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  • 1
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    German Medical Science; Düsseldorf, Köln
    In:  51. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie; 20060910-20060914; Leipzig; DOC06gmds442 /20060901/
    Publication Date: 2006-09-25
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    International urology and nephrology 3 (1971), S. 271-282 
    ISSN: 1573-2584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of angiotensin infused via the renal artery, and subsequently by the venous route, have been studied on the renal function in anaesthetized dogs. 1. Infusion of angiotensin into the renal artery in large doses (0.5 or 1.0 μg per min) produces a fall in the parameters of renal function to a certain level which even more massive doses fail to lower any further. 2. Infusion of angiotensin reduces PAH- and creatinine clearances as well as the excretion of water and sodium. 3. The angiotensin-induced impairment of renal function is attributed to glomerular changes. The results of the present study rule out tubular involvement. 4. The blood pressure changes resulting from administration of angiotensin by the intravenous route are connected with a prompt tachyphylactic effect. 5. In the present study no angiotensin-tachyphylaxis was demonstrable in the renal vessels. 6. The angiotensin-induced retention of sodium and water may reduce the therapeutic value of this substance.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1573-2584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The functional parameters of renal function of non-hydrated and hydrated dogs (saline-infused to an extent of 1–2% of the body weight) have been compared. The directly measured renal blood flow and the total renal vascular resistance were the same in the two groups. No difference has been found in glomerular filtration rate, theC inulin was the same in the two groups. There was no important difference in the PAH clearance and PAH extraction. In the hypervolaemic group, the sodium and water excretion was about threefold that of the non-hydrated animals. The plasma protein concentration was significantly lower in the hydrated group. In our experiments we did not find glomerular factors responsible for the increase of sodium and water excretion. The decrease of tubular reabsorption is attributed partly to the decreased plasma protein concentration, partly to unknown (perhaps natriuretic) humoral factors.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1573-2584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of ethyl alcohol infused directly via the renal artery and by the venous route were studied on the renal function in 10 anaesthetized dogs with the following results: 1) Ethyl alcohol lowers blood pressure. The hypotensive effect is more marked on direct renal arterial than on intravenous infusion. 2) Ethyl alcohol dilates the renal blood vessels parallel with a fall in total renal vascular resistance. 3) Ethyl alcohol reduces the glomerular filtration rate in the anaesthetized dog, as reflected by a reduction in the values of CPAH and Ccreat. 4) Infusion of ethyl alcohol was accompanied by a decrease in the renal excretion of water and sodium, in all likelihood due to an impairment of glomerular function. The results seem to indicate that the effect of ethyl alcohol on the kidney is associated with a readjustment of renal function to a new glomerulo-tubular equilibrium at a reduced level.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    International urology and nephrology 3 (1971), S. 437-440 
    ISSN: 1573-2584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-2013
    Keywords: Dehydration ; Glomerular Filtration Rate ; Isolated Kidney
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The two kidneys of one dog were perfused separately with the same blood pool and at a constant arterial pressure. After the control periods, one of the kidneys was replaced by another one taken from a dehydrated dog. The presence of the “dehydrated” kidney resulted in significant and almost immediate decreases of creatinin clearance, urine flow and sodium excretion by the contralateral kidney, without any change in the overall renal blood flow. These changes disappeared, after the removal of the “dehydrated” kidney. They were not observed if the “dehydrated” kidney was replaced either by a kidney taken from a salt-depleted, non water-deprived dog, or by a simple arterio-venous shunt. These results suggest that in the status of dehydration, the kidney releases some humoral material which might be responsible for the decrease of the measured GFR (C creat) perhaps by the way of permeability changes.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-2013
    Keywords: Sodium Excretion ; Natriuretic Factors ; Transplanted Kidneys
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The increase in fractional excretion of sodium following intravenous infusion of saline has been investigated in dogs fed with sodium-rich or poor diets after transplantation to the neck of these animals of kidneys removed from dogs submitted previously to either diet. The response of “in situ” and of transplanted organs has been compared in the four possible combinations of perfusors and kidney donors. No significant differences were observed between the four series, for the same net saline load, in arterial and venous pressures, extravascular and intravascular expansion, or blood dilution. The response in each series was independent of extracellular expansion and was best related to the degree of blood dilution. However, the magnitude of the response to the same net saline load depended on a resetting of the sensitivity of the kidney itself to the blood changes, this resetting depending on the previous dietary sodium balance. This sensitivity was related also to the presence in the blood of a potentiating material which might be, at least partly, of renal origin, and which might represent an intrarenal mediator of the natriuretic response.
    Type of Medium: Electronic Resource
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