; OVARIAN-CANCER ; WOMEN ; CIGARETTE-SMOKING ; MEN ; PROSTATE-CANCER ; adenocarcinoma ; EUROPE ; ONCOLOGY ; small cell lung carcinoma ; ASSOCIATIONS ; PATTERN ; METAANALYSIS ; development ; HORMONES ; CANCERS ; SQUAMOUS-CELL ; sex differences ; SPCs
    Abstract: BACKGROUND: Patterns of second primary cancers (SPCs) following first primary lung cancers (FPLCs) may provide aetiological insights into FPLC. METHODS: Cases of FPLCs in 13 cancer registries in Europe, Australia, Canada, and Singapore were followed up from the date of FPLC diagnosis to the date of SPC diagnosis, date of death, or end of follow-up. Standardised incidence ratios (SIRs) were calculated to estimate the magnitude of SPC development following squamous cell carcinoma (SCC), small cell lung carcinoma (SCLC), and adenocarcinoma (ADC). RESULTS: Among SCC patients, male SIR = 1.58 (95% confidence interval (CI) 1.50-1.66) and female SIR = 2.31 (1.94-2.72) for smoking-related SPC. Among SCLC patients, the respective ratios were 1.39 (1.20-1.60) and 2.28 (1.73-2.95), and among ADC patients, they were 1.73 (1.57-1.90) and 2.24 (1.91-2.61). We also observed associations between first primary lung ADC and second primary breast cancer in women (SIR = 1.25, 95% CI 1.05-1.48) and prostate cancer (1.56, 1.39-1.79) in men. CONCLUSION: The FPLC patients carried excess risks of smoking-related SPCs. An association between first primary lung ADC and second primary breast and ovarian cancer in women at younger age and prostate cancers in men may reflect an aetiological role of hormones in lung ADC. British Journal of Cancer (2010) 102, 1190-1195. doi:10.1038/sj.bjc.6605616 www.bjcancer.com (C) 2010 Cancer Research UK
    Type of Publication: Journal article published
    PubMed ID: 20354532
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  • 7
    Keywords: neoplasms ; FOLLOW-UP ; RISK ; UNITED-STATES ; CHILDREN ; SURVIVORS ; EWINGS-SARCOMA ; soft-tissue sarcoma ; WILMS-TUMOR ; childhood solid cancer ; INTERNATIONAL-CLASSIFICATION ; second malignant neoplasm
    Abstract: Children diagnosed with noncentral nervous system solid cancers (NCNSSC) experience several adverse late effects, including second malignant neoplasm. The aim of our study was to assess the risk of specific second malignancies after a childhood NCNSSC. Diagnosis and follow-up data on 10,988 cases of NCNSSC in children (0-14 years) were obtained from 13 registries. Standardized incidence ratios (SIRs) with 95% confidence intervals (CI) and cumulative incidence of second malignancies were computed. We observed 175 second malignant neoplasms, yielding a SIR of 4.6, 95% CI: 3.9-5.3. When considering second cancers with at least 10 occurrences, highest relative risks were found for second malignant bone tumors (SIR = 26.4, 16.6-40.0), soft tissue sarcomas (SIR = 14.1, 6.7-25.8) and myeloid leukemia (SIR = 12.7, 6.3-22.8). Significant increased risks for all malignancies combined were observed after sympathetic nervous system tumors (SIR = 11.4, 5.2-21.6), retinoblastomas (SIR = 7.3, 5.4-9.8), renal tumors (SIR = 5.7, 3.8-8.0), malignant bone tumors (SIR = 5.6, 3.7-8.2), soft tissue sarcomas (SIR = 4.7, 3.2-6.8), germ-cell, trophoblastic and other gonadal neoplasms (SIR = 2.5, 1.1-4.9), carcinomas and other malignant epithelial neoplasms (SIR = 2.2, 1.4-3.3). The highest risk of a second malignancy of any type occurred 5 to 9 years after NCNSSC (SIR = 9.9, 6.8-13.9). The cumulative incidence of second malignancies 10 years after the first neoplasm was eight times higher among NCNSSC survivors than in the general population, with the absolute difference between observed and expected cumulative incidence still increasing after 50 years of follow-up. Children who survived a NCNSSC experience a large increased risk of developing a new malignancy, even many years after their initial diagnosis
    Type of Publication: Journal article published
    PubMed ID: 21520035
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  • 8
    Keywords: CANCER ; carcinoma ; PATHWAY ; PATHWAYS ; RISK ; GENE ; TUMORS ; TIME ; DNA ; kidney ; MECHANISM ; RISK-FACTORS ; colon ; mechanisms ; SKIN ; ASSOCIATION ; LYMPHOMA ; NUMBER ; AGE ; DNA-REPAIR ; REPAIR ; DIETARY ; ADENOCARCINOMAS ; INDIVIDUALS ; SMALL-INTESTINE ; NONPOLYPOSIS COLORECTAL-CANCER ; 2ND PRIMARY NEOPLASMS ; DNA repair ; CLUSTER ; REGISTRY ; pancreas ; ASSOCIATIONS ; cancer registries ; INCREASE ; GLAND ; SMALL-BOWEL ; INTERVAL ; GENDER ; second primary cancers ; rectum ; cancer registry ; pooled analysis ; CANCER INCIDENCE ; registry-based study ; small intestine cancer
    Abstract: Cancer of the small intestine is a rare neoplasm, and its etiology remains poorly understood. Analysis of other primary cancers in individuals with small intestine cancer may help elucidate the causes of this neoplasm and the underlying mechanisms. We included 10,946 cases of first primary small intestine cancer from 13 cancer registries in a pooled analysis. The observed numbers of 44 types of second primary cancer were compared to the expected numbers derived from the age-, gender- and calendar period-specific cancer incidence rates in each registry. We also calculated the standardized incidence ratios (SIR) for small intestine cancer as a second primary after other cancers. There was a 68% overall increase in the risk of a new primary cancer after small intestine carcinoma (SIR = 1.68, 95% confidence interval [CI] = 1.47-1.71), that remained constant over time. The overall SIR was 1.18 (95% CI = 1.05-1.32) after carcinoid, 1.29 (1.01-1.63) after sarcoma, and 1.27 (0.78-1.94) after lymphoma. Significant (p 〈 0.05) increases were observed for cancers of the oropharynx, colon, rectum, ampulla of Vater, pancreas, corpus uteri, ovary, prostate, kidney, thyroid gland, skin and soft (issue sarcomas. Small intestine cancer as a second primary was increased significantly after all these cancers, except after oropharyngeal and kidney cancers. Although some of the excess may be attributable to overdiagnosis, it is plausible that most additional cases of second primary cancers were clinically relevant and were due to common genetic (e.g., defects in mismatch or other DNA repair pathways) and environmental (e.g., dietary) factors. (c) 2005 Wiley-Liss, Inc
    Type of Publication: Journal article published
    PubMed ID: 16003748
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  • 9
    Keywords: CANCER ; radiotherapy ; SURVIVAL ; FOLLOW-UP ; RISK ; TUMORS ; kidney ; treatment ; BREAST-CANCER ; chemotherapy ; LONG-TERM SURVIVORS ; ETOPOSIDE ; TESTICULAR CANCER ; COMBINATION CHEMOTHERAPY ; leukaemia ; nonseminoma ; BLEOMYCIN ; NORWEGIAN MALE-PATIENTS ; SECONDARY LEUKEMIA ; seminomas
    Abstract: We investigated the risk of second malignancies among 29,511 survivors of germ-cell testicular cancer recorded in 13 cancer registries. Standardized incidence ratios (SIRs) were estimated comparing the observed numbers of second malignancies with the expected numbers obtained from sex-, age-, period- and population-specific incidence rates. Seminomas and nonseminomas, the 2 main histological groups of testicular cancer, were analyzed separately. During a median follow-up period of 8.3 years (0-35 years), we observed 1,811 second tumors, with a corresponding SIR of 1.65 (95% confidence interval (CI): 1.57-1.73). Statistically significant increased risks were found for fifteen cancer types, including SIRs of 2.0 or higher for cancers of the stomach, gallbladder and bile ducts, pancreas, bladder, kidney, thyroid, and for soft-tissue sarcoma. nonmelanoma skin cancer and myeloid leukemia. The SIR for myeloid leukemia was 2.39 (95% CI: 1.41-3.77) after seminomas. and 6.77 (95% CI: 4.14-10.5) after nonseminomas. It increased to 37.9 (95% CI: 18.9-67.8; based on 11 observed cases of leukemia) among nonseminoma patients diagnosed since 1990. SIRs for most solid cancers increased with follow-up duration, whereas they, did not change with year of testicular cancer diagnosis. Among subjects diagnosed before 1980, 20 year survivors of seminoma had a cumulative risk of solid cancer of 9.6% (95% CI: 8.7-10.5%) vs. 6.5% expected, whereas 20 years survivors of nonseminoma had a risk of 5.0% (95% CI: 4.2-6.0%) vs. 3.1% expected. In conclusion, survivors of testicular cancers have an increased risk of several second primaries, where the effect of the treatment seems to play a major role. (c) 2006 Wiley-Liss, Inc
    Type of Publication: Journal article published
    PubMed ID: 17096341
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  • 10
    Keywords: brain ; CANCER ; neoplasms ; DIAGNOSIS ; FOLLOW-UP ; incidence ; POPULATION ; RISK ; RISKS ; TIME ; PATIENT ; SKIN ; BREAST ; breast cancer ; BREAST-CANCER ; LYMPHOMA ; MALIGNANCIES ; EXPERIENCE ; RATES ; leukemia ; ACUTE LYMPHOBLASTIC-LEUKEMIA ; HIGH-RISK ; POPULATIONS ; CHILDREN ; LONG-TERM SURVIVORS ; NON-HODGKINS-LYMPHOMA ; MALIGNANCY ; ONCOLOGY ; CHILDHOOD ; REGISTRY ; POPULATION-BASED COHORT ; cancer registries ; non-Hodgkin lymphoma ; INTERVAL ; methods ; cancer registry ; USA ; UNIT ; HODGKIN LYMPHOMA ; REGISTRIES ; NORDIC COUNTRIES ; GENERAL-POPULATION ; ACUTE LYMPHOCYTIC-LEUKEMIA ; CANCER SURVIVOR ; CRANIAL IRRADIATION ; THYROID-CANCER
    Abstract: Background Survivors of childhood leukemia and lymphoma experience high risks of second malignant neoplasms. We quantified such risk using a large dataset from 13 population-based cancer registries. Methods The registries provided individual data on cases of leukemia, Hodgkin lymphoma, and non-Hodgkin lymphoma occurring in children aged 0-14 years and on subsequent second malignant neoplasms for different time periods from 1943 to 2000. Risks of second malignant neoplasms were assessed through standardized incidence ratios (SIRs) and corresponding 95% confidence intervals (Cls), using the incidence rates in the general populations covered by the registries as a reference. Cumulative absolute risks were also calculated. Results A total of 133 second malignant neoplasms were observed in 16540 patients (12731 leukemias, 1246 Hodgkin lymphomas, and 2563 non-Hodgkin lymphomas) after an average follow-up of 6.5 years. The most frequent second malignancies after leukemia were brain cancer (19 cases, SIR = 8.52, 95% Cl = 5.13 to 13.3), non-Hodgkin lymphoma (nine cases, SIR = 9.41, 95% Cl = 4.30 to 17.9), and thyroid cancer (nine cases, SIR = 18.8, 95% Cl = 8.60 to 35.7); the most frequent after Hodgkin lymphoma were thyroid cancer (nine cases, SIR = 52.5, 95% Cl = 24.0 to 99.6), breast cancer (six cases, SIR = 20.9, 95% Cl = 7.66 to 45.4), and neoplasms of skin (non-melanoma) (six cases, SIR = 34.0, 95% Cl = 12.5 to 74.0); and the most frequent after non-Hodgkin lymphoma were thyroid cancer (six cases, SIR = 40.4, 95% Cl = 14.8 to 88.0) and brain cancer (four cases, SIR = 6.97, 95% Cl = 1.90 to 17.9). Cumulative incidence of any second malignant neoplasm was 2.43% (95% Cl = 1.09 to 3.78), 12.7% (95% Cl = 8.29 to 17.2), and 2.50% (95% Cl = 1.04 to 3.96) within 30 years from diagnosis of leukemia, Hodgkin lymphoma, and non-Hodgkin lymphoma, respectively. Conclusions This population-based study provides, to our knowledge, the most precise and up-to-date estimates for relative and absolute risks of second malignant neoplasms after childhood leukemia and lymphoma
    Type of Publication: Journal article published
    PubMed ID: 17505074
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