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  • 1
    Publication Date: 2016-02-11
    Description: Gene expression can be regulated post-transcriptionally through dynamic and reversible RNA modifications. A recent noteworthy example is N(6)-methyladenosine (m(6)A), which affects messenger RNA (mRNA) localization, stability, translation and splicing. Here we report on a new mRNA modification, N(1)-methyladenosine (m(1)A), that occurs on thousands of different gene transcripts in eukaryotic cells, from yeast to mammals, at an estimated average transcript stoichiometry of 20% in humans. Employing newly developed sequencing approaches, we show that m(1)A is enriched around the start codon upstream of the first splice site: it preferentially decorates more structured regions around canonical and alternative translation initiation sites, is dynamic in response to physiological conditions, and correlates positively with protein production. These unique features are highly conserved in mouse and human cells, strongly indicating a functional role for m(1)A in promoting translation of methylated mRNA.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dominissini, Dan -- Nachtergaele, Sigrid -- Moshitch-Moshkovitz, Sharon -- Peer, Eyal -- Kol, Nitzan -- Ben-Haim, Moshe Shay -- Dai, Qing -- Di Segni, Ayelet -- Salmon-Divon, Mali -- Clark, Wesley C -- Zheng, Guanqun -- Pan, Tao -- Solomon, Oz -- Eyal, Eran -- Hershkovitz, Vera -- Han, Dali -- Dore, Louis C -- Amariglio, Ninette -- Rechavi, Gideon -- He, Chuan -- GM113194/GM/NIGMS NIH HHS/ -- GM71440/GM/NIGMS NIH HHS/ -- HG006699/HG/NHGRI NIH HHS/ -- HG008688/HG/NHGRI NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2016 Feb 25;530(7591):441-6. doi: 10.1038/nature16998. Epub 2016 Feb 10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA. ; Howard Hughes Medical Institute, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA. ; Cancer Research Center, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel. ; Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel. ; Department of Biochemistry and Molecular Biology, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA. ; The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan 52900, Israel.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26863196" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 2
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 184 (1959), S. 49-50 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A cloud of air-dispersed rutile titanium dioxide pigment was formed by passing air from a high-pressure jet through a flask containing the dry pigment. The degree of dispersion in this cloud was assessed by collecting a specimen on a 'Formvar'-coated electron microscope specimen grid (Fig. 1). To ...
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 198 (1963), S. 278-279 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Experimental observations on the behaviour of titanium dioxide often conflict with conclusions drawn from this simple picture. Conductivity measurements indicate that oxygen diffusion through rutile is insignificant at room temperature3. This is borne out by the comparative failure of the ...
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  • 4
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 203 (1964), S. 635-636 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] During investigations into this reaction, interesting reflectance changes were observed on specimens after they had been exposed to ultra-violet radiation. The specimens were prepared by mixing 10 gm of a commercial rutile titanium dioxide pigment with 10 ml. of N/10 aqueous solution of silver ...
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  • 5
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 216 (1967), S. 826-827 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The attractive force caused by a liquid bridge between equal spheres shows an approximate linear decrease with sphere separation from a maximum J^max? near contact, to zero, at the rupture separation xr. There is a linear relation between xr and the bridge neck diameter at contact, so that xr may ...
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  • 6
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 181 (1958), S. 137-138 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Comparable responses may be produced by stimulating herbivorous gastropods with carnivorous ones. This was first observed in Nature on a dry rock surface which had recently been left by the receding tide. A thaisid whelk, Lepsia haustrum (Martyn) crawled towards a trochid MelagrapMa aethiops ...
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  • 7
    ISSN: 0739-4462
    Keywords: enzyme induction ; Drosophila ; steroid hormone ; 20-hydroxyecdysone ; Chemistry ; Food Science, Agricultural, Medicinal and Pharmaceutical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: Transcripts of the dopa decarboxylase (Ddc) gene accumulate within 4 h of the administration of 20-OH-ecdysone to mature larvae of Drosophila. The increase can be explained as the sum of a direct steroid effect, independent of protein synthesis, and an indirect effect, dependent on proteins synthesized after an increase in the hormone titer. By contrast, the peaks of DDC activity in embryos, and perhaps in the first two larval instars and in imaginal discs as well, cannot be ascribed to any direct steroid effects. In fact, a decreasing hormone titer might be required before the Ddc gene can be expressed at these stages. The stage-specific differences in the molecular mechanisms regulating Ddc gene activity may be reflected in the phenotype of an activity variant, Ddc+4. Molecular studies now underway on the variant Ddc gene might help us to understand the complex multifunctional region that we believe lies upstream of the gene and regulates its expression during development.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1573-5192
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Cylicospirura (Cylicospirura) advena n.sp. described from specimens obtained from a feral cat in New Zealand is characterized by the presence of toothless rounded knobs on the anterior ends of the longitudinal supporting ribs in the buccal capsule; a vulva either anterior or posterior to the oesophago-intestinal junction; its small size (less than 6 mm) and the presence of a thin, disc-like process on the tip of the short spicule. Additional figures are provided of Cyathospirura dasyuridis Mawson, 1968, and the presence of conspicuous lateral alae of Cylicospirura (C.) heydoni (Baylis, 1927) is noted for the first time. ac]19810222
    Type of Medium: Electronic Resource
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  • 9
    Publication Date: 2018-06-21
    Description: KRAS is the most frequently mutated driver oncogene in human adenocarcinoma of the lung. There are presently no clinically proven strategies for treatment of KRAS-driven lung cancer. Activating mutations in KRAS are thought to confer independence from upstream signaling; however, recent data suggest that this independence may not be absolute. We show that initiation and progression of KRAS-driven lung tumors require input from ERBB family receptor tyrosine kinases (RTKs): Multiple ERBB RTKs are expressed and active from the earliest stages of KRAS-driven lung tumor development, and treatment with a multi-ERBB inhibitor suppresses formation of KRAS G12D -driven lung tumors. We present evidence that ERBB activity amplifies signaling through the core RAS pathway, supporting proliferation of KRAS-mutant tumor cells in culture and progression to invasive disease in vivo. Brief pharmacological inhibition of the ERBB network enhances the therapeutic benefit of MEK (mitogen-activated protein kinase kinase) inhibition in an autochthonous tumor setting. Our data suggest that lung cancer patients with KRAS-driven disease may benefit from inclusion of multi-ERBB inhibitors in rationally designed treatment strategies.
    Print ISSN: 1946-6234
    Electronic ISSN: 1946-6242
    Topics: Medicine
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