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  • 1
    Keywords: Medicine ; Cancer Research ; Immunology ; Oncology ; Cell Biology ; Biomedicine ; Immunology ; Cancer Research ; Oncology ; Cell Biology ; Springer eBooks
    Description / Table of Contents: Controversies in Neoplastic Myeloplasia -- Differentiation of Murine Myeloid-derived Suppressor Cells -- Human MDSCs -- Ex Vivo MDSC Differentiation Models -- Immunoregulatory myeloid cells in the tumor microenvironment -- Signal Transducer and Activation of Transcription 3: A Master Regulator of Myeloid-derived Suppressor Cells -- Future Perspectives
    Abstract: The book starts with an introduction to and history of myeloid-derived suppressor cells (MDSCs), followed by a description of their differentiation, their role in the tumour microenvironment and their therapeutic targeting. It closes with an outlook on future developments. In cancer patients, myelopoiesis is perturbed and instead of generating immunogenic myeloid cells (such as dendritic cells, inflammatory macrophages and granulocytes), there is an increase in highly immature MDSCs. These cells are distributed systemically, resulting in general immunosuppression. They also infiltrate tumours, promoting their progression and metastasis by inhibiting the natural anti-tumour immune response. As these cells also interact with classical anti-neoplastic treatments, they have become major therapeutic targets in the pharmaceutical industry and in oncology research
    Pages: IX, 102 p. 8 illus. in color. : online resource.
    Edition: 1st ed. 2016.
    ISBN: 9783319268217
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  • 2
    ISSN: 1573-7276
    Keywords: IFN-γ, IL-2 ; metastasis ; T lymphoma cell ; transfection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have previously reported that transfection of mouse interferon γ (IFN-γ) in H-2K k -positive BW vari-ants (BW-Sp3) abolishes tumorigenicity and reduces metastatic capacity. To further increase the immuno-genicity of BW-Sp3 cells, the gene for human interleukin 2 (huIL-2) was transfected in these cancer cells. Single BW-Sp3(huIL-2) and double BW-Sp3(huIL-2+IFN-γ) transfectants were generated and their behavior was investigated as compared to parental and IFN-γ-transfected BW-Sp3. Although expression of huIL-2 was equally effective as IFN-γ in preventing tumor formation and reducing experimental metastasis, it did not confer protection to spontaneous metastases and even reversed the anti-metastatic activity of IFN-γ. Inoculation of the BW variants in immunocompromised mice revealed that expression of IL-2 activates both T cells and aspecific immune effectors. However, in immunocompromised mice a clear pro-metastatic effect of IL-2 was recorded. Analysis of membrane antigens on the different variants showed a selective effect of huIL-2 on the expression of two surface antigens, i.e. L-selectin and metastatic T cell hybridoma antigen (MTH), which may contribute to metastasis. Hence upon expression of huIL-2 in T lymphoma variants, tumor outcome will depend on the balanced effects of the transfected cytokines on the immune response and the redirected effect on tumor progression. © Rapid Science Ltd.
    Type of Medium: Electronic Resource
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