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  • 1
    Keywords: Life sciences ; Human Genetics ; Psychiatry ; Systems Biology ; Life sciences ; Systems Biology ; Human Genetics ; Psychiatry ; Springer eBooks
    Description / Table of Contents: Consciousness, Crosstalk, and the Mereological Fallacy -- A Cognitive Paradigm for Gene Expression -- Western Atomism and its Culture-Bound Syndromes -- Environmental Induction of Neurodevelopmental Disorders -- Sleep, Psychopathology and Culture -- Embodied cognition and its disorders -- Tools for the Future: Hidden Symmetries -- Psychopathologies of automata I: autonomous vehicle systems -- Psychopathologies of automata II: autonomous weapons and centaur systems -- The dynamics of environmental insult -- Social psychopathology: military doctrine and the madness of crowds -- Mathematical Appendix -- Index
    Abstract: This book explores mental disorders from a uniquely evolutionary perspective. Although there have been many attempts to mathematically model neural processes and, to some extent, their dysfunction, there is very little literature that models mental function within a sociocultural, socioeconomic, and environmental context. Addressing this gap in the extant literature, this book explores essential aspects of mental disorders, recognizing the ubiquitous role played by the exaptation of crosstalk between cognitive modules at many different scales and levels of organization, the missing heritability of complex diseases, and cultural epigenetics. Further, it introduces readers to valuable control theory tools that permit the exploration of the environmental induction of neurodevelopmental disorders, as well as the study of the synergism between culture, psychopathology and sleep disorders, offering a distinctively unique resource
    Pages: XII, 236 p. 31 illus. : online resource.
    ISBN: 9783319539102
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  • 2
    Keywords: Medicine ; Human Genetics ; Public Health ; Epidemiology ; Bioinformatics ; Biochemistry ; Biomedicine ; Human Genetics ; Epidemiology ; Biochemistry, general ; Computational Biology/Bioinformatics ; Public Health ; Springer eBooks
    Description / Table of Contents: Introduction -- 1. Toward new tools -- 2. Models of development -- 3. Groupoid symmetries -- 4. Epigenetic catalysis -- 5. Developmental disorders -- 6. An interim perspective -- 7. The obesity pandemic in the US -- 8. Coronary heart disease in the US. - 9. Cancer: a developmental perspective -- 10. Autoimmune disorders -- 11. Demoralization and obesity in Upper Manhattan -- 12. Death at an early age: AIDS and related mortality in New York City -- 13. Mental Disorders I: Western atomism and its culture-bound syndromes -- 14. Mental Disorders II: Psychopathology and sleep -- 15. Diabetes and Thyroid Cancer in Manhattan's Chinatown -- 16. Right-To-Work Laws and Alzheimer's Disease -- 17. Stress as an Environmental Exposure -- 18. Final Thoughts -- 19. Mathematical Appendix
    Abstract: This book describes how epigenetic context, in a large sense, affects gene expression and the development of an organism, using the asymptotic limit theorems of information theory to construct statistical models useful in data analysis. The approach allows deep understanding of how embedding context affects development. We find that epigenetic information sources act as tunable catalysts, directing ontogeny into characteristic pathways, a perspective having important implications for epigenetic epidemiology. In sum, environmental stressors can induce a broad spectrum of developmental dysfunctions, and the book explores a number of pandemic chronic diseases, using U.S. data at different scales and levels of organization. In particular, we find the legacy of slavery has been grossly compounded by accelerating industrial decline and urban decay. Individual chapters are dedicated to obesity and its sequelae, coronary heart disease, cancer, mental disorders, autoimmune dysfunction, Alzheimer’s disease, and other conditions. Developmental disorders are driven by environmental factors channeled by historical trajectory and are unlikely to respond to medical interventions at the population level in the face of persistent individual and community stress. Drugs powerful enough to affect deleterious epigenetic programming will likely have side effects leading to shortened lifespan. Addressing chronic conditions and developmental disorders requires significant large-scale changes in public policy and resource allocation
    Pages: XIII, 344 p. 52 illus. : online resource.
    Edition: 2nd ed. 2017.
    ISBN: 9783319480787
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  • 3
    Keywords: Medicine ; Human Genetics ; Public Health ; Epidemiology ; Bioinformatics ; Biomedicine ; Human Genetics ; Computational Biology/Bioinformatics ; Public Health/Gesundheitswesen ; Epidemiology ; Springer eBooks
    Pages: : digital
    ISBN: 9781441914828
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  • 4
    ISSN: 1432-1246
    Keywords: Fire-fighter retirements ; Fire-fighter work load ; New York City fire crisis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Reductions in the fire service in New York City from 1972 to 1976 appear to have caused a disproportionate increase in fire-fighter work load through several unexpected mechanisms of fire contagion. In turn, the work load increase has itself had a disproportionate physiologic impact: A classic dose-response relation has been observed between a composite measure of per capita structural fire work load and the percentage of the fire-fighting work force retiring under conditions of disability. After 1974, the increase in work load seems to have caused entry to the ‘linear’ portion of the dose-response curve. Implications of this synergism are explored for both New York City and other American urban areas now suffering ‘fiscal crises’ or planning fire service reductions.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Human ecology 6 (1978), S. 423-433 
    ISSN: 1572-9915
    Keywords: structural fires ; Rand fire-service models ; South Bronx ; fire-service efficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Energy, Environment Protection, Nuclear Power Engineering , Ethnic Sciences
    Notes: Abstract The recent proliferation of structural fires in New York City is analyzed from an ecological viewpoint. Fireservice cutbacks recommended by the Rand Corporation and largely implemented before the city's “fiscal crisis” are found to have markedly increased the annual number of structural fires.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Human ecology 9 (1981), S. 433-464 
    ISSN: 1572-9915
    Keywords: fire epidemic ; South Bronx ; fire-service efficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Energy, Environment Protection, Nuclear Power Engineering , Ethnic Sciences
    Notes: Abstract Empirical measures of fire-service quality and efficiency are examined for New York City in the period 1968–1979. Marked decreases in the ability to control and contain structural fires are found to result from a program of fire-service reductions begun in 1972. Exacerbated by the New York City “fiscal crisis” of 1975, decreases in fire-service efficiency since 1972 appear to have initiated a geographically spreading and apparently recurrent fire epidemic. The decreases have accelerated since 1976, implying that recurring epidemic episodes could be more severe than the 1974–1977 crisis, which destroyed large areas in some neighborhoods of the city, including the South Bronx, Bushwick, Brownsville, East New York, East Harlem, and others. The results of an extensive data analysis are contrasted with the methods and conclusions of a widely circulated study entitled Setting Municipal Priorities 1981.
    Type of Medium: Electronic Resource
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