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  • 1
    Unknown
    Tokyo ; New York : United Nations University Press
    Keywords: Developing countries, Economic policy, Congresses. ; Developing countries, Social policy, Congresses. ; Economic development, Congresses. ; Education and state, Developing countries, Congresses. ; Poverty, Developing countries, Congresses.
    Pages: xxvi, 302 p.
    ISBN: 0-585-48562-3
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  • 2
    Keywords: Life sciences ; Microbiology ; Microbial genetics ; Life sciences ; Microbiology ; Microbial Genetics and Genomics ; Medical Microbiology ; Springer eBooks
    Description / Table of Contents: 〈p〉Discovery and seminal developments in the CRISPR field -- Occurrence, diversity of CRISPR-Cas systems and genotyping implications -- ℗ Evolution and classification of CRISPR-Cas systems and Cas protein families -- Regulation of CRISPR-based immune responses -- crRNA Biogenesis -- Distribution and mechanism of the Type I CRISPR/Cas Systems -- Type II ́€“ 〈i〉Streptococcus thermophilus〈/i〉 -- Type III CRISPR-Cas Systems and the Roles CRISPR-Cas in Bacterial Virulence -- CRISPR-Cas Systems to Probe Ecological Diversity and Host-Viral Interactions -- Roles of CRISPR in regulation of physiological processes -- Applications of the versatile CRISPR-Cas systems -- CRISPRs in microbial community context.〈/p〉
    Abstract: 〈p〉CRISPR-Cas is a recently discovered defense system which protects bacteria and archaea against invasion by mobile genetic elements such as viruses and plasmids. A wide spectrum of distinct CRISPR-Cas immune systems has been identified in at least half of the available prokaryotic genomes. On-going biochemical and functional analyses have resulted in substantial insight into the functions and possible applications of these fascinating systems, although many secrets remain to be uncovered. 〈/p〉〈p〉In this book, experts summarize the state of the art℗ of this exciting field.〈/p〉
    ISBN: 9783642346576
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  • 3
    Keywords: Medicine ; Pharmaceutical technology ; Biomedicine ; Pharmaceutical Sciences/Technology ; Biomedicine general ; Springer eBooks
    Description / Table of Contents: The℗ International Conference on Harmonisation. History of Safety Guidelines -- EU Perspective on ICH -- The Value and Benefits of the International Conference on Harmonisation (ICH) to Drug Regulatory Authorities Advancing Harmonization for Better Public Health -- A Japanese Perspective on Implementation of the Three Rs: Incorporating Best Scientific Practices into Regulatory Process -- Towards more Scientific Relevance in Carcinogenicity Testing -- The Evolution, Scientific Reasoning and Use of ICH S2 Guidelines for Genotoxicity Testing of Pharmaceuticals -- Toxicokinetics: A Guidance for Assessing Systemic Exposure in Toxicology Studies , Where are we now;℗ an℗ S3A/S3B update (1995-2011) -- Duration of Acute and Chronic Toxicity Testing in Animals (ICH S4A and S4B) -- Why and how did Reproduction Toxicity Testing make its early entry into and Rapid Success in ICH? -- ICH S6 Preclinical Safety Evaluation of Biotechnology-Derived Pharmaceuticals -- Safety Pharmacology: Guidelines S7A and S7B -- ICH S8:℗ History and Perspectives -- ICH S9: Nonclinical Evaluation of Anticancer Pharmaceuticals a Perspective from Regulators on the Development of the Guideline -- Non-Clinical Safety Studies for the Conduct of Human Clinical Trials for Pharmaceuticals ICH M3 and M3(R2)
    Abstract: The International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) is a unique project that brings together the regulatory authorities of Europe, Japan and the US and experts from the pharmaceutical industry in the three regions to discuss scientific and technical aspects of product registration. In Japan, the members are the Ministry of Health, Labour and Welfare (MHLW), and the Japan Pharmaceutical Manufacturers Association (JPMA). In Europe, the members are the EU (Representatives of the European Commission and the European Medicines Agency [EMA]), and the European Federation of Pharmaceutical Industries and Associations (EFPIA). In the United States, the members are the Food and Drug Administration (FDA), and the Pharmaceutical Research and Manufacturers of America (PhRMA). The International Federation of Pharmaceutical Manufacturers Associations (IFPMA)℗ is the secretariat of the ICH. Additional members include Observers from WHO, European Free Trade Association (EFTA), and Canada. The Observers represent non-ICH countries and regions.℗ This volume considers one of℗ ICH́€™s major categories, Safety,℗ covering topics relating to in vitro and in vivo pre-clinical studies (Carcinogenicity Testing, Genotoxicity Testing, etc.). Since the start of the ICH process, many guidelines have been written, but℗ in most cases℗ there is a lack of awareness of the many issues that were addressed during the development of the consensus guidances.℗ Further, just as it is important to understand what the guidances state, it is also important to understand the thoughts, debates, and intent of the experts involved, which are not included in the guidance documents. Why has the guideline been written as it is written,℗ why are some topics ignored, and ℗ why have some initial guidance proposals have℗ been deleted. These and other related questions and answers are the contents of this book, written by experts who were directly involved in writing the ICH guidances that drive drug development today
    Pages: : digital.
    ISBN: 9781461459507
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  • 4
    Keywords: Life sciences ; Human Genetics ; Bioinformatics ; Life sciences ; Bioinformatics ; Human Genetics ; Springer eBooks
    Description / Table of Contents: R for Genome-Wide Association Studies -- Descriptive Statistics of Data: Understanding the Data Set and Phenotypes of Interest -- Designing a Genome-Wide Association Studies (GWAS): Power, Sample Size, and Data Structure -- Managing Large SNP Datasets with SNPpy -- Quality Control for Genome-Wide Association Studies -- Overview of Statistical Methods for Genome-Wide Association Studies (GWAS) -- Statistical Analysis of Genomic Data -- Using PLINK for Genome-Wide Association Studies (GWAS) and Data Analysis -- Genome-Wide Complex Trait Analysis (GCTA): Methods, Data Analyses, and Interpretations -- Bayesian Methods Applied to Genome-Wide Association Studies (GWAS) -- Implementing a QTL Detection Study (GWAS) Using Genomic Prediction Methodology -- Genome-Enabled Prediction Using the BLR (Bayesian Linear Regression) R-Package -- Genomic Best Linear Unbiased Prediction (gBLUP) for the Estimation of Genomic Breeding Values -- Detecting Regions of Homozygosity to Map the Cause of Recessively Inherited Disease -- Use of Ancestral Haplotypes in Genome-Wide Association Studies -- Genotype Phasing in Populations of Closely Related Individuals -- Genotype Imputation to Increase Sample Size in Pedigreed Populations -- Validation of Genome-Wide Association Studies (GWAS) Results -- Detection of Signatures of Selection Using FST -- Association Weight Matrix: A Network-Based Approach Towards Functional Genome-Wide Association Studies -- Mixed Effects Structural Equation Models and Phenotypic Causal Networks -- Epistasis, Complexity, and Multifactor Dimensionality Reduction -- Applications of Multifactor Dimensionality Reduction to Genome-Wide Data Using the R Package ‘MDR’ -- Higher Order Interactions: Detection of Epistasis Using Machine Learning and Evolutionary Computation -- Incorporating Prior Knowledge to Increase the Power of Genome-Wide Association Studies -- Genomic Selection in Animal Breeding Programs
    Abstract: With the detailed genomic information that is now becoming available, we have℗ a plethora of data that allows researchers to address questions in a variety of areas. Genome-wide association studies (GWAS) have become a vital approach to identify candidate regions associated with complex diseases in human medicine, production traits in agriculture, and variation in wild populations. ℗ Genomic prediction goes a step further, attempting to predict phenotypic variation in these traits from genomic information. ℗ Genome-Wide Association Studies and Genomic Prediction pulls together expert contributions to address this important area of study. ℗ The volume begins with a section covering the phenotypes of interest as well as design issues for GWAS, then moves on to discuss efficient computational methods to store and handle large datasets, quality control measures, phasing, haplotype inference, and imputation. ℗ Later chapters deal with statistical approaches to data analysis where the experimental objective is either to confirm the biology by identifying genomic regions associated to a trait or to use the data to make genomic predictions about a future phenotypic outcome (e.g. predict onset of disease). As part of the Methods in Molecular Biology series, chapters provide helpful, real-world implementation advice
    Pages: XI, 566 p. 67 illus., 31 illus. in color. : digital.
    ISBN: 9781627034470
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  • 5
    Call number: C060:37
    Keywords: Nonparametric statistics ; Longitudinal method ; Estimation theory
    Pages: xii, 397 p. : ill.
    ISBN: 0387955569
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    C060:37 departmental collection or stack – please contact the library
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  • 6
    Unknown
    Beijing : O'Reilly
    Call number: B050:261
    Keywords: XML (Document markup language)
    Notes: Translation of: XML Schema.
    Pages: xiii, 415 p.
    ISBN: 3-89721-345-1
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    B050:261 departmental collection or stack – please contact the library
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  • 7
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    Unknown
    Berlin : Springer-Verlag
    Call number: 09-Q:524/2
    Keywords: Algebra, Abstract
    Pages: x, 300 p.
    Edition: 5. Aufl. der Modernen Algebra.
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    09-Q:524/2 departmental collection or stack – please contact the library
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  • 8
    Unknown
    Burlington : Elsevier Science
    Keywords: Drugs -- Dosage forms ; Peptides -- administration & dosage ; Peptides -- Therapeutic use -- Administration ; Protein drugs -- Administration ; Proteins -- Therapeutic use -- Administration
    Description / Table of Contents: Front Cover; Peptide and Protein Delivery; Copyright; Contents; Foreword; Preface; Contributors; Chapter 1 An Overview of the Field of Peptide and Protein Delivery; 1.1 Introduction; 1.2 Current Formulation Development; 1.3 Case Studies of Delivery Approaches: Cyclosporine A and Insulin; 1.4 Controlled Delivery; 1.5 Future Trends; 1.6 Toxicity Profiles; 1.7 Regulatory Matters; 1.8 Commercialization Considerations; References; Chapter 2 Pulmonary Delivery of Peptides and Proteins; 2.1 Introduction; 2.2 Clinical Applications of Pulmonary Protein Delivery
    Abstract: The growing area of peptide and protein therapeutics research is of paramount importance to medical application and advancement. A needed reference for entry level researchers and researchers working in interdisciplinary / collaborative projects, Peptide and Protein Delivery addresses the current and emerging routes for delivery of therapeutics. Covering cerebral delivery, pulmonary delivery, transdermal delivery, intestinal delivery, ocular delivery, parenteral delivery, and nasal delivery, this resource offers an overview of the main routes in therapeutics. Researchers across biochemistry
    Notes: Description based upon print version of record.
    Pages: 1 online resource (381 p.)
    ISBN: 9780123849366
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  • 9
    Keywords: Medicine ; Human Genetics ; Internal Medicine ; Cardiology ; Medicine & Public Health ; Cardiology ; Human Genetics ; Internal Medicine ; Springer eBooks
    Pages: : digital
    ISBN: 9781849964715
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  • 10
    Call number: 09-Q:126
    Keywords: Mathematical Statistics
    Pages: ix, 360 p. : illus.
    Edition: 2. Aufl.
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    09-Q:126 departmental collection or stack – please contact the library
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