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  • 1
    Keywords: APOPTOSIS ; CANCER ; tumor ; carcinoma ; CELL ; Germany ; LUNG ; lung cancer ; LUNG-CANCER ; SYSTEM ; EXPOSURE ; RISK ; GENE ; GENES ; PATIENT ; RISK-FACTORS ; cell cycle ; CELL-CYCLE ; CYCLE ; ASSOCIATION ; polymorphism ; POLYMORPHISMS ; SUSCEPTIBILITY ; VARIANTS ; BREAST-CANCER ; risk factors ; smoking ; p53 ; cancer risk ; MUTATIONS ; TRANSFORMATION ; SQUAMOUS-CELL CARCINOMA ; adenocarcinoma ; case-control studies ; squamous cell carcinoma ; GASTRIC-CANCER ; DNA repair ; DNA-REPAIR GENES ; molecular epidemiology ; ONCOLOGY ; case-control study ; REGRESSION ; RE ; TUMOR-SUPPRESSOR ; VARIANT ; INCREASE ; CARCINOGEN ; case control studies ; analysis ; SUPPRESSOR ; GENOTYPE ; adenocarcinoma of the lung ; HISTOLOGY ; RISK-FACTOR ; CANCER-RISK ; PROLINE ; SQUAMOUS-CELL ; INCREASES ; cell cycle control ; CODON-72 ; P53 POLYMORPHISM
    Abstract: Alterations in cell cycle regulation and apoptosis leading to malignant transformation could be caused by common genetic variants in tumor suppressor genes. The effects of the TP53 polymorphism Arg72Pro on lung cancer risk have been investigated in numerous studies with, however, conflicting results. In many studies, important risk modifiers such as smoking or tumor histology were not taken into account. We therefore investigated the combined effects of polymorphisms in TP53 (Arg72Pro) and p21/CDKN1A (Ser31Arg) and smoking on lung cancer risk. Our case-control study consisted of 405 patients with lung cancer, mainly squamous-cell carcinoma (185) and adenocarcinoma (177) and 404 unmatched tumor-free hospital controls. Multivariate regression analysis showed a moderate but statistically significant risk of lung cancer overall. and especially of squamous-cell carcinoma (OR, 1.65; CI, 1.10-2.47) for TP53 72Pro allele carriers. The risk was markedly increased in heavy smokers (〉 20 pack-years) with squamous-cell carcinoma (OR, 2.80 in patients homozygous for 72Pro; CI, 1.19-6.58), but not in tight smokers (〈= 20 pack-years). The results for the p21 Ser31Arg polymorphism suggested that 31Ser is a moderate-risk allele for squamous-cell carcinoma. Analysis of the combined effects of the two polymorphisms revealed a higher OR for TP53 72Pro carriers homozygous for p21 31Ser than for 72Pro carriers in general; this effect being most pronounced in heavy smokers with squamous-cell carcinoma (OR, 3.84; CI, 1.46-10.1). Our data indicate that the TP53 Arg72Pro polymorphism increases the risk for squamous-cell carcinoma mainly in heavy smokers. The observed interaction with smoking is biologically plausible as, for the 72Pro p53 variant, decreased apoptosis and extended G1 cell cycle arrest is reported after carcinogen exposure. Nevertheless, confirmation by further molecular and epidemiological studies is warranted. (c) 2006 Elsevier Ireland Ltd. All rights reserved
    Type of Publication: Journal article published
    PubMed ID: 17059853
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  • 2
    Keywords: CANCER ; IONIZING-RADIATION ; tumor ; PATHWAY ; HISTORY ; incidence ; NEW-YORK ; POPULATION ; RISK ; GENE ; GENES ; radiation ; DNA ; FAMILY ; INDEX ; BASE ; ASSOCIATION ; polymorphism ; POLYMORPHISMS ; SUSCEPTIBILITY ; VARIANTS ; BREAST ; breast cancer ; BREAST-CANCER ; AGE ; family history ; WOMEN ; REPAIR ; smoking ; cancer risk ; DAMAGE ; DNA-DAMAGE ; PARAMETERS ; MULTIVARIATE ; INDIVIDUALS ; sensitivity ; ALCOHOL ; TOBACCO SMOKING ; education ; DNA repair ; EXCISION-REPAIR ; POSTMENOPAUSAL WOMEN ; BODIES ; ONCOLOGY ; case-control study ; REGRESSION ; RE ; FAMILIES ; VARIANT ; CAPACITY ; XRCC1 POLYMORPHISMS ; XRCC1 ; ALLELES ; analysis ; DNA damage ; GENOTYPE ; MASS ; FAMILY-HISTORY ; USA ; CANCER INCIDENCE ; CANCER-RISK ; OGG1 ; CONTRACEPTIVES ; postmenopausal ; body mass ; ALCOHOL-DRINKING ; breast cancer risk ; oxidative DNA damage ; APEX1 ; MENOPAUSAL STATUS ; HOGG1 GENE ; SER326CYS POLYMORPHISM
    Abstract: DNA repair plays an important role in tumor development. The base excision repair (BER) pathway mainly removes DNA damage caused by ionizing radiation and reactive oxidative species. Here, we examined possible associations between polymorphisms in three important BER genes (OGG1 Ser326Cys, APEX1 Asp148Glu, XRCC1 Arg194Trp, XRCC1 Arg280His, XRCC1 Arg399Gln) and breast cancer incidence in Thai women. The study population consisted of 507 breast cancer cases and 425 controls. Odds ratios (OR) were adjusted by multivariate logistic regression analysis for age, body mass index, age at menarche, family history of breast cancer, menopausal status, reproduction parameters, use of contraceptives, tobacco smoking, involuntary tobacco smoking, alcohol drinking, and education. For homozygous carriers of the Glu allele in APEX1, a significant protective effect was found when compared to Asp/Asp carriers (odds ratio (OR) = 0.60, 95% confidence interval (CI) = 0.38-0.94). Subgroup analysis based on menopausal status revealed increased breast cancer risk in postmenopausal women and OGG1 (OR = 2.05, 95% CI 1.14-3.69). Reconstructed diplotypes for XRCC1 showed that CGA/CGA carriers had an increased risk of breast cancer compared with carriers of the wild type diplotype CGG/CGG (OR = 2.56, 95% CI 1.28-5.15). When the joint effects of XRCC1, APEX1 and OGG1 polymorphisms were evaluated, individuals homozygous for two or three risk alleles were at increased risk (OR = 1.88, 95% CI 1.26-2.82). In conclusion, our data suggest that Thai women with a certain XRCC1 diplotype or homozygous for two or three variant alleles of XRCC1, OGG1, and APEX1 are likely to have an increased susceptibility to breast cancer
    Type of Publication: Journal article published
    PubMed ID: 17922186
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  • 3
    ISSN: 1432-1181
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Description / Table of Contents: Zusammenfassung Das Einsetzen der Konvektion in einer horizontalen von unten gekühlten Wasserschicht im Temperaturbereich 0°C bis 20°C wird analytisch und experimentell untersucht. Die, für verschiedene Randbedingungen an den beiden Begrenzungsflächen, berechneten Stabilitätsgrenzen werden durch drei Parameter, die Rayleigh-Zahl Ra, die Nichtlinearitat N und die Biot-Zahl Bi vollstandig beschrieben. Die Nichtlinearitat N ist ein Maß für die Abweichung des tatsachlichen Dichteverlaufs von einem der Temperatur proportionalen Dichteverlauf, wie er beim klassischen “Bénard-Problem” vorliegt. Die experimentellen Ergebnisse stimmen mit den berechneten Werten sehr gut überein.
    Notes: Abstract The onset of convection was analytically and experimentally investigated for a horizontal water layer cooled from below. The water temperature varied from 0°C to 20°C. The neutral stability curves, predicted for different boundary conditions, are described by three parameters, the Rayleigh-Number Ra, the Nonlinearity N and the Biot-Number Bi. The Nonlinearity N considers the deviation of the real density-distribution from a linear distribution, the case of the well known Benard-problem. The experimental results are in good agreement with the predicted values.
    Type of Medium: Electronic Resource
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