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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Matrix Biology 14 (1994), S. 364-365 
    ISSN: 0945-053X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-5195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé. Nous avons produit des souris transgéniques experimant un collagène mutant α 1(IX) et constaté que ces sujets développaient avec l’âge une dégénérescence progressive des articulations alliée à une dégénérescence accélérée des disques intervertébraux. Les examens radiologiques et histologiques ont montré que ce processus e’tait plus avancé sur les souris transgéniques que sur les sujets de référence. La dégénérescence prend la forme du rétrécissement jusqu’à disparition du tissu pulpeux du noyau cellulaire et d’une fissuration du tissue fibreux annulaire avec, dans certains cas, herniation de la matière discale et légère formation d’ostéophytes. Ces constatations nous suggèrent que les mutations de type collagène IX pourraient entraîner certaines affections dégénératives du rachis et des articulations.
    Notes: Summary. Transgenic mice expressing mutant α 1(IX) collagen were produced and found to develop progressive joint degeneration with age, as well as accelerated intervertebral disc degeneration. Radiological and histological studies showed that cervical and lumbar disc degeneration was more advanced in the transgenic mice than in control litter-mates. The changes included shrinkage or disappearance of the nucleus pulposus, and fissures in the annulus fibrosus which sometimes lead to herniation of disc material and slight osteophyte formation. These findings suggest that mutations of the type IX collagen may cause certain forms of degenerative disease in the spine as well as in joints.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-5195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé. Nous avons proposé une approche intervertébrale à un seul niveau pour décomprimer deux racines de nerfs adjacents ipsilatérales qui étaient impliquées. Cette opération a été réalisée dans 4 cas de radiculopathie cervicale impliquant deux racines de nerfs adjacents. Nous avons effectué une discectomie, une corporectomie partielle et l’ablation de la partie antéromédiale des pédicules ainsi que l’ablation des ostéophytes et du ligament longitudinal postérieur, qui ont été suivies d’une fusion intercorporéale. Il y a eu une diminution de la douleur chez tous les patients et/ou une certaine faiblesse motrice. La fusion rachidienne a été obtenue aves un alignement lordosique normal, sans aucune complication pour l’ensemble des patients. Nous désirons mettre l’accent sur les avantages de cette technique: elle peut conserver le segment en mouvement au niveau d’un disque supplémentaire et elle peut aussi avoir un taux de fusion meilleur qu’une arthrodise corporéale à plusieurs étages.
    Notes: Summary. We describe a single level intervertebral approach to decompress two adjacent involved nerve roots in cases of cervical spondylosis. The operation was undertaken in 4 patients. We carried out discectomy, partial excision of the vertebral body with removal of the anteromedial part of the pedicles, removal of osteophytes and excision of the posterior longitudinal ligament, followed by an anterior interbody fusion. Fusion was achieved with the spine in normal lordosis and without complications. Pain and motor weakness was relieved in every case. This procedure can maintain movement at one additional disc level and has a better fusion rate than multilevel interbody fusion.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1435-232X
    Keywords: Key words Metaphyseal chondrodysplasia Schmid type (MCDS) ; Mutation ; Type X collagen gene (COL10A1) ; Carboxyl-terminal noncollagenous (NC1) domain ; Spondylometaphyseal dysplasia (SMD) ; Type X collagenopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Metaphyseal chondrodysplasia of the Schmid type (MCDS) is a skeletal dysplasia affecting the long bone metaphyses; it is characterized by short stature, bowlegs, and coxa vara. The spine is generally not involved. Here we report a novel missense mutation of the type X collagen gene in a sporadic case of MCDS. The mutation was a heterozygous single base-pair transition of G-to-A at nucleotide 1783, which predicted a substitution of glycine by arginine at codon 595 (G595R) in the carboxyl-terminal noncollagenous domain. Interestingly, another mutation of the same codon, in which glycine is substituted by glutamic acid (G595E), was previously reported to cause spondylometaphyseal dysplasia (SMD), another group of skeletal dysplasias with involvement of the spine in addition to the long tubular bones. The novel G595R mutation identified in the present study supports the concept of type X collagenopathy.
    Type of Medium: Electronic Resource
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  • 6
    Publication Date: 2018-03-29
    Description: Hiroki Goto, Miki Nishio, Yoko To, Tatsuya Oishi, Yosuke Miyachi, Tomohiko Maehama, Hiroshi Nishina, Haruhiko Akiyama, Tak Wah Mak, Yuma Makii, Taku Saito, Akihiro Yasoda, Noriyuki Tsumaki, and Akira Suzuki Hippo signaling is modulated in response to cell density, external mechanical forces, and rigidity of the extracellular matrix (ECM). The Mps one binder kinase activator (MOB) adaptor proteins are core components of Hippo signaling and influence Yes-associated protein 1 (YAP1) and transcriptional co-activator with PDZ-binding motif (TAZ), which are potent transcriptional regulators. YAP1/TAZ are key contributors to cartilage and bone development but the molecular mechanisms by which the Hippo pathway controls chondrogenesis are largely unknown. Cartilage is rich in ECM and also subject to strong external forces – two upstream factors regulating Hippo signaling. Chondrogenesis and endochondral ossification are tightly controlled by growth factors, morphogens, hormones, and transcriptional factors that engage in crosstalk with Hippo-YAP1/TAZ signaling. Here, we generated tamoxifen-inducible, chondrocyte-specific Mob1a/b -deficient mice and show that hyperactivation of endogenous YAP1/TAZ impairs chondrocyte proliferation and differentiation/maturation, leading to chondrodysplasia. These defects were linked to suppression of SOX9, a master regulator of chondrogenesis, the expression of which is mediated by TEAD transcription factors. Our data indicate that a MOB1-dependent YAP1/TAZ-TEAD complex functions as a transcriptional repressor of SOX9 and thereby negatively regulates chondrogenesis.
    Keywords: Musculoskeletal system
    Print ISSN: 0950-1991
    Electronic ISSN: 1477-9129
    Topics: Biology
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