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  • 1
    Unknown
    Lehmanns
    Call number: ALLG-BERUF-QA76.7:23
    ISBN: 9783865419460
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    ALLG-BERUF-QA76.7:23 available
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  • 2
    Keywords: Medicine ; Cardiology ; Biomedical Engineering ; Medicine & Public Health ; Cardiology ; Biomedical Engineering ; Springer eBooks
    Description / Table of Contents: Preface -- Introduction -- Quantitative Poincare plot -- Poincare plot interpretation of HRV using Physiological Model -- Poincare plot in capturing nonlinear temporal dynamics of HRV -- Heart rate asymmetry (HRA) analysis using Poincare plot -- Segmented Poincare plot Analysis (SPPA) and Lagged Segmented Poincare Plot Analysis (LSPPA) -- Index
    Abstract: The Poincaré plot (named after Henri Poincaré) is a popular two-dimensional visualization tool for dynamic systems due to its intuitive display of the dynamic properties of a system from a time series. This book presents the basis of Poincaré plot and focus especially on traditional and new methods for analysing the geometry, temporal and spatial dynamics disclosed by the Poincaré plot to evaluate heart rate variability (HRV). Mathematical descriptors of Poincaré plot have been developed to quantify the autonomic nervous system activity (sympathetic and parasympathetic modulation of heart rate). Poincaré plot analysis has also been used in various clinical diagnostic settings like diabetes, chronic heart failure, chronic renal failure and sleep apnea syndrome. The primary aims of quantification of the Poincaré plots are to discriminate healthy physiological systems from pathological conditions and to classify the stage of a disease. The HRV analysis by Poincaré plot has opened up ample opportunities for important clinical and research applications. Therefore, the present book can be used either for self-study, as a supplement to courses in linear and nonlinear systems, or as a modern monograph by researchers in this field of HRV analysis
    Pages: XV, 146 p. 59 illus., 19 illus. in color. : online resource.
    ISBN: 9781461473756
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  • 3
    Unknown
    München : Hanser
    Call number: ATV-MAT:146(2)
    Pages: 478 p. : ill. + 1 CD-ROM
    Edition: 2., vollst. überarb. Aufl.
    ISBN: 3-446-19223-9
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    ATV-MAT:146(2) departmental collection or stack – please contact the library
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  • 4
    Call number: 01-SichIng:370 ; 01-SichIng:371 ; 01-SichIng:372 ; 01-SichIng:373 ; 01-SichIng:374
    Keywords: Occupational Health
    Pages: 313 p. : ill.
    ISBN: 3-87156-361-7
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    01-SichIng:370 departmental collection or stack – please contact the library
    01-SichIng:371 departmental collection or stack – please contact the library
    01-SichIng:372 departmental collection or stack – please contact the library
    01-SichIng:373 departmental collection or stack – please contact the library
    01-SichIng:374 departmental collection or stack – please contact the library
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  • 5
    Call number: YY Diss Voss/Mag
    Keywords: DKFZ-publications / academic dissertations
    Pages: 195 p.
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    YY Diss Voss/Mag available
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  • 6
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary 2-Sulfa-3-methoxypyrazine (SMOP), a long-acting sulfonamide, was examined with regard to its action in persons with glucose-6-phosphate dehydrogenase deficiency of the erythrocytes. Neither in vitro (incubation in 5 mM SMOP) nor in vivo (after a single dose of 2 g SMOP) was a hemolytic action demonstrable.
    Notes: Zusammenfassung 2-Sulfanilamido-3-methoxypyrazin, ein Langzeit-Sulfonamid, wurde im Hinblick auf seine Wirkung bei Personen mit Glucose-6-Phosphat-Dehydrogenase-Mangel der Erythrocyten untersucht. Weder in vitro (Inkubation von Erythrocyten in 5 mM Lösung des Sulfonamids) noch in vivo (nach einmaliger Verabreichung von 2 g) ließ sich eine hämolytische Wirkung nachweisen.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Bovine aortic endothelial cells (BAEC) can be isolated in large numbers without major contamination by other cells and maintained in culture with a limited life span for about 100 population doublings. In order to study phenotypic changes of BAEC during long-term culture, stocks of different passages of BAEC were established and their morphological, migratory, and proliferative properties analyzed. Early-passage BAEC (passages 5-15) rapidly produce dense, cobblestone-like monolayers. Their growth beyond the monolayer configuration is characterized by the formation of an irregular network of spindle-shaped, crisscrossing BAEC growing either on top or beneath the monolayer, and by the assembly of elongated BAEC into well-differentiated capillary-like tubes. In contrast, senescent BAEC (passages 35-45) form perfect cobblestone monolayers that contain several, often multinucleated giant cells and a few capillary-like tubes but not the crisscrossing networks of their early-passage counterparts. The rates of BAEC migration and proliferation gradually decline during in vitro senescence. This decline is neutralized by exogenous basic fibroblast growth factor (bFGF) which elevates the migratory and proliferative capacities of early-passage and senescent BAEC to uniformly high levels. Northern blot analysis shows a gradual decline in bFGF message and an increase in laminin message during in vitro BAEC senescence. The present study supports the concept of autocrine growth regulation of BAEC and associates a decreased bFGF message with decreased rates of migration and proliferation as well as loss of the crisscrossing BAEC morphotype in senescent cultures. © 1993 Wiley-Liss, Inc.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1435-1544
    Keywords: Schlüsselwörter Herzfrequenzvariabilität – Blutdruckvariabilität –¶Baroreflex – nichtlineare Kopplung – nichtlineare Dynamik –¶implantierbarer Defibrillator ; Key words Heart rate variability – blood pressure variability – baroreflex – nonlinear coupling – nonlinear dynamics – implantable defibrillator
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The main intention of this contribution is to discuss different nonlinear approaches to heart rate and blood pressure variability analysis for a better understanding of the cardiovascular regulation. We investigate measures of complexity which are based on symbolic dynamics, renormalised entropy and the finite time growth rates. The dual sequence method to estimate the baroreflex sensitivity and the maximal correlation method to estimate the nonlinear coupling between time series are employed for analysing bivariate data. The latter appears to be a suitable method to estimate the strength of the nonlinear coupling and the coupling direction. Heart rate and blood pressure data from clinical pilot studies and from very large clinical studies are analysed. We demonstrate that parameters from nonlinear dynamics are useful for risk stratification after myocardial infarction, for the prediction of life-threatening cardiac events even in short time series, and for modelling the relationship between heart rate and blood pressure regulation. These findings could be of importance for clinical diagnostics, in algorithms for risk stratification, and for therapeutic and preventive tools of next generation implantable cardioverter defibrillators.
    Notes: Zusammenfassung Das Hauptanliegen dieses Beitrages ist es, verschiedene Ansätze in der Herzfrequenz- und Blutdruckvariabilität zu diskutieren und damit das Verständnis der kardiovaskulären Regulation zu verbessern. Wir betrachten Komplexitätsmaße basierend auf der symbolischen Dynamik, die renormierte Entropie und die ,finite-time’ Wachstumsraten. Weiterhin werden die duale Sequenzmethode zur Bestimmung der Baroreflexsensitivität sowie die Maximalkorrelationsmethode zur Schätzung der nichtlinearen Kopplung in bivariaten Daten vorgestellt. Letztere stellt eine geeignete Methode zur Bestimmung der Kopplungsstärke und –richtung dar. Herzfrequenz- und Blutdruckvariabilitätsdaten einer klinischen Pilotstudie und einer großangelegten klinischen Studie werden analysiert. Wir demonstrieren in diesem Beitrag, dass Methoden der nichtlinearen Dynamik nützlich sind für die Risikostratifizierung nach Herzinfarkt, für die Vorhersage von lebensbedrohlichen Rhythmusstörungen sowie für die Modellierung der Herzfrequenz- und Blutdruckregulation. Diese Ergebnisse könnten in der klinischen Diagnostik sowie für therapeutische und präventive Zwecke von implantierbaren Defibrillatoren der nächsten Generation von Bedeutung sein.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1435-1803
    Keywords: Key words Bowditch-effect – hypertrophic cardiomyopathy – myocardial contraction – human myocardium – calcium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The present study was designed to test the hypothesis that in hypertrophied myocardium of patients with hypertrophic obstructive cardiomyopathy (HOCM) a reduced contractile reserve provided by frequency dependent potentiation of force of contraction contributes to the myocardial dysfunction. Myectomy was performed in 8 HOCM patients with normal systolic left ventricular function at rest. Nonfailing myocardium from the hearts of three multiorgan donors was investigated for comparison. In thin myocardial strips we measured the inotropic effects of different stimulation frequencies (0,5–3.0Hz) at different extracellular Ca2+ concentrations (1.8–16.2 mmol/l). At 1.8 mmol/l extracellular Ca2+ concentration, increasing stimulation rates had no positive inotropic effect in HOCM myocardium, whereas in nonfailing myocardium force of contraction increased up to 3 Hz. Increasing extracellular Ca2+ concentrations induced a positive force-frequency relation in HOCM with a maximum at 5.4 mmol/l Ca2+. A further increase to 16.2 mmol/l Ca2+ resulted in a negative force-frequency relation in these specimens. The time to peak tension and the time to relaxation decreased at increasing stimulation frequencies at all Ca2+ concentrations investigated. In conclusion, in hypertrophied myocardium of HOCM patients increasing stimulation frequencies failed to have a positive inotropic effect at physiological extracellular Ca2+ concentrations. The induction of a positive force-frequency relation by higher Ca2+ concentrations suggests that an abnormal cellular Ca2+ handling may play an important pathophysiological role.
    Type of Medium: Electronic Resource
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