Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    facet.materialart.
    Unknown
    German Medical Science GMS Publishing House; Düsseldorf
    In:  3. Wissenschaftlicher Kongress der Deutschen Gesellschaft für Essstörungen; 20120223-20120225; Hannover; DOC12dgess089 /20120208/
    Publication Date: 2012-02-21
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    Keywords: RECEPTOR ; APOPTOSIS ; CANCER ; proliferation ; CELL-PROLIFERATION ; Germany ; DISEASE ; RISK ; SITE ; GENE ; GENES ; PROTEIN ; transcription ; DIFFERENTIATION ; GENETIC POLYMORPHISMS ; BINDING ; ASSOCIATION ; FREQUENCY ; polymorphism ; POLYMORPHISMS ; SUSCEPTIBILITY GENES ; BREAST ; breast cancer ; BREAST-CANCER ; PROMOTER ; AGE ; BRCA1 ; WOMEN ; PROSTATE-CANCER ; cancer risk ; LENGTH ; CARRIERS ; SERIES ; BINDING PROTEIN ; BINDING-PROTEIN ; case-control study ; RE ; VARIANT ; FACTOR-BINDING PROTEIN-3 ; interaction ; cell proliferation ; GROWTH-FACTOR-I ; ALLELES ; CARRIER ; IGFBP3 ; SERUM-LEVELS ; IGF-1 ; SEQUENCE REPEAT
    Abstract: Binding of IGF-1 to the type I IGF receptor starts a signalling cascade that plays an important role in regulating cell proliferation, differentiation and apoptosis. The interaction between the IGF-1 and its receptor is mainly regulated by a binding protein, IGFBP3. We studied a CA repeat polymorphism 969 bp upstream of the transcription start site in the IGF-1 gene and an A-202C polymorphism in the IGFBP3 gene and tested their association with breast cancer risk using four case-control series with a total of 787 cases and 900 controls. We did not find any association between the breast cancer risk and the IGF-1 repeat length (19 versus non-19) or the IGFBP3 A-202C polymorphism in the postmenopausal breast cancer series or in women diagnosed for breast cancer under the age of 50. In the familial breast cancer series we observed a non-significantly increased odds-ratio (OR) in homozygotes for the non-19 alleles of the IGF-1 gene (OR 1.51, 95% CI 0.96-2.39, p=0.07). Similarly, in the familial breast cancer series we detected an increased frequency of the IGFBP3 -202C allele carriers (OR 1.50, 95% CI 1.05-2.14, p=0.03). The association was stronger in individuals homozygous for these alleles (OR 3.76, 95% CI 1.44-9.81, p=0.006). Thus, the polymorphisms in the IGF-1 and IGFBP3 genes associated with an increased risk of breast cancer in familial cases carrying the variant alleles
    Type of Publication: Journal article published
    PubMed ID: 15986122
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    Keywords: AGE, APOPTOSIS, ASSOCIATION, BINDING, BINDING PROTEIN-3, BREAST, breast cancer, BREAST-CANCER, CANCE
    Abstract: The regulation of growth hormone 1 (GH1) and insulin-like-growth factor-1 (IGF-1) release is under the influence of three pituitary hormones [growth hormone releasing hormone (GHRH), ghrelin (GHRL) and somatostatin (SST)], which act in an autocrine/paracrine fashion in the breast. By binding to their respective receptors, they control cell proliferation, differentiation and apoptosis in a GH1/IGF-1-dependent manner. We investigated single nucleotide polymorphisms (SNPs) in the GHRH, GHRHR, GHRL, GHSR, SST and SSTR2 gene regions in a Polish and a German cohort of 798 breast cancer cases and 1011 controls. Our study revealed an association of a novel TC repeat polymorphism in the SST promoter with a decreased breast cancer risk in the Polish study population [odds ratio (OR), 0.65; 95% confidence interval (CI), 0.44-0.96]. The closely linked SNP IVS1 A+46G showed the same trend. For both polymorphisms the association was stronger in women above the age of 50 (OR, 0.33; 95% CI, 0.14-0.76 and OR, 0.39; 95% CI, 0.18-0.87, respectively). The protective effect of these polymorphisms was confirmed in a haplotype analysis among women above 50 years of age and carrying the two variant alleles (OR, 0.37; 95% CI, 0.17-0.80). In the independent German population, we observed slightly decreased ORs among women above the age of 50 years. In the SSTR2 gene, carriers of the promoter 21/21 TG repeat genotype were at a decreased breast cancer risk (OR, 0.62; 95% CI, 0.41-0.94) compared to carriers of the other genotypes in the Polish population. Furthermore, we identified a protective effect of the GHRHR C-261T SNP in both populations (joint analysis CT+TT versus CC: OR, 0.80; 95% CI, 0.65-0.99). This effect was carried by a haplotype containing the protective allele. Thus, our study concludes a possible protective influence of distinct polymorphisms in genes involved in GH1 release on breast cancer risk
    Type of Publication: Journal article published
    PubMed ID: 16606630
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    Keywords: RECEPTOR ; APOPTOSIS ; CANCER ; GROWTH ; GROWTH-FACTOR ; proliferation ; CELL ; CELL-PROLIFERATION ; Germany ; PATHWAY ; RISK ; SITE ; GENE ; GENES ; PROTEIN ; PROTEINS ; transcription ; DIFFERENTIATION ; SERA ; BINDING ; ASSOCIATION ; LINKAGE ; polymorphism ; POLYMORPHISMS ; BREAST-CANCER ; NO ; SNP ; colorectal cancer ; COLORECTAL-CANCER ; PROSTATE-CANCER ; REGION ; REGIONS ; LINKAGE DISEQUILIBRIUM ; case-control studies ; BINDS ; BINDING PROTEIN ; insulin ; CELL-GROWTH ; signaling ; SERUM ; SINGLE ; ONCOLOGY ; BINDING-PROTEIN ; case control study ; case-control study ; RE ; SNPs ; cell proliferation ; PROMOTER POLYMORPHISM ; GROWTH-FACTOR-I ; LEVEL ; case control studies ; methods ; HAPLOTYPE ; HAPLOTYPES ; single-nucleotide ; IGFBP3 ; SERUM-LEVELS ; HAPLOTYPE RECONSTRUCTION ; CIRCULATING LEVELS ; ENGLAND ; IGFBP-3 ; MULTIETHNIC COHORT ; colorectal ; case control ; UPSTREAM ; REPEAT ; IGF1 ; CASCADE ; GENETIC-VARIATION ; IGF ; INSULIN-LIKE ; cell growth ; BONE-MINERAL DENSITY ; INSULIN-LIKE-GROWTH-FACTOR-1
    Abstract: Background: The insulin-like growth factor1 (IGF1) pathway plays a significant role in both the normal and malignant cell growth. IGF1 binds to the IGF1 receptor and starts a signaling cascade that regulates cell proliferation, differentiation, and apoptosis. The bioavailability of IGF1 is regulated by the binding protein IGFBP3. A CA repeat polymorphism, in the IGF1 gene, which is located 969 bp upstream from the transcription start site and the rs2854744 and rs2854746 single nucleotide polyrnorphisms (SNPs) in the IGFBP3 gene have been associated with the serum levels of the respective proteins and colorectal cancer (CRC), but the results are inconsistent. We wanted to study if these polymorphisms or any haplotypes of the IGF1 and the IGFBP3 genes are associated with CRC. Methods: High linkage disequilibrium was seen in these gene regions. Therefore, the CA repeat along with two SNPs in the IGF1 gene, and rs2854744 (A-202C), rs2854746 (Ala32Gly) and two additional SNPs in the IGFBP3 gene were selected to cover the whole gene regions. A case-control study was carried out using 661 German CRC cases and 607 matched controls. Results: We did not find any association between the CA repeat length or any of the SNPs in the IGF1 and the IGFBP3 genes and the risk of CRC. Nor did the haplotypes of these genes affect the risk of CRC. Conclusion: Our study suggests no major role of the assessed genetic variation within the IGF1 and the IGFBP3 genes in CRC risk. (c) 2007 International Society for Preventive Oncology. Published by Elsevier Ltd. All rights reserved
    Type of Publication: Journal article published
    PubMed ID: 18031946
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    Keywords: APOPTOSIS ; CANCER ; Germany ; NEW-YORK ; POPULATION ; RISK ; GENE ; ASSOCIATION ; polymorphism ; SUSCEPTIBILITY ; BREAST ; breast cancer ; BREAST-CANCER ; DELETION ; NO ; PROMOTER ; REDUCED RISK ; cancer risk ; REGION ; case-control studies ; ONCOLOGY ; case-control study ; RE ; VARIANT ; PROMOTER POLYMORPHISM ; USA ; caspases ; PROMOTER REGION ; CANCER-RISK ; COMMON VARIANT ; breast cancer risk ; Sp1 binding site ; CASP8-652 6N del
    Abstract: A recent study on an Asian population reported a six-nucleotide insertion-deletion polymorphism (-652 6N del) in the CASP8 promoter region to be strongly associated with a decreased risk of multiple types of cancer, including breast cancer (BC). Here, we investigate the effect of this deletion in four independent large European BC case-control studies, including data from a total of 7,753 cases and 7,921 controls. The combined per allele odds ratio (OR) was 0.97 (95% confidence interval (CI), 95% CI = 0.93-1.02). The present result indicates that the CASP8 -652 6N del variant has no significant effect on BC risk in Europeans
    Type of Publication: Journal article published
    PubMed ID: 17891485
    Signatur Availability
    BibTip Others were also interested in ...
  • 6
    Keywords: adaptation, ADRENAL AXIS, ADULT, ADULT-RATS, AGE, ANXIETY, BEHAVIOR, brain, CHRONIC SOCIAL STRESS, C
    Abstract: A tight regulation of hypothalamic-pituitary-adrenal (HPA) axis activity is essential for successful adaptation to stressful stimuli. Disruption of normal HPA axis development is a main risk factor for diseases such as posttraumatic stress disorder or depression, but the molecular mechanisms that lead to these long-term consequences are poorly understood. Here, we test the hypothesis that the pituitary glucocorticoid receptor (GR) is involved in regulating HPA axis function in neonatal and adult animals. Furthermore, we investigate whether postnatal hypercortisolism induced by pituitary GR deficiency is a main factor contributing to the persistent effects of early-life stress. Conditional knockout mice with a deletion of the GR at the pituitary (GR(POMCCre)) show excessive basal corticosterone levels during postnatal development, but not in adulthood. The hypercortisolemic state of neonatal GR(POMCCre) mice is accompanied by central gene expression changes of CRH and vasopressin in the paraventricular nucleus, but these alterations normalize at later ages. In adult mice, pituitary GR deficiency results in impaired glucocorticoid negative feedback. Furthermore, adult GR(POMCCre) mice display a more active coping strategy in the forced swim test, with no alterations in anxiety like behavior or cognitive functions. Postnatal GR antagonist treatment is able to prevent the long-term behavioral effects in GR(POMCCre) mice. In conclusion, we show that pituitary GRs are centrally involved in regulating HPA axis activity in neonates and mediate negative feedback regulation in adult animals. Postnatal glucocorticoid excess results in an altered stress-coping behavior in adult animals, with no effects on anxiety like behavior or cognition. (Endocrinology 150: 2709-2716, 2009)
    Type of Publication: Journal article published
    PubMed ID: 19213843
    Signatur Availability
    BibTip Others were also interested in ...
  • 7
    facet.materialart.
    Unknown
    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Current Posters in Otorhinolaryngology - Head and Neck Surgery; VOL: 10; DOC148 /20140519/
    Publication Date: 2014-05-20
    Description: Einleitung: In den letzten Jahren werden zur operativen Planung bei obstruktiver Schlafapnoe (OSA) medikamentös induzierte Schlafendoskopien durchgeführt. Im Rahmen dieser Studie sollte geklärt werden, ob die Sedierungstiefe einen Einfluss auf den Grad der Obstruktion und auf das Auftreten verschiedener Obstruktionsmuster der oberen Atemwege hat.Methoden: Eingeschlossen wurden OSA-Patienten mit CPAP-Intoleranz. Im Rahmen des Münchner Schlafvideoendoskopie-Protokolls wurde eine Propofol-Sedierung mittels eines Target-Controlled-Infusion-Systems durchgeführt. Die Sedierungstiefe der Patienten wurde über eine State-Entropie-Messung beurteilt. Der Grad der Obstruktionen wurde anhand der VOTE-Klassifikation auf Velum-, Zungengrund und Epiglottisebene während einer leichten und tiefen Sezierung bestimmt und der Effekt des Esmarch-Manövers dokumentiert.Ergebnisse: Durch eine Vertiefung der Sedierung konnte keine signifikante Änderung des Obstruktionsgrades und Obstruktionsmusters beobachtet werden.Schlussfolgerung: Mit zunehmender Sedierungstiefe und damit verbundener erhöhter Propofolkonzentration ist es zu keiner wesentlichen Änderung des Obstruktionsmusters gekommen. Lediglich zwischen leichter und mittlerer Sedierungstiefe sah man, dass es zu weiteren Obstruktionsorten auf anderen Ebenen (von kranial nach kaudal) kam und dass sich auf Velumebene ein anteriorer-posterior Kollaps in einen konzentrischen Kollaps wandelte. Zwischen mittlerer und tiefer Sedierungstiefe änderte sich der Obstruktionsort und das Obstruktionsmuster nicht.Der Erstautor gibt keinen Interessenkonflikt an.
    Keywords: ddc: 610
    Language: German
    Type: article
    Signatur Availability
    BibTip Others were also interested in ...
  • 8
    facet.materialart.
    Unknown
    German Medical Science GMS Publishing House; Düsseldorf
    In:  16. Deutscher Kongress für Versorgungsforschung (DKVF); 20171004-20171006; Berlin; DOCP057 /20170926/
    Publication Date: 2017-09-26
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
    Signatur Availability
    BibTip Others were also interested in ...
  • 9
    facet.materialart.
    Unknown
    German Medical Science GMS Publishing House; Düsseldorf
    In:  65. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC); 20140511-20140514; Dresden; DOCMI.16.04 /20140513/
    Publication Date: 2014-05-14
    Keywords: amygdalohippocampectomy ; transsylvian approach ; mesiotemporal epilepsy ; ddc: 610
    Language: English
    Type: conferenceObject
    Signatur Availability
    BibTip Others were also interested in ...
  • 10
    facet.materialart.
    Unknown
    German Medical Science GMS Publishing House; Düsseldorf
    In:  85. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie; 20140528-20140601; Dortmund; DOC14hnod663 /20140414/
    Publication Date: 2014-04-15
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...