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  • 1
    Abstract: Postnatal colonization of the body with microbes is assumed to be the main stimulus to postnatal immune development. By transiently colonizing pregnant female mice, we show that the maternal microbiota shapes the immune system of the offspring. Gestational colonization increases intestinal group 3 innate lymphoid cells and F4/80(+)CD11c(+) mononuclear cells in the pups. Maternal colonization reprograms intestinal transcriptional profiles of the offspring, including increased expression of genes encoding epithelial antibacterial peptides and metabolism of microbial molecules. Some of these effects are dependent on maternal antibodies that potentially retain microbial molecules and transmit them to the offspring during pregnancy and in milk. Pups born to mothers transiently colonized in pregnancy are better able to avoid inflammatory responses to microbial molecules and penetration of intestinal microbes.
    Type of Publication: Journal article published
    PubMed ID: 26989247
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  • 2
    ISSN: 1432-0533
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Electronmicroscopical examination of the cerebral cortex of a typical case of gargoylism shows numerous abnormal corpuscles in the nerve cells as well as in the pericytes and the adventitial cells. The corpuscles within the nerve cells are characterized by stratification due to transverse osmiophilic layers: ranging from mitochondrion- or lysosome-like structures to monstrous conglomerates. Besides these, there are also corpuscles of concentric structure. Contrasting to this is the low electron density and the homogeneous or fine granular appearance of the vacuoles in the pericytes and in the adventitial cells. These findings confirm and add to the already known histopathological and chemical data of this disease. The nature of the abnormal substances and their interrelations are discussed.
    Notes: Zusammenfassung Die elektronenmikroskopische Untersuchung der Hirnrinde eines typischen Gargoylismus0Falles ergibt massenhaftes Auftreten von abnormen Körperchen sowohl in den Nervenzellen als auch in den Pericyten und Adventitialzellen. Die Körperchen in den Nervenzellen sind hauptsächlich durch den querlamellär geschichteten osmiophilen Aufbau von der mitochondrien- oder lysosomen-ähnlichen Natur bis zur monströsen Konglomeratbildung charakterisiert. Nebenbei finden sich auch Körper mit konzentrischer Struktur. Im Kontrast hierzu stehen die niedrige Elektronendichte und das homogene oder fein granuläre Aussehen der Vacuolen in den Pericyten und Adventitialzellen. Die Befunde können die bisherigen histopathologischen und chemischen Kenntnisse über diese Krankheit bestätigen und teilweise verfeinern. Dazu werden Bemerkungen über die Natur der abnormen Substanzen und ihre wechselseitige Beziehung gemacht.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Medical microbiology and immunology 92 (1921), S. 291-320 
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Publication Date: 2016-03-19
    Description: Postnatal colonization of the body with microbes is assumed to be the main stimulus to postnatal immune development. By transiently colonizing pregnant female mice, we show that the maternal microbiota shapes the immune system of the offspring. Gestational colonization increases intestinal group 3 innate lymphoid cells and F4/80(+)CD11c(+) mononuclear cells in the pups. Maternal colonization reprograms intestinal transcriptional profiles of the offspring, including increased expression of genes encoding epithelial antibacterial peptides and metabolism of microbial molecules. Some of these effects are dependent on maternal antibodies that potentially retain microbial molecules and transmit them to the offspring during pregnancy and in milk. Pups born to mothers transiently colonized in pregnancy are better able to avoid inflammatory responses to microbial molecules and penetration of intestinal microbes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gomez de Aguero, Mercedes -- Ganal-Vonarburg, Stephanie C -- Fuhrer, Tobias -- Rupp, Sandra -- Uchimura, Yasuhiro -- Li, Hai -- Steinert, Anna -- Heikenwalder, Mathias -- Hapfelmeier, Siegfried -- Sauer, Uwe -- McCoy, Kathy D -- Macpherson, Andrew J -- New York, N.Y. -- Science. 2016 Mar 18;351(6279):1296-302. doi: 10.1126/science.aad2571.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Maurice Muller Laboratories (DKF), Universitatsklinik fur Viszerale Chirurgie und Medizin Inselspital, Murtenstrasse 35, University of Bern, 3010 Bern, Switzerland. ; Institute of Molecular Systems Biology, Swiss Federal Institute of Technology (ETH) Zurich, 8093 Zurich, Switzerland. ; Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany. ; Institute for Infectious Diseases, University of Bern, 3010 Bern, Switzerland. ; Maurice Muller Laboratories (DKF), Universitatsklinik fur Viszerale Chirurgie und Medizin Inselspital, Murtenstrasse 35, University of Bern, 3010 Bern, Switzerland. andrew.macpherson@insel.ch.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26989247" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies/immunology ; Escherichia coli/immunology ; Female ; Gastrointestinal Microbiome/*immunology ; Germ-Free Life ; Immune System/*growth & development/*microbiology ; Immunity, Innate/genetics/*immunology ; Immunity, Maternally-Acquired/genetics/*immunology ; Intestines/*immunology ; Lymphocytes/immunology ; Mice ; Mice, Inbred C57BL ; Pregnancy ; Symbiosis ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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