Life and Medical Sciences
Cell & Developmental Biology
Wiley InterScience Backfile Collection 1832-2000
Chemistry and Pharmacology
Histopathology, morphometry, tritiated thymidin incorporation and immunohistochemistry were studied in 221 esophageal biospies from subjects with cytologica hyperplasia in Linxian, China. A spectrum of 7 morphologic entities were found (1) normal/near normal (NN); (2) basal cell hyperplasia 0 (BHO); (3) simple hyperplasia (SH); (4) mixed basal and spinous cell hyperplasia (MBS); (5) basal cell hyperplasia 1 (BH1); (6) dysplasia (D); and (7) non-profilerative lesion (NP). Forty percent of the biospies had combinations of histologic types. The thickness of the epithelium was increased in SH, MBS, and BH1, but not in BHO and NP Elongation of papiallae was frequent seen in SH, MBS, BH1, and D. Papillary bleeding was very prevalent in the esophageal specimens studied. A variety of cellular changes were found in peripapillary areas especially when bleeding occurred. [3H]-thymidine labeling index was dramatically increased in the entire epithelium in dysplasia, and also increased in cell layer 3 of MBS, BH1 and D. Blood group antigen LeY and lectin WGA showed consistent positivity in cellular membranes of the squamous cells, and these changes ocuurred before gross morphologic alterations. These findings provide a hypothesis for the sequences of pathogenetic events leading to esophgeal carcinoma, and define each step with corresponding biomakers for cancer prevention studies. © 1992 Wiley-Liss, Inc.
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