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  • 1
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    Dordrecht : Springer Netherlands
    Keywords: Medicine ; Oncology ; Medical genetics ; Neurosciences ; Nanotechnology ; Biomedicine ; Molecular Medicine ; Gene Function ; Cancer Research ; Neurosciences ; Nanotechnology ; Springer eBooks
    ISBN: 9789400730274
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  • 2
    Keywords: Medicine ; Complementary medicine ; Health Promotion ; Medical Education ; Health ; Biomedicine ; Biomedicine general ; Health Promotion and Disease Prevention ; Popular Science in Medicine and Health ; Medical Education ; Complementary & Alternative Medicine ; Springer eBooks
    Description / Table of Contents: PART I Ashwagandha - Phytogenomics and Pharmacology -- Phytochemical Genomics of Ashwagandha -- Phyto-pharmacology of Ashwagandha as An Anti-Diabetic Herb -- Allium cepa Root Chromosomal Aberration Assay: An Application in Assessing Anti-genotoxic Potential of Ashwagandha -- Withania somnifera: From Traditional Use to Evidence Based Medicinal Prominence -- Withanolides: A Prospective Drug for Infectious and Tropical Diseases -- Withania somnifera Extract/Withaferin A As A Prospective Anti-pigmenting Agent -- PART II Ashwagandha for Cancer -- Ashwagandha Bioactives for Cancer Treatment: Experimental Evidence and Their Mechanism(s) of Action -- Scientific Evidence for Anticancer Effects of Withania somnifera And its Primary Bioactive Component Withaferin A -- Withaferin A for Cancer Treatment: Experimental Evidence for its Effect on Telomerase Plus and Minus Cancer Cells -- Withania somnifera Has Potential to Treat Cancer -- The Effects of Withaferin A on Normal And Malignant Immune Cells -- Ashwagandha for Cancer Metastasis: Bioactives and Basics of their Function -- Computational Methods to Understand The Anticancer Mechanism of Withanolides -- PART III Ashwagandha for Brain -- Ashwagandha for Brain Health: Experimental Evidence to its Neuroregenerative Activities -- Cellular and Molecular Targets Underpinning Memory Enhancement by Ashwagandha -- Using Human Neural Stem Cells as A Model to Understand The Science of Ashwagandha -- The Potential Utility of Ashwagandha for Improving Cognitive Dysfunction in Persons with Bipolar or Other Neurocognitive Disorders -- Neuroprotective Potential of Withania somnifera (Ashwagandha) in Neurological Conditions -- Potential Therapeutic Use of Withania somnifera for Treatment of Amyotrophic Lateral Sclerosis -- Neuromodulatory Role of Withania somnifera -- Therapeutic Effects of Ashwagandha in Brain Aging and Clock Disfunction -- PART IV Active Ingredient Enriched Ashwagandha - Biotechnologies -- Biotechnological Approaches in Propagation And Improvement of Withania somnifera (L.) Dunal -- Plant Tissue Culture Based Strategies for Production of Withanolides -- Establishment of Hydroponic Cultivation of Ashwagandha for Active Ingredient Enriched Leaves
    Abstract: Rapidly increasing aging population and environmental stressors are the two main global concerns of increasing incidence of a variety of pathologies in the modern society. The complex etiologies and pathologies cause major challenges to disease treatment. On the other hand, several herbs are known for their health-caring and disease-curing activities. Ashwagandha, a popular herb in Indian traditional home medicine, Ayurveda, has gathered increasing recognition in recent years when the chemically synthesized drugs for single target therapies showed limited success and adverse toxic effects. Ashwagandha is known as a powerful adaptogen and trusted to enhance function of the brain, reproductive system, cell-mediated immunity and increase the body's defense against disease, and possess anti-inflammatory, anticancer and anti-arthritic activities. In this book, for the first time, we provide a complete portrait on scientific understanding of the effects of Ashwagandha and its active principles for a variety of preventive and therapeutic activities
    Pages: XX, 508 p. 102 illus., 76 illus. in color. : online resource.
    ISBN: 9783319591926
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  • 3
    ISSN: 1574-4647
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two antioxidative enzymes, catalase and peroxidase, were studied in banana fruit flies fed on cornmeal agar media (CMA) as well as ascorbic acid (0.05 M) supplemented CMA. Females of Zaprionus paravittiger recorded higher enzyme activity as compared to males, and ascorbic acid feeding resulted in increased activity of both the enzymes in each sex.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1574-4647
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The median and maximum life spans of the drosophilid insect Zaprionus paravittiger reared on corn meal agar medium at 26±2°C were 35 and 70 days for males and 40 and 77 days for females, respectively. The addition of different concentrations of an antioxidant, sodium hypophosphite (SHP), in the diet resulted in increased median and maximum life spans of both the sexes: maximum by 21.7% and 34.2% in males and by 27.5% and 27.2% in females, respectively. DNA and RNA contents were found to decrease in normal as well as SHP fed insects, but the rate of decline was significantly lower in the latter. The results suggest that the damaging effect of free radicals is diminished by the antioxidizing property of SHP, thus supporting the free radical theory of aging.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Biogerontology 1 (2000), S. 103-121 
    ISSN: 1573-6768
    Keywords: human ; immortalization ; senescence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Following a limited number of population doublings(PD), human diploid somatic cells enter the terminalproliferation arrest state of senescence. This is anintrinsic mechanism which involves p53- andpRB/p16INK4-mediated pathways. The mostpopular candidate for the counting mechanism whichmeasures the age of a cell in PD is telomereshortening. Recent studies have shown that senescencecan also be induced independently of a PD levelby various factors; this premature senescence alsoappears to involve the activity of p53 and/orp16INK4. Immortalization of cells requiresabrogation of p53 and pRB-mediated terminalproliferation arrest and/or activation of a telomeremaintenance mechanism. The central role of telomeresin human cell senescence and immortalization hasreceived much attention; however there is evidencethat senescence can occur independently of telomerelength and that genes that are not necessarily involved in telomere maintenance are involved in immortalization.
    Type of Medium: Electronic Resource
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