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  • 1
    Keywords: Medicine ; Neurosciences ; Neurology ; Psychiatry ; Neurobiology ; Biomedicine ; Neurosciences ; Neurology ; Psychiatry ; Neurobiology ; Springer eBooks
    Description / Table of Contents: PART I A NEW CONCEPT OF NEURODEGENERATION IN BIOLOGY AND PATHOPHYSIOLOGY -- 1 Conformational disease and RNA disease theory in the context of neurodegenerative diseases -- 2 Brain-peripheral organ communication -- 3 The brain-immune network in spinal cord injury -- PART II CHANGES IN CLINICAL EVALUATION AND NEW BIOMARKERS -- 4 Renovation of clinical evaluation and new biomarkers -- 5 Clinical Systems Neuroscience -- PART III RISK FACTORS IN NEURODEGENERATION -- 6 Genetic risk factors for neurodegenerative diseases -- 7 Intermediate phenotypes approach for neuropsychiatric disorders -- PART IV FUTURE DIRECTIONS FOR THERAPY -- 8 Significance of mechanism-oriented research toward neuronal protection therapy against neurodegenerative disorders ~ ZNRF1 E3 ubiquitin ligase as a critical mediator for Wallerian degeneration and neuronal apoptosis -- 9 Drug development for neurodegenerative diseases -- 10 Physical therapy and rehabilitation in patients with degenerative cerebellar diseases: current evidence and future direction -- 11 Home- and Community-based medical care for neurodegenerative diseases -ALS as an illustration- -- PART V HEALTH PROMOTION: PREVENTION AND QUALITY OF LIFE -- 12 Information Environment and Brain Function: A New Concept of the Environment for the Brain -- 13 Social Implementation of Neurodegenerative Disease Research and Neuroethics.-
    Abstract: This book sheds new light on neurodegenerative disorders as systemic diseases. Classically, neuronal cell death was a hallmark of such disorders. However, it has become evident that neural dysfunction is more important in the pathophysiology of neurodegenerative disorders. More recently, the prionoid-spreading hypothesis of disease-causing molecules has attracted a great deal of attention. Therapeutic strategies thus must be reconsidered in the light that neurodegenerative disorders are indeed systemic diseases. The first part of this book introduces the concept of neurodegeneration in biology and pathophysiology. The second part focuses on clinical evaluation and biomarkers from the perspective of this new concept, while the third summarizes the risk factors of neurodegeneration. The fourth part of this work indicates future directions of treatment, and the final part discusses health promotion for prevention and quality of life. This book will be of interest to both researchers and medical personnel, and provides a fresh approach to neurodegenerative diseases, paving the way to new research and improved quality of health care for patients
    Pages: VIII, 304 p. 34 illus., 19 illus. in color. : online resource.
    Edition: 1st ed. 2015.
    ISBN: 9784431545415
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  • 2
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Hereditary ceruloplasmin deficiency with hemosiderosis (aceruloplasminemia) is a new disease characterized by systemic hemosiderosis, diabetes mellitus, neurological abnormalities and pigment degeneration of the retina. Loss of the ferroxidase activity of ceruloplasmin results in systemic iron deposition and tissue damage. Neuroimaging studies reveal iron deposition in basal ganglia and in the red and dentate nuclei. Cerebellar ataxia, extrapyramidal signs and dementia develop after middle age. We report a patient with undetectable serum ceruloplasmin levels and the above clinical manifestations. Sequence analysis of the cDNA of ceruloplasmin from this patient revealed an insertion of adenine in exon 3; this produced a premature stop codon.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Mammalian bombesin-like peptides are widely distributed in the central nervous system as well as in the gastrointestinal tract, where they modulate smooth-muscle contraction, exocrine and endocrine processes, metabolism and behaviour. They bind to G-protein-coupled receptors on the cell surface ...
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 63 (1993), S. 379-381 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A few-atomic-layer deposition of InP-related compounds on a GaAs surface greatly improves the surface properties. Tenfold enhancement in the photoluminescence intensity is observed at the GaAs band edge, which indicates a reduction in the surface recombination. Relaxation of the surface pinning, which results in photoluminescence intensity enhancement, is observed by x-ray photoelectron spectroscopy. Based on the results, we propose a novel concept of surface passivation by atomic-layer deposition, where the surface band structure of GaAs is modulated by the ultrathin strained layer.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Advanced Materials 5 (1993), S. 212-214 
    ISSN: 0935-9648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Hereditary ceruloplasmin deficiency with hemosiderosis (aceruloplasminemia) is a new disease characterized by systemic hemosiderosis, diabetes mellitus, neurological abnormalities and pigment degeneration of the retina. Loss of the ferroxidase activity of ceruloplasmin results in systemic iron deposition and tissue damage. Neuroimaging studies reveal iron deposition in basal ganglia and in the red and dentate nuclei. Cerebellar ataxia, extrapyramidal signs and dementia develop after middle age. We report a patient with undetectable serum ceruloplasmin levels and the above clinical manifestations. Sequence analysis of the cDNA of ceruloplasmin from this patient revealed an insertion of adenine in exon 3; this produced a premature stop codon.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1573-4943
    Keywords: Catalytic antibody ; abzyme ; sequence determination ; prediction of 3D structure ; chemical modification
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Monoclonal antibodies catalyzing the hydrolysis of p-nitrophenyl alkyl carbonate were obtained using p-nitrophenyl phosphonate as hapten. One of the antibodies, 4A1, has a relatively high activity for the substrate having a bulky group. To determine the amino acid residues related to the binding of the bulky group, we determined the amino acid sequences of VL and VH regions of 4A1 by the cycle sequencing method, built the three-dimensional structure of the V regions, labeled 4A1 with [14C]phenyl glyoxal in the presence and absence of I-1 or I-13, and analyzed the labeled incubation mixture with SDS–PAGE. From these results, the possibility that Arg-H28 of the heavy chain is involved in binding the bulky group of the substrate is discussed.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1573-2568
    Keywords: Peutz-Jeghers syndrome ; gallbladder polyp ; gallbladder carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Peutz-Jeghers syndrome is a genetic condition characterized by mucocutaneous pigmentation and gastrointestinal polyposis. A variety of neoplasms have been found in the alimentary tract or else-where in patients with this entity. A 39-year-old female patient who had carcinoma and two polyps in the gallbladder in association with Peutz-Jeghers syndrome is described. Since the polyps consisted of the normal lining epithelium of the gallbladder and pseudopyloric gland-type metaplastic cells and obviously lacked cellular atypism, the authors would consider them hamartomatous. The carcinoma partly showing submucosal invasion existed in an area other than the polyps. This is the first documented case of the syndrome having gallbladder carcinoma.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1435-5922
    Keywords: Key words: rectal carcinoid ; Peutz-Jeghers syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: A 16-year-old man who had been diagnosed with the Peutz-Jeghers syndrome at the age of 8 years presented with crampy abdominal pain. Thorough examinations revealed a large jejunal polyp causing intussusception, as well as multiple polyps in the small and large intestines. Preoperative proctoscopy demonstrated the coexistence of a submucosal tumor in the rectum. Proctoscopic mucosal resection was performed and histological and immunohistochemical examinations led to a diagnosis of carcinoid tumor. Additional transanal resection of the rectal wall showed no residual tumor and the patient has been well for 2 years to date. Although malignant tumors are increasingly reported in association with the Peutz-Jeghers syndrome, to our knowledge, there have been no previous reports of such an association in the English-language and Japanese literature.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 61 (1992), S. 2993-2995 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: This letter describes the suppression of (NH4)2S-treated GaAs surface degradation by coating the treated surface with an evaporated As2S3 film. The photoluminescence intensity of the treated GaAs surface shows no decrease even after 100 days. The properties of the As2S3/GaAs interface were also evaluated by metal-insulator-semiconductor techniques. A small hysteresis capacitance-voltage curve with reduced frequency dispersion was obtained, which indicates low interface state density. The passivation of the (NH4)2S-treated surface by coating with an As2S3 film is very promising for GaAs surface electronic property improvements.
    Type of Medium: Electronic Resource
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